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Home Other Building Blocks ([13C6]Leu17)-Thymosin b4 (human, bovine, horse, rat) trifluoroacetate salt Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-[13C6]Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH trifluoroacetate salt

([13C6]Leu17)-Thymosin b4 (human, bovine, horse, rat) trifluoroacetate salt Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-[13C6]Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH trifluoroacetate salt

CAS No.:
77591-33-4
Catalog Number:
AG01E9SW
Molecular Formula:
C212H350N56O78S
Molecular Weight:
4963.4408
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Product Description
Catalog Number:
AG01E9SW
Chemical Name:
([13C6]Leu17)-Thymosin b4 (human, bovine, horse, rat) trifluoroacetate salt Ac-Ser-Asp-Lys-Pro-Asp-Met-Ala-Glu-Ile-Glu-Lys-Phe-Asp-Lys-Ser-Lys-[13C6]Leu-Lys-Lys-Thr-Glu-Thr-Gln-Glu-Lys-Asn-Pro-Leu-Pro-Ser-Lys-Glu-Thr-Ile-Glu-Gln-Glu-Lys-Gln-Ala-Gly-Glu-Ser-OH trifluoroacetate salt
CAS Number:
77591-33-4
Molecular Formula:
C212H350N56O78S
Molecular Weight:
4963.4408
IUPAC Name:
(4S)-4-[[2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2-[[(2S)-2-acetamido-3-hydroxypropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]pyrrolidine-2-carbonyl]amino]-3-carboxypropanoyl]amino]-4-methylsulfanylbutanoyl]amino]propanoyl]amino]-4-carboxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-3-phenylpropanoyl]amino]-3-carboxypropanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-methylpentanoyl]amino]-6-aminohexanoyl]amino]-6-aminohexanoyl]amino]-3-hydroxybutanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-4-amino-4-oxobutanoyl]pyrrolidine-2-carbonyl]amino]-4-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-3-hydroxypropanoyl]amino]-6-aminohexanoyl]amino]-4-carboxybutanoyl]amino]-3-hydroxybutanoyl]amino]-3-methylpentanoyl]amino]-4-carboxybutanoyl]amino]-5-amino-5-oxopentanoyl]amino]-4-carboxybutanoyl]amino]-6-aminohexanoyl]amino]-5-amino-5-oxopentanoyl]amino]propanoyl]amino]acetyl]amino]-5-[[(1S)-1-carboxy-2-hydroxyethyl]amino]-5-oxopentanoic acid
InChI:
InChI=1S/C212H350N56O78S/c1-16-106(7)166(261-190(323)131(64-75-160(292)293)231-172(305)109(10)228-174(307)134(78-91-347-15)245-196(329)140(98-165(302)303)255-201(334)147-53-39-88-266(147)209(342)135(52-29-38-87-221)250-197(330)139(97-164(300)301)254-198(331)143(100-269)229-113(14)276)204(337)246-129(62-73-158(288)289)187(320)233-118(47-24-33-82-216)179(312)252-137(94-114-42-19-18-20-43-114)194(327)253-138(96-163(298)299)195(328)237-121(50-27-36-85-219)181(314)258-144(101-270)199(332)239-119(48-25-34-83-217)178(311)251-136(92-104(3)4)193(326)236-116(45-22-31-80-214)175(308)235-122(51-28-37-86-220)189(322)263-168(110(11)273)207(340)249-133(66-77-162(296)297)192(325)264-169(111(12)274)206(339)248-126(58-69-152(224)279)184(317)243-128(61-72-157(286)287)186(319)234-120(49-26-35-84-218)180(313)256-142(95-153(225)280)211(344)268-90-40-54-148(268)202(335)257-141(93-105(5)6)210(343)267-89-41-55-149(267)203(336)259-145(102-271)200(333)238-117(46-23-32-81-215)177(310)244-132(65-76-161(294)295)191(324)265-170(112(13)275)208(341)262-167(107(8)17-2)205(338)247-130(63-74-159(290)291)188(321)241-125(57-68-151(223)278)183(316)242-127(60-71-156(284)285)185(318)232-115(44-21-30-79-213)176(309)240-124(56-67-150(222)277)173(306)227-108(9)171(304)226-99-154(281)230-123(59-70-155(282)283)182(315)260-146(103-272)212(345)346/h18-20,42-43,104-112,115-149,166-170,269-275H,16-17,21-41,44-103,213-221H2,1-15H3,(H2,222,277)(H2,223,278)(H2,224,279)(H2,225,280)(H,226,304)(H,227,306)(H,228,307)(H,229,276)(H,230,281)(H,231