MPEP
| Title | Journal |
|---|---|
| Downregulation of metabotropic glutamate receptor 5 inhibits hepatoma development in a neurotoxin rotenone-induced Parkinson's disease model. | Toxicology letters 20180515 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Discovery and structure-activity relationship of 1,3-cyclohexyl amide derivatives as novel mGluR5 negative allosteric modulators. | Bioorganic & medicinal chemistry letters 20130301 |
| Acute and sustained effects of a metabotropic glutamate 5 receptor antagonist in the novelty-suppressed feeding test. | Behavioural brain research 20121201 |
| Synthesis and characterization of two PET radioligands for the metabotropic glutamate 1 (mGlu1) receptor. | Synapse (New York, N.Y.) 20121201 |
| Discovery and characterization of AZD9272 and AZD6538-Two novel mGluR5 negative allosteric modulators selected for clinical development. | Bioorganic & medicinal chemistry letters 20121115 |
| Effects of metabotropic glutamate mGlu5 receptor antagonist on tyrosine phosphorylation of NMDA receptor subunits and cell death in the hippocampus after brain ischemia in rats. | Neuroscience letters 20121114 |
| The suppressive effect of metabotropic glutamate receptor 5 (mGlu5) inhibition on hepatocarcinogenesis. | Biochimie 20121101 |
| Epileptic stimulus increases Homer 1a expression to modulate endocannabinoid signaling in cultured hippocampal neurons. | Neuropharmacology 20121101 |
| Pharmacological characterization and modeling of the binding sites of novel 1,3-bis(pyridinylethynyl)benzenes as metabotropic glutamate receptor 5-selective negative allosteric modulators. | Molecular pharmacology 20121101 |
| Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine produces antidepressant effects in rats: role of brain-derived neurotrophic factor. | Neuroscience 20121025 |
| Electrophysiological and behavioral effects of group I metabotropic glutamate receptors on pallidal neurons in rats. | Brain research 20121005 |
| Transient mGlu5R inhibition enhances the survival of granule cell precursors in the neonatal cerebellum. | Neuroscience 20120906 |
| Role of metabotropic glutamate receptors in the mechanisms of experimental parkinsonism development. | Bulletin of experimental biology and medicine 20120901 |
| Involvement of metabotropic glutamate receptor 5 in cardiomyocyte differentiation from mouse embryonic stem cells. | Stem cells and development 20120810 |
| Involvement of metabotropic glutamate receptor 5 signaling in activity-related proliferation of adult hippocampal neural stem cells. | The European journal of neuroscience 20120801 |
| Activation of type 5 metabotropic glutamate receptors and diacylglycerol lipase-α initiates 2-arachidonoylglycerol formation and endocannabinoid-mediated analgesia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20120711 |
| Blockade of metabotropic glutamate receptors inhibits cognition and neurodegeneration in an MPTP-induced Parkinson's disease rat model. | Pharmacology, biochemistry, and behavior 20120701 |
| Metabotropic glutamate receptors (mGluR5) activate transient receptor potential canonical channels to improve the regularity of the respiratory rhythm generated by the pre-Bötzinger complex in mice. | The European journal of neuroscience 20120601 |
| Nitrative stress in cerebral endothelium is mediated by mGluR5 in hyperhomocysteinemia. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120501 |
| The mGlu5 receptor antagonist MPEP activates specific stress-related brain regions and lacks neurotoxic effects of the NMDA receptor antagonist MK-801: significance for the use as anxiolytic/antidepressant drug. | Neuropharmacology 20120401 |
| Structure-activity relationships for negative allosteric mGluR5 modulators. | ChemMedChem 20120305 |
| Extracellular cysteine (Cys)/cystine (CySS) redox regulates metabotropic glutamate receptor 5 activity. | Biochimie 20120301 |
| Pharmacological interference with metabotropic glutamate receptor subtype 7 but not subtype 5 differentially affects within- and between-session extinction of Pavlovian conditioned fear. | Neuropharmacology 20120301 |
| Action of molecular switches in GPCRs--theoretical and experimental studies. | Current medicinal chemistry 20120301 |
| Changes in cannabinoid receptor subtype 1 activity and interaction with metabotropic glutamate subtype 5 receptors in the periaqueductal gray-rostral ventromedial medulla pathway in a rodent neuropathic pain model. | CNS & neurological disorders drug targets 20120301 |
| New perspectives on glutamate receptor antagonists as antidepressants. | Archives of pharmacal research 20120301 |
