Home Halogens 1-(4-(4-(((2S,4R)-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone

1-(4-(4-(((2S,4R)-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone

CAS No.:
142128-57-2
Catalog Number:
AG01E214
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$196
- +
50mg
99%
1 week
United States
$543
- +
Product Description
Catalog Number:
AG01E214
Chemical Name:
1-(4-(4-(((2S,4R)-2-((1H-Imidazol-1-yl)methyl)-2-(2,4-dichlorophenyl)-1,3-dioxolan-4-yl)methoxy)phenyl)piperazin-1-yl)ethanone
CAS Number:
142128-57-2
MDL Number:
MFCD25509433
IUPAC Name:
1-[4-[4-[[(2S,4R)-2-(2,4-dichlorophenyl)-2-(imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazin-1-yl]ethanone
InChI:
InChI=1S/C26H28Cl2N4O4/c1-19(33)31-10-12-32(13-11-31)21-3-5-22(6-4-21)34-15-23-16-35-26(36-23,17-30-9-8-29-18-30)24-7-2-20(27)14-25(24)28/h2-9,14,18,23H,10-13,15-17H2,1H3/t23-,26-/m1/s1
InChI Key:
XMAYWYJOQHXEEK-ZEQKJWHPSA-N
EC Number:
265-667-4
UNII:
2DJ8R0NT7K
RTECS Number:
TK7912300
UN Number:
2811
Properties
Complexity:
735  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
530.149g/mol
Formal Charge:
0
Heavy Atom Count:
36  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
531.434g/mol
Monoisotopic Mass:
530.149g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
69.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3  
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Investigating the effect of moisture protection on solid-state stability and dissolution of fenofibrate and ketoconazole solid dispersions using PXRD, HSDSC and Raman microscopy. Drug development and industrial pharmacy 20110901
Arachidonic acid products in airway nociceptor activation during acute lung injury. Experimental physiology 20110901
Molecular complexes of ketaconazole and oxatomide with p-chloranil: spectroscopic and spectrofluorimetric studies. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20110901
Design, synthesis and antimicrobial activity of chiral 2-(substituted-hydroxyl)-3-(benzo[d]oxazol-5-yl)propanoic acid derivatives. European journal of medicinal chemistry 20110901
A novel biotransformation of alkyl aminopyrrolidine to aminopiperidine ring by human CYP3A. Drug metabolism and disposition: the biological fate of chemicals 20110901
Effect of ketoconazole-mediated CYP3A4 inhibition on clinical pharmacokinetics of panobinostat (LBH589), an orally active histone deacetylase inhibitor. Cancer chemotherapy and pharmacology 20110901
Mitotane, metyrapone, and ketoconazole combination therapy as an alternative to rescue adrenalectomy for severe ACTH-dependent Cushing's syndrome. The Journal of clinical endocrinology and metabolism 20110901
A phase II clinical trial of neoadjuvant ketoconazole and docetaxel chemotherapy before radical prostatectomy in high risk patients. The Journal of urology 20110901
Editorial comment. The Journal of urology 20110901
Synthesis and studies of novel 2-(4-cyano-3-trifluoromethylphenyl amino)-4-(quinoline-4-yloxy)-6-(piperazinyl/piperidinyl)-s-triazines as potential antimicrobial, antimycobacterial and anticancer agents. European journal of medicinal chemistry 20110901
Pulmonary histoplasmosis presenting with the reversed halo sign on high-resolution CT scan. Chest 20110901
In vitro susceptibility of fluconazole-susceptible and -resistant isolates of Malassezia pachydermatis against azoles. Veterinary microbiology 20110826
Cytotoxic bipyridines from the marine-derived actinomycete Actinoalloteichus cyanogriseus WH1-2216-6. Journal of natural products 20110826
Hydroxylation of DHEA, androstenediol and epiandrosterone by Mortierella isabellina AM212. Evidence indicating that both constitutive and inducible hydroxylases catalyze 7α- as well as 7β-hydroxylations of 5-ene substrates. Organic & biomolecular chemistry 20110807
The effect of vitamin D3 and ketoconazole combination on VDR-mediated P-gp expression and function in human colon adenocarcinoma cells: implications in drug disposition and resistance. Basic & clinical pharmacology & toxicology 20110801
Effects of strong CYP2D6 and 3A4 inhibitors, paroxetine and ketoconazole, on the pharmacokinetics and cardiovascular safety of tamsulosin. British journal of clinical pharmacology 20110801
Substrate specificity and ligand interactions of CYP26A1, the human liver retinoic acid hydroxylase. Molecular pharmacology 20110801
Hepatic cytochrome P450s attenuate the cytotoxicity induced by leflunomide and its active metabolite A77 1726 in primary cultured rat hepatocytes. Toxicological sciences : an official journal of the Society of Toxicology 20110801
Synthesis and antimicrobial evaluation of new benzofuran derivatives. European journal of medicinal chemistry 20110801
The pharmacological inhibition of sterol biosynthesis in Leishmania is counteracted by enhancement of LDL endocytosis. Acta tropica 20110801
Improved treatment of visceral leishmaniasis (kala-azar) by using combination of ketoconazole, miltefosine with an immunomodulator-Picroliv. Acta tropica 20110801
Higher throughput human hepatocyte assays for the evaluation of time-dependent inhibition of CYP3A4. Drug metabolism letters 20110801
Auto-inhibition of verapamil metabolism in rat hepatocytes of gel entrapment culture. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20110801
Bioactive 11,20-epoxy-3,5(16)-diene briarane diterpenoids from the South China Sea gorgonian Dichotella gemmacea. Journal of natural products 20110722
Spanlastics--a novel nanovesicular carrier system for ocular delivery. International journal of pharmaceutics 20110715
Bioavailability considerations in evaluating drug-drug interactions using the population pharmacokinetic approach. Journal of clinical pharmacology 20110701
Low dose of ketoconazole in patients with prostate adenocarcinoma resistant to pharmacological castration. BJU international 20110701
Nanoparticle formation and growth during in vitro dissolution of ketoconazole solid dispersion. Journal of pharmaceutical sciences 20110701
Fenretinide metabolism in humans and mice: utilizing pharmacological modulation of its metabolic pathway to increase systemic exposure. British journal of pharmacology 20110701
Secondary hormonal manipulations in the treatment of castration refractory prostate cancer. BJU international 20110701
Design, synthesis and antifungal activities of novel 1,2,4-triazole derivatives. European journal of medicinal chemistry 20110701
Antifungal quinazolinones from marine-derived Bacillus cereus and their preparation. Bioorganic & medicinal chemistry letters 20110701
Practical synthesis, anticonvulsant, and antimicrobial activity of N-allyl and N-propargyl di(indolyl)indolin-2-ones. Bioorganic & medicinal chemistry letters 20110701
4-alkoxy-3-arylfuran-2(5H)-ones as inhibitors of tyrosyl-tRNA synthetase: synthesis, molecular docking and antibacterial evaluation. Bioorganic & medicinal chemistry 20110701
Efficacious and safe management of moderate to severe scalp seborrhoeic dermatitis using clobetasol propionate shampoo 0·05% combined with ketoconazole shampoo 2%: a randomized, controlled study. The British journal of dermatology 20110701
Synergistic effects of tetrandrine on the antifungal activity of topical ketoconazole cream in the treatment of dermatophytoses: a clinical trial. Chinese journal of integrative medicine 20110701
Drug metabolism of CYP3A4, CYP2C9 and CYP2D6 substrates in pigs and humans. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20110614
Investigating effect of microemulsion components: In vitro permeation of ketoconazole. Pharmaceutical development and technology 20110601
Prevalence and antifungal resistance profile of Candida spp. oral isolates from patients with type 1 and 2 diabetes mellitus. Archives of oral biology 20110601
Cushing's syndrome due to a pancreatic neuroendocrine tumor metastatic to the ovaries: a clinicopathological description of a case. Endocrine pathology 20110601
Melatonin and steroid hormones activate intermembrane Cu,Zn-superoxide dismutase by means of mitochondrial cytochrome P450. Free radical biology & medicine 20110601
Tinea capitis versus acne keloidalis nuchae with Trichophyton violaceum superinfection. Giornale italiano di dermatologia e venereologia : organo ufficiale, Societa italiana di dermatologia e sifilografia 20110601
[Bilateral conjunctival oedema as a symptom of adrenal adenocarcinoma]. Archivos de la Sociedad Espanola de Oftalmologia 20110601
Pseudotumor cerebri during Cushing's disease treatment with ketoconazole. Arquivos brasileiros de endocrinologia e metabologia 20110601
Thiazole-based chalcones as potent antimicrobial agents. Synthesis and biological evaluation. Bioorganic & medicinal chemistry 20110515
Enhancement of triclabendazole action in vivo against a triclabendazole-resistant isolate of Fasciola hepatica by co-treatment with ketoconazole. Veterinary parasitology 20110511
In vivo investigation in pigs of intestinal absorption, hepatobiliary disposition, and metabolism of the 5α-reductase inhibitor finasteride and the effects of coadministered ketoconazole. Drug metabolism and disposition: the biological fate of chemicals 20110501
Synthesis, antimicrobial, antioxidant, anti-hemolytic and cytotoxic evaluation of new imidazole-based heterocycles. European journal of medicinal chemistry 20110501
Assessment of milling-induced disorder of two pharmaceutical compounds. Journal of pharmaceutical sciences 20110501
Management of pituitary tumors in pregnancy. Nature reviews. Endocrinology 20110501
Antifungal, cytotoxic and SAR studies of a series of N-alkyl, N-aryl and N-alkylphenyl-1,4-pyrrolediones and related compounds. Bioorganic & medicinal chemistry 20110501
The effects of concurrent administration of cytochrome P-450 inhibitors on the pharmacokinetics of oral methadone in healthy dogs. Veterinary anaesthesia and analgesia 20110501
[Management of invasive fungal infections in children]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20110501
An azole-resistant isolate of Malassezia pachydermatis. Veterinary microbiology 20110421
Fine-tuning the selectivity of aldosterone synthase inhibitors: structure-activity and structure-selectivity insights from studies of heteroaryl substituted 1,2,5,6-tetrahydropyrrolo[3,2,1-ij]quinolin-4-one derivatives. Journal of medicinal chemistry 20110414
Synthesis and biological activity of 2-(bis((1,3,4-oxadiazolyl/1,3,4-thiadiazolyl)methylthio)methylene)malononitriles. European journal of medicinal chemistry 20110401
Concurrent assessment of hepatic and intestinal cytochrome P450 3A activities using deuterated alfentanil. Clinical pharmacology and therapeutics 20110401
Pharmacokinetics of oral neratinib during co-administration of ketoconazole in healthy subjects. British journal of clinical pharmacology 20110401
Pharmacokinetic interactions between alitretinoin and ketoconazole or simvastatin or ciclosporin A. Clinical and experimental dermatology 20110401
Inhibitory effects of ketoconazole and rifampin on OAT1 and OATP1B1 transport activities: considerations on drug-drug interactions. Biopharmaceutics & drug disposition 20110401
Nonhealing scalp wound infected with Aspergillus niger in an elderly patient. Cutis 20110401
Low dose of ketoconazole in patients with prostate adenocarcinoma resistant to pharmacological castration. BJU international 20110401
Design, synthesis, and biological evaluation of imidazolyl derivatives of 4,7-disubstituted coumarins as aromatase inhibitors selective over 17-α-hydroxylase/C17-20 lyase. Journal of medicinal chemistry 20110324
Marginal increase of sunitinib exposure by grapefruit juice. Cancer chemotherapy and pharmacology 20110301
Crucial role of cytochrome P450 in hepatotoxicity induced by 2,3-dimethoxy-1,4-naphthoquinone in rats. Journal of applied toxicology : JAT 20110301
Evaluation of the origin of a sample of Sporothrix schenckii that caused contamination of a researcher in Southern Brazil. Mycopathologia 20110301
CYP3A-mediated generation of aldehyde and hydrazine in atazanavir metabolism. Drug metabolism and disposition: the biological fate of chemicals 20110301
Synthesis, structure, molecular docking, and structure-activity relationship analysis of enamines: 3-aryl-4-alkylaminofuran-2(5H)-ones as potential antibacterials. Bioorganic & medicinal chemistry 20110301
[Castration resistant prostate cancer 2011]. Aktuelle Urologie 20110301
First description of onychomycosis caused by Chrysosporium keratinophilum in captive Bennett's wallabies (Macropus rufogriseus rufogriseus). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20110301
Unexpected effect of rifampin on the pharmacokinetics of linezolid: in silico and in vitro approaches to explain its mechanism. Journal of clinical pharmacology 20110201
Effects of ketoconazole on the in vivo biotransformation and hepatobiliary transport of the thrombin inhibitor AZD0837 in pigs. Drug metabolism and disposition: the biological fate of chemicals 20110201
The effect of increased lipoprotein levels on the pharmacokinetics of ketoconazole enantiomers in the rat. Xenobiotica; the fate of foreign compounds in biological systems 20110201
Application of validated RP-HPLC method for simultaneous determination of docetaxel and ketoconazole in solid lipid nanoparticles. Journal of chromatographic science 20110201
Mechanism of cytochrome P450-3A inhibition by ketoconazole. The Journal of pharmacy and pharmacology 20110201
[Evaluation of efficacy of ketoconazole 800 mg-clindamycin 100 mg tablets vaginal against ketoconazole 800 mg- clindamycin 100 mg vaginal capsules in candida vaginitis and vaginosis]. Ginecologia y obstetricia de Mexico 20110201
Cytochrome P450 3A4 inhibitory constituents of the wood of Taxus yunnanensis. Journal of natural products 20110128
Radical scavenging and antioxidant activities of isocoumarins and a phthalide from the endophytic fungus Colletotrichum sp. Journal of natural products 20110128
New drug-like hydroxyphenylnaphthol steroidomimetics as potent and selective 17β-hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of estrogen-dependent diseases. Journal of medicinal chemistry 20110127
A species-specific approach to the use of non-antimony treatments for cutaneous leishmaniasis. The American journal of tropical medicine and hygiene 20110105
A case of kerion celsi caused by Microsporum gypseum in a boy following dermatoplasty for a scalp wound from a road accident. Medical mycology 20110101
Effects of rifampin and ketoconazole on the pharmacokinetics of nilotinib in healthy participants. Journal of clinical pharmacology 20110101
Effect of the inhibition of CYP3A4 or CYP2D6 on the pharmacokinetics and pharmacodynamics of oxycodone. European journal of clinical pharmacology 20110101
Identification of human liver cytochrome P450 enzymes involved in the metabolism of SCH 530348 (Vorapaxar), a potent oral thrombin protease-activated receptor 1 antagonist. Drug metabolism and disposition: the biological fate of chemicals 20110101
Ketoconazole and miconazole alter potassium homeostasis in Saccharomyces cerevisiae. Biochimica et biophysica acta 20110101
N-(Pyridin-3-yl)benzamides as selective inhibitors of human aldosterone synthase (CYP11B2). Bioorganic & medicinal chemistry letters 20110101
3-[Benzimidazo- and 3-[benzothiadiazoleimidazo-(1,2-c)quinazolin-5-yl]-2H-chromene-2-ones as potent antimicrobial agents. Bioorganic & medicinal chemistry letters 20110101
CYP1A2-mediated biotransformation of cardioactive 2-thienylidene-3,4-methylenedioxybenzoylhydrazine (LASSBio-294) by rat liver microsomes and human recombinant CYP enzymes. European journal of medicinal chemistry 20110101
Fixed drug eruptions induced by cross-reactive imidazoles. Allergologia et immunopathologia 20110101
[Onychomycosis-causing yeasts in four Mexican dermatology centers and their antifungal susceptibility to azolic compounds]. Revista iberoamericana de micologia 20110101
Evaluation of the pharmacokinetic interaction of midazolam with ursodeoxycholic acid, ketoconazole and dexamethasone by brain benzodiazepine receptor occupancy. The Journal of pharmacy and pharmacology 20110101
Inhibitory effects of Phyllanthus amarus and its major lignans on human microsomal cytochrome P450 activities: evidence for CYP3A4 mechanism-based inhibition. Drug metabolism and pharmacokinetics 20110101
In vitro antifungal susceptibility of Candida spp. oral isolates from HIV-positive patients and control individuals. Brazilian oral research 20110101
Patient preferences and treatment safety for uncomplicated vulvovaginal candidiasis in primary health care. BMC public health 20110101
Oropharyngeal histoplasmosis: report of eleven cases and review of the literature. Revista da Sociedade Brasileira de Medicina Tropical 20110101
[Determination of hemolytic activity and in vitro antifungal susceptibility of Trichophyton rubrum clinical strains]. Mikrobiyoloji bulteni 20110101
Disturbance in hemoglobin metabolism and in vivo antimalarial activity of azole antimycotics. Revista do Instituto de Medicina Tropical de Sao Paulo 20110101
Physicochemical characterization and dissolution study of solid dispersions of ketoconazole with nicotinamide. Chemical & pharmaceutical bulletin 20110101
Overexpression of CYP3A4, but not of CYP2D6, promotes hypoxic response and cell growth of Hep3B cells. Drug metabolism and pharmacokinetics 20110101
Cushing syndrome due to ectopic adrenocorticotropic hormone secretion in a 3-year-old child. Journal of pediatric endocrinology & metabolism : JPEM 20110101
[Scedosporium apiospermum disseminated infection in a single lung transplant recipient]. Revista iberoamericana de micologia 20110101
Effectiveness of chronic treatment with ketoconazole in a patient with diabetic Cushing's disease resistant to surgery. Endokrynologia Polska 20110101
Oral cavity eumycetoma. Revista do Instituto de Medicina Tropical de Sao Paulo 20110101
[Immunorehabilitation in patients with paecilomycosis-complicated echinococcosis and asthma]. Meditsinskaia parazitologiia i parazitarnye bolezni 20110101
Trypanosoma cruzi epimastigotes are able to store and mobilize high amounts of cholesterol in reservosome lipid inclusions. PloS one 20110101
Nocardia transvalensis keratitis: an emerging pathology among travelers returning from Asia. BMC infectious diseases 20110101
Prevalence of exocrine pancreatic insufficiency in women with obesity syndrome: assessment by pancreatic fecal elastase 1. ISRN gastroenterology 20110101
Pneumocystis pneumonia during medicamentous treatment of Cushing's syndrome--a description of two cases. Acta medica (Hradec Kralove) 20110101
New aspects in the clinical course of pityriasis versicolor. Anais brasileiros de dermatologia 20110101
Oral antifungal therapy for chronic rhinosinusitis and its subtypes: a systematic review. International forum of allergy & rhinology 20110101
Pilot Study of 15 Patients Receiving a New Treatment Regimen for Androgenic Alopecia: The Effects of Atopy on AGA. ISRN dermatology 20110101
Prophylactic ketoconazole shampoo for tinea capitis in a high-risk pediatric population. The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG 20110101
Optimization of a novel method based on solidification of floating organic droplet by high-performance liquid chromatography for evaluation of antifungal drugs in biological samples. Talanta 20101215
Structural interpretation in composite systems using powder X-ray diffraction: applications of error propagation to the pair distribution function. Pharmaceutical research 20101201
Metabolism and action of proteasome inhibitors in primary human hepatocytes. Drug metabolism and disposition: the biological fate of chemicals 20101201
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
Characterisation of zuclopenthixol metabolism by in vitro and therapeutic drug monitoring studies. Acta psychiatrica Scandinavica 20101201
[Probable basidiobolomycosis in a Togolese rural young successfully treated with ketoconazole]. Bulletin de la Societe de pathologie exotique (1990) 20101201
High performance liquid chromatographic assay for the simultaneous determination of midazolam and ketoconazole in plasma. Journal of pharmaceutical and biomedical analysis 20101102
Azole drugs trap cytochrome P450 EryK in alternative conformational states. Biochemistry 20101102
Pharmacokinetics and pharmacodynamics of docetaxel with or without ketoconazole modulation in chemonaive breast cancer patients. Annals of oncology : official journal of the European Society for Medical Oncology 20101101
Effects on plasma corticosterone levels and brain serotonin from interference with methamphetamine-induced corticosterone release in neonatal rats. Stress (Amsterdam, Netherlands) 20101101
Prediction of the intestinal first-pass metabolism of CYP3A substrates in humans using cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals 20101101
Synthesis and biological evaluation of N-antipyrine-4-substituted amino-3-chloromaleimide derivatives. European journal of medicinal chemistry 20101101
Regulation of the hypoxic response in Candida albicans. Eukaryotic cell 20101101
Tumor necrosis factor alpha increases P-glycoprotein expression in a BME-UV in vitro model of mammary epithelial cells. Biopharmaceutics & drug disposition 20101101
Structure and mechanism of the complex between cytochrome P4503A4 and ritonavir. Proceedings of the National Academy of Sciences of the United States of America 20101026
Severe retention hyperkeratosis occurring with Susac syndrome. Dermatology online journal 20101015
Subcutaneous zygomycosis: report of 10 cases from two institutions in North India. Journal of the European Academy of Dermatology and Venereology : JEADV 20101001
Anticandidal effect of Ocimum sanctum essential oil and its synergy with fluconazole and ketoconazole. Phytomedicine : international journal of phytotherapy and phytopharmacology 20101001
Synthesis and CYP24A1 inhibitory activity of (E)-2-(2-substituted benzylidene)- and 2-(2-substituted benzyl)-6-methoxy-tetralones. European journal of medicinal chemistry 20101001
Synthesis and antifungal evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. European journal of medicinal chemistry 20101001
Biorelevant media to simulate fluids in the ascending colon of humans and their usefulness in predicting intracolonic drug solubility. Pharmaceutical research 20101001
Synthesis and antimicrobial activities of novel 1H-dibenzo[a,c]carbazoles from dehydroabietic acid. European journal of medicinal chemistry 20101001
Sources of variability in ketoconazole inhibition of human cytochrome P450 3A in vitro. Xenobiotica; the fate of foreign compounds in biological systems 20101001
Retrospective analysis of the consequences of acid suppressive therapy on ketoconazole efficacy in advanced castration-resistant prostate cancer. The Annals of pharmacotherapy 20101001
[Cardiac safety of cinitapride]. Gastroenterologia y hepatologia 20101001
Presumptive Nocardia spp. infection in a dog treated with cyclosporin and ketoconazole. New Zealand veterinary journal 20101001
Comparative evaluation of ketoconazole-β-cyclodextrin systems prepared by coprecipitation and kneading. Drug discoveries & therapeutics 20101001
Synthesis and evaluation of anti-Toxoplasma gondii and antimicrobial activities of thiosemicarbazides, 4-thiazolidinones and 1,3,4-thiadiazoles. European journal of medicinal chemistry 20100901
A study of cytotoxicity of novel chlorokojic acid derivatives with their antimicrobial and antiviral activities. European journal of medicinal chemistry 20100901
CYP24A1 inhibition enhances the antitumor activity of calcitriol. Endocrinology 20100901
In vitro and in vivo metabolism of a novel cannabinoid-1 receptor inverse agonist, taranabant, in rats and monkeys. Xenobiotica; the fate of foreign compounds in biological systems 20100901
Synthesis and bioassay of aminosulfonyl-1,3,4-oxadiazoles and their interconversion to 1,3,4-thiadiazoles. European journal of medicinal chemistry 20100901
Synthesis and biochemical evaluation of a range of (4-substituted phenyl)sulfonate derivatives of 4-hydroxybenzyl imidazole-based compounds as potent inhibitors of 17alpha-hydroxylase/17,20-lyase (P45017alpha) derived from rat testicular microsomes. Bioorganic & medicinal chemistry letters 20100901
Effects of drug interactions on biotransformation and antiplatelet effect of clopidogrel in vitro. British journal of pharmacology 20100901
Primary cutaneous aspergillosis. Acta dermato-venereologica 20100901
[Metabolism of 3-cyanomethyl-4-methyl-DCK, a new anti-HIV candidate, in human intestinal microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica 20100901
New antifungal peptides. Synthesis, bioassays and initial structure prediction by CD spectroscopy. Bioorganic & medicinal chemistry letters 20100815
Replacement of imidazolyl by pyridyl in biphenylmethylenes results in selective CYP17 and dual CYP17/CYP11B1 inhibitors for the treatment of prostate cancer. Journal of medicinal chemistry 20100812
Ketoconazole in the treatment of central serous chorioretinopathy: a pilot study. Acta ophthalmologica 20100801
The post-antifungal effect (PAFE) of amphotericin B, nystatin, ketoconazole and 5-fluorocytosine and its impact on the colonization traits of Candida glabrata. Medical mycology 20100801
Ketoconazole and rifampin significantly affect the pharmacokinetics, but not the safety or QTc interval, of casopitant, a neurokinin-1 receptor antagonist. Journal of clinical pharmacology 20100801
Infantile hypercalcemia and hypercalciuria: new insights into a vitamin D-dependent mechanism and response to ketoconazole treatment. The Journal of pediatrics 20100801
Antimicrobial activity and a SAR study of some novel benzimidazole derivatives bearing hydrazone moiety. European journal of medicinal chemistry 20100801
In vitro-in vivo extrapolation predicts drug-drug interactions arising from inhibition of codeine glucuronidation by dextropropoxyphene, fluconazole, ketoconazole, and methadone in humans. The Journal of pharmacology and experimental therapeutics 20100801
Advantages of human hepatocyte-derived transformants expressing a series of human cytochrome p450 isoforms for genotoxicity examination. Toxicological sciences : an official journal of the Society of Toxicology 20100801
Differential effects of ketoconazole and primaquine on the pharmacokinetics and tissue distribution of imatinib in mice. Anti-cancer drugs 20100801
A single-dose, crossover, placebo- and moxifloxacin-controlled study to assess the effects of neratinib (HKI-272) on cardiac repolarization in healthy adult subjects. Clinical cancer research : an official journal of the American Association for Cancer Research 20100801
Synthesis and CYP24A1 inhibitory activity of N-(2-(1H-imidazol-1-yl)-2-phenylethyl)arylamides. Bioorganic & medicinal chemistry 20100715
Isopropylidene substitution increases activity and selectivity of biphenylmethylene 4-pyridine type CYP17 inhibitors. Journal of medicinal chemistry 20100708
Synthesis of some N-alkyl substituted urea derivatives as antibacterial and antifungal agents. European journal of medicinal chemistry 20100701
Synthesis and bioassay of pyrrolyl oxazolines and thiazolines. European journal of medicinal chemistry 20100701
Androgen blockade for the treatment of high-flow priapism. The journal of sexual medicine 20100701
Enhancement of the drug susceptibility of a triclabendazole-resistant isolate of Fasciola hepatica using the metabolic inhibitor ketoconazole. Parasitology research 20100701
Cutaneous lymphoid hyperplasia associated with Leishmania panamensis infection. Acta dermato-venereologica 20100701
