Home Other Building Blocks Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat

Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat

CAS No.:
211439-12-2
Catalog Number:
AG01CP91
Molecular Formula:
Molecular Weight:
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Purity
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Product Description
Catalog Number:
AG01CP91
Chemical Name:
Activity-Dependent Neuroprotective Protein Fragment 74-81, mouse, rat
CAS Number:
211439-12-2
MDL Number:
MFCD03787945
IUPAC Name:
(2S)-5-amino-2-[[(2S)-1-[(2S,3S)-2-[[(2S)-2-[[(2S)-2-[[(2S)-1-[(2S)-2-[[(2S)-2,4-diamino-4-oxobutanoyl]amino]propanoyl]pyrrolidine-2-carbonyl]amino]-3-methylbutanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylpentanoyl]pyrrolidine-2-carbonyl]amino]-5-oxopentanoic acid
InChI:
InChI=1S/C36H60N10O12/c1-6-18(4)28(35(56)46-14-8-9-23(46)31(52)41-21(36(57)58)11-12-25(38)48)44-30(51)22(16-47)42-33(54)27(17(2)3)43-32(53)24-10-7-13-45(24)34(55)19(5)40-29(50)20(37)15-26(39)49/h17-24,27-28,47H,6-16,37H2,1-5H3,(H2,38,48)(H2,39,49)(H,40,50)(H,41,52)(H,42,54)(H,43,53)(H,44,51)(H,57,58)/t18-,19-,20-,21-,22-,23-,24-,27-,28-/m0/s1
InChI Key:
DWLTUUXCVGVRAV-XWRHUKJGSA-N
UNII:
GF00K3IIWE
Properties
Complexity:
1560  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0
Exact Mass:
824.439g/mol
Formal Charge:
0
Heavy Atom Count:
58  
Hydrogen Bond Acceptor Count:
13  
Hydrogen Bond Donor Count:
10  
Isotope Atom Count:
0
Molecular Weight:
824.934g/mol
Monoisotopic Mass:
824.439g/mol
Rotatable Bond Count:
22  
Topological Polar Surface Area:
356A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-5.6  
Literature
Title Journal
From anti-Parkinson's drug rasagiline to novel multitarget iron chelators with acetylcholinesterase and monoamine oxidase inhibitory and neuroprotective properties for Alzheimer's disease. Journal of Alzheimer's disease : JAD 20120101
Davunetide (NAP) as a preventative treatment for central nervous system complications in a diabetes rat model. Neurobiology of disease 20111201
NAP prevents acute cerebral oxidative stress and protects against long-term brain injury and cognitive impairment in a model of neonatal hypoxia-ischemia. Neurobiology of disease 20111001
Activity-dependent neuroprotective protein (ADNP)-derived peptide (NAP) ameliorates hypobaric hypoxia induced oxidative stress in rat brain. Peptides 20110601
Neuroprotective fractalkine in fetal alcohol syndrome. American journal of obstetrics and gynecology 20110501
Prevention of learning deficit in a Down syndrome model. Obstetrics and gynecology 20110201
NAP (davunetide) provides functional and structural neuroprotection. Current pharmaceutical design 20110101
Microtubules (tau) as an emerging therapeutic target: NAP (davunetide). Current pharmaceutical design 20110101
Effects of ethanol and NAP on cerebellar expression of the neural cell adhesion molecule L1. PloS one 20110101
Expression of peptide NAP in rat retinal Müller cells prevents hypoxia-induced retinal injuries and promotes retinal neurons growth. Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100701
NAP (davunetide) enhances cognitive behavior in the STOP heterozygous mouse--a microtubule-deficient model of schizophrenia. Peptides 20100701
Prevention of the alcohol-induced changes in brain-derived neurotrophic factor expression using neuroprotective peptides in a model of fetal alcohol syndrome. American journal of obstetrics and gynecology 20100501
Reversal of alcohol-induced learning deficits in the young adult in a model of fetal alcohol syndrome. Obstetrics and gynecology 20100201
Expression of activity-dependent neuroprotective protein in the immune system: possible functions and relevance to multiple sclerosis. Neuroimmunomodulation 20100101
NAP prevents hippocampal oxidative damage in neonatal rats subjected to hypoxia-induced seizures. Neurobiology of disease 20091201
The microtubule interacting drug candidate NAP protects against kainic acid toxicity in a rat model of epilepsy. Journal of neurochemistry 20091201
Short neuroprotective peptides, ADNF9 and NAP, are structurally disordered and monomeric in PBS. International journal of biological macromolecules 20090701
Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and gamma-aminobutyric acid receptors. American journal of obstetrics and gynecology 20090501