| Lifelong CRF overproduction is associated with altered gene expression and sensitivity of discrete GABA(A) and mGlu receptor subtypes. | Psychopharmacology 20120201 |
| Counteracting roles of metabotropic glutamate receptor subtypes 1 and 5 in regulation of pain-related spatial and temporal synaptic plasticity in rat entorhinal-hippocampal pathways. | Neuroscience letters 20120117 |
| Rescue of synaptic plasticity and spatial learning deficits in the hippocampus of Homer1 knockout mice by recombinant Adeno-associated viral gene delivery of Homer1c. | Neurobiology of learning and memory 20120101 |
| Differential involvement of mGluR1 and mGluR5 in memory reconsolidation and retrieval in a passive avoidance task in 1-day old chicks. | Neurobiology of learning and memory 20120101 |
| Hemodynamic responses evoked by neuronal stimulation via channelrhodopsin-2 can be independent of intracortical glutamatergic synaptic transmission. | PloS one 20120101 |
| Anti-Alcohol and Anxiolytic Properties of a New Chemical Entity, GET73. | Frontiers in psychiatry 20120101 |
| Developmental regulation of CB1-mediated spike-time dependent depression at immature mossy fiber-CA3 synapses. | Scientific reports 20120101 |
| Glutamate induces the elongation of early dendritic protrusions via mGluRs in wild type mice, but not in fragile X mice. | PloS one 20120101 |
| The mGluR5 antagonist AFQ056 does not affect methylation and transcription of the mutant FMR1 gene in vitro. | BMC medical genetics 20120101 |
| Metabotropic glutamate receptor 5 (mGluR5) regulates bladder nociception. | Molecular pain 20120101 |
| mGlu5 Receptor Functional Interactions and Addiction. | Frontiers in pharmacology 20120101 |
| Inhibition mechanism and model of an angiotensin I-converting enzyme (ACE)-inhibitory hexapeptide from yeast (Saccharomyces cerevisiae). | PloS one 20120101 |
| Controlled-release levodopa methyl ester/benserazide-loaded nanoparticles ameliorate levodopa-induced dyskinesia in rats. | International journal of nanomedicine 20120101 |
| Matrix metalloproteinases and minocycline: therapeutic avenues for fragile X syndrome. | Neural plasticity 20120101 |
| Differential effects of diazepam and MPEP on habituation and neuro-behavioural processes in inbred mice. | Behavioral and brain functions : BBF 20120101 |
| Modulation of endocannabinoid-mediated long-lasting disinhibition of striatal output by cholinergic interneurons. | Neuropharmacology 20111201 |
| Metabotropic glutamate receptor 5 antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) microinfusions into the nucleus accumbens shell or ventral tegmental area attenuate the reinforcing effects of nicotine in rats. | Neuropharmacology 20111201 |
| Metabotropic glutamate antagonists alone and in combination with morphine: comparison across two models of acute pain and a model of persistent, inflammatory pain. | Behavioural pharmacology 20111201 |
| Early, time-dependent disturbances of hippocampal synaptic transmission and plasticity after in utero immune challenge. | Biological psychiatry 20111115 |
| Polymodal activation of the endocannabinoid system in the extended amygdala. | Nature neuroscience 20111106 |
| CTEP: a novel, potent, long-acting, and orally bioavailable metabotropic glutamate receptor 5 inhibitor. | The Journal of pharmacology and experimental therapeutics 20111101 |
| Pain-related deactivation of medial prefrontal cortical neurons involves mGluR1 and GABA(A) receptors. | Journal of neurophysiology 20111101 |
| Blockade of mGluR5 reverses abnormal firing of subthalamic nucleus neurons in 6-hydroxydopamine partially lesioned rats. | The Chinese journal of physiology 20111031 |
| Complex effects of mGluR5 antagonism on sociability and stereotypic behaviors in mice: possible implications for the pharmacotherapy of autism spectrum disorders. | Brain research bulletin 20111010 |
| The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl) pyridine decreases striatal VGlut2 expression in association with an attenuation of L-DOPA-induced dyskinesias. | Synapse (New York, N.Y.) 20111001 |
| Impairments of exploration and memory after systemic or prelimbic D1-receptor antagonism in rats. | Behavioural brain research 20111001 |
| The mGluR5 antagonist MPEP elevates accumbal dopamine and glycine levels; interaction with strychnine-sensitive glycine receptors. | Addiction biology 20111001 |
| Metabotropic glutamate receptor 5 promotes proliferation of human neural stem/progenitor cells with activation of mitogen-activated protein kinases signaling pathway in vitro. | Neuroscience 20110929 |