Validation of a differential in situ perfusion method with mesenteric blood sampling in rats for intestinal drug interaction profiling. Biopharmaceutics & drug disposition 20100701
[Ketoconazole antagonizes the immune and gonadotropic systems in the forced swimming test in male Wistar rats]. Canadian journal of physiology and pharmacology 20100701
Conazoles. Molecules (Basel, Switzerland) 20100609
Effectiveness of cabergoline in monotherapy and combined with ketoconazole in the management of Cushing's disease. Pituitary 20100601
Naftifine-analogues as anti-Trypanosoma cruzi agents. European journal of medicinal chemistry 20100601
CYP3A4 catalytic activity is induced in confluent Huh7 hepatoma cells. Drug metabolism and disposition: the biological fate of chemicals 20100601
Increases in discontinuous rib cartilage and fused carpal bone in rat fetuses exposed to the teratogens, busulfan, acetazolamide, vitamin A, and ketoconazole. Human & experimental toxicology 20100601
A phase I clinical study of high dose ketoconazole plus weekly docetaxel for metastatic castration resistant prostate cancer. The Journal of urology 20100601
The effects of CYP2D6 and CYP3A activities on the pharmacokinetics of immediate release oxycodone. British journal of pharmacology 20100601
Trichodermaketones A-D and 7-O-methylkoninginin D from the marine fungus Trichoderma koningii. Journal of natural products 20100528
Chemical epigenetics alters the secondary metabolite composition of guttate excreted by an atlantic-forest-soil-derived Penicillium citreonigrum. Journal of natural products 20100528
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. Journal of medicinal chemistry 20100527
Determination of commonly used azole antifungals in various waters and sewage sludge using ultra-high performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. A 20100521
Pharmacophore modeling strategies for the development of novel nonsteroidal inhibitors of human aromatase (CYP19). Bioorganic & medicinal chemistry letters 20100515
Pasireotide alone or with cabergoline and ketoconazole in Cushing's disease. The New England journal of medicine 20100513
Activity of ketoconazole after taxane-based chemotherapy in castration-resistant prostate cancer. BJU international 20100501
Synthesis and the selective antifungal activity of 5,6,7,8-tetrahydroimidazo[1,2-a]pyridine derivatives. European journal of medicinal chemistry 20100501
Oral fingolimod for the treatment of relapsing-remitting multiple sclerosis. Drugs of today (Barcelona, Spain : 1998) 20100501
Sex differences in subacute toxicity and hepatic microsomal metabolism of triptolide in rats. Toxicology 20100430
Structural basis of human CYP51 inhibition by antifungal azoles. Journal of molecular biology 20100409
Probing possible egress channels for multiple ligands in human CYP3A4: a molecular modeling study. Journal of molecular modeling 20100401
Genotoxicity of a freshwater cyanotoxin, cylindrospermopsin, in two human cell lines: Caco-2 and HepaRG. Environmental and molecular mutagenesis 20100401
In vitro investigation of antifungal activity of allicin alone and in combination with azoles against Candida species. Mycopathologia 20100401
Testosterone hydroxylation in bovine liver: enzyme kinetic and inhibition study. Xenobiotica; the fate of foreign compounds in biological systems 20100401
Kinetics of removal of intravenous testosterone pulses in normal men. European journal of endocrinology 20100401
An eco-friendly synthesis and antimicrobial activities of dihydro-2H-benzo- and naphtho-1,3-oxazine derivatives. European journal of medicinal chemistry 20100401
In vitro and in vivo evaluation of oral tablet formulations prepared with ketoconazole and hydroxypropyl-beta-cyclodextrin. Drug delivery 20100401
Potent and selective inhibition of human cytochrome P450 3A4 by seco-pancratistatin structural analogs. Bioorganic & medicinal chemistry letters 20100401
Predictions of metabolic drug-drug interactions using physiologically based modelling: Two cytochrome P450 3A4 substrates coadministered with ketoconazole or verapamil. Clinical pharmacokinetics 20100401
Effects of ketoconazole on the biodistribution and metabolism of [11C]loperamide and [11C]N-desmethyl-loperamide in wild-type and P-gp knockout mice. Nuclear medicine and biology 20100401
[Malassezia folliculitis: 21 cases]. Annales de dermatologie et de venereologie 20100401
Pyrenochaeta keratinophila sp. nov., isolated from an ocular infection in Spain. Revista iberoamericana de micologia 20100331
Phase I clinical trial of the CYP17 inhibitor abiraterone acetate demonstrating clinical activity in patients with castration-resistant prostate cancer who received prior ketoconazole therapy. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20100320
Phase 1 pharmacokinetic and drug-interaction study of dasatinib in patients with advanced solid tumors. Cancer 20100315
Response to azolic antifungal agents for treating feline sporotrichosis. The Veterinary record 20100306
Current concepts in systemic and topical therapy for superficial mycoses. Clinics in dermatology 20100304
Intralesional sodium stibogluconate alone or its combination with either intramuscular sodium stibogluconate or oral ketoconazole in the treatment of localized cutaneous leishmaniasis: a comparative study. Journal of the European Academy of Dermatology and Venereology : JEADV 20100301
Potent in vitro inhibition of CYP3A4 and P-glycoprotein by Rhodiola rosea. Planta medica 20100301
Synthesis, characterization and biocidal activity of new organotin complexes of 2-(3-oxocyclohex-1-enyl)benzoic acid. European journal of medicinal chemistry 20100301
Antimicrobial study of newly synthesized 6-substituted indolo[1,2-c]quinazolines. European journal of medicinal chemistry 20100301
Pulmonary toxicity and metabolic activation of dauricine in CD-1 mice. The Journal of pharmacology and experimental therapeutics 20100301
Composition optimization and stability testing of a parenteral antifungal solution based on a ternary solvent system. AAPS PharmSciTech 20100301
Comparative evaluation of ketoconazole tablet and topical ketoconazole 2% in orabase in treatment of Candida-infected denture stomatitis. The journal of contemporary dental practice 20100301
Effect of ketoconazole on the pharmacokinetics of udenafil in healthy Korean subjects. British journal of clinical pharmacology 20100301
Absorption barriers in the rat intestinal mucosa: 2. Application of physiologically based mathematical models to quantify mechanisms of drug permeation and metabolism. Journal of pharmaceutical sciences 20100201
Quantitative prediction and clinical observation of a CYP3A inhibitor-based drug-drug interactions with MLN3897, a potent C-C chemokine receptor-1 antagonist. The Journal of pharmacology and experimental therapeutics 20100201
Ketoconazole enantiomer for the treatment of diabetes mellitus. Expert opinion on investigational drugs 20100201
Use of antifungal agents for oral candidiasis: results of a national survey. International journal of dental hygiene 20100201
Sulfonamide-1,2,4-thiadiazole derivatives as antifungal and antibacterial agents: synthesis, biological evaluation, lipophilicity, and conformational studies. Chemical & pharmaceutical bulletin 20100201
The pharmacokinetics of ketoconazole and its effects on the pharmacokinetics of midazolam and fentanyl in dogs. Journal of veterinary pharmacology and therapeutics 20100201
Cutaneous malasseziasis: four case reports of atypical dermatitis and onychomycosis caused by Malassezia. International journal of dermatology 20100201
Adrenocorticotrophic hormone (ACTH) responsiveness to ghrelin increases after 6 months of ketoconazole use in patients with Cushing's disease: comparison with GH-releasing peptide-6 (GHRP-6). Clinical endocrinology 20100101
In young men, a moderate inhibition of testosterone synthesis capacity is only partly compensated by increased activity of the pituitary and the hypothalamus. Clinical endocrinology 20100101
Synergistic anti-candidal activity of tetrandrine on ketoconazole: an experimental study. Planta medica 20100101
Identification of the human cytochrome P450 enzymes involved in the two oxidative steps in the bioactivation of clopidogrel to its pharmacologically active metabolite. Drug metabolism and disposition: the biological fate of chemicals 20100101
The application of in vitro technologies to study the metabolism of the androgenic/anabolic steroid stanozolol in the equine. Steroids 20100101
Novel 4-thiazolidinone derivatives as potential antifungal and antibacterial drugs. Bioorganic & medicinal chemistry 20100101
Screening of antimycotics in Swedish sewage treatment plants--waters and sludge. Water research 20100101
CYP3A catalyses schizandrin biotransformation in human, minipig and rat liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems 20100101
Candida albicans enhances experimental hepatic melanoma metastasis. Clinical & experimental metastasis 20100101
Esthesioneuroblastoma (Olfactory Neuroblastoma) with Ectopic ACTH Syndrome: a multidisciplinary case presentation from the Joan Karnell cancer center of Pennsylvania Hospital. The oncologist 20100101
Hormonal therapy for acne: why not as first line therapy? facts and controversies. Clinics in dermatology 20100101
[Acquired pigmented lesion of the foot]. Annales de dermatologie et de venereologie 20100101
Everolimus versus azathioprine in a cyclosporine and ketoconazole-based immunosuppressive therapy in kidney transplant: 3-year follow-up of an open-label, prospective, cohort, comparative clinical trial. Transplantation proceedings 20100101
Effectiveness and cost of replacing a calcineurin inhibitor with sirolimus to slow the course of chronic kidney disease in renal allografts. Transplantation proceedings 20100101
[Echinococcosis complicated by paecilomycosis]. Meditsinskaia parazitologiia i parazitarnye bolezni 20100101
Medical therapy of Cushing's disease: where are we now? Frontiers of hormone research 20100101
Diagnostic and therapeutic challenge in the management of a patient with ectopic adrenocorticotropin secretion. Journal of endocrinological investigation 20100101
The sensitivity and specificity of potassium hydroxide smear and fungal culture relative to clinical assessment in the evaluation of tinea pedis: a pooled analysis. Dermatology research and practice 20100101
Colletotrichum graminicola keratitis: first case report from India. Indian journal of ophthalmology 20100101
Management of diabetes mellitus in Cushing's syndrome. Neuroendocrinology 20100101
Management of dyslipidemia in Cushing's syndrome. Neuroendocrinology 20100101
Medical treatment of Cushing's syndrome: adrenal-blocking drugs and ketaconazole. Neuroendocrinology 20100101
Evaluation of terfenadine and ketoconazole-induced QT prolongation in conscious telemetered guinea pigs. Pharmacological reports : PR 20100101
High-performance thin-layer chromatographic determination of ketoconazole in pharmaceutical formulations. Journal of cosmetic science 20100101
A noninferiority clinical trial comparing fluconazole and ketoconazole in combination with cephalexin for the treatment of dogs with Malassezia dermatitis. Veterinary therapeutics : research in applied veterinary medicine 20100101
Sporothrix schenckii associated with armadillo hunting in Southern Brazil: epidemiological and antifungal susceptibility profiles. Revista da Sociedade Brasileira de Medicina Tropical 20100101
Use of granisetron transdermal system in the prevention of chemotherapy-induced nausea and vomiting: a review. Cancer management and research 20100101
Novel medical treatment of pituitary adrenocorticotropic hormone-dependent hypercortisolism: a case study. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20100101
Childhood acute generalized exanthematous pustulosis induced by oral ketoconazole. Acta dermatovenerologica Croatica : ADC 20100101
Antioxidant and antimicrobial activity of some lichen species. Mikrobiologiia 20100101
[White piedra in a pediatric patient: a case report]. Revista iberoamericana de micologia 20091231
Rapid LC-MS drug metabolite profiling using microsomal enzyme bioreactors in a parallel processing format. Analytical chemistry 20091215
Simultaneous determination of five systemic azoles in plasma by high-performance liquid chromatography with ultraviolet detection. Journal of pharmaceutical and biomedical analysis 20091205
Synergistic anticandidal activity of xanthorrhizol in combination with ketoconazole or amphotericin B. FEMS yeast research 20091201
Inhibition and stimulation of intestinal and hepatic CYP3A activity: studies in humanized CYP3A4 transgenic mice using triazolam. Drug metabolism and disposition: the biological fate of chemicals 20091201
Side chain azasteroids and thiasteroids as sterol methyltransferase inhibitors in ergosterol biosynthesis. Bioorganic & medicinal chemistry 20091201
Synthesis and biological activities of new substituted thiazoline-quinoline derivatives. Acta pharmaceutica (Zagreb, Croatia) 20091201
Drugs in the medical treatment of Cushing's syndrome. Expert opinion on emerging drugs 20091201
The effects of ketoconazole and rifampicin on the pharmacokinetics of mirodenafil in healthy Korean male volunteers: an open-label, one-sequence, three-period, three-treatment crossover study. Clinical therapeutics 20091201
Rhabdomyomatous mesenchymal hamartoma: clinical overview and report of a case with spontaneous regression. The West Indian medical journal 20091201
Strategy of accelerated method development for high-throughput bioanalytical assays using ultra high-performance liquid chromatography coupled with mass spectrometry. Analytical chemistry 20091115
Phase II study of androgen synthesis inhibition with ketoconazole, hydrocortisone, and dutasteride in asymptomatic castration-resistant prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20091115
Influence of quinidine, cimetidine, and ketoconazole on the enantioselective pharmacokinetics and metabolism of metoprolol in rats. Chirality 20091101
Synthesis of some novel pyrazolo[3,4-b]pyridine and pyrazolo[3,4-d]pyrimidine derivatives bearing 5,6-diphenyl-1,2,4-triazine moiety as potential antimicrobial agents. European journal of medicinal chemistry 20091101
Synthesis, antimicrobial and antioxidant activities of substituted pyrazoles, isoxazoles, pyrimidine and thioxopyrimidine derivatives. European journal of medicinal chemistry 20091101
Roles of different CYP enzymes in the formation of specific fluvastatin metabolites by human liver microsomes. Basic & clinical pharmacology & toxicology 20091101
Different effects of ketoconazole on the stereoselective first-pass metabolism of R/S-verapamil in the intestine and the liver: important for the mechanistic understanding of first-pass drug-drug interactions. Drug metabolism and disposition: the biological fate of chemicals 20091101
Partial restoration of GH responsiveness to ghrelin in Cushing's disease after 6 months of ketoconazole treatment: comparison with GHRP-6 and GHRH. European journal of endocrinology 20091101
Synthesis, Raman, FT-IR, NMR spectroscopic characterization, antimicrobial activity, cytotoxicity and DNA binding of new mixed aza-oxo-thia macrocyclic compounds. European journal of medicinal chemistry 20091101
Evaluation of drug-polymer miscibility in amorphous solid dispersion systems. Pharmaceutical research 20091101
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. Bioorganic & medicinal chemistry 20091101
Deactivation of anti-cancer drug letrozole to a carbinol metabolite by polymorphic cytochrome P450 2A6 in human liver microsomes. Xenobiotica; the fate of foreign compounds in biological systems 20091101
In vitro antimalarial interactions between mefloquine and cytochrome P450 inhibitors. Acta tropica 20091001
Superficial distribution and identification of antifungal/antimicrobial agents on a modified tissue conditioner by SEM-EDS microanalysis: a preliminary study. Journal of prosthodontics : official journal of the American College of Prosthodontists 20091001
Ketoconazole-induced JNK phosphorylation and subsequent cell death via apoptosis in human osteosarcoma cells. Toxicology in vitro : an international journal published in association with BIBRA 20091001
Ketoconazole and prednisone to prevent recurrent ischemic priapism. The Journal of urology 20091001
Structure-activity studies on seco-pancratistatin analogs: potent inhibitors of human cytochrome P450 3A4. Bioorganic & medicinal chemistry letters 20091001
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1Delta mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiency. Journal of veterinary pharmacology and therapeutics 20091001
Activity of dutasteride plus ketoconazole in castration-refractory prostate cancer after progression on ketoconazole alone. Clinical genitourinary cancer 20091001
In vitro and in vivo evaluation of the inhibition potential of risperidone toward clozapine biotransformation. British journal of clinical pharmacology 20091001
A novel class of highly potent multidrug resistance reversal agents: disubstituted adamantyl derivatives. Bioorganic & medicinal chemistry letters 20090915
Transfer of rolf S3-S4 linker to HERG eliminates activation gating but spares inactivation. Biophysical journal 20090902
The amino acid residues of transmembrane helix 5 of multidrug resistance protein CaCdr1p of Candida albicans are involved in substrate specificity and drug transport. Biochimica et biophysica acta 20090901
The arachidonic acid epoxygenase is a component of the signaling mechanisms responsible for VEGF-stimulated angiogenesis. Archives of biochemistry and biophysics 20090901
Prednisone reduces ketoconazole-induced skeletal defects in rat fetuses. Archives of toxicology 20090901
In vitro synergistic effects of antituberculous drugs plus antifungals against Coccidioides posadasii. International journal of antimicrobial agents 20090901
Infectious keratitis caused by Aspergillus tubingensis. Cornea 20090901
Aetiological treatment with itraconazole or ketoconazole in individuals with Trypanosoma cruzi/HIV co-infection. Annals of tropical medicine and parasitology 20090901
The effect on sotrastaurin pharmacokinetics of strong CYP3A inhibition by ketoconazole. British journal of clinical pharmacology 20090901
Inhibitory effects of ketoconazole, cimetidine and erythromycin on hepatic CYP3A activities in cats. The Journal of veterinary medical science 20090901
Synthesis and biochemical evaluation of a range of sulfonated derivatives of 4-hydroxybenzyl imidazole as highly potent inhibitors of rat testicular 17alpha-hydroxylase/17,20-lyase (P-450(17alpha)). Bioorganic & medicinal chemistry letters 20090815
Electron paramagnetic resonance method for the quantitative assay of ketoconazole in pharmaceutical preparations. Analytical chemistry 20090815
Differential effect of Shenmai injection, a herbal preparation, on the cytochrome P450 3A-mediated 1'-hydroxylation and 4-hydroxylation of midazolam. Chemico-biological interactions 20090814
Identification and chromosomal localization of one locus of Leishmania (L.) major related with resistance to itraconazole. Parasitology research 20090801
Spondylodiscitis due to an emergent fungal pathogen: Blastoschizomyces capitatus, a case report and review of the literature. Rheumatology international 20090801
Mono and bis-6-arylbenzimidazo[1,2-c]quinazolines: a new class of antimicrobial agents. European journal of medicinal chemistry 20090801
Synthesis and antimultidrug resistance evaluation of icariin and its derivatives. Bioorganic & medicinal chemistry letters 20090801
About the role of enantioselective selector-selectand interactions and the mobilities of diastereomeric associates in enantiomer separations using CE. Electrophoresis 20090801
Dermatomycosis in a pet inland bearded dragon (Pogona vitticeps) caused by a Chrysosporium species related to Nannizziopsis vriesii. Veterinary dermatology 20090801
Metabolism of loratadine and further characterization of its in vitro metabolites. Drug metabolism letters 20090801
Revisiting the metabolism of ketoconazole using accurate mass. Drug metabolism letters 20090801
Side chain flexibilities in the human ether-a-go-go related gene potassium channel (hERG) together with matched-pair binding studies suggest a new binding mode for channel blockers. Journal of medicinal chemistry 20090723
Hypokalemia, metabolic alkalosis, and hypertension in a lung cancer patient. Kidney international 20090701
Nonlinear stereoselective pharmacokinetics of ketoconazole in rat after administration of racemate. Chirality 20090701
In vitro inhibition of CYP3A4 by herbal remedies frequently used by cancer patients. Phytotherapy research : PTR 20090701
Novel CYP17 inhibitors: synthesis, biological evaluation, structure-activity relationships and modelling of methoxy- and hydroxy-substituted methyleneimidazolyl biphenyls. European journal of medicinal chemistry 20090701
Limited sampling strategy in rats to predict the inhibited activities of hepatic CYP3A. Laboratory animals 20090701
Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts. The Journal of steroid biochemistry and molecular biology 20090701
Regioselective synthesis and biological evaluation of bis(indolyl)methane derivatized 1,4-disubstituted 1,2,3-bistriazoles as anti-infective agents. Bioorganic & medicinal chemistry letters 20090701
Single-center experience with cyclosporine for treatment of idiopathic minimal change nephrotic syndrome in children. Iranian journal of kidney diseases 20090701
In vitro response of cutaneous mycosis fungal agents to the most widely used systemic antifungals in dermatology. Anais brasileiros de dermatologia 20090701
Drug-drug interaction prediction assessment. Journal of biopharmaceutical statistics 20090701
Cytotoxicity of ginkgolic acid in HepG2 cells and primary rat hepatocytes. Toxicology letters 20090622
Selective cytochrome P450 3A4 inhibitory activity of Amaryllidaceae alkaloids. Bioorganic & medicinal chemistry letters 20090615
An inhibition study of beauvericin on human and rat cytochrome P450 enzymes and its pharmacokinetics in rats. Journal of enzyme inhibition and medicinal chemistry 20090601
Neurocryptococcosis in a 10-year-old immunocompetent girl. Acta neurochirurgica 20090601
Evaluation of drug-drug interactions with fesoterodine. European journal of clinical pharmacology 20090601
CYP3A5*1/*3 genotype influences the blood concentration of tacrolimus in response to metabolic inhibition by ketoconazole. Pharmacogenetics and genomics 20090601
Effect of ketoconazole on the pharmacokinetic profile of ambrisentan. Journal of clinical pharmacology 20090601
Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase. Microbial drug resistance (Larchmont, N.Y.) 20090601
Bulky 1,4-benzoxazine derivatives with antifungal activity. Bioorganic & medicinal chemistry 20090601
Therapies for pediatric seborrheic dermatitis. Pediatric annals 20090601
Randomised controlled trial of the treatment of pastern dermatitis with a formulation containing kunzea oil. The Veterinary record 20090516
Synthesis and bioassay of a new class of heterocycles pyrrolyl oxadiazoles/thiadiazoles/triazoles. European journal of medicinal chemistry 20090501
Synthesis and anti-microbial screening of some Schiff bases of 3-amino-6,8-dibromo-2-phenylquinazolin-4(3H)-ones. European journal of medicinal chemistry 20090501
Synthesis, antimicrobial and cytotoxic activities of some 5-arylidene-4-thioxo-thiazolidine-2-ones. European journal of medicinal chemistry 20090501
Synthesis, antimicrobial evaluation and QSAR study of some 3-hydroxypyridine-4-one and 3-hydroxypyran-4-one derivatives. European journal of medicinal chemistry 20090501
Design, synthesis, and biological evaluation of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase. European journal of medicinal chemistry 20090501
Electronic, Raman and FT-IR spectral investigations of the charge transfer interactions between ketoconazole and povidone drugs with iodine. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20090501
Novel secondary hormonal therapy in advanced prostate cancer: an update. Current opinion in urology 20090501
Identification of quinone methide metabolites of dauricine in human liver microsomes and in rat bile. Chemical research in toxicology 20090501
Antimicrobial ambiguine isonitriles from the cyanobacterium Fischerella ambigua. Journal of natural products 20090501
Ketoconazole retains activity in patients with docetaxel-refractory prostate cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20090501
New acyclic nucleosides analogues as potential analgesic, anti-inflammatory, anti-oxidant and anti-microbial derived from pyrimido[4,5-b]quinolines. European journal of medicinal chemistry 20090401
Contact allergy to ketoconazole cross-sensitive to miconazole. Clinical and experimental dermatology 20090401
In vitro activities of retigeric acid B alone and in combination with azole antifungal agents against Candida albicans. Antimicrobial agents and chemotherapy 20090401
Exploratory study on the clinical and mycological effectiveness of a herbal medicinal product from Solanum chrysotrichum in patients with Candida yeast-associated vaginal infection. Planta medica 20090401
Relative contributions of the Candida albicans ABC transporters Cdr1p and Cdr2p to clinical azole resistance. Antimicrobial agents and chemotherapy 20090401
Effect of different durations of ketoconazole dosing on the single-dose pharmacokinetics of midazolam: shortening the paradigm. Journal of clinical pharmacology 20090401
[Treatment of Cushing's disease with ketoconazole]. Anales de pediatria (Barcelona, Spain : 2003) 20090401
In vitro metabolism and inhibitory effects of pranlukast in human liver microsomes. Biological & pharmaceutical bulletin 20090401
Effects of ketoconazole and carbamazepine on lapatinib pharmacokinetics in healthy subjects. British journal of clinical pharmacology 20090401
Ketoconazole allergy. Clinics (Sao Paulo, Brazil) 20090401
[Enzyme kinetics of ligustilide metabolism in rat liver microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica 20090401
Direct antifungal susceptibility testing of positive Candida blood cultures by sensititre YeastOne. The new microbiologica 20090401
Steroidogenesis-disrupting compounds can be effectively studied for major fertility-related endpoints using in vitro cultured mouse follicles. Toxicology letters 20090328
Rational modification of a candidate cancer drug for use against Chagas disease. Journal of medicinal chemistry 20090326
Design, synthesis, and biological evaluation of novel 1-(1H-1,2,4-triazole-1-yl)-2-(2,4-difluorophenyl)-3-substituted benzylamino-2-propanols. Bioorganic & medicinal chemistry letters 20090315
Relation between lipophilicity of alkyl gallates and antifungal activity against yeasts and filamentous fungi. Bioorganic & medicinal chemistry letters 20090315
Modulation of the antifungal activity of new medicinal plant extracts active on Candida glabrata by the major transporters and regulators of the pleiotropic drug-resistance network in Saccharomyces cerevisiae. Microbial drug resistance (Larchmont, N.Y.) 20090301
Pharmacological interactions of anti-microbial agents in odontology. Medicina oral, patologia oral y cirugia bucal 20090301
Quantitative evaluation of pharmacokinetic inhibition of CYP3A substrates by ketoconazole: a simulation study. Journal of clinical pharmacology 20090301
The need for multiple doses of 400 mg ketoconazole as a precipitant inhibitor of a CYP3A substrate in an in vivo drug-drug interaction study. Journal of clinical pharmacology 20090301
