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Home Other Building Blocks CC-220

CC-220

CAS No.:
1323403-33-3
Catalog Number:
AG01EB1L
Molecular Formula:
C25H27N3O5
Molecular Weight:
449.4990
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$91
- +
2mg
98%
1 week
United States
$154
- +
5mg
≥98%
1 week
United States
$214
- +
10mg
≥98%
1 week
United States
$335
- +
25mg
98%
1 week
United States
$640
- +
50mg
98%
1 week
United States
$1098
- +
100mg
98%
1 week
United States
$1707
- +
Product Description
Catalog Number:
AG01EB1L
Chemical Name:
CC-220
CAS Number:
1323403-33-3
Molecular Formula:
C25H27N3O5
Molecular Weight:
449.4990
MDL Number:
MFCD31382133
IUPAC Name:
(3S)-3-[7-[[4-(morpholin-4-ylmethyl)phenyl]methoxy]-3-oxo-1H-isoindol-2-yl]piperidine-2,6-dione
InChI:
InChI=1S/C25H27N3O5/c29-23-9-8-21(24(30)26-23)28-15-20-19(25(28)31)2-1-3-22(20)33-16-18-6-4-17(5-7-18)14-27-10-12-32-13-11-27/h1-7,21H,8-16H2,(H,26,29,30)/t21-/m0/s1
InChI Key:
IXZOHGPZAQLIBH-NRFANRHFSA-N
SMILES:
O=C1CC[C@@H](C(=O)N1)N1Cc2c(C1=O)cccc2OCc1ccc(cc1)CN1CCOCC1
UNII:
8V66F27X44
Properties
Complexity:
732  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
449.195g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
449.507g/mol
Monoisotopic Mass:
449.195g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
88.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.1  
Literature
Title Journal
A Cereblon Modulator (CC-220) with Improved Degradation of Ikaros and Aiolos. Journal of medicinal chemistry 20180125
Rate of CRL4(CRBN) substrate Ikaros and Aiolos degradation underlies differential activity of lenalidomide and pomalidomide in multiple myeloma cells by regulation of c-Myc and IRF4. Blood cancer journal 20151001
Association between polymorphisms of the IKZF3 gene and systemic lupus erythematosus in a Chinese Han population. PloS one 20140101
Properties