| Subchronic administration and combination metabotropic glutamate and GABAB receptor drug therapy in fragile X syndrome. | The Journal of pharmacology and experimental therapeutics 20110901 |
| Neural circuit architecture defects in a Drosophila model of Fragile X syndrome are alleviated by minocycline treatment and genetic removal of matrix metalloproteinase. | Disease models & mechanisms 20110901 |
| Discriminative stimulus effects of NMDA, AMPA, and mGluR5 glutamate receptor ligands in methamphetamine-trained rats. | Behavioural pharmacology 20110901 |
| Capsaicin prevents the hyperalgesia induced by peripheral group I mGluRs activation. | Neuroscience letters 20110818 |
| Selective mGluR5 antagonism attenuates the stress-induced reduction of MK-801's antiseizure potency in the genetically inbred Balb/c mouse. | Epilepsy & behavior : E&B 20110801 |
| Progress in structure based drug design for G protein-coupled receptors. | Journal of medicinal chemistry 20110714 |
| A role for glutamate in subjective response to smoking and its action on inhibitory control. | Psychopharmacology 20110701 |
| Astrocytes display complex and localized calcium responses to single-neuron stimulation in the hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110615 |
| The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on the stimulation of dopamine release evoked by nicotine in the rat brain. | Behavioural brain research 20110601 |
| A prolonged pharmacological blockade of type-5 metabotropic glutamate receptors protects cultured spinal cord motor neurons against excitotoxic death. | Neurobiology of disease 20110601 |
| Group I mGluR-regulated translation of the neuronal glutamate transporter, excitatory amino acid carrier 1. | Journal of neurochemistry 20110601 |
| Potent mGluR5 antagonists: pyridyl and thiazolyl-ethynyl-3,5-disubstituted-phenyl series. | Bioorganic & medicinal chemistry letters 20110601 |
| Interactive effects of mGlu5 and 5-HT2A receptors on locomotor activity in mice. | Psychopharmacology 20110501 |
| Early continuous inhibition of group 1 mGlu signaling partially rescues dendritic spine abnormalities in the Fmr1 knockout mouse model for fragile X syndrome. | Psychopharmacology 20110501 |
| Design and synthesis of substituted N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamides as positive allosteric modulators of the metabotropic glutamate receptor subtype 5. | Bioorganic & medicinal chemistry letters 20110501 |
| Therapeutic significance of NR2B-containing NMDA receptors and mGluR5 metabotropic glutamate receptors in mediating the synaptotoxic effects of β-amyloid oligomers on long-term potentiation (LTP) in murine hippocampal slices. | Neuropharmacology 20110501 |
| Quantitative analysis reveals multiple mechanisms of allosteric modulation of the mGlu5 receptor in rat astroglia. | Molecular pharmacology 20110501 |
| Fragile X mental retardation protein regulates protein expression and mRNA translation of the potassium channel Kv4.2. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110413 |
| Group I mGluR agonist-evoked long-term potentiation in hippocampal oriens interneurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110413 |
| Dissociable roles of mGlu5 and dopamine receptors in the rewarding and sensitizing properties of morphine and cocaine. | Psychopharmacology 20110401 |
| Fragile X mental retardation protein regulates heterosynaptic plasticity in the hippocampus. | Learning & memory (Cold Spring Harbor, N.Y.) 20110401 |
| Cocaine withdrawal impairs metabotropic glutamate receptor-dependent long-term depression in the nucleus accumbens. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20110316 |
| Blockade of mGLUR5 receptors differentially alters amphetamine-induced enhancement of locomotor activity and of brain stimulation reward. | Journal of psychopharmacology (Oxford, England) 20110301 |
| Involvement of the metabotropic glutamate receptor mGluR5 in NMDA receptor-dependent, learning-facilitated long-term depression in CA1 synapses. | Cerebral cortex (New York, N.Y. : 1991) 20110301 |
| Effects of CNQX and MPEP on sensitization to the rewarding effects of morphine. | European journal of pharmacology 20110301 |
| Synaptic activation of mGluR1 generates persistent depression of a fast after-depolarizing potential in CA3 pyramidal neurons. | The European journal of neuroscience 20110301 |
| Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist produces anxiolytic-like effects and reverses abnormal firing activity of projection neurons in the basolateral nucleus of the amygdala in rats with bilateral 6-OHDA lesions. | Brain research bulletin 20110227 |