A single-center, open-label, one-sequence study of dalcetrapib coadministered with ketoconazole, and an in vitro study of the S-methyl metabolite of dalcetrapib. Clinical therapeutics 20090301
Flexible structure of cytochrome P450: promiscuity of ligand binding in the CYP3A4 heme pocket. Anticancer research 20090301
Ketoconazole treatment for Cushing syndrome in McCune-Albright syndrome. The Journal of pediatrics 20090301
Aqueous solvent system for the solubilization of azole compounds. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20090215
Rhinosporidiosis in a dog native to the UK. The Veterinary record 20090214
CYP1A1 induction and CYP3A4 inhibition by the fungicide imazalil in the human intestinal Caco-2 cells-comparison with other conazole pesticides. Toxicology letters 20090210
Clearance and clearance inhibition of the HIV-1 protease inhibitors ritonavir and saquinavir in sandwich-cultured rat hepatocytes and rat microsomes. Toxicology in vitro : an international journal published in association with BIBRA 20090201
Synthesis and antifungal activity of 1,2,3-triazole containing fluconazole analogues. Bioorganic & medicinal chemistry letters 20090201
Ketoconazole increases fingolimod blood levels in a drug interaction via CYP4F2 inhibition. Journal of clinical pharmacology 20090201
A new probabilistic rule for drug-dug interaction prediction. Journal of pharmacokinetics and pharmacodynamics 20090201
Inhibition of cytochrome P450 activity enhances the systemic availability of triclabendazole metabolites in sheep. Journal of veterinary pharmacology and therapeutics 20090201
Pharmacokinetic interaction between efavirenz and ketoconazole in rats. Xenobiotica; the fate of foreign compounds in biological systems 20090201
Effects of oral posaconazole on the pharmacokinetic properties of oral and intravenous midazolam: a phase I, randomized, open-label, crossover study in healthy volunteers. Clinical therapeutics 20090201
Clinical practice. Seborrheic dermatitis. The New England journal of medicine 20090122
Novel non-active site inhibitor of Cryptosporidium hominis TS-DHFR identified by a virtual screen. Bioorganic & medicinal chemistry letters 20090115
Synthesis, trypanocidal activity and docking studies of novel quinoxaline-N-acylhydrazones, designed as cruzain inhibitors candidates. Bioorganic & medicinal chemistry 20090115
Synthesis, Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of mixed aza-oxo-thia macrocyclic compounds. European journal of medicinal chemistry 20090101
An open, randomized, prospective, comparative study of topical pimecrolimus 1% cream and topical ketoconazole 2% cream in the treatment of seborrheic dermatitis. The Journal of dermatological treatment 20090101
Decreased oral absorption of cyclosporine A after liver ischemia-reperfusion injury in rats: the contribution of CYP3A and P-glycoprotein to the first-pass metabolism in intestinal epithelial cells. The Journal of pharmacology and experimental therapeutics 20090101
Effect of oral ketoconazole on oral and intravenous pharmacokinetics of simvastatin and its acid in cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals 20090101
Fungistatic effects of optical brightener 220 against Trichophyton tonsurans, Aspergillus fumigatus and Candida albicans. The Journal of dermatological treatment 20090101
Assessment of the CYP3A-mediated drug interaction potential of anacetrapib, a potent cholesteryl ester transfer protein (CETP) inhibitor, in healthy volunteers. Journal of clinical pharmacology 20090101
Inhibition of CYP3A4 expression by ketoconazole is mediated by the disruption of pregnane X receptor, steroid receptor coactivator-1, and hepatocyte nuclear factor 4alpha interaction. Pharmacogenetics and genomics 20090101
Etomidate infusion in the critical care setting for suppressing the acute phase of Cushing's syndrome. Anesthesia and analgesia 20090101
Glucocorticoid inhibition in the treatment of depression: can we think outside the endocrine hypothalamus? Depression and anxiety 20090101
A study to evaluate the efficacy and safety of oral fluconazole in the treatment of tinea versicolor. Mymensingh medical journal : MMJ 20090101
[Fungicidal activity of liranaftate against dermatophytes]. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101
In vitro susceptibility testing of dermatophytes isolated in Goiania, Brazil, against five antifungal agents by broth microdilution method. Revista do Instituto de Medicina Tropical de Sao Paulo 20090101
Alterations in growth and branching of Neurospora crassa caused by sub-inhibitory concentrations of antifungal agents. Revista Argentina de microbiologia 20090101
Tinea capitis due to Trichophyton soudanense in Chicago, Illinois: report of a case. Pediatric dermatology 20090101
Bioequivalence studies and sugar-based excipients effects on the properties of new generic ketoconazole tablets formulations and stability evaluation by using direct compression method. Pharmaceutical development and technology 20090101
High-throughput fluorescence assay of cytochrome P450 3A4. Nature protocols 20090101
Determination of ketoconazole in capsules by high-performance liquid chromatography and microbiological assay. Journal of AOAC International 20090101
Two-year experience with tacrolimus in renal transplantation after late conversion from cyclosporine therapy. Transplantation proceedings 20090101
Ketoconazole inhibits the growth and development of Ichthyophonus sp. (Mesomycetozoa) in vitro. The Journal of eukaryotic microbiology 20090101
[Guidelines for diagnosis and treatment of mucocutaneous candidiasis]. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20090101
Prediction of drug-drug interactions based on time-dependent inhibition from high throughput screening of cytochrome P450 3A4 inhibition. Drug metabolism and pharmacokinetics 20090101
Effect of the CYP3A inhibitor ketoconazole on the pharmacokinetics and pharmacodynamics of bortezomib in patients with advanced solid tumors: a prospective, multicenter, open-label, randomized, two-way crossover drug-drug interaction study. Clinical therapeutics 20090101
[Nizoral - an effective and affordable drug to treat vaginal candidiasis ]. Akusherstvo i ginekologiia 20090101
In vivo active aldosterone synthase inhibitors with improved selectivity: lead optimization providing a series of pyridine substituted 3,4-dihydro-1H-quinolin-2-one derivatives. Journal of medicinal chemistry 20081225
Phase III trial of androgen ablation with or without three cycles of systemic chemotherapy for advanced prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20081220
Use of ketoconazole to treat dogs with pituitary-dependent hyperadrenocorticism: 48 cases (1994-2007). Journal of the American Veterinary Medical Association 20081215
Biopositive effects of low-dose UVB on epidermis: coordinate upregulation of antimicrobial peptides and permeability barrier reinforcement. The Journal of investigative dermatology 20081201
The combination of chemical and antibody inhibitors for superior P450 3A inhibition in reaction phenotyping studies. Drug metabolism and disposition: the biological fate of chemicals 20081201
Effects of an ergosterol synthesis inhibitor on gene transcription of terpenoid biosynthesis in Blakeslea trispora. Current microbiology 20081201
Confirmation that cytochrome P450 2C8 (CYP2C8) plays a minor role in (S)-(+)- and (R)-(-)-ibuprofen hydroxylation in vitro. Drug metabolism and disposition: the biological fate of chemicals 20081201
A double transgenic mouse model expressing human pregnane X receptor and cytochrome P450 3A4. Drug metabolism and disposition: the biological fate of chemicals 20081201
Interindividual variation in relative CYP1A2/3A4 phenotype influences susceptibility of clozapine oxidation to cytochrome P450-specific inhibition in human hepatic microsomes. Drug metabolism and disposition: the biological fate of chemicals 20081201
Bone-targeted therapy: phase II study of strontium-89 in combination with alternating weekly chemohormonal therapies for patients with advanced androgen-independent prostate cancer. American journal of clinical oncology 20081201
Susceptibility to voriconazole, fluconazole, and ketoconazole of yeast isolated from patients with hematological malignancies. Journal of chemotherapy (Florence, Italy) 20081201
Presystemic elimination of budesonide in man when administered locally at different levels in the gut, with and without local inhibition by ketoconazole. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20081115
Comparative efficacy and tolerability of Ketomousse (ketoconazole foam 1%) and ketoconazole cream 2% in the treatment of pityriasis versicolor: results of a prospective, multicentre, randomised study. Mycoses 20081101
Widespread, chronic, and fluconazole-resistant Trichophyton rubrum infection in an immunocompetent patient. Mycoses 20081101
Effect of commonly used herbicides on the virulence factor CDR1 in Candida albicans. Environmental toxicology and chemistry 20081101
Hypocortisolemic clamp unmasks jointly feedforward- and feedback-dependent control of overnight ACTH secretion. European journal of endocrinology 20081101
Effect of single and repeated doses of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide. Journal of clinical pharmacology 20081101
Pharmacokinetics of the oral direct renin inhibitor aliskiren in combination with digoxin, atorvastatin, and ketoconazole in healthy subjects: the role of P-glycoprotein in the disposition of aliskiren. Journal of clinical pharmacology 20081101
Re: Oral ketoconazole for prevention of postoperative penile erection: a placebo controlled, randomized, double-blind trial: B. J. DeCastro, R. A. Costabile, L. P. McMann and A. C. Peterson. J Urol 2008; 179: 1930-1932. The Journal of urology 20081101
1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. The Journal of steroid biochemistry and molecular biology 20081101
Human CYP3A4-introduced HepG2 cells: in vitro screening system of new chemicals for the evaluation of CYP3A4-inhibiting activity. Xenobiotica; the fate of foreign compounds in biological systems 20081101
Monodictyochromes A and B, dimeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. Journal of natural products 20081101
In vitro CYP3A4 metabolism: inhibition by Echinacea purpurea and choice of substrate for the evaluation of herbal inhibition. Basic & clinical pharmacology & toxicology 20081101
Influence of quinidine, fluvoxamine, and ketoconazole on the enantioselective pharmacokinetics of citalopram in rats. Canadian journal of physiology and pharmacology 20081101
Histopathological effect of ketoconazole on rat placenta. The Journal of veterinary medical science 20081101
[Mixed vaginitis prevalence in Latin-American women, according to physician perception. Preference, effectiveness and security of clindamycin plus ketoconazole]. Ginecologia y obstetricia de Mexico 20081101
Activation of the proopiomelanocortin gene with ketoconazole as a treatment for Parkinson's disease: a new hypothesis. Annals of the New York Academy of Sciences 20081101
Ketoconazole increases the plasma levels of ivermectin in sheep. Veterinary parasitology 20081020
Novel aldosterone synthase inhibitors with extended carbocyclic skeleton by a combined ligand-based and structure-based drug design approach. Journal of medicinal chemistry 20081009
Structural requirements for drug inhibition of the liver specific human organic cation transport protein 1. Journal of medicinal chemistry 20081009
Condensed bridgehead nitrogen heterocyclic system: synthesis and pharmacological activities of 1,2,4-triazolo-[3,4-b]-1,3,4-thiadiazole derivatives of ibuprofen and biphenyl-4-yloxy acetic acid. European journal of medicinal chemistry 20081001
Effect of coadministration of ketoconazole, a strong CYP3A4 inhibitor, on pharmacokinetics and tolerability of motesanib diphosphate (AMG 706) in patients with advanced solid tumors. Investigational new drugs 20081001
Maraviroc: in vitro assessment of drug-drug interaction potential. British journal of clinical pharmacology 20081001
Differential azole antifungal efficacies contrasted using a Saccharomyces cerevisiae strain humanized for sterol 14 alpha-demethylase at the homologous locus. Antimicrobial agents and chemotherapy 20081001
Inhibition of hERG channel trafficking: an under-explored mechanism for drug-induced QT prolongation. ChemMedChem 20081001
Management of recurrent and refractory Cushing disease. Nature clinical practice. Endocrinology & metabolism 20081001
Medical treatments for male and female pattern hair loss. Journal of the American Academy of Dermatology 20081001
Ocular pharmacokinetics of topically-applied ketoconazole solution containing hydroxypropyl beta-cyclodextrin to rabbits. Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20081001
Evidence for the mechanism of action of the antifungal phytolaccoside B isolated from Phytolacca tetramera Hauman. Journal of natural products 20081001
[Synergy between ajoene and ketoconazole in isolates of Microsporum canis. A preliminary study using fractional inhibitory concentration technique (FIC)]. Revista iberoamericana de micologia 20080930
Screening of herbal constituents for aromatase inhibitory activity. Bioorganic & medicinal chemistry 20080915
Enamines as novel antibacterials and their structure-activity relationships. European journal of medicinal chemistry 20080901
Differential enzymatic reductions governing the differential hypoxia-selective cytotoxicities of phenazine 5,10-dioxides. Chemical research in toxicology 20080901
NO-donors. Part 17: Synthesis and antimicrobial activity of novel ketoconazole-NO-donor hybrid compounds. Bioorganic & medicinal chemistry 20080901
In vitro antifungal activity of polyfunctionalized 2-(hetero)arylquinolines prepared through imino Diels-Alder reactions. Bioorganic & medicinal chemistry 20080901
Steroidal saponins from the roots of Smilax aspera subsp. mauritanica. Chemical & pharmaceutical bulletin 20080901
Responses of the medaka HPG axis PCR array and reproduction to prochloraz and ketoconazole. Environmental science & technology 20080901
Comparison of the anti-inflammatory activities of imidazole antimycotics in relation to molecular structure. Chemical biology & drug design 20080901
Combined treatment with ketoconazole and cyproterone acetate in a boy with McCune-Albright syndrome and peripheral precocious puberty. Journal of endocrinological investigation 20080901
[A limited sampling strategy of phenotyping probe midazolam to predict inhibited activities of hepatic CYP3A in rats]. Yao xue xue bao = Acta pharmaceutica Sinica 20080901
Overcoming undesirable CYP1A2 inhibition of pyridylnaphthalene-type aldosterone synthase inhibitors: influence of heteroaryl derivatization on potency and selectivity. Journal of medicinal chemistry 20080828
Synthesis, biological evaluation, and molecular modeling of abiraterone analogues: novel CYP17 inhibitors for the treatment of prostate cancer. Journal of medicinal chemistry 20080828
Synthesis, biological evaluation, and molecular modeling studies of methylene imidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17)--part II: Core rigidification and influence of substituents at the methylene bridge. Bioorganic & medicinal chemistry 20080815
In situ dissolution testing using potentiometric sensors. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20080807
Cushing's disease in dogs: cabergoline treatment. Research in veterinary science 20080801
Effects of ketoconazole and quinidine on pharmacokinetics of pactimibe and its plasma metabolite, R-125528, in humans. Drug metabolism and disposition: the biological fate of chemicals 20080801
Pharmacokinetics of darunavir/ritonavir and ketoconazole following co-administration in HIV-healthy volunteers. British journal of clinical pharmacology 20080801
Adverse effects of ketoconazole in dogs--a retrospective study. Veterinary dermatology 20080801
Dysgonic strain of Microsporum canis pseudomycetoma in a Domestic Long-hair cat. Australian veterinary journal 20080801
What's your assessment? Pityrosporum folliculitis. Dermatology nursing 20080801
[Effect of ketoconazole on the activity of CYP4503A4 and CYP450 1A2 of hepatic microsomes in healthy adults]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20080801
Microsome biocolloids for rapid drug metabolism and inhibition assessment by LC-MS. Drug metabolism letters 20080801
A statistical methodology for drug-drug interaction surveillance. Statistics in medicine 20080720
Chemosensitization prevents tolerance of Aspergillus fumigatus to antimycotic drugs. Biochemical and biophysical research communications 20080718
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle. Bioorganic & medicinal chemistry 20080715
Synthesis of novel ketoconazole derivatives as inhibitors of the human Pregnane X Receptor (PXR; NR1I2; also termed SXR, PAR). Bioorganic & medicinal chemistry letters 20080715
Expression of microsomal lanosterol 14alpha-demethylase (CYP51) in an engineered soluble monomeric form. Biochemical and biophysical research communications 20080711
1-[(3-Aryloxy-3-aryl)propyl]-1H-imidazoles, new imidazoles with potent activity against Candida albicans and dermatophytes. Synthesis, structure-activity relationship, and molecular modeling studies. Journal of medicinal chemistry 20080710
A phase I study of docetaxel with ketoconazole modulation in patients with advanced cancers. Cancer chemotherapy and pharmacology 20080701
Synthesis and antimicrobial activities of 7-O-modified genistein derivatives. European journal of medicinal chemistry 20080701
Long-term treatment of familial male-limited precocious puberty (testotoxicosis) with cyproterone acetate or ketoconazole. Clinical endocrinology 20080701
Paecilomyces lilacinus olecranon bursitis in an immunocompromised host: case report and review. Diagnostic microbiology and infectious disease 20080701
Prediction of pharmacokinetic drug-drug interactions using human hepatocyte suspension in plasma and cytochrome P450 phenotypic data. II. In vitro-in vivo correlation with ketoconazole. Drug metabolism and disposition: the biological fate of chemicals 20080701
Perturbation of gene expression and steroidogenesis with in vitro exposure of fathead minnow ovaries to ketoconazole. Marine environmental research 20080701
Potent in vitro antifungal activities of naturally occurring acetylenic acids. Antimicrobial agents and chemotherapy 20080701
Evaluation and treatment of oral candidiasis in HIV/AIDS patients in Enugu, Nigeria. Oral and maxillofacial surgery 20080701
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of phenyl alkyl imidazole-based compounds as potent inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)). The Journal of steroid biochemistry and molecular biology 20080701
Validation and application of Caco-2 assays for the in vitro evaluation of development candidate drugs as substrates or inhibitors of P-glycoprotein to support regulatory submissions. Xenobiotica; the fate of foreign compounds in biological systems 20080701
[Ketoconazole and clindamycin efficacy vs oral clindamycin in premature membranes rupture prevention]. Ginecologia y obstetricia de Mexico 20080701
Biotypes, genotypes and ketoconazole susceptibility of Candida albicans isolates from a group of Thai AIDS patients. The new microbiologica 20080701
Prediction and identification of drug interactions with the human ATP-binding cassette transporter multidrug-resistance associated protein 2 (MRP2; ABCC2). Journal of medicinal chemistry 20080612
Differential effects of ketoconazole on exposure to temsirolimus following intravenous infusion of temsirolimus. British journal of cancer 20080603
Malassezia folliculitis in China. Mycopathologia 20080601
In vitro antifungal susceptibility and molecular characterization of clinical isolates of Fusarium verticillioides (F. moniliforme) and Fusarium thapsinum. Antimicrobial agents and chemotherapy 20080601
Biweekly doxorubicin/ketoconazole as second-line treatment in docetaxel-resistant, hormone-refractory prostate cancer. Urology 20080601
Cutaneous hyalohyphomycosis caused by a Chrysosporium species related to Nannizziopsis vriesii in two green iguanas (Iguana iguana). Medical mycology 20080601
Synthesis and SAR studies of biaryloxy-substituted triazoles as antifungal agents. Bioorganic & medicinal chemistry letters 20080601
Safety profile and metabolic effects of 14 days of treatment with DIO-902: results of a phase IIa multicenter, randomized, double-blind, placebo-controlled, parallel-group trial in patients with type 2 diabetes mellitus. Clinical therapeutics 20080601
Application of micellar electrokinetic capillary chromatography for evaluation of inhibitory effects on cytochrome P450 reaction. Journal of chromatography. A 20080502
Synthesis and antimicrobial activity of novel sulfone-linked bis heterocycles. European journal of medicinal chemistry 20080501
An examination of the effect of intestinal first pass extraction on intestinal lymphatic transport of saquinavir in the rat. Pharmaceutical research 20080501
A stereospecific high-performance liquid chromatographic assay for the determination of ketoconazole enantiomers in rat plasma. Biomedical chromatography : BMC 20080501
Contribution of the N-glucuronidation pathway to the overall in vitro metabolic clearance of midazolam in humans. Drug metabolism and disposition: the biological fate of chemicals 20080501
Application of CYP3A4 in vitro data to predict clinical drug-drug interactions; predictions of compounds as objects of interaction. British journal of clinical pharmacology 20080501
In vitro inhibition of CYP3A4 metabolism and P-glycoprotein-mediated transport by trade herbal products. Basic & clinical pharmacology & toxicology 20080501
Oral ketoconazole for prevention of postoperative penile erection: a placebo controlled, randomized, double-blind trial. The Journal of urology 20080501
Identification of the human cytochrome P450 enzymes involved in the in vitro biotransformation of lynestrenol and norethindrone. The Journal of steroid biochemistry and molecular biology 20080501
Chiral separations in sub- and supercritical fluid chromatography. Journal of separation science 20080501
Identification of human cytochrome P450 enzymes involved in the metabolism of IN-1130, a novel activin receptor-like kinase-5 (ALK5) inhibitor. Xenobiotica; the fate of foreign compounds in biological systems 20080501
Effects of ketoconazole on the pharmacokinetics and pharmacodynamics of morphine in healthy Greyhounds. American journal of veterinary research 20080501
The effect of ketoconazole on the pharmacokinetics and pharmacodynamics of ixabepilone: a first in class epothilone B analogue in late-phase clinical development. Clinical cancer research : an official journal of the American Association for Cancer Research 20080501
Selected endocrine disrupting compounds (vinclozolin, flutamide, ketoconazole and dicofol): effects on survival, occurrence of males, growth, molting and reproduction of Daphnia magna. Environmental science and pollution research international 20080501
Ketoconazole: a review of a workhorse antifungal molecule with a focus on new foam and gel formulations. Drugs of today (Barcelona, Spain : 1998) 20080501
Significance of isolation and drug susceptibility testing of non-Candida albicans species causing oropharyngeal candidiasis in HIV patients. The Southeast Asian journal of tropical medicine and public health 20080501
[Effect of polyoxyl ether analogous surfactants on the activity of cytochromes P450 3A in rats in vivo]. Yao xue xue bao = Acta pharmaceutica Sinica 20080501
Design, synthesis, and biological evaluation of (hydroxyphenyl)naphthalene and -quinoline derivatives: potent and selective nonsteroidal inhibitors of 17beta-hydroxysteroid dehydrogenase type 1 (17beta-HSD1) for the treatment of estrogen-dependent diseases. Journal of medicinal chemistry 20080410
New selective inhibitors of steroid 11beta-hydroxylation in the adrenal cortex. Synthesis and structure-activity relationship of potent etomidate analogues. Journal of medicinal chemistry 20080410
Spectroscopic and kinetic studies on the interaction of ketoconazole and povidone drugs with DDQ. Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy 20080401
Ketoconazole-induced testicular damage in rats reduced by Gentiana extract. Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie 20080401
[Management of hypercortisolism]. La Revue de medecine interne 20080401
Unexpected emergence of acute hepatic injury in patients treated repeatedly with ketoconazole. Journal of clinical gastroenterology 20080401
Effects of CYP3A4 inhibitors on the pharmacokinetics of maraviroc in healthy volunteers. British journal of clinical pharmacology 20080401
'Anti-cortisolic' treatment of warts. Journal of the European Academy of Dermatology and Venereology : JEADV 20080401
Combinatorial anti-Trichophyton effects of Ligusticum chuanxiong essential oil components with antibiotics. Archives of pharmacal research 20080401
Phaeohyphomycosis caused by Ulocladium species in a cat. The Veterinary record 20080329
Predominant role of 25OHD in the negative regulation of PTH expression: clinical relevance for hypovitaminosis D. Life sciences 20080326
Synthesis, crystal structure and antimicrobial activity of deoxybenzoin derivatives from genistein. European journal of medicinal chemistry 20080301
Inhibition of luteinizing hormone secretion by testosterone in men requires aromatization for its pituitary but not its hypothalamic effects: evidence from the tandem study of normal and gonadotropin-releasing hormone-deficient men. The Journal of clinical endocrinology and metabolism 20080301
Mixed inhibition of P450 3A4 as a chemoprotective mechanism against aflatoxin B1-induced cytotoxicity with cis-terpenones. Chemical research in toxicology 20080301
A novel ketoconazole bioadhesive effervescent tablet for vaginal delivery: design, in vitro and 'in vivo' evaluation. International journal of pharmaceutics 20080227
Synthesis, biological evaluation and molecular modelling studies of methyleneimidazole substituted biaryls as inhibitors of human 17alpha-hydroxylase-17,20-lyase (CYP17). Part I: Heterocyclic modifications of the core structure. Bioorganic & medicinal chemistry 20080215
Ethnoveterinary study for antidermatophytic activity of Piper betle, Alpinia galanga and Allium ascalonicum extracts in vitro. Research in veterinary science 20080201
Pharmacological evaluation of C-3 modified Betulinic acid derivatives with potent anticancer activity. Investigational new drugs 20080201
Antifungal canthin-6-one series accumulate in lipid droplets and affect fatty acid metabolism in Saccharomyces cerevisiae. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20080201
Coexistence of hERG current block and disruption of protein trafficking in ketoconazole-induced long QT syndrome. British journal of pharmacology 20080201
Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models. Xenobiotica; the fate of foreign compounds in biological systems 20080201
Ketoconazole, an antifungal imidazole, increases the sensitivity of rainbow trout to 17alpha-ethynylestradiol exposure. Aquatic toxicology (Amsterdam, Netherlands) 20080131
Antifungal and cytotoxic activities of some N-substituted aniline derivatives bearing a hetaryl fragment. Bioorganic & medicinal chemistry 20080115
[Prophylactic antifungal treatment in critically ill patients. A survey of a Cochrane review]. Ugeskrift for laeger 20080107
New triazole and triazolothiadiazine derivatives as possible antimicrobial agents. European journal of medicinal chemistry 20080101