,305)(H,232,318)(H,233,320)(H,234,319)(H,235,308)(H,236,326)(H,237,328)(H,238,333)(H,239,332)(H,240,309)(H,241,321)(H,242,316)(H,243,317)(H,244,310)(H,245,329)(H,246,337)(H,247,338)(H,248,339)(H,249,340)(H,250,330)(H,251,311)(H,252,312)(H,253,327)(H,254,331)(H,255,334)(H,256,313)(H,257,335)(H,258,314)(H,259,336)(H,260,315)(H,261,323)(H,262,341)(H,263,322)(H,264,325)(H,265,324)(H,282,283)(H,284,285)(H,286,287)(H,288,289)(H,290,291)(H,292,293)(H,294,295)(H,296,297)(H,298,299)(H,300,301)(H,302,303)(H,345,346)/t106-,107-,108-,109-,110+,111+,112+,115-,116-,117-,118-,119-,120-,121-,122-,123-,124-,125-,126-,127-,128-,129-,130-,131-,132-,133-,134-,135-,136-,137-,138-,139-,140-,141-,142-,143-,144-,145-,146-,147-,148-,149-,166-,167-,168-,169-,170-/m0/s1
InChI Key:
UGPMCIBIHRSCBV-XNBOLLIBSA-N
SMILES:
NCCCCC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)N1CCCC1C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NC(C(=O)NCC(=O)NC(C(=O)NC(C(=O)O)CO)CCC(=O)O)C)CCC(=O)N)CCCCN)CCC(=O)O)CCC(=O)N)CCC(=O)O)C(CC)C)C(O)C)CCC(=O)O)CCCCN)CO)CC(C)C)CC(=O)N)CCCCN)CCC(=O)O)CCC(=O)N)C(O)C)CCC(=O)O)C(O)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(C(CC)C)NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C(NC(=O)C1CCCN1C(=O)C(NC(=O)C(NC(=O)C(NC(=O)C)CO)CC(=O)O)CCCCN)CC(=O)O)CCSC)C)CCC(=O)O)CCC(=O)O)CCCCN)Cc1ccccc1)CC(=O)O)CCCCN)CO)CCCCN)CC(C)C)CCCCN
Properties
Complexity:
12200  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
47  
Defined Bond Stereocenter Count:
0
Exact Mass:
4962.493g/mol
Formal Charge:
0
Heavy Atom Count:
347  
Hydrogen Bond Acceptor Count:
88  
Hydrogen Bond Donor Count:
72  
Isotope Atom Count:
0
Molecular Weight:
4963.506g/mol
Monoisotopic Mass:
4960.486g/mol
Rotatable Bond Count:
180  
Topological Polar Surface Area:
2250A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-43.5  
Literature
Title Journal
Thymosin β4 promotes the recovery of peripheral neuropathy in type II diabetic mice. Neurobiology of disease 20121201
Protective effects of thymosin β4 on carbon tetrachloride-induced acute hepatotoxicity in rats. Annals of the New York Academy of Sciences 20121001
Thymosin β4 and cardiac protection: implication in inflammation and fibrosis. Annals of the New York Academy of Sciences 20121001
The use of angiogenic-antimicrobial agents in experimental wounds in animals: problems and solutions. Annals of the New York Academy of Sciences 20121001
Thymosin β4: a potential novel dry eye therapy. Annals of the New York Academy of Sciences 20121001
Use of the cardioprotectants thymosin β4 and dexrazoxane during congenital heart surgery: proposal for a randomized, double-blind, clinical trial. Annals of the New York Academy of Sciences 20121001
NMR structural studies of thymosin α1 and β-thymosins. Annals of the New York Academy of Sciences 20121001
Identification of interaction partners of β-thymosins: application of thymosin β4 labeled by transglutaminase. Annals of the New York Academy of Sciences 20121001
Thymosin β4 promotes the migration of endothelial cells without intracellular Ca2+ elevation. Experimental cell research 20120815
Thymosin beta 4 ameliorates hyperglycemia and improves insulin resistance of KK Cg-Ay/J mouse. Diabetes research and clinical practice 20120401
Controlling charge states of peptides through inductive electrospray ionization mass spectrometry. Analytical chemistry 20111201
Thymosin beta4 levels after successful primary percutaneous coronary intervention for acute myocardial infarction. Turk Kardiyoloji Dernegi arsivi : Turk Kardiyoloji Derneginin yayin organidir 20111201