| Syntheses of 2-amino and 2-halothiazole derivatives as high-affinity metabotropic glutamate receptor subtype 5 ligands and potential radioligands for in vivo imaging. | Journal of medicinal chemistry 20110210 |
| Assessment of GABA-B, metabotropic glutamate, and opioid receptor involvement in an animal model of binge drinking. | Alcohol (Fayetteville, N.Y.) 20110201 |
| The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates conditioned place preference induced by various addictive and non-addictive drugs in rats. | Addiction biology 20110101 |
| Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse. | Neurobiology of disease 20110101 |
| Metabotropic glutamate receptors transduce signals for neurite outgrowth after binding of the prion protein to laminin γ1 chain. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20110101 |
| Aqueous and Ethanolic Valeriana officinalis Extracts Change the Binding of Ligands to Glutamate Receptors. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| mGluR5 positive modulators both potentiate activation and restore inhibition in NMDA receptors by PKC dependent pathway. | Journal of biomedical science 20110101 |
| [Effects of chronic, systemic treatment with metabotropic glutamate receptor 5 antagonist on behavioral activity and neuroprotection in a preclinical rat model of Parkinson's disease]. | Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition 20110101 |
| Metabotropic glutamate receptors as novel therapeutic targets on visceral sensory pathways. | Frontiers in neuroscience 20110101 |
| Selective Interactions of Valeriana officinalis Extracts and Valerenic Acid with [H]Glutamate Binding to Rat Synaptic Membranes. | Evidence-based complementary and alternative medicine : eCAM 20110101 |
| Ictal but not interictal epileptic discharges activate astrocyte endfeet and elicit cerebral arteriole responses. | Frontiers in cellular neuroscience 20110101 |
| Sleep-deprivation induces changes in GABA(B) and mGlu receptor expression and has consequences for synaptic long-term depression. | PloS one 20110101 |
| Dopamine-induced plasticity, phospholipase D (PLD) activity and cocaine-cue behavior depend on PLD-linked metabotropic glutamate receptors in amygdala. | PloS one 20110101 |
| mGluR5-antagonist mediated reversal of elevated stereotyped, repetitive behaviors in the VPA model of autism. | PloS one 20110101 |
| Reversal of fragile X phenotypes by manipulation of AβPP/Aβ levels in Fmr1KO mice. | PloS one 20110101 |
| Differential Modulation of Thresholds for Intracranial Self-Stimulation by mGlu5 Positive and Negative Allosteric Modulators: Implications for Effects on Drug Self-Administration. | Frontiers in pharmacology 20110101 |
| Validating γ oscillations and delayed auditory responses as translational biomarkers of autism. | Biological psychiatry 20101215 |
| Discovery of novel allosteric modulators of metabotropic glutamate receptor subtype 5 reveals chemical and functional diversity and in vivo activity in rat behavioral models of anxiolytic and antipsychotic activity. | Molecular pharmacology 20101201 |
| Hypersensitivity to mGluR5 and ERK1/2 leads to excessive protein synthesis in the hippocampus of a mouse model of fragile X syndrome. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101117 |
| Regional differences in neurovascular coupling in rat brain as determined by fMRI and electrophysiology. | NeuroImage 20101101 |
| A post-burst after depolarization is mediated by group i metabotropic glutamate receptor-dependent upregulation of Ca(v)2.3 R-type calcium channels in CA1 pyramidal neurons. | PLoS biology 20101101 |
| Drosophila PQBP1 regulates learning acquisition at projection neurons in aversive olfactory conditioning. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20101020 |
| Metabotropic glutamate mGlu5 receptor-mediated serine phosphorylation of NMDA receptor subunit NR1 in hippocampal CA1 region after transient global ischemia in rats. | European journal of pharmacology 20101010 |
| Endocannabinoids potentiate synaptic transmission through stimulation of astrocytes. | Neuron 20101006 |
| The metabotropic glutamate receptor subtype 5 mediates sensitivity to the sedative properties of ethanol. | Pharmacogenetics and genomics 20100901 |
| Beyond the dopamine receptor: novel therapeutic targets for treating schizophrenia. | Dialogues in clinical neuroscience 20100901 |
| Pharmacological effects of metabotropic glutamate receptor ligands on prepulse inhibition in DBA/2J mice. | European journal of pharmacology 20100810 |
