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Tea tree oil

CAS No.:
68647-73-4
Catalog Number:
AG01FG05
Molecular Formula:
Molecular Weight:
Pack Size
Purity
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Product Description
Catalog Number:
AG01FG05
Chemical Name:
Tea tree oil
CAS Number:
68647-73-4
IUPAC Name:
zinc;diheptoxy-sulfanylidene-sulfido-λ5-phosphane
InChI:
InChI=1S/2C14H31O2PS2.Zn/c2*1-3-5-7-9-11-13-15-17(18,19)16-14-12-10-8-6-4-2;/h2*3-14H2,1-2H3,(H,18,19);/q;;+2/p-2
InChI Key:
ZKAQFYDDTYGBBV-UHFFFAOYSA-L
FEMA Number:
3902
Properties
Complexity:
209  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
714.214g/mol
Formal Charge:
0
Heavy Atom Count:
39  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
716.352g/mol
Monoisotopic Mass:
714.214g/mol
Rotatable Bond Count:
28  
Topological Polar Surface Area:
103A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Over-the-counter treatments for acne and rosacea. Seminars in cutaneous medicine and surgery 20160601
Activity of tea tree oil and nerolidol alone or in combination against Pediculus capitis (head lice) and its eggs. Parasitology research 20121101
Efficacy and tolerability of hyaluronic acid, tea tree oil and methyl-sulfonyl-methane in a new gel medical device for treatment of haemorrhoids in a double-blind, placebo-controlled clinical trial. Updates in surgery 20120901
Topically applied Melaleuca alternifolia (tea tree) oil causes direct anti-cancer cytotoxicity in subcutaneous tumour bearing mice. Journal of dermatological science 20120801
Bioactivity of tea tree oil from Melaleuca alternifolia against sheep lice (Bovicola ovis Schrank) in vitro. Veterinary parasitology 20120706
Characterization, antibiofilm, and mechanism of action of novel PEG-stabilized lipid nanoparticles loaded with terpinen-4-ol. Journal of agricultural and food chemistry 20120620
Plant essential oils and mastitis disease: their potential inhibitory effects on pro-inflammatory cytokine production in response to bacteria related inflammation. Natural product communications 20120501
Insecticidal and repellent effects of tea tree (Melaleuca alternifolia) oil against Lucilia cuprina. Veterinary parasitology 20120323
α-Terpinene, an antioxidant in tea tree oil, autoxidizes rapidly to skin allergens on air exposure. Chemical research in toxicology 20120319
Treatment of ocular itching associated with ocular demodicosis by 5% tea tree oil ointment. Cornea 20120101
Tea tree oil as a novel antipsoriasis weapon. Skin pharmacology and physiology 20120101
The essential oil of Melaleuca alternifolia (tea tree oil) and its main component, terpinen-4-ol protect mice from experimental oral candidiasis. Biological & pharmaceutical bulletin 20120101
Ascaridole, a sensitizing component of tea tree oil, patch tested at 1% and 5% in two series of patients. Contact dermatitis 20111001
Clinical and immunological responses in ocular demodecosis. Journal of Korean medical science 20110901
Tea tree oil attenuates experimental contact dermatitis. Archives of dermatological research 20110701
The art and science of new advances in cosmeceuticals. Clinics in plastic surgery 20110701
Effect of trap type, trap position, time of year, and beetle density on captures of the redbay ambrosia beetle (Coleoptera: Curculionidae: Scolytinae). Journal of economic entomology 20110401
Evaluation of double-decker traps for emerald ash borer (Coleoptera: Buprestidae). Journal of economic entomology 20110401
Lavender, tea tree and lemon oils as antimicrobials in washing liquids and soft body balms. International journal of cosmetic science 20110201
Tea tree oil might combat melanoma. Planta medica 20110101
Activity of Melaleuca alternifolia (tea tree) oil on Influenza virus A/PR/8: study on the mechanism of action. Antiviral research 20110101
MRSA colonisation (eradicating colonisation in people without active/invasive infection). BMJ clinical evidence 20110101
An ex vivo, assessor blind, randomised, parallel group, comparative efficacy trial of the ovicidal activity of three pediculicides after a single application--melaleuca oil and lavender oil, eucalyptus oil and lemon tea tree oil, and a 'suffocation' pediculicide. BMC dermatology 20110101
Inhibition of established subcutaneous murine tumour growth with topical Melaleuca alternifolia (tea tree) oil. Cancer chemotherapy and pharmacology 20101101