Amniotic fluid stem cells are cardioprotective following acute myocardial infarction. Stem cells and development 20111101
Thymosin β4 activates integrin-linked kinase and decreases endothelial progenitor cells apoptosis under serum deprivation. Journal of cellular physiology 20111101
Trichinella spiralis infection induces angiogenic factor thymosin β4 expression. Veterinary parasitology 20110927
Expression pattern of thymosin beta 4 in the adult human liver. European journal of histochemistry : EJH 20110921
Thymosin β₄ knockdown disrupts mitochondrial functions of SW480 human colon cancer cells. Cancer science 20110901
Prolyl oligopeptidase induces angiogenesis both in vitro and in vivo in a novel regulatory manner. British journal of pharmacology 20110801
Intraocular expression of thymosin β4 in proliferative diabetic retinopathy. Acta ophthalmologica 20110801
Thymosin-β4 (Tβ4) blunts PDGF-dependent phosphorylation and binding of AKT to actin in hepatic stellate cells. The American journal of pathology 20110501
Regenerative protein thymosin beta-4 is a novel regulator of purinergic signaling. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110301
β-Thymosins and interstitial lung disease: study of a scleroderma cohort with a one-year follow-up. Respiratory research 20110101
Significance of thymosin β4 and implication of PINCH-1-ILK-α-parvin (PIP) complex in human dilated cardiomyopathy. PloS one 20110101
[Biotechnological production of acetylated thymosin beta4]. Bioorganicheskaia khimiia 20110101
Thymosin beta 4 prevents oxidative stress by targeting antioxidant and anti-apoptotic genes in cardiac fibroblasts. PloS one 20110101
Immunoreactivity of thymosin beta 4 in human foetal and adult genitourinary tract. European journal of histochemistry : EJH 20101221
Whole blood, flow-chamber studies in real-time indicate a biphasic role for thymosin β-4 in platelet adhesion. Biochimica et biophysica acta 20101201
Effect of toll-like receptor activation on thymosin beta-4 production by chicken macrophages. Molecular and cellular biochemistry 20101101
Actin-sequestering protein, thymosin beta-4, induces paclitaxel resistance through ROS/HIF-1alpha stabilization in HeLa human cervical tumor cells. Life sciences 20100828
Identification of Thymosin β4 as an effector of Hand1-mediated vascular development. Nature communications 20100727
Thymosin beta4 and its posttranslational modifications. Annals of the New York Academy of Sciences 20100401
Repolymerization of actin from actin:thymosin beta4 complex induced by diaphanous related formins and gelsolin. Annals of the New York Academy of Sciences 20100401
Overexpression of the natural tetrapeptide acetyl-N-ser-asp-lys-pro derived from thymosin beta4 in neoplastic diseases. Annals of the New York Academy of Sciences 20100401
Thymosin beta4 enhances repair by organizing connective tissue and preventing the appearance of myofibroblasts. Annals of the New York Academy of Sciences 20100401
Thymosin beta 4 expression in normal skin, colon mucosa and in tumor infiltrating mast cells. European journal of histochemistry : EJH 20100320
Photorhabdus luminescens toxins ADP-ribosylate actin and RhoA to force actin clustering. Science (New York, N.Y.) 20100226
Serum thymosin beta4 levels in patients with hepatitis B virus-related liver failure. World journal of gastroenterology 20100207
Thymosin-beta4 attenuates ethanol-induced neurotoxicity in cultured cerebral cortical astrocytes by inhibiting apoptosis. Cellular and molecular neurobiology 20100101
Evaluation of skeletal and cardiac muscle function after chronic administration of thymosin beta-4 in the dystrophin deficient mouse. PloS one 20100101