| Functional interaction of metabotropic glutamate receptor 5 and NMDA-receptor by a metabotropic glutamate receptor 5 positive allosteric modulator. | European journal of pharmacology 20100810 |
| The HIV-1 viral protein Tat increases glutamate and decreases GABA exocytosis from human and mouse neocortical nerve endings. | Cerebral cortex (New York, N.Y. : 1991) 20100801 |
| Increased group I metabotropic glutamate receptor activity in paraventricular nucleus supports elevated sympathetic vasomotor tone in hypertension. | American journal of physiology. Regulatory, integrative and comparative physiology 20100801 |
| Carbamoyloximes as novel non-competitive mGlu5 receptor antagonists. | Bioorganic & medicinal chemistry letters 20100801 |
| D-aspartate activates mGlu receptors coupled to polyphosphoinositide hydrolysis in neonate rat brain slices. | Neuroscience letters 20100712 |
| Metabotropic glutamate receptors (mGluRs) regulate noxious stimulus-induced glutamate release in the spinal cord dorsal horn of rats with neuropathic and inflammatory pain. | Journal of neurochemistry 20100701 |
| The effects of the mGluR5 receptor antagonist 6-methyl-2-(phenylethynyl)-pyridine (MPEP) on behavioural responses to nicotine. | Psychopharmacology 20100701 |
| Sensory and cortical activation of distinct glial cell subtypes in the somatosensory thalamus of young rats. | The European journal of neuroscience 20100701 |
| Metabotropic glutamate receptors as a target for anticonvulsant and anxiolytic action in immature rats. | Epilepsia 20100701 |
| Modulators of metabotropic glutamate receptors microinfused into perirhinal cortex: anticonvulsant effects in rats challenged with soman. | European journal of pharmacology 20100625 |
| Activation of metabotropic glutamate receptor 5 in the amygdala modulates pain-like behavior. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100616 |
| Delayed stabilization of dendritic spines in fragile X mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100609 |
| Effect of the metabotropic glutamate receptor type 5 antagonists MPEP and MTEP in parkinsonian monkeys. | Neuropharmacology 20100601 |
| Abnormal mGlu 5 receptor/endocannabinoid coupling in mice lacking FMRP and BC1 RNA. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100601 |
| Beyond acid suppression: new pharmacologic approaches for treatment of GERD. | Current gastroenterology reports 20100601 |
| Metabotropic glutamate receptor 5 activity in the nucleus accumbens is required for the maintenance of ethanol self-administration in a rat genetic model of high alcohol intake. | Biological psychiatry 20100501 |
| The glutamatergic compounds sarcosine and N-acetylcysteine ameliorate prepulse inhibition deficits in metabotropic glutamate 5 receptor knockout mice. | Psychopharmacology 20100501 |
| Structure-activity relationships in a novel series of 7-substituted-aryl quinolines and 5-substituted-aryl benzothiazoles at the metabotropic glutamate receptor subtype 5. | Bioorganic & medicinal chemistry 20100501 |
| Effects of early and delayed treatment with an mGluR5 antagonist on motor impairment, nigrostriatal damage and neuroinflammation in a rodent model of Parkinson's disease. | Brain research bulletin 20100429 |
| An excitatory loop with astrocytes contributes to drive neurons to seizure threshold. | PLoS biology 20100401 |
| The modified Geller-Seifter test in rats was insensitive to GABAB receptor positive modulation or blockade, or 5-HT1A receptor activation. | Behavioural brain research 20100317 |
| Repetitive self-grooming behavior in the BTBR mouse model of autism is blocked by the mGluR5 antagonist MPEP. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20100301 |
| Interaction between Ephrins and mGlu5 metabotropic glutamate receptors in the induction of long-term synaptic depression in the hippocampus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20100224 |
| Nicotine-induced conditioned place preference in rats: sex differences and the role of mGluR5 receptors. | Neuropharmacology 20100201 |
| Developmental alteration of endocannabinoid retrograde signaling in the hippocampus. | Journal of neurophysiology 20100201 |
| Reduction of increased repetitive self-grooming in ASD mouse model by metabotropic 5 glutamate receptor antagonism; randomized controlled trial of Early Start Denver Model. | Autism research : official journal of the International Society for Autism Research 20100201 |
| Electrophysiological characterization of the rat trigeminal caudalis (Vc) neurons following intramuscular injection of capsaicin. | Neuroscience letters 20100129 |