Ritonavir 100 mg does not cause QTc prolongation in healthy subjects: a possible role as CYP3A inhibitor in thorough QTc studies. Clinical pharmacology and therapeutics 20080101
Biochemical and functional evidence for the control of pain mechanisms by dehydroepiandrosterone endogenously synthesized in the spinal cord. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20080101
Prediction of onset of crystallization from experimental relaxation times. II. Comparison between predicted and experimental onset times. Journal of pharmaceutical sciences 20080101
Pharmacokinetic interaction of ketoconazole and itraconazole with ciprofloxacin. Biopharmaceutics & drug disposition 20080101
Spectrofluorimetric study and detection of ketoconazole in the presence of beta-cyclodextrin. Journal of fluorescence 20080101
N-Phenyl and N-phenylalkyl-maleimides acting against Candida spp.: time-to-kill, stability, interaction with maleamic acids. Bioorganic & medicinal chemistry 20080101
Novel cholesterol biosynthesis inhibitors targeting human lanosterol 14alpha-demethylase (CYP51). Bioorganic & medicinal chemistry 20080101
The effects of CYP3A4 inhibition on erlotinib pharmacokinetics: computer-based simulation (SimCYP) predicts in vivo metabolic inhibition. European journal of clinical pharmacology 20080101
Synthesis, biological evaluation and molecular modelling studies of novel ACD- and ABD-ring steroidomimetics as inhibitors of CYP17. Bioorganic & medicinal chemistry letters 20080101
Activity of caspofungin and voriconazole against clinical isolates of Candida and other medically important yeasts by the CLSI M-44A disk diffusion method with Neo-Sensitabs tablets. Chemotherapy 20080101
Ketoconazole revisited: a preoperative or postoperative treatment in Cushing's disease. European journal of endocrinology 20080101
[Medical treatment for Cushing's syndrome]. Nihon rinsho. Japanese journal of clinical medicine 20080101
[Ectopic Cushing's syndrome caused by a functioning pancreatic neuroendocrine tumour in a patient with von Hippel-Lindau disease]. Revista espanola de medicina nuclear 20080101
Novel concepts in androgen receptor blockade. Cancer journal (Sudbury, Mass.) 20080101
[Itraconazole treatment in the suspension of pathological fungal colonization of the airway in patients with pulmonary tuberculosis]. Problemy tuberkuleza i boleznei legkikh 20080101
Dermatophyte susceptibilities to antifungal azole agents tested in vitro by broth macro and microdilution methods. Revista do Instituto de Medicina Tropical de Sao Paulo 20080101
The effectiveness of retinoic acid treatment in bladder cancer: impact on recurrence, survival and TGFalpha and VEGF as end-point biomarkers. Cancer biology & therapy 20080101
Prevention of bladder cancer recurrence by retinoic acid-ketoconazole: a promising strategy? Cancer biology & therapy 20080101
Effect of coadministered ketoconazole, a strong cytochrome P450 3A4 enzyme inhibitor, on the pharmacokinetics of ciclesonide and its active metabolite desisobutyryl-ciclesonide. Clinical pharmacokinetics 20080101
The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20080101
CYP2D6 is primarily responsible for the metabolism of clomiphene. Drug metabolism and pharmacokinetics 20080101
[Susceptibility to antifungal agents among Cryptococcus neoformans varieties isolated from patients at a university hospital]. Revista da Sociedade Brasileira de Medicina Tropical 20080101
Reduction of fluconazole susceptibility of Candida albicans in APECED patients due to long-term use of ketoconazole and miconazole. Scandinavian journal of infectious diseases 20080101
[Mycetoma]. Annales de dermatologie et de venereologie 20080101
Protothecosis as a cause of chronic diarrhoea in a dog. Polish journal of veterinary sciences 20080101
A novel approach to the prediction of drug-drug interactions in humans based on the serum incubation method. Drug metabolism and pharmacokinetics 20080101
A Bayesian meta-analysis on published sample mean and variance pharmacokinetic data with application to drug-drug interaction prediction. Journal of biopharmaceutical statistics 20080101
Diffuse cutaneous leishmaniasis: co-infection with human immunodeficiency virus (HIV). Indian journal of dermatology, venereology and leprology 20080101
Tinea nigra by Hortaea werneckii, a report of 22 cases from Mexico. Studies in mycology 20080101
[Modern approach to treatment of trophic ulcers of legs with perifocal varicose eczema, associated with mycotic infection]. Khirurgiia 20080101
Evaluation of the relationship between androgenetic alopecia and demodex infestation. Indian journal of dermatology 20080101
[Resistance to azolic compounds in clinical Trichophyton spp. strains]. Revista iberoamericana de micologia 20071231
Composition, enantiomeric distribution, and antimicrobial activity of Tanacetum argenteum subsp. flabellifolium essential oil. Journal of pharmaceutical and biomedical analysis 20071221
Induction of the NAD(P)H:quinone oxidoreductase 1 by ketoconazole and itraconazole: a mechanism of cancer chemoprotection. Cancer letters 20071208
Interactions of azole antifungal agents with the human breast cancer resistance protein (BCRP). Journal of pharmaceutical sciences 20071201
Identification of human liver cytochrome P450 enzymes involved in biotransformation of vicriviroc, a CCR5 receptor antagonist. Drug metabolism and disposition: the biological fate of chemicals 20071201
Cyclic conversion of the novel Src kinase inhibitor [7-(2,6-dichloro-phenyl)-5-methyl-benzo[1,2,4]triazin-3-yl]-[4-(2-pyrrolidin-1-yl-ethoxy)-phenyl]-amine (TG100435) and Its N-oxide metabolite by flavin-containing monoxygenases and cytochrome P450 reductase. Drug metabolism and disposition: the biological fate of chemicals 20071201
Effect of hydration on the permeation of ketoconazole through human nail plate in vitro. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20071201
Phase II study of ketoconazole plus granulocyte-macrophage colony-stimulating factor for prostate cancer: effect of extent of disease on outcome. The Journal of urology 20071201
Cytochrome P3A4 inhibitors and other constituents of Fibraurea tinctoria. Journal of natural products 20071201
Bioactive polychlorinated bibenzyls from the liverwort Riccardia polyclada. Journal of natural products 20071201
Pharmacokinetic interaction between ketoconazole and praziquantel in healthy volunteers. Journal of clinical pharmacy and therapeutics 20071201
Nodular pulmonary histoplasmosis in Cushing's disease: a case report and literature review. Tennessee medicine : journal of the Tennessee Medical Association 20071201
Quantitative correlations among CYP3A sensitive substrates and inhibitors: literature analysis. Current drug metabolism 20071201
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. Journal of medicinal chemistry 20071129
Induction of drought stress tolerance by ketoconazole in Catharanthus roseus is mediated by enhanced antioxidant potentials and secondary metabolite accumulation. Colloids and surfaces. B, Biointerfaces 20071115
Rational prescription of drugs within similar therapeutic or structural class for gastrointestinal disease treatment: drug metabolism and its related interactions. World journal of gastroenterology 20071114
Adaptive therapy for androgen-independent prostate cancer: a randomized selection trial of four regimens. Journal of the National Cancer Institute 20071107
Pharmacokinetic modulation of oral etoposide by ketoconazole in patients with advanced cancer. Cancer chemotherapy and pharmacology 20071101
The cytochrome p450 inhibitor ketoconazole potentiates 5-hydroxytryptamine-induced contraction in rat aorta. The Journal of pharmacology and experimental therapeutics 20071101
Use of isolated hepatocyte preparations for cytochrome P450 inhibition studies: comparison with microsomes for Ki determination. Drug metabolism and disposition: the biological fate of chemicals 20071101
Synthesis and antifungal activities of novel 2-aminotetralin derivatives. Journal of medicinal chemistry 20071101
Cytotoxic doses of ketoconazole affect expression of a subset of hepatic genes. Journal of toxicology and environmental health. Part A 20071101
[Malassezia folliculitis: characteristics and therapeutic response in 26 patients]. Annales de dermatologie et de venereologie 20071101
Formulation compatibility of myristyl nicotinate with drugs used to treat dermatological conditions involving an impaired skin barrier. Drug development and industrial pharmacy 20071101
Pharmacological management of Cushing's syndrome: an update. Arquivos brasileiros de endocrinologia e metabologia 20071101
33-Year-old man with cough, fever, and weight loss. Mayo Clinic proceedings 20071001
Metabolism of tacrolimus (FK506) and recent topics in clinical pharmacokinetics. Drug metabolism and pharmacokinetics 20071001
A novel foam formulation of ketoconazole 2% for the treatment of seborrheic dermatitis on multiple body regions. Journal of drugs in dermatology : JDD 20071001
Efficacy of low-dose ketoconazole in hormone refractory prostate cancer patients at the National Cancer Centre and The Cancer Institute, Singapore. Annals of the Academy of Medicine, Singapore 20071001
The role of ketoconazole in seborrheic dermatitis. Cutis 20071001
Effect of one month ketoconazole treatment on GH, cortisol and ACTH release after ghrelin, GHRP-6 and GHRH administration in patients with Cushing's disease. Arquivos brasileiros de endocrinologia e metabologia 20071001
[Metabolic products and pathway of neferine in rat liver]. Yao xue xue bao = Acta pharmaceutica Sinica 20071001
Drug-drug interaction prediction: a Bayesian meta-analysis approach. Statistics in medicine 20070910
Influence of ketoconazole on the fecal and urinary disposition of docetaxel. Cancer chemotherapy and pharmacology 20070901
Diagnosis and treatment of ocular coccidioidomycosis in a female captive chimpanzee (Pan troglodytes): a case study. Annals of the New York Academy of Sciences 20070901
Synthesis of novel triazole derivatives as inhibitors of cytochrome P450 14alpha-demethylase (CYP51). European journal of medicinal chemistry 20070901
Azole therapy of clinical and experimental coccidioidomycosis. Annals of the New York Academy of Sciences 20070901
Ciclosporin use in multi-drug therapy for meningoencephalomyelitis of unknown aetiology in dogs. The Journal of small animal practice 20070901
Effects of endocrine disrupting chemicals on expression of phospholipid hydroperoxide glutathione peroxidase mRNA in rat testes. Journal of veterinary science 20070901
Restoration of hormonal action and muscle protein. Critical care medicine 20070901
Effective treatment for dermatophytoses of the foot: effect on restoration of depressed cell-mediated immunity. Journal of the European Academy of Dermatology and Venereology : JEADV 20070901
Candida interface keratitis after deep anterior lamellar keratoplasty: clinical, microbiologic, histopathologic, and confocal microscopic reports. Cornea 20070901
Ketoconazole in the treatment of chronic idiopathic central serous chorioretinopathy. Retina (Philadelphia, Pa.) 20070901
Development of an in vivo rat screen model to predict pharmacokinetic interactions of CYP3A4 substrates. Xenobiotica; the fate of foreign compounds in biological systems 20070901
Raman, FT-IR, NMR spectroscopic data and antimicrobial activity of bis[micro2-(benzimidazol-2-yl)-2-ethanethiolato-N,S,S-chloro-palladium(II)] dimer, [(micro2-CH2CH2NHNCC6H4)PdCl]2.C2H5OH complex. European journal of medicinal chemistry 20070801
Antiepileptic drugs affect neuronal androgen signaling via a cytochrome P450-dependent pathway. The Journal of pharmacology and experimental therapeutics 20070801
Transcription of key genes regulating gonadal steroidogenesis in control and ketoconazole- or vinclozolin-exposed fathead minnows. Toxicological sciences : an official journal of the Society of Toxicology 20070801
Combination of surgical avulsion and topical therapy for single nail onychomycosis: a randomized controlled trial. The British journal of dermatology 20070801
Activity of ketoconazole against Mycobacterium tuberculosis in vitro and in the mouse model. Journal of medical microbiology 20070801
Tinea capitis: no incision nor excision. Journal of pediatric surgery 20070801
Ketoconazole is inferior to ritonavir as an alternative booster for saquinavir in a once daily regimen in Thai HIV-1 infected patients. AIDS (London, England) 20070731
The prokinetic cinitapride has no clinically relevant pharmacokinetic interaction and effect on QT during coadministration with ketoconazole. Drug metabolism and disposition: the biological fate of chemicals 20070701
Eumycetoma presenting as a cerebellopontine angle mass lesion. Clinical neurology and neurosurgery 20070701
In vitro susceptibilities of 217 clinical isolates of zygomycetes to conventional and new antifungal agents. Antimicrobial agents and chemotherapy 20070701
Cytochrome P450-dependent metabolism of vitamin E isoforms is a critical determinant of their tissue concentrations in rats. Lipids 20070701
Identification and in vitro antifungal susceptibility testing of 200 clinical isolates of Candida spp. responsible for fingernail infections. Mycopathologia 20070701
Comparison between fluconazole and ketoconazole effectivity in the treatment of pityriasis versicolor. Mycoses 20070701
Oral paracoccidioidomycosis: a case without lung manifestations. The journal of contemporary dental practice 20070701
Melanin biosynthesis in Madurella mycetomatis and its effect on susceptibility to itraconazole and ketoconazole. Microbes and infection 20070701
Preparation, characterization, and scale-up of ketoconazole with enhanced dissolution and bioavailability. Drug development and industrial pharmacy 20070701
Tailored hormonal therapy in secretory adrenocortical cancer. Annals of oncology : official journal of the European Society for Medical Oncology 20070701
[Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica 20070701
Optimisation of hydrocortisone production by Curvularia lunata. Applied biochemistry and biotechnology 20070701
Comparison of fast liquid chromatography/tandem mass spectrometric methods for simultaneous determination of cladribine and clofarabine in mouse plasma. Journal of pharmaceutical and biomedical analysis 20070628
Discovery of novel indazole-linked triazoles as antifungal agents. Bioorganic & medicinal chemistry letters 20070615
Possible inhibitory mechanism of Curcuma drugs on CYP3A4 in 1alpha,25 dihydroxyvitamin D3 treated Caco-2 cells. International journal of pharmaceutics 20070607
Hepatitis and rhabdomyolysis in a patient with hormone refractory prostate cancer on ketoconazole and concurrent lovastatin therapy. Investigational new drugs 20070601
Pharmacological prevention of the deleterious effects of cardiopulmonary bypass. Asian cardiovascular & thoracic annals 20070601
A new ketoconazole topical gel formulation in seborrhoeic dermatitis: an updated review of the mechanism. Expert opinion on pharmacotherapy 20070601
Ketoconazole in the fathead minnow (Pimephales promelas): reproductive toxicity and biological compensation. Environmental toxicology and chemistry 20070601
Life-threatening Pneumocystis jiroveci pneumonia following treatment of severe Cushing's syndrome. The Netherlands journal of medicine 20070601
Non-interventional management of obstructive acute renal-failure in hormone-naïve prostate cancer. The Canadian journal of urology 20070601
Electrochemical reduction of sterol-14alpha-demethylase from Mycobacterium tuberculosis (CYP51b1). Biochemistry. Biokhimiia 20070601
Ketoconazole gel 2% in the treatment of moderate to severe seborrheic dermatitis. Cutis 20070601
[Mediastinal lymph nodes during the course of a metastatic prostate cancer]. Actas urologicas espanolas 20070601
Schistosoma haematobium and urinary tract pathogens co-infections in a rural community of Edo State, Nigeria. The Journal of communicable diseases 20070601
A lesson for everyone in drug-drug interactions. International journal of cardiology 20070516
MgMfs1, a major facilitator superfamily transporter from the fungal wheat pathogen Mycosphaerella graminicola, is a strong protectant against natural toxic compounds and fungicides. Fungal genetics and biology : FG & B 20070501
Induction of cytochrome P450 1A1 by ketoconazole and itraconazole but not fluconazole in murine and human hepatoma cell lines. Toxicological sciences : an official journal of the Society of Toxicology 20070501
Sequential metabolism is responsible for diltiazem-induced time-dependent loss of CYP3A. Drug metabolism and disposition: the biological fate of chemicals 20070501
Antifungal susceptibility testing of Trichophyton rubrum by E-test. Archives of dermatological research 20070501
Effect of efavirenz on the pharmacokinetics of ketoconazole in HIV-infected patients. European journal of clinical pharmacology 20070501
Cytochrome P450 3A inhibition by ketoconazole affects prasugrel and clopidogrel pharmacokinetics and pharmacodynamics differently. Clinical pharmacology and therapeutics 20070501
Estimation of intragastric solubility of drugs: in what medium? Pharmaceutical research 20070501
Electrochemical properties of cytochroms P450 using nanostructured electrodes: direct electron transfer and electro catalysis. Journal of inorganic biochemistry 20070501
Lecythophora hoffmannii isolated from a case of canine osteomyelitis in Japan. Medical mycology 20070501
Flutrimazole shampoo 1% versus ketoconazole shampoo 2% in the treatment of pityriasis versicolor. A randomised double-blind comparative trial. Mycoses 20070501
Plasma pharmacokinetics and CYP3A12-dependent metabolism of c-kit inhibitor imatinib in dogs. Xenobiotica; the fate of foreign compounds in biological systems 20070501
Interventions for treating oral candidiasis for patients with cancer receiving treatment. The Cochrane database of systematic reviews 20070418
Activated pregnenolone X-receptor is a target for ketoconazole and its analogs. Clinical cancer research : an official journal of the American Association for Cancer Research 20070415
Antifungal treatment in sarcoidosis--a pilot intervention trial. Respiratory medicine 20070401
Characterization of hot-melt extruded drug delivery systems for onychomycosis. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20070401
Synthesis and antimicrobial activities of Schiff bases derived from 5-chloro-salicylaldehyde. European journal of medicinal chemistry 20070401
Luteinizing hormone-induced caspase activation in rat preovulatory follicles is coupled to mitochondrial steroidogenesis. Endocrinology 20070401
Deacetylclivorine: a gender-selective metabolite of clivorine formed in female Sprague-Dawley rat liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20070401
Second generation of 5-ethenylbenzofuroxan derivatives as inhibitors of Trypanosoma cruzi growth: synthesis, biological evaluation, and structure-activity relationships. Bioorganic & medicinal chemistry 20070401
Synthesis of DL-standishinal and its related compounds for the studies on structure-activity relationship of inhibitory activity against aromatase. Bioorganic & medicinal chemistry 20070401
In vitro activity of an ear rinse containing tromethamine, EDTA, benzyl alcohol and 0.1% ketoconazole on Malassezia organisms from dogs with otitis externa. Veterinary dermatology 20070401
Adrenal androgen levels as predictors of outcome in prostate cancer patients treated with ketoconazole plus antiandrogen withdrawal: results from a cancer and leukemia group B study. Clinical cancer research : an official journal of the American Association for Cancer Research 20070401
Pharmacokinetic modelling of pentoxifylline and lisofylline after oral and intravenous administration in mice. The Journal of pharmacy and pharmacology 20070401
[Lithium gluconate 8% in the treatment of seborrheic dermatitis]. Annales de dermatologie et de venereologie 20070401
Inhibitory or scavenging action of ketoconazole and ciclopiroxolamine against reactive oxygen species released by primed inflammatory cells. The British journal of dermatology 20070401
Effect of ion suppression on judgment of enzyme inhibition and avoidance of error by utilizing a stable isotope-labeled probe substrate: example of CYP3A4 inhibition with [13C4,15N] labeled midazolam as a substrate. Drug metabolism and pharmacokinetics 20070401
[Cushing syndrome]. Revue de l'infirmiere 20070401
[Effectiveness of the treatment plan for androgenetic alopecia]. Georgian medical news 20070401
Eumycetoma pedis due to Exophiala jeanselmei. Indian journal of medical microbiology 20070401
The development of a cocktail CYP2B6, CYP2C8, and CYP3A5 inhibition assay and a preliminary assessment of utility in a drug discovery setting. Drug metabolism and disposition: the biological fate of chemicals 20070301
Effect of oral ketoconazole on intestinal first-pass effect of midazolam and fexofenadine in cynomolgus monkeys. Drug metabolism and disposition: the biological fate of chemicals 20070301
Three-dimensional quantitative structure-activity relationship analysis of human CYP51 inhibitors. Drug metabolism and disposition: the biological fate of chemicals 20070301
Antifungal activities of azole agents against the Malassezia species. International journal of antimicrobial agents 20070301
Development of quantitative real-time PCR assays for fathead minnow (Pimephales promelas) gonadotropin beta subunit mRNAs to support endocrine disruptor research. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070301
Potential cancer chemopreventive in vitro activities of monomeric xanthone derivatives from the marine algicolous fungus Monodictys putredinis. Journal of natural products 20070301
Potentiating effects of nonactive/active vitamin D analogues and ketoconazole in parathyroid cells. Clinical endocrinology 20070301
Metronidazole 0.75% gel vs. ketoconazole 2% cream in the treatment of facial seborrheic dermatitis: a randomized, double-blind study. Journal of the European Academy of Dermatology and Venereology : JEADV 20070301
Clinical inquiries. What's the best treatment for cradle cap? The Journal of family practice 20070301
Antiplasmodial interactions between artemisinin and triclosan or ketoconazole combinations against blood stages of Plasmodium falciparum in vitro. The American journal of tropical medicine and hygiene 20070301
Report of an imported cutaneous disseminated case of paracoccidioidomycosis. Revista iberoamericana de micologia 20070301
Hyperadrenocorticism: treating dogs. Compendium (Yardley, PA) 20070301
CP-154,526, a CRF type-1 receptor antagonist, attenuates the cue-and methamphetamine-induced reinstatement of extinguished methamphetamine-seeking behavior in rats. Psychopharmacology 20070201
Evidence of Oatp and Mdr1 in cryopreserved rat hepatocytes. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20070201
Synthesis, characterization and antimicrobial activity of Fe(II), Zn(II), Cd(II) and Hg(II) complexes with 2,6-bis(benzimidazol-2-yl) pyridine ligand. European journal of medicinal chemistry 20070201
Inhibition of CYP3A4 and CYP3A5 catalyzed metabolism of alprazolam and quinine by ketoconazole as racemate and four different enantiomers. European journal of clinical pharmacology 20070201
Transporter-mediated drug interactions: clinical implications and in vitro assessment. Expert opinion on drug metabolism & toxicology 20070201
[A text-book case of tropical facial elephantiasis]. Revue de stomatologie et de chirurgie maxillo-faciale 20070201
Concentrations of mycophenolic acid and glucuronide metabolites under concomitant therapy with cyclosporine or tacrolimus. Therapeutic drug monitoring 20070201
[Oral isolates of Saccharomyces in patients with oral fungal infection and their susceptibility to antifungal drugs]. Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology 20070201
[Acanthamoeba keratitis: about the first two Tunisian cases]. Bulletin de la Societe de pathologie exotique (1990) 20070201
[Cutaneous sporotricosis in a Malagasy patient]. Medecine tropicale : revue du Corps de sante colonial 20070201
Determination of antifungal activity of polyenzyme preparation Candidaseb using in vitro methods. Hindustan antibiotics bulletin 20070201
Inhibition of drug metabolism by blocking the activation of nuclear receptors by ketoconazole. Oncogene 20070111
Effects of three cytochrome P450 inhibitors, ketoconazole, fluconazole, and paroxetine, on the pharmacokinetics of lasofoxifene. British journal of clinical pharmacology 20070101
Reversal of androgenetic alopecia by topical ketoconzole: relevance of anti-androgenic activity. Journal of dermatological science 20070101
A novel model for the prediction of drug-drug interactions in humans based on in vitro cytochrome p450 phenotypic data. Drug metabolism and disposition: the biological fate of chemicals 20070101
Synthesis and antifungal activity of (Z)-5-arylidenerhodanines. Bioorganic & medicinal chemistry 20070101
Design of endoperoxides with anti-Candida activity. Bioorganic & medicinal chemistry 20070101
Molecular evidence and functional expression of multidrug resistance associated protein (MRP) in rabbit corneal epithelial cells. Experimental eye research 20070101
Antimicrobial effectiveness of ketoconazole against metronidazole-resistant Helicobacter pylori isolates from Iranian dyspeptic patients. The Journal of antimicrobial chemotherapy 20070101
The stereoselective metabolism of halofantrine to desbutylhalofantrine in the rat: evidence of tissue-specific enantioselectivity in microsomal metabolism. Chirality 20070101
CYP3A4 mediated in vitro metabolism of vinflunine in human liver microsomes. Acta pharmacologica Sinica 20070101
1H NMR monitoring of the canine metabolic profile after oral administration of xenobiotics using multivariate statistics. Molecular pharmaceutics 20070101
Value of colposcopy in the diagnosis of candidiasis in patients with vulvodynia. The Journal of reproductive medicine 20070101
Simultaneous determination of docetaxel and ketoconazole in rat plasma by liquid chromatography/electrospray ionization tandem mass spectrometry. Rapid communications in mass spectrometry : RCM 20070101
Comparison of different perrmeation enhancers on topical ketoconazole formulations. Arzneimittel-Forschung 20070101
Human intestinal P-glycoprotein activity estimated by the model substrate digoxin. Scandinavian journal of clinical and laboratory investigation 20070101
Ketoconazole therapy: an efficacious alternative to achieve eucortisolism in patients with Cushing's syndrome. Medicina 20070101
Antiviral and antimicrobial profiles of selected isoquinoline alkaloids from Fumaria and Corydalis species. Zeitschrift fur Naturforschung. C, Journal of biosciences 20070101
Abdominal wall mycetoma presented as obstructed incisional hernia of cesarean section in eastern Sudan. Infectious diseases in obstetrics and gynecology 20070101
Significant prostate-specific antigen (PSA) response to low-dose ketoconazole in a patient with non-metastatic androgen-independent prostate cancer (AIPC) and a review of the literature. American journal of therapeutics 20070101
Pharmacokinetics of cinacalcet hydrochloride when administered with ketoconazole. Clinical pharmacokinetics 20070101
Clinical efficacies of shampoos containing ciclopirox olamine (1.5%) and ketoconazole (2.0%) in the treatment of seborrhoeic dermatitis. The Journal of dermatological treatment 20070101
Simultaneous ectopic adrenocorticotropic hormone syndrome and adrenal metastasis of a medullary thyroid carcinoma causing paraneoplastic Cushing's syndrome. International seminars in surgical oncology : ISSO 20070101
