Ro20-1724
| Title | Journal |
|---|---|
| Evaluating the significance of cyclic adenosine monophosphate-mediated signaling in human prostate: a functional and biochemical study. | Urology 20121001 |
| Neuroprotective effect of RO-20-1724-a phosphodiesterase4 inhibitor against intracerebroventricular streptozotocin induced cognitive deficit and oxidative stress in rats. | Pharmacology, biochemistry, and behavior 20120401 |
| Linalool from rosewood (Aniba rosaeodora Ducke) oil inhibits adenylate cyclase in the retina, contributing to understanding its biological activity. | Phytotherapy research : PTR 20120101 |
| Hesperetin, a Selective Phosphodiesterase 4 Inhibitor, Effectively Suppresses Ovalbumin-Induced Airway Hyperresponsiveness without Influencing Xylazine/Ketamine-Induced Anesthesia. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness. | Journal of medicinal chemistry 20111208 |
| Inhibition of phosphodiesterase-4 decreases ethanol intake in mice. | Psychopharmacology 20111101 |
| Effect of phoshpodiesterase 4 (PDE4) inhibibtors on eotaxin expression in humen bronchial epithelial cells. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20110601 |
| S-Petasin, the Main Sesquiterpene of Petasites formosanus, Inhibits Phosphodiesterase Activity and Suppresses Ovalbumin-Induced Airway Hyperresponsiveness. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Biochanin a, a phytoestrogenic isoflavone with selective inhibition of phosphodiesterase 4, suppresses ovalbumin-induced airway hyperresponsiveness. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Hesperetin-7,3'-O-dimethylether selectively inhibits phosphodiesterase 4 and effectively suppresses ovalbumin-induced airway hyperresponsiveness with a high therapeutic ratio. | Journal of biomedical science 20110101 |
| Exposure of human seminal vesicle tissue to phosphodiesterase (PDE) inhibitors antagonizes the contraction induced by norepinephrine and increases production of cyclic nucleotides. | Urology 20101201 |
| Regulation of 3',5'-cAMP in preglomerular smooth muscle and endothelial cells from genetically hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20101201 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Acute stress impairs hippocampal mossy fiber-CA3 long-term potentiation by enhancing cAMP-specific phosphodiesterase 4 activity. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601 |
| Decreased expression and activity of cAMP phosphodiesterases in cardiac hypertrophy and its impact on beta-adrenergic cAMP signals. | Circulation research 20091009 |
| Regulation of renovascular adenosine 3',5'-cyclic monophosphate in spontaneously hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20090801 |
| Endothelin downregulates SERCA2 gene and protein expression in adult rat ventricular myocytes: regulation by pertussis toxin-sensitive Gi protein and cAMP. | American journal of physiology. Heart and circulatory physiology 20090301 |
| Intravenously administered phosphodiesterase 4 inhibitors dilate retinal blood vessels in rats. | European journal of pharmacology 20090105 |
| Adrenomedullin-induced relaxation of rat brain pericytes is related to the reduced phosphorylation of myosin light chain through the cAMP/PKA signaling pathway. | Neuroscience letters 20090102 |
| Selective phosphodiesterase inhibitors: a promising target for cognition enhancement. | Psychopharmacology 20090101 |
| Inhibition of phosphodiesterase has an additive effect on estrogen's ability to inhibit collagen synthesis in vascular smooth muscle cells. | Vascular pharmacology 20090101 |
| Impact of anti-inflammatory agents on the gene expression profile of stimulated human neutrophils: unraveling endogenous resolution pathways. | PloS one 20090101 |
| Antipsychotic-like properties of phosphodiesterase 4 inhibitors: evaluation of 4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinone (RO-20-1724) with auditory event-related potentials and prepulse inhibition of startle. | The Journal of pharmacology and experimental therapeutics 20080701 |
| Spatiotemporal dynamics of beta-adrenergic cAMP signals and L-type Ca2+ channel regulation in adult rat ventricular myocytes: role of phosphodiesterases. | Circulation research 20080509 |