| Potent homocysteine-induced ERK phosphorylation in cultured neurons depends on self-sensitization via system Xc(-). | Toxicology and applied pharmacology 20100115 |
| Repeated cocaine administration increases B-cell leukemia/lymphoma 2 phosphorylation in the rat dorsal striatum. | Neuroscience letters 20100104 |
| Reduction of glutamatergic neurotransmission by prolonged exposure to dieldrin involves NMDA receptor internalization and metabotropic glutamate receptor 5 downregulation. | Toxicological sciences : an official journal of the Society of Toxicology 20100101 |
| Regulation of increased glutamatergic input to spinal dorsal horn neurons by mGluR5 in diabetic neuropathic pain. | Journal of neurochemistry 20100101 |
| MPEP reduces seizure severity in Fmr-1 KO mice over expressing human Abeta. | International journal of clinical and experimental pathology 20100101 |
| Pyk2 uncouples metabotropic glutamate receptor G protein signaling but facilitates ERK1/2 activation. | Molecular brain 20100101 |
| The effect of treadmill training pre-exercise on glutamate receptor expression in rats after cerebral ischemia. | International journal of molecular sciences 20100101 |
| Alterations in mGluR5 expression and signaling in Lewy body disease and in transgenic models of alpha-synucleinopathy--implications for excitotoxicity. | PloS one 20100101 |
| Operant sensation seeking requires metabotropic glutamate receptor 5 (mGluR5). | PloS one 20100101 |
| Metabotropic glutamate receptors: potential drug targets for psychiatric disorders. | The open medicinal chemistry journal 20100101 |
| Metabotropic glutamate receptors: their therapeutic potential in anxiety. | Current topics in behavioral neurosciences 20100101 |
| Activation of group I metabotropic glutamate receptors leads to brain-derived neurotrophic factor expression in rat C6 cells. | Neuroscience letters 20091225 |
| Glial inhibitors influence the mRNA and protein levels of mGlu2/3, 5 and 7 receptors and potentiate the analgesic effects of their ligands in a mouse model of neuropathic pain. | Pain 20091215 |
| Effects of mGluR5 and mGluR1 antagonists on anxiety-like behavior and learning in developing rats. | Behavioural brain research 20091201 |
| Synaptic plasticity in the adult visual cortex is regulated by the metabotropic glutamate receptor, mGluR5. | Experimental brain research 20091201 |
| Synthesis and SAR of novel, non-MPEP chemotype mGluR5 NAMs identified by functional HTS. | Bioorganic & medicinal chemistry letters 20091201 |
| Metabotropic glutamate mGluR5 receptor blockade opposes abnormal involuntary movements and the increases in glutamic acid decarboxylase mRNA levels induced by l-DOPA in striatal neurons of 6-hydroxydopamine-lesioned rats. | Neuroscience 20091110 |
| Non-competitive metabotropic glutamate 1 receptor antagonists block activity of slowly adapting type I mechanoreceptor units in the rat sinus hair follicle. | Neuroscience 20091020 |
| Effects of glutamate and alpha2-noradrenergic receptor antagonists on the development of neurotoxicity produced by chronic rotenone in rats. | Toxicology and applied pharmacology 20091015 |
| Dopamine D1 receptor-dependent modifications in the dopamine and cAMP-regulated phosphoprotein of Mr 32 kDa phosphorylation pattern in striatal areas of morphine-sensitized rats. | Neuroscience 20091006 |
| Effect of the metabotropic glutamate antagonist MPEP on striatal expression of the Homer family proteins in levodopa-treated hemiparkinsonian rats. | Psychopharmacology 20091001 |
| Metabotropic glutamate receptor 5 (mGluR5) antagonists attenuate cocaine priming- and cue-induced reinstatement of cocaine seeking. | Behavioural brain research 20090914 |
| Depolarization-induced slow current in cerebellar Purkinje cells does not require metabotropic glutamate receptor 1. | Neuroscience 20090901 |
| A proof-of-concept study evaluating the effect of ADX10059, a metabotropic glutamate receptor-5 negative allosteric modulator, on acid exposure and symptoms in gastro-oesophageal reflux disease. | Gut 20090901 |
| Antagonists of group I metabotropic glutamate receptors and cortical afterdischarges in immature rats. | Epilepsia 20090901 |
| The metabotropic glutamate receptor subtype 5 antagonist fenobam is analgesic and has improved in vivo selectivity compared with the prototypical antagonist 2-methyl-6-(phenylethynyl)-pyridine. | The Journal of pharmacology and experimental therapeutics 20090901 |