Extina foam (2%). Skinmed 20070101
Multiple oral dosing of ketoconazole increases dog exposure to ivermectin. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20070101
Ketoconazole-evoked [Ca2+]i rises and non-Ca2+-triggered cell death in rabbit corneal epithelial cells (SIRC). Journal of receptor and signal transduction research 20070101
[Quo vadis, hypophysis? Some news and prospects]. Vnitrni lekarstvi 20070101
Localized cutaneous leishmaniasis in South India: successful treatment with ketoconazole. Indian journal of dermatology, venereology and leprology 20070101
CYP3A4 and pregnane X receptor humanized mice. Journal of biochemical and molecular toxicology 20070101
[The 50th Anniversary Educational Symposium of the Japanese Society for Medical Mycology: Dermatomycoses caused by Malassezia]. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20070101
Effect of hypercortisolism control on high blood pressure in Cushing's syndrome. Medicina 20070101
Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes. European journal of drug metabolism and pharmacokinetics 20070101
In vitro release--in vivo microbiological and toxicological studies on ketoconazole lipid granules. Pharmaceutical development and technology 20070101
Identification of CYP3A4 as the primary cytochrome P450 responsible for the metabolism of tandospirone by human liver microsomes. European journal of drug metabolism and pharmacokinetics 20070101
In vitro antifungal activity of 2-(4-substituted phenyl)-3(2H)-isothiazolones. Folia microbiologica 20070101
Pregnenolone and dexamethasone, modulators of cytochrome P450-3A, not increase but reduce urinary alpha-CEHC excretion in rats. BioFactors (Oxford, England) 20070101
Seborrhoeic dermatitis. BMJ clinical evidence 20070101
Treatment algorithm in hormone-resistant prostate cancer: Practical guidelines. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Repeated 28-day oral toxicity study of ketoconazole in rats based on the draft protocol for the 'Enhanced OECD Test Guideline No. 407' to detect endocrine effects. Archives of toxicology 20061201
The role of P-glycoprotein in the bioactivation of raloxifene. Drug metabolism and disposition: the biological fate of chemicals 20061201
Drug-metabolizing enzyme inhibition by ketoconazole does not reduce interindividual variability of CYP3A activity as measured by oral midazolam. Drug metabolism and disposition: the biological fate of chemicals 20061201
Antifungal susceptibilities of the species of the Pseudallescheria boydii complex. Antimicrobial agents and chemotherapy 20061201
Antifolates as antimycotics? Connection between the folic acid cycle and the ergosterol biosynthesis pathway in Candida albicans. International journal of antimicrobial agents 20061201
Cytochrome P450-dependent metabolism of midazolam in hepatic microsomes from chickens, turkeys, pheasant and bobwhite quail. Journal of veterinary pharmacology and therapeutics 20061201
White piedra in children. Journal of the American Academy of Dermatology 20061201
In vitro antifungal efficacy of ciclopirox olamine alone and associated with zinc pyrithione compared to ketoconazole against Malassezia globosa and Malassezia restricta reference strains. Mycopathologia 20061201
Mechanisms of venoocclusive disease resulting from the combination of cyclophosphamide and roxithromycin. Therapeutic drug monitoring 20061201
Preoperative immunosuppressive therapy and surgery as a treatment for anal furunculosis. Veterinary surgery : VS 20061201
Bioactive oligostilbenoids from the stem bark of Hopea exalata. Journal of natural products 20061201
Evaluation of the effects of hydrophilic organic solvents on CYP3A-mediated drug-drug interaction in vitro. Human & experimental toxicology 20061201
[Study on metabolism of tetramethylpyrazine in system of rat liver microsomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20061201
[Canine lymphadenitis caused by Cryptococcus neoformans. First case in Chile]. Revista iberoamericana de micologia 20061201
Common pharmacophores for uncharged human ether-a-go-go-related gene (hERG) blockers. Journal of medicinal chemistry 20061116
Human adrenocarcinoma (H295R) cells for rapid in vitro determination of effects on steroidogenesis: hormone production. Toxicology and applied pharmacology 20061115
The H295R system for evaluation of endocrine-disrupting effects. Ecotoxicology and environmental safety 20061101
Effectiveness and tolerability of a standardized extract from Ageratina pichinchensis on patients with tinea pedis: an explorative pilot study controlled with ketoconazole. Planta medica 20061101
In vitro methods for antifungal susceptibility testing of Trichophyton spp. Mycological research 20061101
Otomycosis: clinical features and treatment implications. Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20061101
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice. PLoS medicine 20061101
Inhibition of the enzymatic activity of heme oxygenases by azole-based antifungal drugs. The Journal of pharmacology and experimental therapeutics 20061001
Characterization of the rhesus monkey CYP3A64 enzyme: species comparisons of CYP3A substrate specificity and kinetics using baculovirus-expressed recombinant enzymes. Drug metabolism and disposition: the biological fate of chemicals 20061001
Metabolism of endosulfan-alpha by human liver microsomes and its utility as a simultaneous in vitro probe for CYP2B6 and CYP3A4. Drug metabolism and disposition: the biological fate of chemicals 20061001
Influence of tartaric acid on the bioadhesion and mechanical properties of hot-melt extruded hydroxypropyl cellulose films for the human nail. Drug development and industrial pharmacy 20061001
Decision support tool to individualize cyclosporine dose in stable, long-term heart transplant recipients receiving metabolic inhibitors: overcoming limitations of cyclosporine C2 monitoring. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20061001
In-vitro susceptibility testing by agar dilution method to determine the minimum inhibitory concentrations of amphotericin B, fluconazole and ketoconazole against ocular fungal isolates. Indian journal of medical microbiology 20061001
A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21. Journal of enzyme inhibition and medicinal chemistry 20061001
Evidence for cytochrome P450 3A expression and catalytic activity in rat blood lymphocytes. Life sciences 20060927
Synthesis, biochemical evaluation and rationalisation of the inhibitory activity of a range of 4-substituted phenyl alkyl imidazole-based inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)). Bioorganic & medicinal chemistry letters 20060915
Retinoic acid as a novel medical therapy for Cushing's disease in dogs. Endocrinology 20060901
Response to low-dose ketoconazole and subsequent dose escalation to high-dose ketoconazole in patients with androgen-independent prostate cancer. Cancer 20060901
Disopyramide: although potentially life-threatening in the setting of long QT, could it be life-saving in short QT syndrome? Journal of molecular and cellular cardiology 20060901
Metabolism and metabolic inhibition of gambogic acid in rat liver microsomes. Acta pharmacologica Sinica 20060901
Metabolic activation of pradefovir by CYP3A4 and its potential as an inhibitor or inducer. Antimicrobial agents and chemotherapy 20060901
RAT CYP3A and CYP2B1/2 were not associated with nevirapine-induced hepatotoxicity. Methods and findings in experimental and clinical pharmacology 20060901
Intervention at the level of the neuroendocrine-immune axis and postoperative pneumonia rate in long-term alcoholics. American journal of respiratory and critical care medicine 20060815
Suppressive effects of antimycotics on tumor necrosis factor-alpha-induced CCL27, CCL2, and CCL5 production in human keratinocytes. Biochemical pharmacology 20060814
The use of a fluorescence-based oxygen uptake assay in the analysis of cytotoxicity. Toxicology in vitro : an international journal published in association with BIBRA 20060801
Novel ketoconazole analogues based on the replacement of 2,4-dichlorophenyl group with 1,4-benzothiazine moiety: design, synthesis, and microbiological evaluation. Bioorganic & medicinal chemistry 20060801
Inhibition of UDP-glucuronosyltransferase 2b7-catalyzed morphine glucuronidation by ketoconazole: dual mechanisms involving a novel noncompetitive mode. Drug metabolism and disposition: the biological fate of chemicals 20060801
Activating mutations in the luteinizing hormone receptor gene: a human model of non-follicle-stimulating hormone-dependent inhibin production and germ cell maturation. The Journal of clinical endocrinology and metabolism 20060801
Synthesis and biochemical evaluation of a range of potent benzyl imidazole-based compounds as potential inhibitors of the enzyme complex 17alpha-hydroxylase/17,20-lyase (P450(17alpha)). Bioorganic & medicinal chemistry letters 20060801
Use of omeprazole sulfone in a single plasma sample as a probe for CYP3A4. European journal of clinical pharmacology 20060801
Secondary hormonal manipulations in prostate cancer. Hematology/oncology clinics of North America 20060801
Transporter-mediated intestinal absorption of fexofenadine in rats. Drug metabolism and pharmacokinetics 20060801
Cushing's paraneoplastic syndrome as first manifestation of an adenocarcinoma of unknown origin. Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 20060801
Optimization and validation of a high-performance liquid chromatographic method with UV detection for the determination of ketoconazole in canine plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060724
Enhancement of DMNQ-induced hepatocyte toxicity by cytochrome P450 inhibition. Toxicology and applied pharmacology 20060715
Clinical results of topical fluconazole for the treatment of filamentous fungal keratitis. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20060701
Stereoselective metabolism of endosulfan by human liver microsomes and human cytochrome P450 isoforms. Drug metabolism and disposition: the biological fate of chemicals 20060701
Quinacrine is mainly metabolized to mono-desethyl quinacrine by CYP3A4/5 and its brain accumulation is limited by P-glycoprotein. Drug metabolism and disposition: the biological fate of chemicals 20060701
Expression, purification, and characterization of mouse CYP2d22. Drug metabolism and disposition: the biological fate of chemicals 20060701
Ketoconazole and miconazole are antagonists of the human glucocorticoid receptor: consequences on the expression and function of the constitutive androstane receptor and the pregnane X receptor. Molecular pharmacology 20060701
Stochastic prediction of CYP3A-mediated inhibition of midazolam clearance by ketoconazole. Drug metabolism and disposition: the biological fate of chemicals 20060701
Influence of high-dose ketoconazole on the pharmacokinetics of docetaxel. Cancer biology & therapy 20060701
In vitro susceptibilities of Malaysian clinical isolates of Cryptococcus neoformans var. grubii and Cryptococcus gattii to five antifungal drugs. Mycoses 20060701
Predictive power of an in vitro system to assess drug interactions of an antimuscarinic medication: a comparison of in vitro and in vivo drug-drug interaction studies of trospium chloride with digoxin. Journal of clinical pharmacology 20060701
Pharmacokinetic effect of ketoconazole on solifenacin in healthy volunteers. Basic & clinical pharmacology & toxicology 20060701
Phytochemistry and antifungal properties of the newly discovered tree Pleodendron costaricense. Journal of natural products 20060701
Chronic mucocutaneous candidiasis associated with malignant thymoma and systemic lupus erythematosus with hypergammaglobulinemia: a case report and literature review. Cutis 20060701
Interaction between ketoconazole and domperidone and the risk of QT prolongation--important safety information. South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde 20060701
Pharmacokinetic interaction between ketoconazole and SPP301 in healthy volunteers. International journal of clinical pharmacology and therapeutics 20060701
Biotransformation of fluticasone: in vitro characterization. Drug metabolism and disposition: the biological fate of chemicals 20060601
Comparison of mouse and rat cytochrome P450-mediated metabolism in liver and intestine. Drug metabolism and disposition: the biological fate of chemicals 20060601
Phase II study of mitoxantrone and ketoconazole for hormone-refractory prostate cancer. Cancer 20060601
In vitro antifungal activities of Allium cepa, Allium sativum and ketoconazole against some pathogenic yeasts and dermatophytes. Fitoterapia 20060601
Man versus machine: is there an optimal method for QT measurements in thorough QT studies? Journal of clinical pharmacology 20060601
Cytoskeleton reassembly in cardiomyocytes infected by Trypanosoma cruzi is triggered by treatment with ergosterol biosynthesis inhibitors. International journal of antimicrobial agents 20060601
Canine intestinal contents vs. simulated media for the assessment of solubility of two weak bases in the human small intestinal contents. Pharmaceutical research 20060601
Antifungal effects of the volatile oils from Allium plants against Trichophyton species and synergism of the oils with ketoconazole. Phytomedicine : international journal of phytotherapy and phytopharmacology 20060601
Ketoconazole as a secondary hormonal intervention in advanced prostate cancer. Clinical journal of oncology nursing 20060601
Polymorphic behaviour of Compritol888 ATO as bulk lipid and as SLN and NLC. Journal of microencapsulation 20060601
Fungal toenail infections. Clinical evidence 20060601
Surface plasmon resonance analysis of antifungal azoles binding to CYP3A4 with kinetic resolution of multiple binding orientations. Biochemistry 20060523
Identification and quantitation of cis-ketoconazole impurity by capillary zone electrophoresis-mass spectrometry. Journal of chromatography. A 20060505
alpha(2)-Adrenergic receptors activate MAPK and Akt through a pathway involving arachidonic acid metabolism by cytochrome P450-dependent epoxygenase, matrix metalloproteinase activation and subtype-specific transactivation of EGFR. Cellular signalling 20060501
Lack of effect of ketoconazole-mediated CYP3A inhibition on sorafenib clinical pharmacokinetics. Cancer chemotherapy and pharmacology 20060501
Metabolism and effect of para-toluene-sulfonamide on rat liver microsomal cytochrome P450 from in vivo and in vitro studies. Acta pharmacologica Sinica 20060501
The use of SLN and NLC as topical particulate carriers for imidazole antifungal agents. Die Pharmazie 20060501
[Skin infection with Fusarium in an immunocompetent patient]. Actas dermo-sifiliograficas 20060501
[Three cases of cutaneous blastomycosis]. Medecine et maladies infectieuses 20060501
Structure-based optimization of azole antifungal agents by CoMFA, CoMSIA, and molecular docking. Journal of medicinal chemistry 20060420
Drugs for treating paracoccidioidomycosis. The Cochrane database of systematic reviews 20060419
Synthesis and evaluation of heteroaryl-substituted dihydronaphthalenes and indenes: potent and selective inhibitors of aldosterone synthase (CYP11B2) for the treatment of congestive heart failure and myocardial fibrosis. Journal of medicinal chemistry 20060406
Inhibition of the HERG K+ channel by the antifungal drug ketoconazole depends on channel gating and involves the S6 residue F656. FEBS letters 20060403
Development, validation and utility of an in vitro technique for assessment of potential clinical drug-drug interactions involving P-glycoprotein. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20060401
In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug metabolism and disposition: the biological fate of chemicals 20060401
Interactions of two major metabolites of prasugrel, a thienopyridine antiplatelet agent, with the cytochromes P450. Drug metabolism and disposition: the biological fate of chemicals 20060401
Identification of human liver cytochrome P450 enzymes responsible for the metabolism of lonafarnib (Sarasar). Drug metabolism and disposition: the biological fate of chemicals 20060401
Antifungal agents for preventing fungal infections in non-neutropenic critically ill and surgical patients: systematic review and meta-analysis of randomized clinical trials. The Journal of antimicrobial chemotherapy 20060401
Formation of 4'-carboxyl acid metabolite of imrecoxib by rat liver microsomes. Acta pharmacologica Sinica 20060401
Long term control of hypercortisolism with fluconazole: case report and in vitro studies. European journal of endocrinology 20060401
In vitro efficacy of a buffered chelating solution as an antimicrobial potentiator for antifungal drugs against fungal pathogens obtained from horses with mycotic keratitis. American journal of veterinary research 20060401
Ketoconazole renders poor CYP3A phenotype status with midazolam as probe drug. Therapeutic drug monitoring 20060401
Acanthamoeba keratitis in a 5-year-old boy without a history of contact lens usage. Cornea 20060401
Aureobasidium pullulans keratitis. Clinical & experimental ophthalmology 20060401
[The effect of propyl gallate on the activity of various antifungal drugs against filamentous fungi in vitro]. [Zhonghua yan ke za zhi] Chinese journal of ophthalmology 20060401
The vitamin D prodrugs 1alpha(OH)D2, 1alpha(OH)D3 and BCI-210 suppress PTH secretion by bovine parathyroid cells. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060301
Coxiella burnetii inhabits a cholesterol-rich vacuole and influences cellular cholesterol metabolism. Cellular microbiology 20060301
Inhibition of Vitamin D3 metabolism enhances VDR signalling in androgen-independent prostate cancer cells. The Journal of steroid biochemistry and molecular biology 20060301
[Penicilliosis in Laos]. Presse medicale (Paris, France : 1983) 20060301
Novel endoperoxides: synthesis and activity against Candida species. Bioorganic & medicinal chemistry letters 20060215
Partial structures of ketoconazole as modulators of the large conductance calcium-activated potassium channel (BK(Ca)). Bioorganic & medicinal chemistry letters 20060215
Griseofulvin and ketoconazole solubilization by bile salts studied using fluorescence spectroscopy. Colloids and surfaces. B, Biointerfaces 20060201
Clinical evolution of paracoccidioidomycosis in 38 children and teenagers. Mycopathologia 20060201
Use of capecitabine after renal allograft transplantation in dog erythrocyte antigen-matched dogs. Veterinary surgery : VS 20060201
CYP3A4 activity in four different animal species liver microsomes using 7-benzyloxyquinoline and HPLC/spectrofluorometric determination. Journal of pharmaceutical and biomedical analysis 20060123
Development of a fluorescence-based assay for screening of modulators of human organic anion transporter 1B3 (OATP1B3). European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20060101
Dysmorphogenic effects of some fungicides derived from the imidazole on rat embryos cultured in vitro. Reproductive toxicology (Elmsford, N.Y.) 20060101
Determination of the enzyme(s) involved in the metabolism of amiodarone in liver and intestine of rat: the contribution of cytochrome P450 3A isoforms. Drug metabolism and disposition: the biological fate of chemicals 20060101
Intestinal and hepatic CYP3A4 catalyze hydroxylation of 1alpha,25-dihydroxyvitamin D(3): implications for drug-induced osteomalacia. Molecular pharmacology 20060101
An unusual presentation of malassezia dermatosis. Dermatology (Basel, Switzerland) 20060101
Hyperkeratotic head and neck Malassezia dermatosis. Dermatology (Basel, Switzerland) 20060101
Impact of the cyclosporine-ketoconazole interaction in children with steroid-dependent idiopathic nephrotic syndrome. European journal of clinical pharmacology 20060101
Effects of cytochrome P450 3A modulators ketoconazole and carbamazepine on quetiapine pharmacokinetics. British journal of clinical pharmacology 20060101
Bioavailability of two oral formulations of loratadine 20 mg with concomitant ketoconazole: an open-label, randomized, two-period crossover comparison in healthy Mexican adult volunteers. Clinical therapeutics 20060101
Effect of drug utilization reviews on the quality of in-hospital prescribing: a quasi-experimental study. BMC health services research 20060101
Recurrent vulvovaginal candidiasis. Missouri medicine 20060101
Carney complex (CNC). Orphanet journal of rare diseases 20060101
Malassezia and seborrheic dermatitis: etiology and treatment. Journal of cosmetic science 20060101
Ketoconazole-tacrolimus coadministration in kidney transplant recipients: two-year results of a prospective randomized study. American journal of nephrology 20060101
In vitro studies on quetiapine metabolism using the substrate depletion approach with focus on drug-drug interactions. Drug metabolism and drug interactions 20060101
Efficacy and safety of a new once-daily topical ketoconazole 2% gel in the treatment of seborrheic dermatitis: a phase III trial. Journal of drugs in dermatology : JDD 20060101
In vitro activity of R126638 and ketoconazole against Malassezia species. Acta dermato-venereologica 20060101
Clinical features and diagnosis of 42 travellers with cutaneous leishmaniasis. Travel medicine and infectious disease 20060101
[Effect of steroid biosynthesis modificators on the progesterone biotransformation by a recombinant yeasts expressing cytochrome P450c17]. Biomeditsinskaia khimiia 20060101
Xolegel (ketoconazole, 2%). Skinmed 20060101
[Drug-related problems in a patient with Cushing's disease]. Farmacia hospitalaria : organo oficial de expresion cientifica de la Sociedad Espanola de Farmacia Hospitalaria 20060101
Mycetoma : a review. American journal of clinical dermatology 20060101
Clinical efficacy of a new ciclopiroxolamine/zinc pyrithione shampoo in scalp seborrheic dermatitis treatment. European journal of dermatology : EJD 20060101
Effect of ketoconazole and rifampicin on the pharmacokinetics of ranitidine in healthy human volunteers: a possible role of P-glycoprotein. Drug metabolism and drug interactions 20060101
Effect of ketoconazole on the pharmacokinetics of ornidazole--a possible role of p-glycoprotein and CYP3A. Drug metabolism and drug interactions 20060101
[Laboratory evolutive aspects of children under paracoccidioidomycosis treatment]. Revista da Sociedade Brasileira de Medicina Tropical 20060101
Co-administration of ketoconazole and tacrolimus therapy: a transplanted rat model. International urology and nephrology 20060101
[Relative bioavailability and bioequivalence of the antimycotics ketoconazole and fluconazole]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20060101
In vitro susceptibility of oral Candida to seven antifungal agents. Oral microbiology and immunology 20051201
Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration. Journal of pharmaceutical sciences 20051201
Bioactive small molecules reveal antagonism between the integrated stress response and sterol-regulated gene expression. Cell metabolism 20051201
Evaluation and treatment of Cushing's syndrome. The American journal of medicine 20051201
A comparison of hair quality and cosmetic acceptance following the use of two anti-dandruff shampoos. The journal of investigative dermatology. Symposium proceedings 20051201
Effects of beta-thujaplicin on anti-Malassezia pachydermatis remedy for canine otitis externa. The Journal of veterinary medical science 20051201
Ketoconazole induced torsades de pointes without concomitant use of QT interval-prolonging drug. Journal of cardiovascular electrophysiology 20051201
Fungal nail infections. Clinical evidence 20051201
Candidiasis (vulvovaginal). Clinical evidence 20051201
Novel tetralone-derived retinoic acid metabolism blocking agents: synthesis and in vitro evaluation with liver microsomal and MCF-7 CYP26A1 cell assays. Journal of medicinal chemistry 20051117
Characterization of rat small intestinal and colon precision-cut slices as an in vitro system for drug metabolism and induction studies. Drug metabolism and disposition: the biological fate of chemicals 20051101
Uncommon clinical presentations of cutaneous leishmaniasis in Sudan. Transactions of the Royal Society of Tropical Medicine and Hygiene 20051101
Upregulation of sterol C14-demethylase expression in Trypanosoma cruzi treated with sterol biosynthesis inhibitors. Molecular and biochemical parasitology 20051101
Effect of azole antifungals ketoconazole and fluconazole on the pharmacokinetics of dexloxiglumide. British journal of clinical pharmacology 20051101
The effect of calcium chelating or binding agents on Candida albicans. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20051101
Clinical status of agents being developed for leishmaniasis. Expert opinion on investigational drugs 20051101
Extraction, hemisynthesis, and synthesis of canthin-6-one analogues. Evaluation of their antifungal activities. Journal of natural products 20051101
An overview of antifungal drugs and their use for treatment of deep and superficial mycoses in animals. Clinical techniques in small animal practice 20051101
[Metabolic kinetics of MN9202 in Beagle dog liver microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica 20051101
Increase of the LC-MS/MS sensitivity and detection limits using on-line sample preparation with large volume plasma injection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20051025
Characterization of human cytochrome P450 isoenzymes involved in the metabolism of vinorelbine. Fundamental & clinical pharmacology 20051001
[Drug-drug interaction of antifungal drugs]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20051001
The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs. Journal of veterinary pharmacology and therapeutics 20051001
Enantiomeric separation of ketoconazole and terconazole antifungals by electrokinetic chromatography: Rapid quantitative analysis of ketoconazole in pharmaceutical formulations. Electrophoresis 20051001
The role of ketoconazole in the prevention of ovarian hyperstimulation syndrome in patients with polycystic ovary syndrome during assisted reproductive technology cycles. Saudi medical journal 20051001
Effects of ketoconazole on glucuronidation by UDP-glucuronosyltransferase enzymes. Clinical cancer research : an official journal of the American Association for Cancer Research 20050915
[Determination of antidangdruff agent salicylic acid, zinc pyrithione, octopirox, climbazole and ketoconazole in shampoo by high performance liquid chromatography]. Wei sheng yan jiu = Journal of hygiene research 20050901
Increased expression and hotspot mutations of the multidrug efflux transporter, CDR1 in azole-resistant Candida albicans isolates from vaginitis patients. FEMS microbiology letters 20050815
Metabolism of the alpha,beta-unsaturated ketones, chalcone and trans-4-phenyl-3-buten-2-one, by rat liver microsomes and estrogenic activity of the metabolites. Drug metabolism and disposition: the biological fate of chemicals 20050801
The advantages of the Ussing chamber in drug absorption studies. Journal of biomolecular screening 20050801
2-O-(2-hydroxybutyl)-beta-cyclodextrin as a chiral selector for the capillary electrophoretic separation of chiral drugs. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050801
DNA fingerprinting pattern and susceptibility to antifungal drugs in Cryptococcus neoformans variety grubii isolates from Barcelona city and rural environmental samples. Mycopathologia 20050801
Identification of OATP1B3 as a high-affinity hepatocellular transporter of paclitaxel. Cancer biology & therapy 20050801