Evaluation of tea tree oil quality and ascaridole: a deep study by means of chiral and multi heart-cuts multidimensional gas chromatography system coupled to mass spectrometry detection. Journal of chromatography. A 20101008
Comparative study on the antiviral activity of selected monoterpenes derived from essential oils. Phytotherapy research : PTR 20100501
Induction of necrosis and cell cycle arrest in murine cancer cell lines by Melaleuca alternifolia (tea tree) oil and terpinen-4-ol. Cancer chemotherapy and pharmacology 20100401
Synergism and postantibiotic effect of tobramycin and Melaleuca alternifolia (tea tree) oil against Staphylococcus aureus and Escherichia coli. Phytomedicine : international journal of phytotherapy and phytopharmacology 20100401
Analysis of fresh and aged tea tree essential oils by using GCxGC-qMS. Journal of chromatographic science 20100401
The effects of excipients for topical preparations on the human skin permeability of terpinen-4-ol contained in Tea tree oil: infrared spectroscopic investigations. Pharmaceutical development and technology 20100101
Pre-treatment with Aloe vera juice does not enhance the in vitro permeation of ketoprofen across skin. Skin pharmacology and physiology 20100101
Physiological effects and mechanisms of action of endocrine disrupting chemicals that alter estrogen signaling. Hormones (Athens, Greece) 20100101
A randomised, assessor blind, parallel group comparative efficacy trial of three products for the treatment of head lice in children--melaleuca oil and lavender oil, pyrethrins and piperonyl butoxide, and a 'suffocation' product. BMC dermatology 20100101
Antimicrobial activity of lavender, tea tree and lemon oils in cosmetic preservative systems. Journal of applied microbiology 20091201
In vitro antiviral activity of Melaleuca alternifolia essential oil. Letters in applied microbiology 20091201
Antifungal activity of tea tree oil from Melaleuca alternifolia against Trichophyton equinum: an in vivo assay. Phytomedicine : international journal of phytotherapy and phytopharmacology 20091101
Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate? Xenobiotica; the fate of foreign compounds in biological systems 20090901
Growth inhibition of pathogenic bacteria and some yeasts by selected essential oils and survival of L. monocytogenes and C. albicans in apple-carrot juice. Foodborne pathogens and disease 20090401
Formulation study of tea tree oil patches. Natural product communications 20090101
The inhibition of Candida species by selected essential oils and their synergism with amphotericin B. Phytomedicine : international journal of phytotherapy and phytopharmacology 20080801
Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080501
Comparison of the cidal activity of tea tree oil and terpinen-4-ol against clinical bacterial skin isolates and human fibroblast cells. Letters in applied microbiology 20080401
Distribution of nobiletin chitosan-based microemulsions in brain following i.v. injection in mice. International journal of pharmaceutics 20080320
Commentary to the article 'Human skin penetration of the major components of Australian tea tree oil applied in its pure form and as a 20% solution in vitro'. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20080301
A randomized controlled trial of tea tree oil (5%) body wash versus standard body wash to prevent colonization with methicillin-resistant Staphylococcus aureus (MRSA) in critically ill adults: research protocol. BMC infectious diseases 20080101
Prepubertal gynecomastia linked to lavender and tea tree oils. The New England journal of medicine 20070614
In vitro antifungal activity of the tea tree (Melaleuca alternifolia) essential oil and its major components against plant pathogens. Letters in applied microbiology 20070601
Corneal manifestations of ocular demodex infestation. American journal of ophthalmology 20070501
In vitro activity of lysostaphin, mupirocin, and tea tree oil against clinical methicillin-resistant Staphylococcus aureus. Diagnostic microbiology and infectious disease 20070401
The effect of tea tree oil and antifungal agents on a reporter for yeast cell integrity signalling. Yeast (Chichester, England) 20070401
In vitro susceptibility of Madurella mycetomatis, prime agent of Madura foot, to tea tree oil and artemisinin. The Journal of antimicrobial chemotherapy 20070301
Mechanisms involved in the anti-inflammatory action of inhaled tea tree oil in mice. Experimental biology and medicine (Maywood, N.J.) 20070301
