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STIRIPENTOL

CAS No.:
137767-55-6
Catalog Number:
AG01DM8S
Molecular Formula:
C14H18O3
Molecular Weight:
234.2909
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Product Description
Catalog Number:
AG01DM8S
Chemical Name:
STIRIPENTOL
CAS Number:
137767-55-6
Molecular Formula:
C14H18O3
Molecular Weight:
234.2909
MDL Number:
MFCD00869310
IUPAC Name:
(E)-1-(1,3-benzodioxol-5-yl)-4,4-dimethylpent-1-en-3-ol
InChI:
InChI=1S/C14H18O3/c1-14(2,3)13(15)7-5-10-4-6-11-12(8-10)17-9-16-11/h4-8,13,15H,9H2,1-3H3/b7-5+
InChI Key:
IBLNKMRFIPWSOY-FNORWQNLSA-N
SMILES:
OC(C(C)(C)C)C=Cc1ccc2c(c1)OCO2
EC Number:
256-480-9
Properties
Complexity:
280  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
1  
Exact Mass:
234.126g/mol
Formal Charge:
0
Heavy Atom Count:
17  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
234.295g/mol
Monoisotopic Mass:
234.126g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
38.7A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
3.6  
Literature
Title Journal
Epilepsy treatment. Targeting LDH enzymes with a stiripentol analog to treat epilepsy. Science (New York, N.Y.) 20150320
Stiripentol in refractory status epilepticus. Epilepsia 20130901
Stiripentol: an example of antiepileptic drug development in childhood epilepsies. European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society 20120901
Concentrations of stiripentol in children and adults with epilepsy: the influence of dose, age, and comedication. Therapeutic drug monitoring 20120801
Efficacy of stiripentol in hyperthermia-induced seizures in a mouse model of Dravet syndrome. Epilepsia 20120701
Design and synthesis of novel stiripentol analogues as potential anticonvulsants. European journal of medicinal chemistry 20120101
[Therapeutic drug monitoring of stiripentol]. Therapie 20120101
Ketogenic diet also benefits Dravet syndrome patients receiving stiripentol: a prospective pilot study. Epilepsia 20110701
New and forthcoming anti-epileptic drugs. Current opinion in neurology 20110401
The effects of stiripentol on GABA(A) receptors. Epilepsia 20110401
Current therapeutic procedures in Dravet syndrome. Developmental medicine and child neurology 20110401
Interactions between modulators of the GABA(A) receptor: Stiripentol and benzodiazepines. European journal of pharmacology 20110305
The efficacy of bromides, stiripentol and levetiracetam in two patients with malignant migrating partial seizures in infancy. Epileptic disorders : international epilepsy journal with videotape 20110301
Interactions of stiripentol with clobazam and valproate in the mouse maximal electroshock-induced seizure model. Epilepsy research 20100801
Stiripentol open study in Japanese patients with Dravet syndrome. Epilepsia 20091101
The anti-convulsant stiripentol acts directly on the GABA(A) receptor as a positive allosteric modulator. Neuropharmacology 20090101
[Clinical and genetic diagnosis of Dravet syndrome: report of 20 cases]. Ideggyogyaszati szemle 20081130
Acute hepatic injury in a child with Dravet syndrome: no protective effect of stiripentol. Seizure 20080701
Severe myoclonic epilepsy in infancy: a systematic review and a meta-analysis of individual patient data. Epilepsia 20080201
The new antiepileptic drugs. Archives of disease in childhood. Education and practice edition 20071201
Stiripentol. Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20070101
Topiramate in the treatment of highly refractory patients with Dravet syndrome. Neuropediatrics 20061201
Characterization of the anticonvulsant, behavioral and pharmacokinetic interaction profiles of stiripentol in combination with clonazepam, ethosuximide, phenobarbital, and valproate using isobolographic analysis. Epilepsia 20061101
Biphasic characteristic of interactions between stiripentol and carbamazepine in the mouse maximal electroshock-induced seizure model: a three-dimensional isobolographic analysis. Naunyn-Schmiedeberg's archives of pharmacology 20061001
Stiripentol in childhood partial epilepsy: randomized placebo-controlled trial with enrichment and withdrawal design. Journal of child neurology 20060601
In vitro and in vivo inhibitory effect of stiripentol on clobazam metabolism. Drug metabolism and disposition: the biological fate of chemicals 20060401
Stiripentol, a putative antiepileptic drug, enhances the duration of opening of GABA-A receptor channels. Epilepsia 20060401
Stiripentol. Expert opinion on investigational drugs 20050701
Stiripentol. A novel antiepileptic drug. Pharmacological reports : PR 20050101
Inhibitory effect of stiripentol on carbamazepine and saquinavir metabolism in human. British journal of clinical pharmacology 20031101
[Long-term efficacy and tolerance of stiripentaol in severe myoclonic epilepsy of infancy (Dravet's syndrome)]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20021101
New antiepileptic drug therapies. Neurologic clinics 20021101
Stiripentol. BCX 2600. Drugs in R&D 20020101
Protective effect of stiripentol on acetaminophen-induced hepatotoxicity in rat. Toxicology and applied pharmacology 20010201
Epileptic encephalopathy. Epilepsia 20010101
Preclinical evaluation of newly approved and potential antiepileptic drugs against cocaine-induced seizures. The Journal of pharmacology and experimental therapeutics 19990901
Infant monkey hyperexcitability after prenatal exposure to antiepileptic compounds. Epilepsia 19961001
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