Home Other Building Blocks Isepamicin Sulphate

Isepamicin Sulphate

CAS No.:
67814-76-0
Catalog Number:
AG01DQ46
Molecular Formula:
C22H45N5O16S
Molecular Weight:
667.6816
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
95%
In Stock USA
United States
$175
- +
100mg
95%
In Stock USA
United States
$515
- +
Product Description
Catalog Number:
AG01DQ46
Chemical Name:
Isepamicin Sulphate
CAS Number:
67814-76-0
Molecular Formula:
C22H45N5O16S
Molecular Weight:
667.6816
MDL Number:
MFCD01683537
IUPAC Name:
(2S)-3-amino-N-[(1R,2S,3S,4R,5S)-5-amino-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-2-[(2R,3R,4R,5R)-3,5-dihydroxy-5-methyl-4-(methylamino)oxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxypropanamide;sulfuric acid
InChI:
InChI=1S/C22H43N5O12.H2O4S/c1-22(35)6-36-20(15(33)18(22)26-2)39-17-8(27-19(34)9(28)4-23)3-7(25)16(14(17)32)38-21-13(31)12(30)11(29)10(5-24)37-21;1-5(2,3)4/h7-18,20-21,26,28-33,35H,3-6,23-25H2,1-2H3,(H,27,34);(H2,1,2,3,4)/t7-,8+,9-,10+,11+,12-,13+,14-,15+,16+,17-,18+,20+,21+,22-;/m0./s1
InChI Key:
DDXRHRXGIWOVDQ-MGAUJLSLSA-N
SMILES:
OS(=O)(=O)O.NC[C@@H](C(=O)N[C@@H]1C[C@H](N)[C@H]([C@@H]([C@H]1O[C@H]1OC[C@]([C@@H]([C@H]1O)NC)(C)O)O)O[C@H]1O[C@H](CN)[C@H]([C@@H]([C@H]1O)O)O)O
UNII:
F2L211KBUV
Properties
Complexity:
899  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
15  
Defined Bond Stereocenter Count:
0
Exact Mass:
667.258g/mol
Formal Charge:
0
Heavy Atom Count:
44  
Hydrogen Bond Acceptor Count:
20  
Hydrogen Bond Donor Count:
14  
Isotope Atom Count:
0
Molecular Weight:
667.681g/mol
Monoisotopic Mass:
667.258g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
381A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Antimicrobial susceptibility of non-fermenting Gram-negative isolates to isepamicin in a region with high antibiotic resistance. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20121101
Susceptibility of Gram-negative bacteria to isepamicin: a systematic review. Expert review of anti-infective therapy 20120201
Necrotic intramuscular chloroma with infection: magnetic resonance imaging features. Japanese journal of radiology 20111201
Antibiotic and synergistic effect of Leu-Lys rich peptide against antibiotic resistant microorganisms isolated from patients with cholelithiasis. Biochemical and biophysical research communications 20100903
Resonance Rayleigh-scattering spectral method for the determination of some aminoglycoside antibiotics using CdTe quantum dots as a probe. Luminescence : the journal of biological and chemical luminescence 20100101
Prophylactic use of isepamicin and levofloxacin for transrectal prostate biopsy: a retrospective single center study. International journal of urology : official journal of the Japanese Urological Association 20090901
Determination of isepamicin in human plasma by HPLC with fluorescence detection after derivatization using 6-aminoquinolyl-N-hydroxysuccinimidyl-carbamate. Biological & pharmaceutical bulletin 20081001
Research and clinical value of antibacterial-application software. Chinese medical journal 20080105
In vitro activity of isepamicin and other aminoglycosides against clinical isolates of Gram-negative bacteria causing nosocomial bloodstream infections. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi 20071201
Old antibiotics for infections in critically ill patients. Current opinion in critical care 20071001
Key pharmacokinetic parameters of isepamicin in febrile neutropenic cancer patients and in women with acute pelvic inflammatory disease. Journal of chemotherapy (Florence, Italy) 20051001
A case of pneumonia caused by Ewingella americana in a patient with chronic renal failure. Journal of Korean medical science 20050201
In vitro activities of tigecycline, ertapenem, isepamicin, and other antimicrobial agents against clinically isolated organisms in Taiwan. Microbial drug resistance (Larchmont, N.Y.) 20050101
[Isepamycin in prophylaxis and treatment of experimental plague due to FI+ and FI- variants of plague microbe]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20050101
High release of antibiotic from a novel hydroxyapatite with bimodal pore size distribution. Journal of biomedical materials research. Part B, Applied biomaterials 20040815
Deficiency of polycystin-2 reduces Ca2+ channel activity and cell proliferation in ADPKD lymphoblastoid cells. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20040501
[Aminoglycoside resistance in gramnegative pathogens of nosocomial infections in Russia]. Antibiotiki i khimioterapiia = Antibiotics and chemoterapy [sic] 20040101
[Iliopsoas abscess accompanied by epidural abscess--a case report]. Masui. The Japanese journal of anesthesiology 20030901
A case of Pasteurella haemolytica sepsis in a patient with mitral valve disease who developed a splenic abscess. Scandinavian journal of infectious diseases 20030101
[Antibacterial activities and PK/PD parameters of aminoglycosides against recent clinical isolates of gram-negative rods]. The Japanese journal of antibiotics 20021001
Diffusion of isepamicin into cancellous and cortical bone tissue. Journal of chemotherapy (Florence, Italy) 20020801
Protective effect of fleroxacin against the nephrotoxicity of isepamicin in rats. Biological & pharmaceutical bulletin 20020401
[In vitro interaction of tazobactam/piperacillin combined with aminoglycosides against Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli AND Staphylococcus aureus]. The Japanese journal of antibiotics 20020201
Invitro comparative evaluation of aminoglycosides at a cancer centre. Indian journal of cancer 20020101
Comparison of isepamicin with amikacin for the empirical treatment of febrile neutropenic children with malignancies. International journal of antimicrobial agents 20011001
Cloning, overexpression, and purification of aminoglycoside antibiotic nucleotidyltransferase (2'')-Ia: conformational studies with bound substrates. Biochemistry 20010619
Comparison of two methods to obtain a desired first isepamicin peak in intensive care patients. Fundamental & clinical pharmacology 20010401
In vitro susceptibility of nosocomial isolates against a new aminoglycoside isepamicin. The Indian journal of medical research 20010201
Determination of isepamicin sulfate and related compounds by high performance liquid chromatography using evaporative light scattering detection. Journal of pharmaceutical and biomedical analysis 20010101
Comparative activities of isepamicin, amikacin, cefepime, and ciprofloxacin alone or in combination with other antibiotics against Stenotrophomonas maltophilia. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010101
Neuromuscular blocking effects of the aminoglycoside antibiotics arbekacin, astromicin, isepamicin and netilmicin on the diaphragm and limb muscles in the rabbit. Pharmacology 20010101
Comparative in vitro activity of isepamicin and other antibiotics against gram-negative bacilli from intensive care units (ICU) in Belgium. Acta clinica Belgica 20010101
Auditory impairment in guinea pigs treated with isepamicin. Journal of chemotherapy (Florence, Italy) 19950601
CI-960 (PD127391 or AM-1091), sparfloxacin, WIN 57273, and isepamicin activity against clinical isolates of Mycobacterium avium-intracellularae complex, M. chelonae, and M. fortuitum. Diagnostic microbiology and infectious disease 19920201
Properties