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As1517499

CAS No.:
919486-40-1
Catalog Number:
AG01EB12
Molecular Formula:
C20H20ClN5O2
Molecular Weight:
397.8581
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$196
- +
10mg
99%
1 week
United States
$265
- +
25mg
99%
1 week
United States
$473
- +
50mg
99%
1 week
United States
$737
- +
100mg
99%
1 week
United States
$1098
- +
Product Description
Catalog Number:
AG01EB12
Chemical Name:
As1517499
CAS Number:
919486-40-1
Molecular Formula:
C20H20ClN5O2
Molecular Weight:
397.8581
MDL Number:
MFCD24038757
IUPAC Name:
4-(benzylamino)-2-[2-(3-chloro-4-hydroxyphenyl)ethylamino]pyrimidine-5-carboxamide
InChI:
InChI=1S/C20H20ClN5O2/c21-16-10-13(6-7-17(16)27)8-9-23-20-25-12-15(18(22)28)19(26-20)24-11-14-4-2-1-3-5-14/h1-7,10,12,27H,8-9,11H2,(H2,22,28)(H2,23,24,25,26)
InChI Key:
OZRMEKAUZBKTTC-UHFFFAOYSA-N
SMILES:
NC(=O)c1cnc(nc1NCc1ccccc1)NCCc1ccc(c(c1)Cl)O
UNII:
2H31HOT08T
Properties
Complexity:
491  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
397.131g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
397.863g/mol
Monoisotopic Mass:
397.131g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
113A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  
Literature
Title Journal
Synephrine inhibits eotaxin-1 expression via the STAT6 signaling pathway. Molecules (Basel, Switzerland) 20140808
Interleukin-4 upregulates RhoA protein via an activation of STAT6 in cultured human bronchial smooth muscle cells. Pharmacological research 20100201
A novel STAT6 inhibitor AS1517499 ameliorates antigen-induced bronchial hypercontractility in mice. American journal of respiratory cell and molecular biology 20091101
Identification of 4-benzylamino-2-[(4-morpholin-4-ylphenyl)amino]pyrimidine-5-carboxamide derivatives as potent and orally bioavailable STAT6 inhibitors. Bioorganic & medicinal chemistry 20080701
Synthesis and evaluation of 2-{[2-(4-hydroxyphenyl)-ethyl]amino}pyrimidine-5-carboxamide derivatives as novel STAT6 inhibitors. Bioorganic & medicinal chemistry 20070115
Suppressor T cells and host resistance to tye 111 pneumococcus after treatment with antilymphocyte serum. Infection and immunity 19751201
Properties