Home Other Building Blocks Bromfenac Sodium

Bromfenac Sodium

CAS No.:
91714-93-1
Catalog Number:
AG01EB15
Molecular Formula:
C15H11BrNNaO3
Molecular Weight:
356.1465
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
≥99%
1 week
United States
$139
- +
50mg
≥99%
1 week
United States
$385
- +
Product Description
Catalog Number:
AG01EB15
Chemical Name:
Bromfenac Sodium
CAS Number:
91714-93-1
Molecular Formula:
C15H11BrNNaO3
Molecular Weight:
356.1465
MDL Number:
MFCD09953182
IUPAC Name:
sodium;2-[2-amino-3-(4-bromobenzoyl)phenyl]acetate
InChI:
InChI=1S/C15H12BrNO3.Na/c16-11-6-4-9(5-7-11)15(20)12-3-1-2-10(14(12)17)8-13(18)19;/h1-7H,8,17H2,(H,18,19);/q;+1/p-1
InChI Key:
HZFGMQJYAFHESD-UHFFFAOYSA-M
SMILES:
[O-]C(=O)Cc1cccc(c1N)C(=O)c1ccc(cc1)Br.[Na+]
UNII:
9X8YF771OU
Properties
Complexity:
372  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
354.982g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
356.151g/mol
Monoisotopic Mass:
354.982g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
83.2A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Topical bromfenac as an adjunctive treatment with intravitreal ranibizumab for exudative age-related macular degeneration. Retina (Philadelphia, Pa.) 20121001
Acute corneal melt associated with topical bromfenac use. Eye & contact lens 20120701
Prospective randomized controlled trial of combination ranibizumab (Lucentis) and bromfenac (Xibrom) for neovascular age-related macular degeneration: a pilot study. Retina (Philadelphia, Pa.) 20120301
A randomized comparison of to-aqueous penetration of ketorolac 0.45%, bromfenac 0.09% and nepafenac 0.1% in cataract patients undergoing phacoemulsification. Current medical research and opinion 20111201
Prostaglandin E2 inhibition of ketorolac 0.45%, bromfenac 0.09%, and nepafenac 0.1% in patients undergoing phacoemulsification. Advances in therapy 20111201
Inflammation after phakic implants. Ophthalmology 20111201
Safety and efficacy of bromfenac ophthalmic solution (Bromday) dosed once daily for postoperative ocular inflammation and pain. Ophthalmology 20111101
NSAIDs inhibit neovascularization of choroid through HO-1-dependent pathway. Laboratory investigation; a journal of technical methods and pathology 20110901
Once daily dosing of bromfenac ophthalmic solution 0.09% for postoperative ocular inflammation and pain. Current medical research and opinion 20110901
Ocular penetration and anti-inflammatory activity of ketorolac 0.45% and bromfenac 0.09% against lipopolysaccharide-induced inflammation. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110401
Pharmacokinetic comparisons of bromfenac in DuraSite and Xibrom. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20110201
Efficacy of bromfenac sodium ophthalmic solution in preventing cystoid macular oedema after cataract surgery in patients with diabetes. Acta ophthalmologica 20101201
Efficacy and safety of bromfenac for the treatment of corneal ulcer pain. Advances in therapy 20101001
NSAIDs in combination therapy for the treatment of chronic pseudophakic cystoid macular edema. Retina (Philadelphia, Pa.) 20100201
Ophthalmic utility of topical bromfenac, a twice-daily nonsteroidal anti-inflammatory agent. Expert opinion on pharmacotherapy 20091001
Differential effects of non-steroidal anti-inflammatory drugs on mitochondrial dysfunction during oxidative stress. Archives of biochemistry and biophysics 20091001
Vitreous nonsteroidal antiinflammatory drug concentrations and prostaglandin E2 levels in vitrectomy patients treated with ketorolac 0.4%, bromfenac 0.09%, and nepafenac 0.1%. Retina (Philadelphia, Pa.) 20091001
Efficacy of ophthalmic nonsteroidal antiinflammatory drugs in suppressing anterior capsule contraction and secondary posterior capsule opacification. Journal of cataract and refractive surgery 20090901
Concentration and dosing of ketorolac versus bromfenac. Journal of cataract and refractive surgery 20090701
Comparison of efficacy of bromfenac sodium 0.1% ophthalmic solution and fluorometholone 0.02% ophthalmic suspension for the treatment of allergic conjunctivitis. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20090601
Aqueous prostaglandin E(2) of cataract patients at trough ketorolac and bromfenac levels after 2 days dosing. Advances in therapy 20090601
Effect of bromfenac ophthalmic solution on ocular inflammation following cataract surgery. Acta ophthalmologica 20090501