| Chronic, systemic treatment with a metabotropic glutamate receptor 5 antagonist in 6-hydroxydopamine partially lesioned rats reverses abnormal firing of dopaminergic neurons. | Brain research 20090825 |
| Converging signal on ERK1/2 activity regulates group I mGluR-mediated Arc transcription. | Neuroscience letters 20090821 |
| [Expression of metabotropic glutamate receptor 5 in spinal cord of morphine tolerant rats]. | Zhonghua yi xue za zhi 20090818 |
| Pharmacological characterization of harmaline-induced tremor activity in mice. | European journal of pharmacology 20090815 |
| A role for SNAP25 in internalization of kainate receptors and synaptic plasticity. | Neuron 20090813 |
| Activation of mGlu2/3 metabotropic glutamate receptors negatively regulates the stimulation of inositol phospholipid hydrolysis mediated by 5-hydroxytryptamine2A serotonin receptors in the frontal cortex of living mice. | Molecular pharmacology 20090801 |
| Interoceptive effects of alcohol require mGlu5 receptor activity in the nucleus accumbens. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090729 |
| Limbic epileptogenesis in a mouse model of fragile X syndrome. | Cerebral cortex (New York, N.Y. : 1991) 20090701 |
| Nefiracetam activation of CaM kinase II and protein kinase C mediated by NMDA and metabotropic glutamate receptors in olfactory bulbectomized mice. | Journal of neurochemistry 20090701 |
| DHPG activation of group 1 mGluRs in BLA enhances fear conditioning. | Learning & memory (Cold Spring Harbor, N.Y.) 20090701 |
| Structure-activity relationships comparing N-(6-methylpyridin-yl)-substituted aryl amides to 2-methyl-6-(substituted-arylethynyl)pyridines or 2-methyl-4-(substituted-arylethynyl)thiazoles as novel metabotropic glutamate receptor subtype 5 antagonists. | Journal of medicinal chemistry 20090611 |
| Differential effects of MPEP and diazepam in tests of conditioned emotional response and Pavlovian-to-instrumental transfer suggests 'anxiolytic' effects are mediated by different mechanisms. | Psychopharmacology 20090601 |
| Neurotensin inhibition of GABAergic transmission via mGluR-induced endocannabinoid signalling in rat periaqueductal grey. | The Journal of physiology 20090601 |
| Metabotropic glutamate receptor 1 activity generates persistent, N-methyl-D-aspartate receptor-dependent depression of hippocampal pyramidal cell excitability. | The European journal of neuroscience 20090601 |
| Selective blockade of mGlu5 metabotropic glutamate receptors is hepatoprotective against fulminant hepatic failure induced by lipopolysaccharide and D-galactosamine in mice. | Journal of applied toxicology : JAT 20090501 |
| The mGlu5 receptor antagonist 2-methyl-6-(phenylethynyl)pyridine (MPEP) supports intravenous self-administration and induces conditioned place preference in the rat. | European journal of pharmacology 20090401 |
| Inhibitory effects of Group I metabotropic glutamate receptors antagonists on the expression of NMDA receptor NR1 subunit in morphine tolerant rats. | Neuroscience letters 20090320 |
| 2-Methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates ketamine and heroin reward as assessed by acquisition, extinction, and reinstatement of conditioned place preference in the rat. | European journal of pharmacology 20090315 |
| Deficits in development of synaptic plasticity in rat dorsal striatum following prenatal and neonatal exposure to low-dose bisphenol A. | Neuroscience 20090303 |
| CB1 receptor knockout mice are hyporesponsive to the behavior-stimulating actions of d-amphetamine: role of mGlu5 receptors. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20090301 |
| Allosteric modulation of metabotropic glutamate receptor 5 affects phosphorylation, internalization, and desensitization of the micro-opioid receptor. | Neuropharmacology 20090301 |
| Neuroimaging and physiological evidence for involvement of glutamatergic transmission in regulation of the striatal dopaminergic system. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20090211 |
| Metabotropic glutamate receptors 5 blockade reverses spatial memory deficits in a mouse model of Parkinson's disease. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20090201 |
| Elevated glycogen synthase kinase-3 activity in Fragile X mice: key metabolic regulator with evidence for treatment potential. | Neuropharmacology 20090201 |
| N-Acetylcysteine reverses cocaine-induced metaplasticity. | Nature neuroscience 20090201 |
| Computing highly correlated positions using mutual information and graph theory for G protein-coupled receptors. | PloS one 20090101 |
| Novel mGluR- and CB1R-independent suppression of GABA release caused by a contaminant of the group I metabotropic glutamate receptor agonist, DHPG. | PloS one 20090101 |