Antibacterial effect of tea-tree oil on methicillin-resistant Staphylococcus aureus biofilm formation of the tympanostomy tube: an in vitro study. In vivo (Athens, Greece) 20070101
The vapor activity of oregano, perilla, tea tree, lavender, clove, and geranium oils against a Trichophyton mentagrophytes in a closed box. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20061201
Allergens of new and emerging significance. Dermatology nursing 20061201
In vitro studies on release and human skin permeation of Australian tea tree oil (TTO) from topical formulations. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20061001
In vitro activity of tea-tree oil against clinical skin isolates of meticillin-resistant and -sensitive Staphylococcus aureus and coagulase-negative staphylococci growing planktonically and as biofilms. Journal of medical microbiology 20061001
Susceptibility of pseudomonads to Melaleuca alternifolia (tea tree) oil and components. The Journal of antimicrobial chemotherapy 20060801
Interaction of tea tree oil with model and cellular membranes. Journal of medicinal chemistry 20060727
Stratum corneum absorption and retention of linalool and terpinen-4-ol applied as gel or oily solution in humans. Journal of dermatological science 20060601
Natural oils affect the human skin integrity and the percutaneous penetration of benzoic acid dose-dependently. Basic & clinical pharmacology & toxicology 20060601
Susceptibility to Melaleuca alternifolia (tea tree) oil of yeasts isolated from the mouths of patients with advanced cancer. Oral oncology 20060501
Topical use of tea tree oil reduces the dermal absorption of benzoic acid and methiocarb. Archives of dermatological research 20060301
The effect of German chamomile (Marticaria recutita L.) extract and tea tree (Melaleuca alternifolia L.) oil used as irrigants on removal of smear layer: a scanning electron microscopy study. International endodontic journal 20060301
In vivo activity of terpinen-4-ol, the main bioactive component of Melaleuca alternifolia Cheel (tea tree) oil against azole-susceptible and -resistant human pathogenic Candida species. BMC infectious diseases 20060101
In vitro and in vivo killing of ocular Demodex by tea tree oil. The British journal of ophthalmology 20051101
Method development and validation for the GC-FID assay of p-cymene in tea tree oil formulation. Journal of pharmaceutical and biomedical analysis 20050915
The antimutagenic activity of Lavandula angustifolia (lavender) essential oil in the bacterial reverse mutation assay. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20050901
Pharmacokinetics and pharmacodynamics of injectable testosterone undecanoate in castrated cynomolgus monkeys (Macaca fascicularis) are independent of different oil vehicles. Journal of medical primatology 20050801
A validated HPTLC method for determination of tea tree oil from cosmeceutical formulations. Journal of pharmaceutical and biomedical analysis 20050601
Is tea tree oil effective at eradicating MRSA colonization? A review. British journal of community nursing 20050301
Tea tree oil concentration in follicular casts after topical delivery: determination by high-performance thin layer chromatography using a perfused bovine udder model. Journal of pharmaceutical sciences 20050201
Reduction of nickel-induced contact hypersensitivity reactions by topical tea tree oil in humans. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050101
The effect of essential oils on methicillin-resistant Staphylococcus aureus using a dressing model. Burns : journal of the International Society for Burn Injuries 20041201
Regulation of wheal and flare by tea tree oil: complementary human and rodent studies. The Journal of investigative dermatology 20041001
Tolerance of Pseudomonas aeruginosa to Melaleuca alternifolia (tea tree) oil is associated with the outer membrane and energy-dependent cellular processes. The Journal of antimicrobial chemotherapy 20040801
Anti-inflammatory effects of Melaleuca alternifolia essential oil on human polymorphonuclear neutrophils and monocytes. Free radical research 20040801
Antifungal effects of Melaleuca alternifolia (tea tree) oil and its components on Candida albicans, Candida glabrata and Saccharomyces cerevisiae. The Journal of antimicrobial chemotherapy 20040601
The effects of a tea tree oil-containing gel on plaque and chronic gingivitis. Australian dental journal 20040601