Different thymosin Beta 4 immunoreactivity in foetal and adult gastrointestinal tract. PloS one 20100101
Microenvironment alters epigenetic and gene expression profiles in Swarm rat chondrosarcoma tumors. BMC cancer 20100101
Thymosins β-4 and β-10 are expressed in bovine ovarian follicles and upregulated in cumulus cells during meiotic maturation. Reproduction, fertility, and development 20100101
Comparison of gene expression profiling between bovine subcutaneous and intramuscular adipose tissues by serial analysis of gene expression. Cell biology international 20091216
Nano-scaled particles of titanium dioxide convert benign mouse fibrosarcoma cells into aggressive tumor cells. The American journal of pathology 20091101
Overexpression of thymosin beta4 increases pseudopodia formation in LNCaP prostate cancer cells. Biological & pharmaceutical bulletin 20090601
Thymosin beta4 induces endothelial progenitor cell migration via PI3K/Akt/eNOS signal transduction pathway. Journal of cardiovascular pharmacology 20090301
Thymosin beta(4) and beta(10) levels in pre-term newborn oral cavity and foetal salivary glands evidence a switch of secretion during foetal development. PloS one 20090101
Thymosin beta4 is cytoprotective in human gingival fibroblasts. European journal of oral sciences 20081001
Thymosin beta4 is involved in stabilin-2-mediated apoptotic cell engulfment. FEBS letters 20080625
Thymosin beta4 is an essential paracrine factor of embryonic endothelial progenitor cell-mediated cardioprotection. Circulation 20080429
Widely distributed residues in thymosin beta4 are critical for actin binding. Biochemistry 20080401
Downregulation of thymosin beta4 expression by androgen in prostate cancer LNCaP cells. Journal of andrology 20080101
Recombinant thymosin beta 4 can promote full-thickness cutaneous wound healing. Protein expression and purification 20071201
Analysis of the function of Spire in actin assembly and its synergy with formin and profilin. Molecular cell 20071130
Neuroprotective function of thymosin-beta and its derivative peptides on the programmed cell death of chick and rat neurons. Biochemical and biophysical research communications 20071026
Contributions from all over: widely distributed residues in thymosin beta-4 affect the kinetics and stability of actin binding. Annals of the New York Academy of Sciences 20070901
Subcellular distribution of thymosin beta4. Annals of the New York Academy of Sciences 20070901
Thymosin beta4 upregulates the expression of hepatocyte growth factor and downregulates the expression of PDGF-beta receptor in human hepatic stellate cells. Annals of the New York Academy of Sciences 20070901
Thymosin beta4: actin regulation and more. Annals of the New York Academy of Sciences 20070901
Neuroprotective effects of thymosin beta4 in experimental models of excitotoxicity. Annals of the New York Academy of Sciences 20070901
Longitudinal analysis of gene expression in porcine skeletal muscle after post-injection local injury. Pharmaceutical research 20070801
Thymosin-alpha1 modulates dendritic cell differentiation and functional maturation from human peripheral blood CD14+ monocytes. Immunology letters 20070615
Biomedicine. Thymosins: clinical promise after a decades-long search. Science (New York, N.Y.) 20070504
Thymosin beta4 and thymosin beta4-derived peptides induce mast cell exocytosis. Peptides 20070401
Thymosin beta4 induces adult epicardial progenitor mobilization and neovascularization. Nature 20070111
Internalization is essential for the antiapoptotic effects of exogenous thymosin beta-4 on human corneal epithelial cells. Investigative ophthalmology & visual science 20070101