Cyclooxygenase (COX)-inhibiting drug reduces HSV-1 reactivation in the mouse eye model. Current eye research 20090301
Topical bromfenac 0.09% vs. ketorolac 0.4% for the control of pain, photophobia, and discomfort following PRK. Journal of refractive surgery (Thorofare, N.J. : 1995) 20090201
Retrospective review of the efficacy of topical bromfenac (0.09%) as an adjunctive therapy for patients with neovascular age-related macular degeneration. Retina (Philadelphia, Pa.) 20090101
Ocular pharmacokinetics of a single dose of bromfenac sodium ophthalmic solution 0.1% in human aqueous humor. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081201
Comparison of ketorolac 0.4% and bromfenac 0.09% at trough dosing: aqueous drug absorption and prostaglandin E2 levels. Journal of cataract and refractive surgery 20080901
Re: Pharmacokinetics and pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. Journal of cataract and refractive surgery 20080801
24-hour evaluation of the ocular distribution of (14)C-labeled bromfenac following topical instillation into the eyes of New Zealand White rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20080801
The systemic safety of bromfenac ophthalmic solution 0.09%. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20071201
Bromfenac ophthalmic solution 0.09% (Xibrom) for postoperative ocular pain and inflammation. Ophthalmology 20070901
In vivo pharmacokinetics and in vitro pharmacodynamics of nepafenac, amfenac, ketorolac, and bromfenac. Journal of cataract and refractive surgery 20070901
Corneal melting and perforation in Stevens Johnson syndrome following topical bromfenac use. Journal of cataract and refractive surgery 20070901
Effect of ophthalmic solution components on acrylic intraocular lenses. Journal of cataract and refractive surgery 20070101
Topical bromfenac sodium for long-term management of vernal keratoconjunctivitis. Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift fur Augenheilkunde 20070101
Effects of nonsteroidal ophthalmic drops on epithelial healing and pain in patients undergoing bilateral photorefractive keratectomy (PRK). Advances in therapy 20070101
Misuse and abuse of topically applied nonsteroidal anti-inflammatory drugs. Cornea 20061201
Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug. Cornea 20061201
Hepatic disorders in patients treated with COX-2 selective inhibitors or nonselective NSAIDs: a case/noncase analysis of spontaneous reports. Clinical therapeutics 20060801
Effects of an opioid (oxycodone/paracetamol) and an NSAID (bromfenac) on driving ability, memory functioning, psychomotor performance, pupil size, and mood. The Clinical journal of pain 20060601
Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Current medical research and opinion 20060601
A systematic review of NSAIDs withdrawn from the market due to hepatotoxicity: lessons learned from the bromfenac experience. Pharmacoepidemiology and drug safety 20060401
Hy's law: predicting serious hepatotoxicity. Pharmacoepidemiology and drug safety 20060401
How can 'Hy's law' help the clinician? Pharmacoepidemiology and drug safety 20060401
Three cases of corneal melting after instillation of a new nonsteroidal anti-inflammatory drug. Cornea 20060201
Global experience with Xibrom (bromfenac ophthalmic solution) 0.09%: the first twice-daily ophthalmic nonsteroidal anti-inflammatory drug. International ophthalmology clinics 20060101
New drugs and dosage forms. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20050501
Comparison of 0.1% bromfenac sodium and 0.1% pemirolast potassium for the treatment of allergic conjunctivitis. Japanese journal of ophthalmology 20040101
Effects of nonsteroidal anti-inflammatory drugs on experimental allergic conjunctivitis in Guinea pigs. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20031201
Drug-induced hepatotoxicity. The New England journal of medicine 20030731
Effect of non-steroidal anti-inflammatory ophthalmic solution on intraocular pressure reduction by latanoprost. The British journal of ophthalmology 20030301
Serious liver injury. Leading reason for drug removals, restrictions. FDA consumer 20010101
Structure toxicity relationships--how useful are they in predicting toxicities of new drugs? Advances in experimental medicine and biology 20010101
Bromfenac (Duract)-associated hepatic failure requiring liver transplantation. The American journal of gastroenterology 19990801
Properties