Ketobemidone is a substrate for cytochrome P4502C9 and 3A4, but not for P-glycoprotein. Xenobiotica; the fate of foreign compounds in biological systems 20050801
SLN and NLC for topical delivery of ketoconazole. Journal of microencapsulation 20050801
[3H]linopirdine binding to rat brain membranes is not relevant for M-channel interaction. European journal of pharmacology 20050725
Development and application of a new on-line SPE system combined with LC-MS/MS detection for high throughput direct analysis of pharmaceutical compounds in plasma. Journal of chromatography. A 20050708
Effect of several compounds on biliary excretion of paclitaxel and its metabolites in guinea-pigs. Anti-cancer drugs 20050701
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes. Life sciences 20050701
Alanine scanning of transmembrane helix 11 of Cdr1p ABC antifungal efflux pump of Candida albicans: identification of amino acid residues critical for drug efflux. The Journal of antimicrobial chemotherapy 20050701
A novel foam vehicle for delivery of topical corticosteroids. Journal of the American Academy of Dermatology 20050701
Rate-limiting biotransformation of triamterene is mediated by CYP1A2. International journal of clinical pharmacology and therapeutics 20050701
Fusarium solani breast abscess. Indian journal of medical microbiology 20050701
[In vitro activity of ketoconazole, itraconazole and terbinafine against Malassezia strains isolated from neonates]. Mikrobiyoloji bulteni 20050701
Characterization of testosterone 11 beta-hydroxylation catalyzed by human liver microsomal cytochromes P450. Drug metabolism and disposition: the biological fate of chemicals 20050601
Long-term outcome for men with androgen independent prostate cancer treated with ketoconazole and hydrocortisone. The Journal of urology 20050601
Ketoconazole increases plasma concentrations of antimalarial mefloquine in healthy human volunteers. Journal of clinical pharmacy and therapeutics 20050601
The effect of ketoconazole on the pharmacokinetics of a selective alpha 1A-adrenoceptor antagonist. Journal of clinical pharmacology 20050601
Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrobial agents and chemotherapy 20050601
Comparison of the clinical efficacy of oral terbinafine and ketoconazole combined with cephalexin in the treatment of Malassezia dermatitis in dogs--a pilot study. Veterinary dermatology 20050601
[Abdominal zygomycosis in a bitch due to Absidia corymbifera]. Revista iberoamericana de micologia 20050601
Effect of 2-(4-aminophenylmethyl)-6-hydroxy-3, 4-dihydronaphthalen-1(2H)-one on all-trans and 13-cis-retinoic acid levels in plasma quantified by high perfomance liquid chromatography coupled to tandem mass spectrometry. Journal of enzyme inhibition and medicinal chemistry 20050601
[Allergic fungal sinusitis and allergic broncho-pulmonary aspergillosis: a fortuitous association or a nosological rhino-bronchial entity?]. Revue des maladies respiratoires 20050601
[Comparison of efficacy of combination of ketokonazol 400 mg + clindamycin 100 mg with ketokonazol 800 mg + clindamycin 100 mg in the treatment of vaginitis due to Candida and bacterial vaginosis]. Ginecologia y obstetricia de Mexico 20050601
Lack of cataleptogenic potentiation with non-imidazole H3 receptor antagonists reveals potential drug-drug interactions between imidazole-based H3 receptor antagonists and antipsychotic drugs. Brain research 20050531
Selective inhibition of dog hepatic CYP2B11 and CYP3A12. The Journal of pharmacology and experimental therapeutics 20050501
Intestinal metabolism of PAH: in vitro demonstration and study of its impact on PAH transfer through the intestinal epithelium. Environmental research 20050501
Anti-proliferative synergy of lysophospholipid analogues and ketoconazole against Trypanosoma cruzi (Kinetoplastida: Trypanosomatidae): cellular and ultrastructural analysis. The Journal of antimicrobial chemotherapy 20050501
Blood concentrations of everolimus are markedly increased by ketoconazole. Journal of clinical pharmacology 20050501
Comparison of in vitro activities of antifungal drugs and ethanolic extract of propolis against Trichophyton rubrum and T. mentagrophytes by using a microdilution assay. Mycoses 20050501
Separation study of cadmium as CdI4(2-) through a bulk liquid membrane containing ketoconazole and oleic acid. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20050501
Effect of solubilizing and microemulsifying excipients in polyethylene glycol 6000 solid dispersion on enhanced dissolution and bioavailability of ketoconazole. Archives of pharmacal research 20050501
Mefloquine resistance reversal action of ketoconazole - a cytochrome P450 inhibitor, against mefloquine-resistant malaria. Parasitology 20050501
Slime production and proteinase activity of Candida species isolated from blood samples and the comparison of these activities with minimum inhibitory concentration values of antifungal agents. Memorias do Instituto Oswaldo Cruz 20050501
Cloning and heterologous expression of the NADPH cytochrome P450 oxidoreductase genes from an industrial dicarboxylic acid-producing Candida tropicalis. Yeast (Chichester, England) 20050430
Novel C-17-heteroaryl steroidal CYP17 inhibitors/antiandrogens: synthesis, in vitro biological activity, pharmacokinetics, and antitumor activity in the LAPC4 human prostate cancer xenograft model. Journal of medicinal chemistry 20050421
Enhancement of nifedipine-induced gingival overgrowth by concomitant ketoconazole in rats. Pharmacology 20050401
Xenobiotics and the glucocorticoid receptor: additive antagonistic effects on tyrosine aminotransferase activity in rat hepatoma cells. Basic & clinical pharmacology & toxicology 20050401
Studies to investigate the pharmacokinetic interactions between ranolazine and ketoconazole, diltiazem, or simvastatin during combined administration in healthy subjects. Journal of clinical pharmacology 20050401
Transient band-like keratopathy after treatment for seborrheic dermatitis. Cornea 20050401
A study of the in vitro interaction between lidocaine and premedications using human liver microsomes. Journal of clinical pharmacy and therapeutics 20050401
Topical application of ketoconazole stimulates hair growth in C3H/HeN mice. The Journal of dermatology 20050401
Hepatotoxicity associated with cyclosporine monitoring using C2 recommendations in adults renal recipients receiving ketoconazole. Transplantation proceedings 20050401
Assessment of the hepatic and intestinal first-pass metabolism of midazolam in a CYP3A drug-drug interaction model rats. Xenobiotica; the fate of foreign compounds in biological systems 20050401
Oxidative stress mediates drug-induced hepatotoxicity in rats: a possible role of DNA fragmentation. Toxicology 20050330
Synthesis and evaluation of imidazolylmethylenetetrahydronaphthalenes and imidazolylmethyleneindanes: potent inhibitors of aldosterone synthase. Journal of medicinal chemistry 20050324
Microbiological assay of ketoconazole in shampoo. International journal of pharmaceutics 20050323
Synthesis and evaluation of (pyridylmethylene)tetrahydronaphthalenes/-indanes and structurally modified derivatives: potent and selective inhibitors of aldosterone synthase. Journal of medicinal chemistry 20050310
Metabolism of alfentanil by cytochrome p4503a (cyp3a) enzymes. Drug metabolism and disposition: the biological fate of chemicals 20050301
Experimentally induced androgen depletion accentuates ethnicity-related contrasts in luteinizing hormone secretion in asian and caucasian men. The Journal of clinical endocrinology and metabolism 20050301
Characterization of human cytochrome P450 enzymes involved in the in vitro metabolism of perospirone. Biopharmaceutics & drug disposition 20050301
Refractory anaphylactic shock associated with ketoconazole treatment. The Annals of pharmacotherapy 20050301
A randomized, phase II trial of ketoconazole plus alendronate versus ketoconazole alone in patients with androgen independent prostate cancer and bone metastases. The Journal of urology 20050301
Population-based case-control study of oral ketoconazole treatment for birth outcomes. Congenital anomalies 20050301
Pityriasis versicolor alba. Journal of the European Academy of Dermatology and Venereology : JEADV 20050301
Co-administration of ketoconazole with H1-antagonists ebastine and loratadine in healthy subjects: pharmacokinetic and pharmacodynamic effects. British journal of clinical pharmacology 20050301
Seborrheic dermatitis. The link between facial rash and neurologic disease. Postgraduate medicine 20050301
Effect of ketoconazole on the pharmacokinetics and safety of telithromycin and clarithromycin in older subjects with renal impairment. International journal of clinical pharmacology and therapeutics 20050301
Pharmacological management of paracoccidioidomycosis. Expert opinion on pharmacotherapy 20050301
Molecular design of two sterol 14alpha-demethylase homology models and their interactions with the azole antifungals ketoconazole and bifonazole. Journal of computer-aided molecular design 20050301
A simultaneous assessment of CYP3A4 metabolism and induction in the DPX-2 cell line. The AAPS journal 20050301
CYP3A4 is a vitamin D-24- and 25-hydroxylase: analysis of structure function by site-directed mutagenesis. The Journal of clinical endocrinology and metabolism 20050201
In vivo effects of cyclosporin A and ketoconazole on the pharmacokinetics of representative substrates for P-glycoprotein and cytochrome P450 (CYP) 3A in rats. Biological & pharmaceutical bulletin 20050201
[Metabolism of bicyclol in rat and human liver microsomes in vitro]. Yao xue xue bao = Acta pharmaceutica Sinica 20050201
Role of ketoconazole in renal transplant recipients. Transplantation 20050127
Antifungal and insect antifeedant 2-phenylethanol esters from the liverwort Balantiopsis cancellata from Chile. Journal of agricultural and food chemistry 20050126
Age and testosterone feedback jointly control the dose-dependent actions of gonadotropin-releasing hormone in healthy men. The Journal of clinical endocrinology and metabolism 20050101
Adult height after ketoconazole treatment in patients with familial male-limited precocious puberty. The Journal of clinical endocrinology and metabolism 20050101
A phase I study of estramustine, weekly docetaxel, and carboplatin chemotherapy in patients with hormone-refractory prostate cancer. Clinical cancer research : an official journal of the American Association for Cancer Research 20050101
Potent CYP3A4 inhibitory constituents of Piper cubeba. Journal of natural products 20050101
Corneofungimetry bioassay on Malassezia spp. under ketoconazole and desonide influences. Skin pharmacology and physiology 20050101
Determination of the absolute configuration and solution conformation of the antifungal agents ketoconazole, itraconazole, and miconazole with vibrational circular dichroism. Chirality 20050101
Co-administration of cyclosporine and ketoconazole in children with minimal change nephrotic syndrome. Nephron. Clinical practice 20050101
[Entomophthoramycosis (zygomycosis) caused by Conidiobolus coronatus in Mato Grosso (Brazil): case report]. Revista da Sociedade Brasileira de Medicina Tropical 20050101
Phaeohyphomycosis in Korea. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20050101
Clinical treatment of corneal infection due to Fonsecaea pedrosoi--case report. Arquivos brasileiros de oftalmologia 20050101
Estimation of potency of HERG channel blockers: impact of voltage protocol and temperature. Journal of pharmacological and toxicological methods 20050101
Antifungal susceptibilities of dermatophytic agents isolated from clinical specimens. European journal of dermatology : EJD 20050101
Case report of subcutaneous entomophthoromycosis with retroperitoneal invasion. Revista da Sociedade Brasileira de Medicina Tropical 20050101
Efficient short-term control of hypercortisolaemia by low-dose etomidate in severe paediatric Cushing's disease. Hormone research 20050101
Trichophyton tonsurans associated tinea corporis infection with the development of Majocchi's granuloma in a renal transplant patient. Journal of drugs in dermatology : JDD 20050101
Co-administration of ketoconazole and tacrolimus therapy: a transplanted rat model. International urology and nephrology 20050101
An evaluation of high-doses ketoconazole with hydrocortisone substitution in hormone-refractory prostate cancer. Acta chirurgica Iugoslavica 20050101
[Effect of tofisopam on CYP3A4 enzyme activity on human recombinant 3A4 supersome]. Acta pharmaceutica Hungarica 20050101
[Successful treatment of a case of extense verrucous chromoblastomychosis with surgical exeresis associated with the use of ketoconazole]. Revista cubana de medicina tropical 20050101
Novel retinoic acid metabolism blocking agents endowed with multiple biological activities are efficient growth inhibitors of human breast and prostate cancer cells in vitro and a human breast tumor xenograft in nude mice. Journal of medicinal chemistry 20041230
Potent, selective and low-calcemic inhibitors of CYP24 hydroxylase: 24-sulfoximine analogues of the hormone 1alpha,25-dihydroxyvitamin D(3). Journal of medicinal chemistry 20041230
In vitro metabolism of carbofuran by human, mouse, and rat cytochrome P450 and interactions with chlorpyrifos, testosterone, and estradiol. Chemico-biological interactions 20041207
Identification and characterization of potent CYP3A4 inhibitors in Schisandra fruit extract. Drug metabolism and disposition: the biological fate of chemicals 20041201
Influence of ketoconazole on azimilide pharmacokinetics in healthy subjects. British journal of clinical pharmacology 20041201
Synergistic interaction between ketoconazole and several antidepressant drugs with allopregnanolone treatments in ovariectomized Wistar rats forced to swim. Progress in neuro-psychopharmacology & biological psychiatry 20041201
In vitro antifungal activity of sertaconazole compared with nine other drugs against 250 clinical isolates of dermatophytes and Scopulariopsis brevicaulis. Chemotherapy 20041201
Combination therapy of once-weekly fluconazole (100, 150, or 300 mg) with topical application of ketoconazole cream in the treatment of onychomycosis. Japanese journal of infectious diseases 20041201
Clinicopathologic features of an unusual outbreak of cryptococcosis in dogs, cats, ferrets, and a bird: 38 cases (January to July 2003). Journal of the American Veterinary Medical Association 20041201
Effect of various cytochrome P450 3A and P-glycoprotein modulators on the biliary clearance of bromosulphaphthalein in male wistar rats. Die Pharmazie 20041201
Synthesis and antileishmanial activity of 3-imidazolylalkylindoles. Part I. Journal of enzyme inhibition and medicinal chemistry 20041201
Gamma-tocotrienol metabolism and antiproliferative effect in prostate cancer cells. Annals of the New York Academy of Sciences 20041201
Seborrhoeic dermatitis. Clinical evidence 20041201
Synthesis and CYP24 inhibitory activity of 2-substituted-3,4-dihydro-2H-naphthalen-1-one (tetralone) derivatives. Bioorganic & medicinal chemistry letters 20041115
Tumor apoptosis induced by ruthenium(II)-ketoconazole is enhanced in nonsusceptible carcinoma by monoclonal antibody to EGF receptor. International journal of cancer 20041110
A phase I trial of pharmacokinetic modulation of carboxyamidotriazole (CAI) with ketoconazole in patients with advanced cancer. Cancer chemotherapy and pharmacology 20041101
Effects of acute and chronic ketoconazole administration on hypothalamo--pituitary--adrenal axis activity and brain corticotropin-releasing hormone. Psychoneuroendocrinology 20041101
(2S,3R)-2-aminododecan-3-ol, a new antifungal agent from the ascidian Clavelina oblonga. Journal of natural products 20041101
Vulvovaginal candidiasis in children and adolescents with type 1 diabetes mellitus. Journal of pediatric endocrinology & metabolism : JPEM 20041101
[Treatment for seborrheic dermatitis]. Annales de dermatologie et de venereologie 20041101
Pharmacokinetic interaction between ketoconazole and imatinib mesylate (Glivec) in healthy subjects. Cancer chemotherapy and pharmacology 20041001
Stress-restress evokes sustained iNOS activity and altered GABA levels and NMDA receptors in rat hippocampus. Psychopharmacology 20041001
Effect of ketoconazole on the pharmacokinetics of rosiglitazone in healthy subjects. British journal of clinical pharmacology 20041001
The systemic treatment of onychomycosis. Clinics in podiatric medicine and surgery 20041001
Pathogenesis of allergic bronchopulmonary aspergillosis and an evidence-based review of azoles in treatment. Respiratory medicine 20041001
Multiple oral dosing of ketoconazole influences pharmacokinetics of quinidine after intravenous and oral administration in beagle dogs. Journal of veterinary pharmacology and therapeutics 20041001
Comparative evaluation of Sensititre YeastOne vs. the NCCLS M27A protocol and E-test for antifungal susceptibility testing of yeasts. Mycoses 20041001
Anti-Candida effects of estragole in combination with ketoconazole or amphotericin B. Phytotherapy research : PTR 20041001
Influence of human nail etching for the assessment of topical onychomycosis therapies. International journal of pharmaceutics 20040910
Concomitant administration of cyclosporine and ketoconazole in idiopathic nephrotic syndrome. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040901
Co-administration of cyclosporine and ketoconazole in idiopathic childhood nephrosis. Pediatric nephrology (Berlin, Germany) 20040901
CYP2B6, CYP3A4, and CYP2C19 are responsible for the in vitro N-demethylation of meperidine in human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20040901
Identification of an N-methyl-4-phenylpyridinium-like metabolite of the antidiarrheal agent loperamide in human liver microsomes: underlying reason(s) for the lack of neurotoxicity despite the bioactivation event. Drug metabolism and disposition: the biological fate of chemicals 20040901
In vitro metabolism of MK-0767 [(+/-)-5-[(2,4-dioxothiazolidin-5-yl)methyl]-2-methoxy-N-[[(4-trifluoromethyl) phenyl]methyl]benzamide], a peroxisome proliferator-activated receptor alpha/gamma agonist. I. Role of cytochrome P450, methyltransferases, flavin monooxygenases, and esterases. Drug metabolism and disposition: the biological fate of chemicals 20040901
Effect of cytochrome P450 inhibitors (diethyl dithiocarbamate, ketoconazole and grapefruit juice) on the pharmacokinetics of all-trans-retinoic acid. Farmaco (Societa chimica italiana : 1989) 20040901
Comparative study of 2% ketoconazole cream and 1% hydrocortisone cream in the treatment of infantile seborrheic dermatitis. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20040901
Use of oral ketoconazole to prevent postoperative erections following penile surgery. International journal of impotence research 20040801
Interaction of triazolam and ketoconazole in P-glycoprotein-deficient mice. Drug metabolism and disposition: the biological fate of chemicals 20040801
Concurrent Fusarium chlamydosporum and Microsphaeropsis arundinis infections in a cat. Journal of feline medicine and surgery 20040801
Ketoconazole, a cytochrome P450 3A4 inhibitor, markedly increases concentrations of levo-acetyl-alpha-methadol in opioid-naive individuals. Clinical pharmacology and therapeutics 20040801
Paranasal sinus aspergillosis: its categorization to develop a treatment protocol. Mycoses 20040801
Invasion of epithelial mammalian cells by Paracoccidioides brasiliensis leads to cytoskeletal rearrangement and apoptosis of the host cell. Microbes and infection 20040801
Specific interactions of steroids, arylhydrocarbons and flavonoids with progesterone receptors from the cytosol of the fungus Rhizopus nigricans. The Journal of steroid biochemistry and molecular biology 20040801
Imidazole analogues of fluoxetine, a novel class of anti-Candida agents. Journal of medicinal chemistry 20040729
Computer-assisted design of selective imidazole inhibitors for cytochrome p450 enzymes. Journal of medicinal chemistry 20040701
Bioequivalence evaluation of two brands of ketoconazole tablets (Onofin-K and Nizoral) in a healthy female Mexican population. Biopharmaceutics & drug disposition 20040701
Sesquiterpenes and flavonol glycosides from Zingiber aromaticum and their CYP3A4 and CYP2D6 inhibitory activities. Journal of natural products 20040701
Ketoconazole, an antifungal agent, protects against adiposity induced by a cafeteria diet. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20040701
Improved outcome of zygomycosis in patients with hematological diseases? Leukemia & lymphoma 20040701
Prescribing practices for seborrheic dermatitis vary with the physician's specialty: implications for clinical practice. The Journal of dermatological treatment 20040701
Antifungal chalcones and new caffeic acid esters from Zuccagnia punctata acting against soybean infecting fungi. Journal of agricultural and food chemistry 20040602
Co-administration of ketoconazole to tacrolimus-treated kidney transplant recipients: a prospective randomized study. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20040601
Oral administration of a low dose of midazolam (75 microg) as an in vivo probe for CYP3A activity. European journal of clinical pharmacology 20040601
Susceptibility of sequential Fonsecaea pedrosoi isolates from chromoblastomycosis patients to antifungal agents. Mycoses 20040601
Lipid raft polarization contributes to hyphal growth in Candida albicans. Eukaryotic cell 20040601
Chromoblastomycosis caused by Rhinocladiella aquaspersa. Medical mycology 20040601
Antifungal susceptibility of 50 Candida isolates from invasive mycoses in Chile. Medical mycology 20040601
Human cytochrome P450: metabolism of testosterone by CYP3A4 and inhibition by ketoconazole. Current protocols in toxicology 20040601
A prospective, randomized study of coadministration of ketoconazole and cyclosporine a in kidney transplant recipients: ten-year follow-up. Transplantation 20040515
An evaluation of intermediate-dose ketoconazole in hormone refractory prostate cancer. European urology 20040501
The use of a cyclosporin-ketoconazole combination: making renal transplantation affordable in developing countries. European journal of clinical pharmacology 20040501
Effect of cytochrome P450 3A4 inhibition on the pharmacokinetics of docetaxel. Clinical pharmacology and therapeutics 20040501
Comparison of capillary zone electrophoresis and high performance liquid chromatography methods for quantitative determination of ketoconazole in drug formulations. Farmaco (Societa chimica italiana : 1989) 20040501
Pharmacologic management of pattern hair loss. Facial plastic surgery clinics of North America 20040501
Efficacy of combined cyclosporine A and ketoconazole treatment of anal furunculosis. The Journal of small animal practice 20040501
Multicentric lymphoma in a dog after cyclosporine therapy. The Journal of small animal practice 20040501
Effects of the antifungal imidazole ketoconazole on CYP1A and CYP3A in rainbow trout and killifish. Environmental toxicology and chemistry 20040501
Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. I: evaluation of cynomolgus monkeys as surrogates for humans. Xenobiotica; the fate of foreign compounds in biological systems 20040501
Model for the drug-drug interaction responsible for CYP3A enzyme inhibition. II: establishment and evaluation of dexamethasone-pretreated female rats. Xenobiotica; the fate of foreign compounds in biological systems 20040501
Identification and relative contributions of human cytochrome P450 isoforms involved in the metabolism of glibenclamide and lansoprazole: evaluation of an approach based on the in vitro substrate disappearance rate. Xenobiotica; the fate of foreign compounds in biological systems 20040501
Role of CYP3A enzymes in the biotransformation of triazolam in rat liver. Xenobiotica; the fate of foreign compounds in biological systems 20040501
Cyclosporine and low-dose ketoconazole in renal transplant recipients: a single-center experience. Transplantation 20040415
In vitro metabolism of fipronil by human and rat cytochrome P450 and its interactions with testosterone and diazepam. Chemico-biological interactions 20040415
The use of the novel substrate-heme complex approach in the derivation of a representation of the active site of the enzyme complex 17alpha-hydroxylase and 17,20-lyase. Biochemical and biophysical research communications 20040409
Comparison of prediction methods for in vivo clearance of (S,S)-3-[3-(methylsulfonyl)phenyl]-1-propylpiperidine hydrochloride, a dopamine D2 receptor antagonist, in humans. Drug metabolism and disposition: the biological fate of chemicals 20040401
Quantitative contribution of CYP2D6 and CYP3A to oxycodone metabolism in human liver and intestinal microsomes. Drug metabolism and disposition: the biological fate of chemicals 20040401
Prevalence of Candida dubliniensis among germ tube-positive yeasts recovered from the respiratory specimens in HIV-negative patients. Mycoses 20040401
Prostate cancer metastasis to supraclavicular lymph node. Clinical advances in hematology & oncology : H&O 20040401
Distinct groups of multidrug resistance modulating agents are distinguished by competition of P-glycoprotein-specific antibodies. Biochemical and biophysical research communications 20040319
Antiandrogen withdrawal alone or in combination with ketoconazole in androgen-independent prostate cancer patients: a phase III trial (CALGB 9583). Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20040315
History of the development of azole derivatives. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20040301
[Ketoconazole in the prevention of acute delirium episodes]. Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999) 20040301
Solubilizing poorly soluble antimycotic agents by emulsification via a solvent-free process. AAPS PharmSciTech 20040301
Chronic mucocutaneous candidiasis: a case report. Journal of the Indian Society of Pedodontics and Preventive Dentistry 20040301
Role of multiple drug resistance protein 1 in neutral but not acidic glycosphingolipid biosynthesis. The Journal of biological chemistry 20040227
Sirolimus and ketoconazole co-prescription in renal transplant recipients. Transplantation 20040215
Synthesis and antifungal activities of phenylenedithioureas. Bioorganic & medicinal chemistry letters 20040209
Enantioselectivity of inhibition of cytochrome P450 3A4 (CYP3A4) by ketoconazole: Testosterone and methadone as substrates. Chirality 20040201
Comparative efficacy of topical therapy with a slow-release mucoadhesive buccal tablet containing miconazole nitrate versus systemic therapy with ketoconazole in HIV-positive patients with oropharyngeal candidiasis. Journal of acquired immune deficiency syndromes (1999) 20040201
Development of an in vivo preclinical screen model to estimate absorption and first-pass hepatic extraction of xenobiotics. II. Use of ketoconazole to identify P-glycoprotein/CYP3A-limited bioavailability in the monkey. Drug metabolism and disposition: the biological fate of chemicals 20040201
Efficacy of a new ketoconazole bioadhesive vaginal tablet on Candida albicans. Farmaco (Societa chimica italiana : 1989) 20040201
[Modern antimycotics. What the treating physician needs to know]. Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete 20040201
Role of phenobarbital-inducible cytochrome P450s as a source of active oxygen species in DNA-oxidation. Cancer letters 20040120
Synthesis of galactopyranosyl amino alcohols as a new class of antitubercular and antifungal agents. Bioorganic & medicinal chemistry letters 20040119