Evaluation of antioxidant activity of Australian tea tree (Melaleuca alternifolia) oil and its components. Journal of agricultural and food chemistry 20040519
Acaricidal activity of Melaleuca alternifolia (tea tree) oil: in vitro sensitivity of sarcoptes scabiei var hominis to terpinen-4-ol. Archives of dermatology 20040501
A randomized, controlled trial of tea tree topical preparations versus a standard topical regimen for the clearance of MRSA colonization. The Journal of hospital infection 20040401
Inhibition of acetylcholinesterase by Tea Tree oil. The Journal of pharmacy and pharmacology 20040301
Terpinen-4-ol, the main component of Melaleuca alternifolia (tea tree) oil inhibits the in vitro growth of human melanoma cells. The Journal of investigative dermatology 20040201
Compound tincture of benzoin: a common contact allergen? The Australasian journal of dermatology 20030801
[Sensitization to tea tree oil in Germany and Austria. A multicenter study of the German Contact Dermatitis Group]. Journal der Deutschen Dermatologischen Gesellschaft = Journal of the German Society of Dermatology : JDDG 20030801
Preferred age for assessment of qualitative and quantitative characteristics of the essential oil of tea tree (Melaleuca alternifolia) seedlings prior to plantation establishment. Journal of agricultural and food chemistry 20030716
In vitro and in vivo activity of tea tree oil against azole-susceptible and -resistant human pathogenic yeasts. The Journal of antimicrobial chemotherapy 20030501
Monoterpenoid accumulation in 1,8-cineole, terpinolene and terpinen-4-ol chemotypes of Melaleuca alternifolia seedlings. Phytochemistry 20030301
Bioactivity of Backhousia citriodora: antibacterial and antifungal activity. Journal of agricultural and food chemistry 20030101
Antimycotic activity of Melaleuca alternifolia essential oil and its major components. Letters in applied microbiology 20030101
Antifungal activity of the components of Melaleuca alternifolia (tea tree) oil. Journal of applied microbiology 20030101
[Effect of mouthwashing with tea tree oil on plaque and inflammation]. Schweizer Monatsschrift fur Zahnmedizin = Revue mensuelle suisse d'odonto-stomatologie = Rivista mensile svizzera di odontologia e stomatologia 20030101
Tea tree oil reduces histamine-induced skin inflammation. The British journal of dermatology 20021201
Gas chromatography: an investigative tool in multiple allergies to essential oils. Contact dermatitis 20021101
Comparison of microdilution and disc diffusion methods in assessing the in vitro activity of fluconazole and Melaleuca alternifolia (tea tree) oil against vaginal Candida isolates. Journal of chemotherapy (Florence, Italy) 20021001
Tea tree oil reduces histamine-induced oedema in murine ears. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020601
Tea tree oil reduces the swelling associated with the efferent phase of a contact hypersensitivity response. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20020501
Phytotherapy of chronic dermatitis and pruritus of dogs with a topical preparation containing tea tree oil (Bogaskin). Schweizer Archiv fur Tierheilkunde 20020501
Monoterpenoid accumulation in Melaleuca alternifolia seedlings. Phytochemistry 20020401
[Quality evaluation of essential oils]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20020301
Efficacy of alcohol-based and alcohol-free melaleuca oral solution for the treatment of fluconazole-refractory oropharyngeal candidiasis in patients with AIDS. HIV clinical trials 20020101
In vitro activity of tea tree oil against Candida albicans mycelial conversion and other pathogenic fungi. Journal of chemotherapy (Florence, Italy) 20010801
The bacterial multiple antibiotic resistant (Mar) phenotype leads to increased tolerance to tea tree oil. Pathology 20010501
The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro. Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20010401
[Allergic contact dermatitis to cosmetics containing Melaleuca alternifolia (tea tree oil)]. Annales de dermatologie et de venereologie 20010201
Flavonoids of Melaleuca quinquenervia. Die Pharmazie 20010101
Percutaneous treatment of chronic MRSA osteomyelitis with a novel plant-derived antiseptic. BMC surgery 20010101
Comparison of the effects in vitro of tea tree oil and plaunotol on methicillin-susceptible and methicillin-resistant strains of Staphylococcus aureus. Microbios 20010101
Properties