Activity-dependent neuroprotective protein-derived peptide, NAP, preventing alcohol-induced apoptosis in fetal brain of C57BL/6 mouse. Neuroscience 20090218
The neuropeptide NAP provides neuroprotection against retinal ganglion cell damage after retinal ischemia and optic nerve crush. Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20080901
NAP and D-SAL: neuroprotection against the beta amyloid peptide (1-42). BMC neuroscience 20080101
NAP, a neuroprotective drug candidate in clinical trials, stimulates microtubule assembly in the living cell. Current Alzheimer research 20071201
The peptide NAP promotes neuronal growth and differentiation through extracellular signal-regulated protein kinase and Akt pathways, and protects neurons co-cultured with astrocytes damaged by ethanol. Journal of neurochemistry 20071001
NAP protects hippocampal neurons against multiple toxins. Peptides 20071001
Understanding the mechanism of learning enhancement: NMDA and GABA receptor expression. American journal of obstetrics and gynecology 20070901
[Effect of neuropeptide NAP on cultured neuroepithelial cells from rabbit retina]. Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20070601
Neuroprotective peptides prevent some alcohol-induced alteration in gamma-aminobutyric acid A-beta3, which plays a role in cleft lip and palate and learning in fetal alcohol syndrome. American journal of obstetrics and gynecology 20070301
NAP and ADNF-9 protect normal and Down's syndrome cortical neurons from oxidative damage and apoptosis. Current pharmaceutical design 20070101
Intranasal NAP administration reduces accumulation of amyloid peptide and tau hyperphosphorylation in a transgenic mouse model of Alzheimer's disease at early pathological stage. Journal of molecular neuroscience : MN 20070101
Prevention of alcohol-induced learning deficits in fetal alcohol syndrome mediated through NMDA and GABA receptors. American journal of obstetrics and gynecology 20060301
[Review of neurobehavioral effects of alcohol-related neurodevelopmental disorder in an animal model]. Nihon Arukoru Yakubutsu Igakkai zasshi = Japanese journal of alcohol studies & drug dependence 20060201
Novel neuroprotective neurotrophic NAP analogs targeting metal toxicity and oxidative stress: potential candidates for the control of neurodegenerative diseases. Journal of neural transmission. Supplementum 20060101
Novel peptides prevent alcohol-induced spatial learning deficits and proinflammatory cytokine release in a mouse model of fetal alcohol syndrome. American journal of obstetrics and gynecology 20050901
The peptides ADNF-9 and NAP increase survival and neurite outgrowth of rat retinal ganglion cells in vitro. Investigative ophthalmology & visual science 20050301
Peptide-mediated protection from ethanol-induced neural tube defects. Developmental neuroscience 20050101
Synergistic effects of the peptide fragment D-NAPVSIPQ on ethanol inhibition of synaptic plasticity and NMDA receptors in rat hippocampus. Neuroscience 20050101
NAP: research and development of a peptide derived from activity-dependent neuroprotective protein (ADNP). CNS drug reviews 20050101
Ethanol antagonist peptides: structural specificity without stereospecificity. The Journal of pharmacology and experimental therapeutics 20040601
Protective peptides that are orally active and mechanistically nonchiral. The Journal of pharmacology and experimental therapeutics 20040601
NAP mechanisms of neuroprotection. Journal of molecular neuroscience : MN 20040101
Characterization of competitive inhibitors for the transferase activity of Pseudomonas aeruginosa exotoxin A. Journal of enzyme inhibition and medicinal chemistry 20020801
Vasoactive intestinal peptide and related molecules induce nitrite accumulation in the extracellular milieu of rat cerebral cortical cultures. Neuroscience letters 20010720
Prevention of fetal demise and growth restriction in a mouse model of fetal alcohol syndrome. The Journal of pharmacology and experimental therapeutics 20010501
Activity-dependent neurotrophic factor: intranasal administration of femtomolar-acting peptides improve performance in a water maze. The Journal of pharmacology and experimental therapeutics 20000601
Properties