| Effect of cyclic AMP on barrier function of human lymphatic microvascular tubes. | Microvascular research 20080501 |
| Numerous distinct PKA-, or EPAC-based, signalling complexes allow selective phosphodiesterase 3 and phosphodiesterase 4 coordination of cell adhesion. | Cellular signalling 20071201 |
| Autoregulation in PC12 cells via P2Y receptors: Evidence for non-exocytotic nucleotide release from neuroendocrine cells. | Purinergic signalling 20070901 |
| Differential regulation of synaptic transmission by adrenergic agonists via protein kinase A and protein kinase C in layer V pyramidal neurons of rat cerebral cortex. | Neuroscience 20070608 |
| Dual regulation of the ATP-sensitive potassium channel by caffeine. | American journal of physiology. Cell physiology 20070601 |
| The effect of oxidative stress on macrophages and lung epithelial cells: the role of phosphodiesterases 1 and 4. | Toxicology letters 20070110 |
| Ca(2+)-dependent K(+) currents and spike-frequency adaptation in medial entorhinal cortex layer II stellate cells. | Hippocampus 20070101 |
| Chronic ethanol feeding suppresses beta-adrenergic receptor-stimulated lipolysis in adipocytes isolated from epididymal fat. | Endocrinology 20060901 |
| Characteristics of taurine release in slices from adult and developing mouse brain stem. | Amino acids 20060701 |
| Inhibition of PGI2 signaling by miconazole in vascular smooth muscle cells. | Prostaglandins & other lipid mediators 20060701 |
| Microsphere-based protease assays and screening application for lethal factor and factor Xa. | Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501 |
| Role of PDE3B in insulin-induced glucose uptake, GLUT-4 translocation and lipogenesis in primary rat adipocytes. | Cellular signalling 20060301 |
| Phosphodiesterase IV and neutral endopeptidase in airways from developing and allergen sensitized rabbits. | Pulmonary pharmacology & therapeutics 20060101 |
| Effects of various selective phosphodiesterase inhibitors on carbachol-induced contraction and cyclic nucleotide contents in the guinea pig gall bladder. | The Journal of veterinary medical science 20050701 |
| Role of the adenosine 3',5'-cyclic monophosphate (cAMP) in enhancing the efficacy of siRNA-mediated gene silencing in neuroblastoma cells. | Oncogene 20050609 |
| Identification and characterization of PDE4A11, a novel, widely expressed long isoform encoded by the human PDE4A cAMP phosphodiesterase gene. | Molecular pharmacology 20050601 |
| Inhibition of mast cell histamine release by specific phosphodiesterase inhibitors. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20050401 |
| NSAIDs increase GM-CSF release by human synoviocytes: comparison with nitric oxide-donating derivatives. | European journal of pharmacology 20050131 |
| Autoinhibition of transmitter release from PC12 cells and sympathetic neurons through a P2Y receptor-mediated inhibition of voltage-gated Ca2+ channels. | The European journal of neuroscience 20041201 |
| Phosphodiesterase type IV inhibitors prevent ischemia-reperfusion-induced gastric injury in rats. | Journal of pharmacological sciences 20040701 |
| Phosphodiesterase-linked inhibition of nonmicturition activity in the isolated bladder. | BJU international 20040601 |
| Sensitivity of proteasome to its inhibitors increases during cAMP-induced differentiation of neuroblastoma cells in culture and causes decreased viability. | Cancer letters 20040210 |
| The effect of selective phosphodiesterase inhibitors, alone and in combination, on a murine model of allergic asthma. | Respiratory research 20040101 |
| Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus. | The Journal of physiology 20031201 |
| Effects of phosphodiesterase inhibitors on spontaneous nuclear maturation and cAMP concentrations in bovine oocytes. | Theriogenology 20031201 |
| Role of cyclic nucleotide phosphodiesterase isoforms in cAMP compartmentation following beta2-adrenergic stimulation of ICa,L in frog ventricular myocytes. | The Journal of physiology 20030815 |
| The human D2 dopamine receptor synergizes with the A2A adenosine receptor to stimulate adenylyl cyclase in PC12 cells. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030701 |
| Type IV phosphodiesterase inhibition improves cardiac contractility in endotoxemic rats. | European journal of pharmacology 20030328 |
