Home Other Building Blocks Dynorphin A (1-13) H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH

Dynorphin A (1-13) H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH

CAS No.:
72957-38-1
Catalog Number:
AG01E9V2
Molecular Formula:
C75H126N24O15
Molecular Weight:
1603.9547
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%
1 week
United States
$173
- +
5mg
98%
1 week
United States
$307
- +
10mg
98%
1 week
United States
$457
- +
25mg
98%
1 week
United States
$873
- +
Product Description
Catalog Number:
AG01E9V2
Chemical Name:
Dynorphin A (1-13) H-Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Ile-Arg-Pro-Lys-Leu-Lys-OH
CAS Number:
72957-38-1
Molecular Formula:
C75H126N24O15
Molecular Weight:
1603.9547
MDL Number:
MFCD00076366
IUPAC Name:
(2S)-6-amino-2-[[(2S)-2-[[(2S)-6-amino-2-[[(2S)-1-[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]pyrrolidine-2-carbonyl]amino]hexanoyl]amino]-4-methylpentanoyl]amino]hexanoic acid
InChI:
InChI=1S/C75H126N24O15/c1-7-45(6)61(70(111)94-53(25-17-35-87-75(83)84)71(112)99-36-18-26-58(99)69(110)93-50(21-11-13-31-76)64(105)96-56(38-44(4)5)67(108)95-54(72(113)114)22-12-14-32-77)98-65(106)52(24-16-34-86-74(81)82)91-63(104)51(23-15-33-85-73(79)80)92-66(107)55(37-43(2)3)97-68(109)57(40-46-19-9-8-10-20-46)90-60(102)42-88-59(101)41-89-62(103)49(78)39-47-27-29-48(100)30-28-47/h8-10,19-20,27-30,43-45,49-58,61,100H,7,11-18,21-26,31-42,76-78H2,1-6H3,(H,88,101)(H,89,103)(H,90,102)(H,91,104)(H,92,107)(H,93,110)(H,94,111)(H,95,108)(H,96,105)(H,97,109)(H,98,106)(H,113,114)(H4,79,80,85)(H4,81,82,86)(H4,83,84,87)/t45-,49-,50-,51-,52-,53-,54-,55-,56-,57-,58-,61-/m0/s1
InChI Key:
OVVIBUHLQIYUEU-IWIISZHXSA-N
SMILES:
NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)CCCCN)CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H]([C@H](CC)C)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccc(cc1)O)N)CC(C)C)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N
UNII:
VFC23V742Z
Properties
Complexity:
3160  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
12  
Defined Bond Stereocenter Count:
0
Exact Mass:
1602.983g/mol
Formal Charge:
0
Heavy Atom Count:
114  
Hydrogen Bond Acceptor Count:
21  
Hydrogen Bond Donor Count:
22  
Isotope Atom Count:
0
Molecular Weight:
1603.986g/mol
Monoisotopic Mass:
1602.983g/mol
Rotatable Bond Count:
54  
Topological Polar Surface Area:
669A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-4.2  
Literature
Title Journal
Controlling charge states of peptides through inductive electrospray ionization mass spectrometry. Analytical chemistry 20111201
Oxytocin in the periaqueductal gray participates in pain modulation in the rat by influencing endogenous opiate peptides. Peptides 20110601
Morphine-induced conditioned place preference in rats is inhibited by electroacupuncture at 2 Hz: role of enkephalin in the nucleus accumbens. Neuropharmacology 20100101
Lack of tolerance and morphine-induced cross-tolerance to the analgesia of chimeric peptide of Met-enkephalin and FMRFa. Peptides 20081201
Development of potent and selective phosphinic peptide inhibitors of angiotensin-converting enzyme 2. Journal of medicinal chemistry 20080410
Central reinforcing effects of ethanol are blocked by catalase inhibition. Alcohol (Fayetteville, N.Y.) 20071101
Influence of acute and chronic treadmill exercise on rat plasma lactate and brain NPY, L-ENK, DYN A1-13. Cellular and molecular neurobiology 20070201
Conformational analysis of dynorphin A (1-13) using hydrogen-deuterium exchange and tandem mass spectrometry. European journal of mass spectrometry (Chichester, England) 20070101
Vasorelaxing effect of U50,488H in pulmonary artery and underlying mechanism in rats. Life sciences 20060418
Through central arginine vasopressin, not oxytocin and endogenous opiate peptides, glutamate sodium induces hypothalamic paraventricular nucleus enhancing acupuncture analgesia in the rat. Neuroscience research 20060101
A Phase II, multicenter, randomized, double-blind, placebo-controlled crossover study of CJC-1008--a long-acting, parenteral opioid analgesic--in the treatment of postherpetic neuralgia. Journal of opioid management 20060101
New tris-alkoxycarbonyl arginine derivatives for peptide synthesis. Journal of peptide science : an official publication of the European Peptide Society 20050101
Metabolism of dynorphin A(1-13). Die Pharmazie 20040501
Aggression and the three opioid families (endorphins, enkephalins, and dynorphins) in mice. Behavior genetics 20030901
Dynorphin and the hypothalamo-pituitary-adrenal axis during fetal development. Life sciences 20030627
[Changes of dynorphinA1-13 on the treatment of hypoxic-ischemic brain injury by the brain-derived neurotrophic factor in neonatal rats]. Zhonghua yi xue za zhi 20021210
Sodium channel blocking actions of the kappa-opioid receptor agonist U50,488 contribute to its visceral antinociceptive effects. Journal of neurophysiology 20020301
[Effect of opioid peptides on the repair regeneration of the bone tissue]. Arkhiv patologii 20020101
Activation of peripheral kappa opioid receptors inhibits capsaicin-induced thermal nociception in rhesus monkeys. The Journal of pharmacology and experimental therapeutics 19990401
Dynorphin A1-13 causes elevation of serum levels of prolactin through an opioid receptor mechanism in humans: gender differences and implications for modulation of dopaminergic tone in the treatment of addictions. The Journal of pharmacology and experimental therapeutics 19990101
Kappa1- and kappa2-opioid receptors mediating presynaptic inhibition of dopamine and acetylcholine release in rat neostriatum. British journal of pharmacology 19971001
Dynorphin A-(1-13) potently improves scopolamine-induced impairment of passive avoidance response in mice. European journal of pharmacology 19950214
Dynorphin A (1-13) in the brain suppresses epinephrine-induced ventricular premature complexes and ventricular tachyarrhythmias. Regulatory peptides 19920922
[The role of the opiate mechanisms of the hippocampus and substantia nigra in the behavioral and convulsive disorders in picrotoxin-induced kindling]. Biulleten' eksperimental'noi biologii i meditsiny 19910301
Effects of dynorphin A(1-13) and of fragments of beta-endorphin on blood pressure and heart rate of anesthetized rats. Canadian journal of physiology and pharmacology 19910301
Possible involvement of beta endorphin(1-31) and dynorphin(1-13) in the central hypotensive mechanism of action of alpha methyldopa. Neuroendocrinology 19890101
Cardiovascular effects of dynorphin A (1-13) in conscious rats and its modulation of morphine bradycardia over time. Peptides 19870101
Sensitivity to morphine-evoked bradycardia in rats is modified by dynorphin (1-13), Leu- and Met-enkephalin. The Journal of pharmacology and experimental therapeutics 19840501
Effect of dynorphin-(1-13) and related peptides on respiratory rate and morphine-induced respiratory rate depression. European journal of pharmacology 19831209
Properties