Overexpression of thymosin beta-4 renders SW480 colon carcinoma cells more resistant to apoptosis triggered by FasL and two topoisomerase II inhibitors via downregulating Fas and upregulating Survivin expression, respectively. Carcinogenesis 20060501
Thymosin beta4 induces a conformational change in actin monomers. Biophysical journal 20060201
Therapeutic potential of thymosin-beta4 and its derivative N-acetyl-seryl-aspartyl-lysyl-proline (Ac-SDKP) in cardiac healing after infarction. American journal of cardiovascular drugs : drugs, devices, and other interventions 20060101
[Regenerative medicine of skeletal muscle]. Rinsho shinkeigaku = Clinical neurology 20051101
Selective nonsteroidal anti-inflammatory drugs induce thymosin beta-4 and alter actin cytoskeletal organization in human colorectal cancer cells. The Journal of pharmacology and experimental therapeutics 20041201
Nuclear localisation of the G-actin sequestering peptide thymosin beta4. Journal of cell science 20041015
Effects of profilin and thymosin beta4 on the critical concentration of actin demonstrated in vitro and in cell extracts with a novel direct assay. The Journal of biological chemistry 20040806
Distinct cellular expressions of creatine synthetic enzyme GAMT and creatine kinases uCK-Mi and CK-B suggest a novel neuron-glial relationship for brain energy homeostasis. The European journal of neuroscience 20040701
Prolyl oligopeptidase is involved in release of the antifibrotic peptide Ac-SDKP. Hypertension (Dallas, Tex. : 1979) 20040501
Thymosin-beta4 inhibits corneal epithelial cell apoptosis after ethanol exposure in vitro. Investigative ophthalmology & visual science 20040401
Mechanism of actin polymerization in cellular ATP depletion. The Journal of biological chemistry 20040213
Structural plasticity of functional actin: pictures of actin binding protein and polymer interfaces. Structure (London, England : 1993) 20031001
Reduction of thymosin beta4 and actin in HL60 cells during apoptosis is preceded by a decrease of their mRNAs. Molecular and cellular biochemistry 20030801
Anti-inflammatory effects in the skin of thymosin-beta4 splice-variants. Immunology 20030501
Chemotherapeutic drugs change actin skeleton organization and the expression of beta-thymosins in human breast cancer cells. Journal of cancer research and clinical oncology 20020501
Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Experimental eye research 20020201
Polymerisation of chemically cross-linked actin:thymosin beta(4) complex to filamentous actin: alteration in helical parameters and visualisation of thymosin beta(4) binding on F-actin. Journal of molecular biology 20020125
Effect of thymosin peptides on the chick chorioallantoic membrane angiogenesis model. Biochimica et biophysica acta 20011107
Structural biology. Actin' up. Science (New York, N.Y.) 20010727
Actin filament cross-linking by MARCKS: characterization of two actin-binding sites within the phosphorylation site domain. The Journal of biological chemistry 20010622
Actin dynamics. Journal of cell science 20010101
Bone marrow endothelial cells secrete thymosin beta4 and AcSDKP. Experimental hematology 20010101
Biochemical and morphogenic effects of the interaction between protein kinase C-epsilon and actin in vitro and in cultured NIH3T3 cells. Journal of cellular biochemistry 20010101
Formation of acetyl-Ser-Asp-Lys-Pro, a new regulator of the hematopoietic system, through enzymatic processing of thymosin beta 4. Annals of the New York Academy of Sciences 19910101
Properties