| 5-HT7 receptor-mediated relaxation of the oviduct in nonpregnant proestrus pigs. | European journal of pharmacology 20030214 |
| Norepinephrine induces slow calcium signalling in murine brown preadipocytes through the beta-adrenoceptor/cAMP/protein kinase A pathway. | Cellular signalling 20030201 |
| Lipopolysaccharide-induced acute renal failure in conscious rats: effects of specific phosphodiesterase type 3 and 4 inhibition. | The Journal of pharmacology and experimental therapeutics 20021001 |
| Subtype-specific roles of cAMP phosphodiesterases in regulation of atrial natriuretic peptide release. | European journal of pharmacology 20020920 |
| Inducible expression of the gap junction protein connexin43 decreases the neoplastic potential of HT-1080 human fibrosarcoma cells in vitro and in vivo. | Molecular carcinogenesis 20020901 |
| Regulation of glypican-1, syndecan-1 and syndecan-4 mRNAs expression by follicle-stimulating hormone, cAMP increase and calcium influx during rat Sertoli cell development. | European journal of biochemistry 20020701 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Altered phosphodiesterase 3-mediated cAMP hydrolysis contributes to a hypermotile phenotype in obese JCR:LA-cp rat aortic vascular smooth muscle cells: implications for diabetes-associated cardiovascular disease. | Diabetes 20020401 |
| Occupancy of adenosine A2a receptors promotes fMLP-induced cyclic AMP accumulation in human neutrophils: impact on phospholipase D activity and recruitment of small GTPases to membranes. | Journal of leukocyte biology 20020201 |
| Nucleotide-evoked relaxation of rat vas deferens: possible mechanisms. | European journal of pharmacology 20020201 |
| Caffeine eliminates gamma-ray-induced G2-phase delay in human tumor cells but not in normal cells. | Radiation research 20020101 |
| Pharmacological characterization of adenosine receptors in PGT-beta mouse pineal gland tumour cells. | British journal of pharmacology 20010901 |
| Role of cyclic nucleotides in vasodilations of the rat thoracic aorta induced by adenosine analogues. | British journal of pharmacology 20010701 |
| 17beta-estradiol modulates prostaglandin E2 release from human amnion-derived wish cells. | Biology of reproduction 20010601 |
| Modulation of excitability in Aplysia tail sensory neurons by tyrosine kinases. | Journal of neurophysiology 20010601 |
| Diazepam and rolipram differentially inhibit cyclic AMP-specific phosphodiesterases PDE4A1 and PDE4B3 in the mouse. | Biochimica et biophysica acta 20010319 |
| Phthalic acid mimics 17beta-estradiol actions in WISH cells. | Toxicology letters 20010103 |
| Chronic type IV phosphodiesterase inhibition protects glomerular filtration rate and renal and mesenteric blood flow in a zymosan-induced model of multiple organ dysfunction syndrome treated with norepinephrine. | The Journal of pharmacology and experimental therapeutics 20010101 |
| [Inhibition of uterine contractions: new in vitro pharmacological approaches on the pregnant human myometrium]. | Therapie 20010101 |
| Phosphodiesterase type 4 inhibitors, but not glucocorticoids, are more potent in suppression of cytokine secretion by mononuclear cells from atopic than nonatopic donors. | The Journal of allergy and clinical immunology 19981101 |
| Decreased presynaptic sensitivity to adenosine after cocaine withdrawal. | The Journal of neuroscience : the official journal of the Society for Neuroscience 19981001 |
| Beta-adrenergic regulation of renin expression in differentiated U-937 monocytic cells. | Biochemical pharmacology 19970615 |
| Expression, purification, and characterization of human cAMP-specific phosphodiesterase (PDE4) subtypes A, B, C, and D. | Biochemical and biophysical research communications 19970519 |
| Differential modulation of cytokine production by drugs: implications for therapy in heart failure. | Journal of molecular and cellular cardiology 19961201 |
| Dipyridamole enhances interleukin-1beta-stimulated nitric oxide production by cultured rat vascular smooth muscle cells. | European journal of pharmacology 19960205 |
| Inhibition of ornithine decarboxylase and S-adenosylmethionine decarboxylase activities of S49 lymphoma cells by agents increasing cyclic AMP. | Journal of cyclic nucleotide research 19810101 |