Highly selective inhibition of human CYP3Aa in vitro by azamulin and evidence that inhibition is irreversible. Drug metabolism and disposition: the biological fate of chemicals 20040101
Ketocazole as an adjunct to finasteride in the treatment of androgenetic alopecia in men. Medical hypotheses 20040101
High-throughput screening for the assessment of time-dependent inhibitions of new drug candidates on recombinant CYP2D6 and CYP3A4 using a single concentration method. Xenobiotica; the fate of foreign compounds in biological systems 20040101
Interventions for treating oral candidiasis for patients with cancer receiving treatment. The Cochrane database of systematic reviews 20040101
Drug-drug interactions evaluated by a highly active reconstituted native human cytochrome P4503A4 and human NADPH-cytochrome P450 reductase system. Arzneimittel-Forschung 20040101
The role of cytochrome-P450 inhibitors in the prevention of hepatotoxicity after paracetamol overdose in rats. Human & experimental toxicology 20040101
Oral paracoccidioidomycosis or squamous cell carcinoma? General dentistry 20040101
Antimycotics: why are they effective in the treatment of seborrheic dermatitis? Dermatology (Basel, Switzerland) 20040101
Effect of concomitant administration of cyclosporine and ketoconazole in children with focal segmental glomerulosclerosis. American journal of nephrology 20040101
In vitro fungitoxic activity of Larrea divaricata cav. extracts. Letters in applied microbiology 20040101
Azoles for allergic bronchopulmonary aspergillosis associated with asthma. The Cochrane database of systematic reviews 20040101
In vitro antifungal susceptibility of Candida spp. isolates from patients with chronic periodontitis and from control patients. Brazilian oral research 20040101
In vitro susceptibility of Candida species isolated from cancer patients to some antifungal agents. Drug metabolism and drug interactions 20040101
[Determination of biological activity of hydrogel preparations based on ketoconazole and clotrimazole]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101
Resistance reversal action of ketoconazole against mefloquine resistance of Plasmodium yoelii nigeriensis. Experimental parasitology 20040101
Determination of pharmaceutical compounds in skin by imaging matrix-assisted laser desorption/ionisation mass spectrometry. Rapid communications in mass spectrometry : RCM 20040101
Antifungal effects of herbal essential oils alone and in combination with ketoconazole against Trichophyton spp. Journal of applied microbiology 20040101
Etest for assessing the susceptibility of filamentous fungi. Acta microbiologica et immunologica Hungarica 20040101
Metastatic hepatic carcinoid associated with ectopic ACTH syndrome, resistant to octreotide and ketoconazole therapy. Annals of Saudi medicine 20040101
In vitro activities of transition metal derivatives of ketoconazole and clotrimazole against a wild type strain of Saccharomyces cerevisiae in absence or presence of human neutrophils. Arzneimittel-Forschung 20040101
Management of androgen-independent prostate cancer. Cancer control : journal of the Moffitt Cancer Center 20040101
Spontaneous remission of Cushing's disease after disappearance of a microadenoma attached to the pituitary stalk. Pituitary 20040101
[Prophylaxis of fungal infection in patients with hematologic neoplasms and severe neutropenia after high-dose chemotherapy]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101
Cushing's disease and pregnancy. Pituitary 20040101
[Current possibilities of using antimyocotic drugs in the treatment of various skin disorders]. Wiadomosci parazytologiczne 20040101
The influence of ketoconazole on the activity of asparagine protease produced by Candida strains. Research communications in molecular pathology and pharmacology 20040101
Microbial transformation of (-)-carvone. Zeitschrift fur Naturforschung. C, Journal of biosciences 20040101
Phase 3 randomized trial evaluating second-line hormonal therapy versus docetaxel-estramustine combination chemotherapy on progression-free survival in asymptomatic patients with a rising prostate-specific antigen level after hormonal therapy for prostate cancer: an Eastern Cooperative Oncology Group (E1899), Intergroup/Clinical Trials Support Unit study. Urology 20031229
QT and RR intervals in conscious and anesthetized guinea pigs with highly varying RR intervals and given QTc-lengthening test articles. Toxicological sciences : an official journal of the Society of Toxicology 20031201
Experimental evaluation of antifungal and antiseptic agents against Rhodotorula spp. Mycoses 20031201
Trypanocidal constituents in plants 2.xanthones from the stem bark of Garcinia subelliptica. Biological & pharmaceutical bulletin 20031201
Acute lung injury in 2003. Acta pharmacologica Sinica 20031201
Successful treatment of dandruff with 1.5% ciclopirox olamine shampoo in Korea. The Journal of dermatological treatment 20031201
Multiple mechanisms account for variation in base-line sensitivity to azole fungicides in field isolates of Mycosphaerella graminicola. Pest management science 20031201
Liver cirrhosis developed after ketoconazole-induced acute hepatic injury. Journal of gastroenterology and hepatology 20031201
Clofibrate, a peroxisome-proliferator, enhances reverse cholesterol transport through cytochrome P450 activation and oxysterol generation. The Tohoku journal of experimental medicine 20031201
New triterpene glycosides from the stems of Anomospermum grandifolium. Journal of natural products 20031201
Identification of the human cytochrome P450s responsible for the in vitro metabolism of a leukotriene B4 receptor antagonist, CP-195,543. Xenobiotica; the fate of foreign compounds in biological systems 20031201
Emerging systemic pharmacologic approaches in acute respiratory distress syndrome. Respiratory care clinics of North America 20031201
Cutaneous blastomycosis presenting as non-healing ulcer and responding to oral ketoconazole. Dermatology online journal 20031201
Clinical strategies in the management of biochemical recurrence after radical prostatectomy. Clinical prostate cancer 20031201
Candidiasis (vulvovaginal). Clinical evidence 20031201
Stripping voltammetric and polarographic techniques for the determination of anti-fungal ketoconazole on the mercury electrode. Journal of pharmaceutical and biomedical analysis 20031124
Threshold for antiproliferative and proapoptotic activity of ttaxol in HepG2 cells expressing human CYP3A4: effect of P-glycoprotein transporters. Pharmacology 20031101
Pharmacokinetic and pharmacodynamic interactions of oral midazolam with ketoconazole, fluoxetine, fluvoxamine, and nefazodone. Journal of clinical pharmacology 20031101
Docetaxel and ketoconazole in advanced hormone-refractory prostate carcinoma: a phase I and pharmacokinetic study. Cancer 20031101
Fungal infection of sutureless self-sealing incision for cataract surgery. Ophthalmology 20031101
A double-blind, randomized, placebo-controlled study to assess the efficacy of ketoconazole for reducing the risk of ovarian hyperstimulation syndrome. Fertility and sterility 20031101
Ketoconazole alters cyclosporine pharmacokinetic profile and may predispose to acute rejection. Transplantation proceedings 20031101
Unintentional rechallenge resulting in a causative relationship between ketoconazole and acute liver injury. International journal of clinical practice 20031101
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry 20031009
Ketoconazole-induced neurologic sequelae. Veterinary and human toxicology 20031001
Ketoconazole and lopinavir/ritonavir coadministration: boosting beyond boosting. AIDS research and human retroviruses 20031001
Antifungal pharmacotherapy for neonatal candidiasis. Seminars in perinatology 20031001
Fungal dermatitis with olanzapine in schizophrenia. Canadian journal of psychiatry. Revue canadienne de psychiatrie 20031001
Clotrimazole, ketoconazole, and clodinafop-propargyl inhibit the in vitro growth of Babesia bigemina and Babesia bovis (Phylum Apicomplexa). Parasitology 20031001
Lem3p is essential for the uptake and potency of alkylphosphocholine drugs, edelfosine and miltefosine. The Journal of biological chemistry 20030919
Genome-wide expression profiling of the response to polyene, pyrimidine, azole, and echinocandin antifungal agents in Saccharomyces cerevisiae. The Journal of biological chemistry 20030912
Effect of ketoconazole on venlafaxine plasma concentrations in extensive and poor metabolisers of debrisoquine. European journal of clinical pharmacology 20030901
The effect of ketoconazole and diltiazem on oestrogen metabolism in postmenopausal women after single dose oestradiol treatment. British journal of clinical pharmacology 20030901
Application of compartmental modeling to an examination of in vitro intestinal permeability data: assessing the impact of tissue uptake, P-glycoprotein, and CYP3A. Drug metabolism and disposition: the biological fate of chemicals 20030901
Metabolism and elimination of quinine in healthy volunteers. European journal of clinical pharmacology 20030901
Antileishmanial activities of dihydrochalcones from piper elongatum and synthetic related compounds. Structural requirements for activity. Bioorganic & medicinal chemistry 20030901
Long-term results of treatment in patients with ACTH-secreting pituitary macroadenomas. European journal of endocrinology 20030901
Disseminated paracoccidioidomycosis: correlation between clinical and in vitro resistance to ketoconazole and trimethoprim sulphamethoxazole. Mycoses 20030901
A red rash on the face. The Journal of family practice 20030901
Gastric function in the elderly: effects on absorption of ketoconazole. Journal of clinical pharmacology 20030901
Limited utility of cyclosporine C2 monitoring in heart transplant recipients receiving ketoconazole. Transplantation proceedings 20030901
Effect of antifungal drugs on pathogenic Naegleria spp isolated from natural water sources. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030901
Fluorine substitution can block CYP3A4 metabolism-dependent inhibition: identification of (S)-N-[1-(4-fluoro-3- morpholin-4-ylphenyl)ethyl]-3- (4-fluorophenyl)acrylamide as an orally bioavailable KCNQ2 opener devoid of CYP3A4 metabolism-dependent inhibition. Journal of medicinal chemistry 20030828
[Therapeutic safety of antimycotics in the treatment of systemic fungal infections]. Orvosi hetilap 20030824
Prediction of hERG potassium channel affinity by traditional and hologram qSAR methods. Bioorganic & medicinal chemistry letters 20030818
Substituent effect on the reductive N-dearylation of 3-(indol-1-yl)-1,2-benzisoxazoles by rat liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20030801
Quantitative determination of some pharmaceutical piperazine derivatives through complexation with iron(III) chloride. Farmaco (Societa chimica italiana : 1989) 20030801
Hepatotoxicity and toxicokinetics of ketoconazole in rabbits. Acta pharmacologica Sinica 20030801
In vitro susceptibility testing of ciclopirox, terbinafine, ketoconazole and itraconazole against dermatophytes and nondermatophytes, and in vitro evaluation of combination antifungal activity. The British journal of dermatology 20030801
Activities of therapeutic agents against Naegleria fowleri in vitro and in a mouse model of primary amebic meningoencephalitis. The Journal of parasitology 20030801
Selectivities of human cytochrome P450 inhibitors toward rat P450 isoforms: study with cDNA-expressed systems of the rat. Drug metabolism and disposition: the biological fate of chemicals 20030701
In vitro metabolism of midazolam, triazolam, nifedipine, and testosterone by human liver microsomes and recombinant cytochromes p450: role of cyp3a4 and cyp3a5. Drug metabolism and disposition: the biological fate of chemicals 20030701
Cyclosporin C(2) and C(0) concentration monitoring in stable, long-term heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20030701
The use of oral antifungal agents to treat onychomycosis. Dermatologic clinics 20030701
Evaluation of different calorimetric methods to determine the glass transition temperature and molecular mobility below T(g) for amorphous drugs. International journal of pharmaceutics 20030618
Involvement of CYP3A4, CYP2C8, and CYP2D6 in the metabolism of (R)- and (S)-methadone in vitro. Drug metabolism and disposition: the biological fate of chemicals 20030601
Comparative efficacies of oral ketoconazole and terbinafine for reducing Malassezia population sizes on the skin of Basset Hounds. Veterinary dermatology 20030601
Variations in color. The Journal of family practice 20030601
Gender differences in microsomal metabolic activation of hepatotoxic clivorine in rat. Chemical research in toxicology 20030601
Influence of drugs interacting with CYP3A4 on the pharmacokinetics, pharmacodynamics, and safety of the prandial glucose regulator repaglinide. Journal of clinical pharmacology 20030601
Antifungal compounds from Zanthoxylum chiloperone var. angustifolium. Phytotherapy research : PTR 20030601
Coadministration of tacrolimus and ketoconazole in renal transplant recipients: cost analysis and review of metabolic effects. Transplantation proceedings 20030601
Lithium gluconate 8% vs ketoconazole 2% in the treatment of seborrhoeic dermatitis: a multicentre, randomized study. The British journal of dermatology 20030601
Clotrimazole, ketoconazole, and clodinafop-propargyl as potent growth inhibitors of equine Babesia parasites during in vitro culture. The Journal of parasitology 20030601
Candidiasis (vulvovaginal). Clinical evidence 20030601
Identification of the cytochrome P450 enzymes involved in the N-oxidation of voriconazole. Drug metabolism and disposition: the biological fate of chemicals 20030501
Expression of the human CYP3A4 gene in the small intestine of transgenic mice: in vitro metabolism and pharmacokinetics of midazolam. Drug metabolism and disposition: the biological fate of chemicals 20030501
Quinine 3-hydroxylation as a biomarker reaction for the activity of CYP3A4 in man. European journal of clinical pharmacology 20030501
Anti-Aspergillus activities of plant essential oils and their combination effects with ketoconazole or amphotericin B. Archives of pharmacal research 20030501
Effectiveness and tolerability of a standardized phytodrug derived from Solanum chrysotrichum on Tinea pedis: a controlled and randomized clinical trial. Planta medica 20030501
Modulatory effect of cAMP on fungal ergosterol level and inhibitory activity of azole drugs. Canadian journal of microbiology 20030501
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry 20030424
Validation of an HPLC method on short columns to assay ketoconazole and formaldehyde in shampoo. Journal of pharmaceutical and biomedical analysis 20030424
Production of progesterone from de novo-synthesized cholesterol in cumulus cells and its physiological role during meiotic resumption of porcine oocytes. Biology of reproduction 20030401
Demonstration of UVB-induced synthesis of 1 alpha,25-dihydroxyvitamin D3 (calcitriol) in human skin by microdialysis. Archives of dermatological research 20030401
Interaction between ketoconazole and almotriptan in healthy volunteers. Journal of clinical pharmacology 20030401
Fluorescent substrates of sister-P-glycoprotein (BSEP) evaluated as markers of active transport and inhibition: evidence for contingent unequal binding sites. Pharmaceutical research 20030401
Differential metabolism of midazolam in mouse liver and intestine microsomes: a comparison of cytochrome P450 activity and expression. Xenobiotica; the fate of foreign compounds in biological systems 20030401
Hepatotoxicity of ketoconazole in Sprague-Dawley rats: glutathione depletion, flavin-containing monooxygenases-mediated bioactivation and hepatic covalent binding. Xenobiotica; the fate of foreign compounds in biological systems 20030401
Effects of novel 17alpha-hydroxylase/C17, 20-lyase (P450 17, CYP 17) inhibitors on androgen biosynthesis in vitro and in vivo. The Journal of steroid biochemistry and molecular biology 20030401
High-content profiling of drug-drug interactions: cellular targets involved in the modulation of microtubule drug action by the antifungal ketoconazole. Journal of biomolecular screening 20030401
Retinoic acid metabolism inhibition by 3-azolylmethyl-1H-indoles and 2, 3 or 5-(alpha-azolylbenzyl)-1H-indoles. Journal of enzyme inhibition and medicinal chemistry 20030401
Prednisone metabolism in recipients of kidney or liver transplants and in lung recipients receiving ketoconazole. Transplantation 20030327
Enhancement of moxidectin bioavailability in lamb by a natural flavonoid: quercetin. Veterinary parasitology 20030325
Randomized, multicenter, phase II trial of two multicomponent regimens in androgen-independent prostate cancer. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20030301
Metabolism and metabolic inhibition of cilnidipine in human liver microsomes. Acta pharmacologica Sinica 20030301
Apparent mechanism-based inhibition of human CYP3A in-vitro by lopinavir. The Journal of pharmacy and pharmacology 20030301
[Nosocomial urinary infection due to Trichosporon asahii. First two cases in Chile]. Revista iberoamericana de micologia 20030301
[Post traumatic subcutaneous mycosis due to Fusarium solani]. Revista iberoamericana de micologia 20030301
Terbinafine effectiveness in ketoconazole-resistant mucocutaneous candidasis in polyglandular autoimmune syndrome type 1. The Journal of the Association of Physicians of India 20030301
Roles of human liver cytochrome P450 3A4 and 1A2 enzymes in the oxidation of myristicin. Toxicology letters 20030203
Rhabdomyolysis from cytochrome p-450 interaction of ketoconazole and simvastatin in prostate cancer. The Journal of urology 20030201
A murine model of coccidioidal meningitis. The Journal of infectious diseases 20030201
The effect of ketoconazole on the in vivo intestinal permeability of fexofenadine using a regional perfusion technique. British journal of clinical pharmacology 20030201
Steroid synthesis inhibition with ketoconazole and its effect upon the regulation of the hypothalamus-pituitary-adrenal system in healthy humans. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20030201
Efficacy and safety of low-dose ketoconazole (50 mg) to reduce the cost of cyclosporine in renal allograft recipients. Transplantation proceedings 20030201
Antifungal agents of use in animal health--chemical, biochemical and pharmacological aspects. Journal of veterinary pharmacology and therapeutics 20030201
Coccidiomycosis in a dog. The Canadian veterinary journal = La revue veterinaire canadienne 20030201
[How to manage seborrheic dermatitis]. Revue medicale de Liege 20030201
Identification of novel enzyme-prodrug combinations for use in cytochrome P450-based gene therapy for cancer. Archives of biochemistry and biophysics 20030101
Oxidative activation of acylguanidine prodrugs: intestinal presystemic activation in rats limits absorption and can be inhibited by co-administration of ketoconazole. Xenobiotica; the fate of foreign compounds in biological systems 20030101
Lack of effect of ketoconazole on the pharmacokinetics of rosuvastatin in healthy subjects. British journal of clinical pharmacology 20030101
Antifungal activity of the essential oil of Agastache rugosa Kuntze and its synergism with ketoconazole. Letters in applied microbiology 20030101
A case of infantile acne due to pityrosporum. Pediatric dermatology 20030101
[Conjunctival infection due to penicillium SP]. Archivos de la Sociedad Espanola de Oftalmologia 20030101
[Molecular biological analysis of Tinea faciei caused by a clinically anomalous strain of Trichophyton mentagrophytes]. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20030101
The effect of granisetron on in vitro metabolism of paclitaxel and docetaxel. Cancer journal (Sudbury, Mass.) 20030101
Seborrheic dermatitis today, gone tomorrow? The link between the biocene and treatment. Dermatology (Basel, Switzerland) 20030101
Randomized, open-labeled, non-inferiority study between ciclopiroxolamine 1% cream and ketoconazole 2% foaming gel in mild to moderate facial seborrheic dermatitis. Dermatology (Basel, Switzerland) 20030101
Ketoconazole in the treatment of prostate cancer. Clinical journal of oncology nursing 20030101
Treatment of cutaneous leishmaniasis with ketoconazole cream. The Journal of dermatological treatment 20030101
Framing the future of antifungals in atopic dermatitis. Dermatology (Basel, Switzerland) 20030101
Tolerance to antidepressant treatment may be overcome by ketoconazole. Report of two cases. Journal of psychiatric research 20030101
Azoles for allergic bronchopulmonary aspergillosis associated with asthma. The Cochrane database of systematic reviews 20030101
[Madura foot (mycetoma)]. Vestnik khirurgii imeni I. I. Grekova 20030101
[Finger agenesis after in utero exposure to ketoconazole: a case report]. Therapie 20030101
Ketoconazole foam--connetics: connetics ketoconazole foam. Drugs in R&D 20030101
In vitro drug-drug interactions with perospirone and concomitantly administered drugs in human liver microsomes. European journal of drug metabolism and pharmacokinetics 20030101
[Vaginal candidiasis--treatment protocols using miconazole and fluconazole]. Akusherstvo i ginekologiia 20030101
Oral manifestations of paracoccidioidomycosis. Report of 21 cases from Argentina. Mycoses 20030101
Fungal peritonitis in 15 patients on continuous ambulatory peritoneal dialysis (CAPD). Mycoses 20030101
Synthesis, in vitro/in vivo antifungal evaluation and structure-activity relationship study of 3(2H)-pyridazinones. Arzneimittel-Forschung 20030101
Occurrence of dermatomycoses and in-vitro therapeutic efficacy of three antifungal drugs on the growth of Epidermophyton floccosum. Mycopathologia 20030101
[Investigation of quantitative and species composition and antifungal drug susceptibility of yeasts isolated from patients with generalized periodontitis complicated by candidosis]. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993) 20030101
[Madura's foot (mycetoma)]. Chirurgia (Bucharest, Romania : 1990) 20030101
Medical treatment of hyperadrenocorticism in the dog. Australian veterinary journal 20030101
Protective effect of ketoconazole against experimentally induced gastric ulcers in rats. Research communications in molecular pathology and pharmacology 20030101
[In vitro sensitivity of Histoplasma capsulatum var. capsulatum to amphotericin B, ketoconazole, itroconazole and fluconazole]. Revista cubana de medicina tropical 20030101
Separation of antifungal chiral drugs by SFC and HPLC: a comparative study. Journal of biochemical and biophysical methods 20021231
Pharmacophore model of drugs involved in P-glycoprotein multidrug resistance: explanation of structural variety (hypothesis). Journal of medicinal chemistry 20021219
Mathematical modelling of antifungal action. Mycoses 20021201
[Observations on the efficacy of Botai ointment in treating dermatosis common among armed forces receiving at-sea training]. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20021201
Application of semisimultaneous midazolam administration for hepatic and intestinal cytochrome P450 3A phenotyping. Clinical pharmacology and therapeutics 20021201
Prevalence and antifungal susceptibilities of yeast isolates during one year at a university hospital in Turkey. Journal of chemotherapy (Florence, Italy) 20021201
Inhibition of the microsomal metabolism of 1,8-cineole in the common brushtail possum (Trichosurus vulpecula) by terpenes and other chemicals. Xenobiotica; the fate of foreign compounds in biological systems 20021201
National Cancer Institute intramural approach to advanced prostate cancer. Clinical prostate cancer 20021201
Triiodide ion and alizarin red S as two new reagents for the determination of clotrimazole and ketoconazole. Journal of pharmaceutical and biomedical analysis 20021107
Paracoccidioidomycosis: report of 2 cases mimicking squamous cell carcinoma. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20021101
Pharmacokinetics and electrocardiographic pharmacodynamics of artemether-lumefantrine (Riamet) with concomitant administration of ketoconazole in healthy subjects. British journal of clinical pharmacology 20021101
Chromatographic determination of clotrimazole, ketoconazole and fluconazole in pharmaceutical formulations. Farmaco (Societa chimica italiana : 1989) 20021101
Corticosteroids and pregnancy. Seminars in reproductive medicine 20021101
Synthesis of novel water soluble benzylazolium prodrugs of lipophilic azole antifungals. Bioorganic & medicinal chemistry letters 20021007
Sirolimus oral absorption in rats is increased by ketoconazole but is not affected by D-alpha-tocopheryl poly(ethylene glycol 1000) succinate. The Journal of pharmacology and experimental therapeutics 20021001
Interaction of cytochrome P450 3A inhibitors with P-glycoprotein. The Journal of pharmacology and experimental therapeutics 20021001
Preclinical activity of ketoconazole in combination with calcitriol or the vitamin D analogue EB 1089 in prostate cancer cells. The Journal of urology 20021001
Efficacy of ozonized sunflower oil in the treatment of tinea pedis. Mycoses 20021001
Vulvovaginal candidiasis. BMJ (Clinical research ed.) 20020914
Expression of paclitaxel-inactivating CYP3A activity in human colorectal cancer: implications for drug therapy. British journal of cancer 20020909
Putative role of the orphan nuclear receptor SXR (steroid and xenobiotic receptor) in the mechanism of CYP3A4 inhibition by xenobiotics. The Journal of biological chemistry 20020906
Macrophage plasma membrane cholesterol contributes to Brucella abortus infection of mice. Infection and immunity 20020901
In vitro, pharmacokinetic, and pharmacodynamic interactions of ketoconazole and midazolam in the rat. The Journal of pharmacology and experimental therapeutics 20020901
Characterization of quinidine 3-hydroxylation as a probe for the CYP 3A enzyme using a novel capillary electrophoresis technique. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020901
Evaluation of a 15-day screening assay using intact male rats for identifying steroid biosynthesis inhibitors and thyroid modulators. Toxicological sciences : an official journal of the Society of Toxicology 20020901
Ketoconazole suppresses interleukin-4 plus anti-CD40-induced IgE class switching in surface IgE negative B cells from patients with atopic dermatitis. The Journal of investigative dermatology 20020901
Azole susceptibility patterns and genetic relationship among oral Candida strains isolated in the era of highly active antiretroviral therapy. Journal of acquired immune deficiency syndromes (1999) 20020901
Design, synthesis, and biological evaluation of aryloxyethyl thiocyanate derivatives against Trypanosoma cruzi. Journal of medicinal chemistry 20020829
Low dose ketoconazole with replacement doses of hydrocortisone in patients with progressive androgen independent prostate cancer. The Journal of urology 20020801
Corneal ulcer caused by the new fungal species Sarcopodium oculorum. Journal of clinical microbiology 20020801
Ketoconazole potentiates the antitumor effects of nocodazole: In vivo therapy for human tumor xenografts in nude mice. Molecular carcinogenesis 20020801
In vivo measurement of human skin absorption of topically applied substances by a photoacoustic technique. Physiological measurement 20020801
Comparative efficacy of various treatment regimens for androgenetic alopecia in men. The Journal of dermatology 20020801
Randomized trial with itraconazole, ketoconazole and sulfadiazine in paracoccidioidomycosis. Medical mycology 20020801
Role of ketoconazole treatment in urinary-free cortisol-to-cortisone and tetrahydrocortisol-to-tetrahydrocortisone ratios in nonectopic Cushing's syndrome. Endocrine 20020801
Modulation of irinotecan metabolism by ketoconazole. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 20020715
Determination of ketoconazole in human plasma by high-performance liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020705
HPLC-MS/MS analysis of the products generated from all-trans-retinoic acid using recombinant human CYP26A. Journal of lipid research 20020701
Application of modeling and simulation to integrate clinical pharmacology knowledge across a new drug application. International journal of clinical pharmacology and therapeutics 20020701
Ketoconazole and kids. Postgraduate medicine 20020701
[Tinea]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020701
Ketoconazole suppresses prostaglandin E(2)-induced cyclooxygenase-2 expression in human epidermoid carcinoma A-431 cells. The Journal of investigative dermatology 20020701
Protothecal colitis in a German shepherd dog. Australian veterinary journal 20020701
Double-blind antiglucocorticoid treatment in schizophrenia and schizoaffective disorder: a pilot study. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20020701
Antifungal agents. 10. New derivatives of 1-[(aryl)[4-aryl-1H-pyrrol-3-yl]methyl]-1H-imidazole, synthesis, anti-candida activity, and quantitative structure-analysis relationship studies. Journal of medicinal chemistry 20020620
New regulators of drug sensitivity in the family of yeast zinc cluster proteins. The Journal of biological chemistry 20020614
Cutaneous candidiasis in a dog caused by Candida guilliermondii. The Veterinary record 20020608
Simultaneous determination of ketoconazole and formaldehyde in a shampoo: liquid chromatography method development and validation. Journal of chromatography. A 20020607
Expression profiling in squamous carcinoma cells reveals pleiotropic effects of vitamin D3 analog EB1089 signaling on cell proliferation, differentiation, and immune system regulation. Molecular endocrinology (Baltimore, Md.) 20020601
Single- and multiple-dose pharmacokinetics of bosentan and its interaction with ketoconazole. British journal of clinical pharmacology 20020601
Oral treatments for toenail onychomycosis: a systematic review. Archives of dermatology 20020601
A randomised, single-blind, single-centre clinical trial to evaluate comparative clinical efficacy of shampoos containing ciclopirox olamine (1.5%) and salicylic acid (3%), or ketoconazole (2%, Nizoral) for the treatment of dandruff/seborrhoeic dermatitis. The Journal of dermatological treatment 20020601
Fluconazole versus ketoconazole in the treatment of tinea versicolor. The Journal of dermatological treatment 20020601
In vitro characterization of the inhibitory effects of ketoconazole on metabolic activities of cytochrome P-450 in canine hepatic microsomes. American journal of veterinary research 20020601
7-Benzyloxyquinoline oxidation by P450eryF A245T: finding of a new fluorescent substrate probe. Chemical research in toxicology 20020601
Effects of ketoconazole on progesterone and cAMP production in MA-10 mouse Leydig tumor cells. Biological & pharmaceutical bulletin 20020601
[Intranasal rhinosporidiosis: presentation of the 1st case seen in the Congo]. Bulletin de la Societe de pathologie exotique (1990) 20020601
Chronic administration of verapamil, ketoconazole and carbamazepine: impact on immunological parameters. International journal of pharmaceutics 20020515
Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein. Molecular pharmacology 20020501
Potential role for the hypothalamo-pituitary-adrenal axis in the conditioned reinforcer-induced reinstatement of extinguished cocaine seeking in rats. Psychopharmacology 20020501
Oral FK 506 blood levels are elevated in pig short bowel model: further investigations with co-administration of an intestinal CYP3A4 inhibitor. Transplantation proceedings 20020501
[Candida infection of the skin and mucous membranes still a topic. Administering azoles with clinical understanding]. MMW Fortschritte der Medizin 20020409
Effects of 3-MeSO2-DDE and some CYP inhibitors on glucocorticoid steroidogenesis in the H295R human adrenocortical carcinoma cell line. Toxicology in vitro : an international journal published in association with BIBRA 20020401
Human CYP3A4 and the metabolism of nefazodone and hydroxynefazodone by human liver microsomes and heterologously expressed enzymes. European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20020401
Ketoconazole increases cocaine and opioid use in methadone maintained patients. Drug and alcohol dependence 20020401
In vitro inhibition of pimozide N-dealkylation by selective serotonin reuptake inhibitors and azithromycin. Journal of clinical psychopharmacology 20020401
Antimicrobial activities of a new schizozygane indoline alkaloid from Schizozygia coffaeoides and the revised structure of isoschizogaline. Journal of natural products 20020401
Black-dot tinea capitis. Patchy hair loss is common in pediatric patients. Postgraduate medicine 20020401
Clinical comparison of the efficacy and tolerability of once daily Canesten with twice daily Nizoral (clotrimazole 1% cream vs. ketoconazole 2% cream) during a 28-day topical treatment of interdigital tinea pedis. Mycoses 20020401
Case report. Nattrassia mangiferae endophthalmitis. Mycoses 20020401
Chronic mucocutaneous candidiasis. JAAPA : official journal of the American Academy of Physician Assistants 20020401
Cyclosporin and ketoconazole interaction for treatment of perianal fistulas in the dog. Australian veterinary journal 20020401
Superficial mycosis superimposing on isolated lichen planus of the lip: a case report and review of the literature. Cutis 20020401
[Identification and antifungal susceptibility of Candida spp isolated from invasive mycoses. Influence of growth inhibition percentage to determine minimal inhibitory concentration]. Revista medica de Chile 20020401
Cyclosporine and ketoconazole for the treatment of perianal fistulas in dogs. Journal of the American Veterinary Medical Association 20020401
Simple high-performance liquid chromatography method for the simultaneous determination of ketoconazole and piperine in rat plasma and hepatocyte culture. Journal of chromatography. A 20020308
Effect of antifungal azoles on the heme detoxification system of malarial parasite. Journal of biochemistry 20020301
Effect of oral ketoconazole on first-pass effect of nifedipine after oral administration in dogs. Journal of pharmaceutical sciences 20020301
Minimal effect of ketoconazole on cyclosporine (SangCyA) oral absorption and first-pass metabolism in rats: evidence of a significant vehicle effect on SangCyA absorption. Biopharmaceutics & drug disposition 20020301
Multicenter Brazilian study of oral Candida species isolated from AIDS patients. Memorias do Instituto Oswaldo Cruz 20020301
Cytochrome P450 enzymes contributing to demethylation of maprotiline in man. Pharmacology & toxicology 20020301
Identification of the human P450 enzymes involved in the in vitro metabolism of the synthetic steroidal hormones Org 4060 and Org 30659. Xenobiotica; the fate of foreign compounds in biological systems 20020201
Infectious keratitis in orthokeratology. Clinical & experimental ophthalmology 20020201
Ring substituted 3-phenyl-1-(2-pyrazinyl)-2-propen-1-ones as potential photosynthesis-inhibiting, antifungal and antimycobacterial agents. Farmaco (Societa chimica italiana : 1989) 20020201
Effect of multiple dosing of ketoconazole on pharmacokinetics of midazolam, a cytochrome P-450 3A substrate in beagle dogs. Drug metabolism and disposition: the biological fate of chemicals 20020101
Peppermint oil enhances cyclosporine oral bioavailability in rats: comparison with D-alpha-tocopheryl poly(ethylene glycol 1000) succinate (TPGS) and ketoconazole. Journal of pharmaceutical sciences 20020101
CYP3A4-mediated hepatic metabolism of the HIV-1 protease inhibitor saquinavir in vitro. Xenobiotica; the fate of foreign compounds in biological systems 20020101
Interventions for treating oral candidiasis for patients with cancer receiving treatment. The Cochrane database of systematic reviews 20020101
Comparison of two methods for antifungal susceptibility testing of Trichophyton rubrum. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20020101
Mycetoma caused by Fusarium solani with osteolytic lesions on the hand: case report. Mycopathologia 20020101
A unique case of bladder mycetoma. Tropical doctor 20020101
Pathology case of the month. Chronic leg ulcer in a missionary worker. Cutaneous leishmaniasis. The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20020101
Ectopic ACTH-syndrome due to a thymic carcinoid tumor. Acta clinica Belgica 20020101
More economical use of cyclosporine through combination drug therapy. Journal of the American Animal Hospital Association 20020101
Sustained release bioadhesive effervescent ketoconazole microcapsules tabletted for vaginal delivery. Journal of microencapsulation 20020101
Post-antifungal effect and effects of sub-MIC concentrations on previously treated Candida spp.: influence of exposure time and concentration. Scandinavian journal of infectious diseases 20020101
Euclidean and fractal computer-assisted corneofungimetry: a comparison of 2% ketoconazole and 1% terbinafine topical formulations. Dermatology (Basel, Switzerland) 20020101
A case of confluent and reticulated papillomatosis responsive to ketoconazole cream. Nihon Ishinkin Gakkai zasshi = Japanese journal of medical mycology 20020101
A double-blind placebo-controlled study of ketoconazole + desonide gel combination in the treatment of facial seborrheic dermatitis. Dermatology (Basel, Switzerland) 20020101
Efficacy and skin tolerability of Saliker in the treatment of dandruff. European journal of dermatology : EJD 20020101
Antifungal topical therapy in oral chronic candidosis. A comparative study. Medicina oral : organo oficial de la Sociedad Espanola de Medicina Oral y de la Academia Iberoamericana de Patologia y Medicina Bucal 20020101
Desloratadine has no clinically relevant electrocardiographic or pharmacodynamic interactions with ketoconazole. Clinical pharmacokinetics 20020101
Ketoconazole potentiates terfenadine-induced apoptosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. Journal of cellular biochemistry 20020101
Atopic dermatitis with mononuclear phagocytic activity deficiency. Allergologia et immunopathologia 20020101
A multicenter randomized trial of ketoconazole 2% and zinc pyrithione 1% shampoos in severe dandruff and seborrheic dermatitis. Skin pharmacology and applied skin physiology 20020101
Efficacy and skin tolerability of saliker in the treatment of dandruff. European journal of dermatology : EJD 20020101
Low dose ketoconazole therapy and thyroid functions in rats. Acta medica (Hradec Kralove) 20020101
The preventive effect of ketoconazole on experimental metastasis from a human pancreatic carcinoma may be related to its effect on prostaglandin synthesis. International journal of gastrointestinal cancer 20020101
Invitro drug sensitivity of Trichophyton species against griseofulvin and ketoconazole. Hindustan antibiotics bulletin 20020101
Ectopic adrenocorticotropic hormone syndrome caused by metastatic carcinoma of the prostate: therapeutic response to ketoconazole. Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists 20020101
Toward a novel metal-based chemotherapy against tropical diseases. 6. Synthesis and characterization of new copper(II) and gold(I) clotrimazole and ketoconazole complexes and evaluation of their activity against Trypanosoma cruzi. Inorganic chemistry 20011231
Fatal aplastic anemia during treatment with ketoconazole. The American journal of medicine 20011215
No evidence of oxidant events in amphotericin B cytotoxicity versus L. infantum promastigotes. Parasite (Paris, France) 20011201
Novel steroidal pyrimidyl inhibitors of P450 17 (17 alpha-hydroxylase/C17-20-lyase). Archiv der Pharmazie 20011201
Effects of ketoconazole on oestrus cycle and convulsant action of pentylenetetrazol in mice. Pharmacology & toxicology 20011201
Diazinon is activated by CYP2C19 in human liver. Toxicology and applied pharmacology 20011115
Enhanced antifungal activity of ketoconazole by Euphorbia characias latex against Candida albicans. Journal of ethnopharmacology 20011101
Quantitative liquid chromatography/mass spectrometry/mass spectrometry warfarin assay for in vitro cytochrome P450 studies. Analytical biochemistry 20011101
Importance of inhibin B in the regulation of FSH secretion in the human male. The Journal of clinical endocrinology and metabolism 20011101
Effects of azoles on human acute myelogenous leukemia blasts and T lymphocytes derived from acute leukemia patients with chemotherapy-induced cytopenia. International immunopharmacology 20011101
Improved responsiveness of PCOS patients to clomiphene after CYP17a inhibitor. Journal of assisted reproduction and genetics 20011101
Gene amplification in amphotericin B-resistant Leishmania tarentolae. Experimental parasitology 20011101
Relative contribution of CYP3A to amitriptyline clearance in humans: in vitro and in vivo studies. Journal of clinical pharmacology 20011001
A clinical case of canine mycotic pneumonia. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20011001
Comparative efficacy of ketoconazole and fluconazole in the treatment of pityriasis versicolor: a one year follow-up study. The Journal of dermatology 20011001
Ketoconazole and Flutamide in the treatment of disseminated intravascular clotting from prostate cancer: a case report and review. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20011001
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7-Deoxyloganin 7-hydroxylase in Lonicera japonica cell cultures. Phytochemistry 20010901
Post-antifungal effect of polyene, azole and DNA-analogue agents against oral Candida albicans and Candida tropicalis isolates in HIV disease. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20010901
A simple algorithm for designing group sequential clinical trials. Biometrics 20010901
Lack of effect of reboxetine on cardiac repolarization. Clinical pharmacology and therapeutics 20010901
Medical treatment of canine pituitary-dependent hyperadrenocorticism (Cushing's disease). The Veterinary clinics of North America. Small animal practice 20010901
Severe respiratory failure secondary to Cushing's myopathy. Journal of endocrinological investigation 20010901
Oral histoplasmosis. The Journal of the Association of Physicians of India 20010901
Comparative study of the efficacy of oral ketoconazole with intra-lesional meglumine antimoniate (Glucantime) for the treatment of cutaneous leishmaniasis. The Journal of dermatological treatment 20010901
Pulmonary candidiasis caused by Candida albicans in a Greek tortoise (Testudo graeca) and treatment with intrapulmonary amphotericin B. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20010901
Cyclosporin immunosuppression of sheep: pharmacokinetics and allograft survival. Veterinary immunology and immunopathology 20010830
Primary culture system of adrenocortical cells from dogs to evaluate direct effects of chemicals on steroidogenesis. Toxicology 20010828
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State-dependent block of rabbit vascular smooth muscle delayed rectifier and Kv1.5 channels by inhibitors of cytochrome P450-dependent enzymes. The Journal of pharmacology and experimental therapeutics 20010801
Rationale for combination ketoconazole/ vitamin D treatment of prostate cancer. Urology 20010801
Modulation of the cytochrome P450-mediated metabolism of ifosfamide by ketoconazole and rifampin. Clinical pharmacology and therapeutics 20010801
A systematic review of the effectiveness of antifungal drugs for the prevention and treatment of oropharyngeal candidiasis in HIV-positive patients. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010801
Application of capillary zone electrophoresis with off-line solid-phase extraction to in vitro metabolism studies of antifungals. Electrophoresis 20010801
Ketoconazole suppresses food restriction-induced increases in heroin self-administration in rats: sex differences. Experimental and clinical psychopharmacology 20010801
Characterization of amorphous ketoconazole using modulated temperature differential scanning calorimetry. Journal of pharmaceutical sciences 20010801
Arthroderma benhamiae infection in a rabbit. The Journal of veterinary medical science 20010801
[Modern local therapy of foot mycoses in servicemen]. Voenno-meditsinskii zhurnal 20010801
Adsorptive behavior and electrochemical determination of the anti-fungal agent ketoconazole. Fresenius' journal of analytical chemistry 20010801
Uptake of Malassezia furfur by human dermal fibroblasts: effect of ketoconazole and cytoskeleton inhibitors. Archives of dermatological research 20010801
Heterogeneity in antifungal susceptibility of clones of Candida albicans isolated on single and sequential visits from a HIV-infected southern Chinese cohort. Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 20010701
Effect of an extract of the root of Scutellaria baicalensis and its flavonoids on aflatoxin B1 oxidizing cytochrome P450 enzymes. Planta medica 20010701
Ca(2+) transport into an intracellular acidic compartment of Candida parapsilosis. FEBS letters 20010629
Application to drug-food interactions of living cells as in vitro model expressing cytochrome P450 activity: enzyme inhibition by lemon juice. Talanta 20010621
Oropharyngeal candidiasis in patients with human immunodeficiency virus: correlation of clinical outcome with in vitro resistance, serum azole levels, and immunosuppression. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010601
Arachidonic acid directly activates members of the mitogen-activated protein kinase superfamily in rabbit proximal tubule cells. Kidney international 20010601
Aromatization mediates testosterone's short-term feedback restraint of 24-hour endogenously driven and acute exogenous gonadotropin-releasing hormone-stimulated luteinizing hormone and follicle-stimulating hormone secretion in young men. The Journal of clinical endocrinology and metabolism 20010601
Photo quiz. Congenital cutaneous candidiasis. Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010601
Successful treatment of Acanthamoeba meningitis with combination oral antimicrobials. The Pediatric infectious disease journal 20010601
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The effect of gut metabolism on tacrolimus bioavailability in renal transplant recipients. Transplantation 20010515
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Low salivary cortisol levels and aggressive behavior. Archives of general psychiatry 20010501
The interaction of saquinavir (soft gelatin capsule) with ketoconazole, erythromycin and rifampicin: comparison of the effect in healthy volunteers and in HIV-infected patients. European journal of clinical pharmacology 20010501
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Application of the relative activity factor approach in scaling from heterologously expressed cytochromes p450 to human liver microsomes: studies on amitriptyline as a model substrate. The Journal of pharmacology and experimental therapeutics 20010401
Hypokalemia, metabolic alkalosis, and hypertension: Cushing's syndrome in a patient with metastatic prostate adenocarcinoma. American journal of kidney diseases : the official journal of the National Kidney Foundation 20010401
Pharmacokinetics of cyclosporine in heart transplant recipients receiving metabolic inhibitors. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20010401
Interaction of two novel 14-epivitamin D3 analogs with vitamin D3 receptor-retinoid X receptor heterodimers on vitamin D3 responsive elements. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20010401
Successful treatment of visceral leishmaniasis with allopurinol plus ketoconazole in an infant who developed pancreatitis caused by meglumine antimoniate. The Pediatric infectious disease journal 20010401
Ranitidine-related Stevens-Johnson syndrome in patients with severe liver diseases: a report of two cases. Journal of gastroenterology and hepatology 20010401
Preparation and physical characterization of alginate microparticles using air atomization method. Drug development and industrial pharmacy 20010401
Hard palate perforation: an unusual finding in paracoccidioidomycosis. International journal of dermatology 20010401
Drug sensitivity of Candida yeast isolated from patients with allergic diseases. Bulletin of experimental biology and medicine 20010401
Treatments for common superficial fungal infections. Dermatology nursing 20010401
Coadministration of ketoconazole and cyclosporine for kidney transplant recipients: long-term follow-up and study of metabolic consequences. American journal of kidney diseases : the official journal of the National Kidney Foundation 20010301
Clinical inquiries. What is the best oral antifungal medication for tinea capitis? The Journal of family practice 20010301
A new class of nonsteroidal aromatase inhibitors: design and synthesis of chromone and xanthone derivatives and inhibition of the P450 enzymes aromatase and 17 alpha-hydroxylase/C17,20-lyase. Journal of medicinal chemistry 20010301
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In vitro/in vivo scaling of alprazolam metabolism by CYP3A4 and CYP3A5 in humans. Biopharmaceutics & drug disposition 20010301
Aminoglutethimide, a steroidogenesis inhibitor, abolishes hormonal induction of ornithine decarboxylase in steroidogenic tissues: evidence for its role as cAMP-dependent protein kinase inhibitor. Biochemical and biophysical research communications 20010216
Muting of androgen negative feedback unveils impoverished gonadotropin-releasing hormone/luteinizing hormone secretory reactivity in healthy older men. The Journal of clinical endocrinology and metabolism 20010201
CYP3A4 is the major CYP isoform mediating the in vitro hydroxylation and demethylation of flunitrazepam. Drug metabolism and disposition: the biological fate of chemicals 20010201
Modulation of P450 CYP3A4-dependent metabolism by P-glycoprotein: implications for P450 phenotyping. The Journal of pharmacology and experimental therapeutics 20010201
A novel sequence element is involved in the transcriptional regulation of expression of the ERG1 (squalene epoxidase) gene in Saccharomyces cerevisiae. European journal of biochemistry 20010201
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Determination of minumum inhibitory concentrations of Candida species isolated from vaginal swab specimens by using broth macrodilution and E-test. Journal of chemotherapy (Florence, Italy) 20010201
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Physical stabilisation of amorphous ketoconazole in solid dispersions with polyvinylpyrrolidone K25. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20010101
Meiosis-activating sterol and the maturation of isolated mouse oocytes. Biology of reproduction 20010101
The combination of oral amphotericin B with azoles prevents the emergence of resistant Candida species in neutropenic patients. British journal of haematology 20010101
Studies on the metabolism of troglitazone to reactive intermediates in vitro and in vivo. Evidence for novel biotransformation pathways involving quinone methide formation and thiazolidinedione ring scission. Chemical research in toxicology 20010101
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Effect of ketoconazole 1% and 2% shampoos on severe dandruff and seborrhoeic dermatitis: clinical, squamometric and mycological assessments. Dermatology (Basel, Switzerland) 20010101
Investigation of ketoconazole copper(II) and cobalt(II) complexes and their spectrophotometric applications. Journal of AOAC International 20010101
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A novel extractionless hplc fluorescence method for the determination of glyburide in the human plasma: application to a bioequivalence study. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20010101
Guess what! Tinea capitis by Trichophyton schöenleinii. European journal of dermatology : EJD 20010101
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A plea to bridge the gap between antifungals and the management of onychomycosis. American journal of clinical dermatology 20010101
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Identification of cytochrome P4503A as the major subfamily responsible for the metabolism of roquinimex in man. Xenobiotica; the fate of foreign compounds in biological systems 20000901
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Cushing's syndrome in pregnancy treated by ketoconazole: case report and review of the literature. Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 19990601
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Cytochrome P450 3A4 in vivo ketoconazole competitive inhibition: determination of Ki and dangers associated with high clearance drugs in general. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 19990101
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Selective biotransformation of the human immunodeficiency virus protease inhibitor saquinavir by human small-intestinal cytochrome P4503A4: potential contribution to high first-pass metabolism. Drug metabolism and disposition: the biological fate of chemicals 19970201
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Novel steroidal inhibitors of human cytochrome P45017 alpha (17 alpha-hydroxylase-C17,20-lyase): potential agents for the treatment of prostatic cancer. Journal of medicinal chemistry 19950623
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Synthesis and structure-activity relationships of phenyl-substituted benzylamine antimycotics: a novel benzylbenzylamine antifungal agent for systemic treatment. Journal of medicinal chemistry 19930723
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Reduction of chromium(VI) to chromium(V) by rat liver cytosolic and microsomal fractions: is DT-diaphorase involved? Carcinogenesis 19920701
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Comparative study of six antifungal treatments in an experimental model of murine cryptococcosis. European journal of epidemiology 19920501
Uroporphyrinogen oxidation catalyzed by reconstituted cytochrome P450IA2. Archives of biochemistry and biophysics 19920501
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The mechanism of bioactivation and antigen formation of amodiaquine in the rat. Biochemical pharmacology 19920401
Placebo-controlled clinical trial of sodium stibogluconate (Pentostam) versus ketoconazole for treating cutaneous leishmaniasis in Guatemala. The Journal of infectious diseases 19920301
Acute renal failure after liver transplantation in patients treated with cyclosporine. Transplantation proceedings 19920201
Ketoconazole and high-dose methylprednisolone predisposing to cyclosporine-induced seizures: report of 3 cases. Acta haematologica 19920101
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Drug induced suicidal ideation. The Israel journal of psychiatry and related sciences 19910101
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Cyclosporine and itraconazole interaction in heart and lung transplant recipients. Annals of internal medicine 19900815
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