| Activity-dependent modulation of neural circuit synaptic connectivity. | Frontiers in molecular neuroscience 20090101 |
| Signal transduction mechanisms underlying group I mGluR-mediated increase in frequency and amplitude of spontaneous EPSCs in the spinal trigeminal subnucleus oralis of the rat. | Molecular pain 20090101 |
| Temporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture. | Frontiers in neural circuits 20090101 |
| Antinociceptive actions of honokiol and magnolol on glutamatergic and inflammatory pain. | Journal of biomedical science 20090101 |
| Fragile X syndrome -- from genes to cognition. | Developmental disabilities research reviews 20090101 |
| Effect of MPEP on rat's behavioral activity in experimental episodes of hypoxia. | Advances in medical sciences 20090101 |
| mGluR(1) Receptors Contribute to Non-Purinergic Slow Excitatory Transmission to Submucosal VIP Neurons of Guinea-Pig Ileum. | Frontiers in neuroscience 20090101 |
| D2 dopamine receptor activation facilitates endocannabinoid-mediated long-term synaptic depression of GABAergic synaptic transmission in midbrain dopamine neurons via cAMP-protein kinase A signaling. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20081224 |
| Role of metabotropic glutamate receptor 5 in the procholinergic effects of neuropsychotherapeutic compounds. | Synapse (New York, N.Y.) 20081201 |
| The potent non-competitive mGlu1 receptor antagonist BAY 36-7620 differentially affects synaptic plasticity in area cornu ammonis 1 of rat hippocampal slices and impairs acquisition in the water maze task in mice. | Neuroscience 20081119 |
| Focal degeneration of astrocytes in amyotrophic lateral sclerosis. | Cell death and differentiation 20081101 |
| Impact of protein kinase C activation on epileptiform activity in the hippocampal slice. | Epilepsy research 20081101 |
| Acute effects of acamprosate and MPEP on ethanol Drinking-in-the-Dark in male C57BL/6J mice. | Alcoholism, clinical and experimental research 20081101 |
| Glutamate: the new frontier in pharmacotherapy for cocaine addiction. | CNS & neurological disorders drug targets 20081101 |
| Attenuation of cocaine self-administration in squirrel monkeys following repeated administration of the mGluR5 antagonist MPEP: comparison with dizocilpine. | Psychopharmacology 20081001 |
| Effect of a metabotropic glutamate receptor 5 antagonist, MPEP, on the nociceptive response induced by intrathecal injection of excitatory aminoacids, substance P, bradykinin or cytokines in mice. | Pharmacology, biochemistry, and behavior 20081001 |
| Spinal Metabotropic Glutamate Receptors (mGluRs) are Involved in the Melittin-induced Nociception in Rats. | The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20081001 |
| Activation of metabotropic glutamate 5 (mGlu5) receptors induces spontaneous excitatory synaptic currents in layer V pyramidal cells of the rat prefrontal cortex. | Neuroscience letters 20080919 |
| In vivo metabotropic glutamate receptor 5 (mGluR5) antagonism prevents cocaine-induced disruption of postsynaptically maintained mGluR5-dependent long-term depression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080910 |
| Metabotropic glutamate receptor 5 (mGluR5) regulation of ethanol sedation, dependence and consumption: relationship to acamprosate actions. | The international journal of neuropsychopharmacology 20080901 |
| Effect of selective antagonists of group I metabotropic glutamate receptors on the micturition reflex in rats. | BJU international 20080901 |
| Activation of group I metabotropic glutamate receptors induces long-term depression in the hippocampal CA1 region of adult rats in vitro. | Neuroscience research 20080901 |
| Dual neurotoxic and neuroprotective role of metabotropic glutamate receptor 1 in conditions of trophic deprivation - possible role as a dependence receptor. | Neuropharmacology 20080901 |
| Switch in the expression of mGlu1 and mGlu5 metabotropic glutamate receptors in the cerebellum of mice developing experimental autoimmune encephalomyelitis and in autoptic cerebellar samples from patients with multiple sclerosis. | Neuropharmacology 20080901 |
| Cue-induced reinstatement of alcohol-seeking behavior is associated with increased ERK1/2 phosphorylation in specific limbic brain regions: blockade by the mGluR5 antagonist MPEP. | Neuropharmacology 20080901 |
| Functional interaction between adenosine A2A and group III metabotropic glutamate receptors to reduce parkinsonian symptoms in rats. | Neuropharmacology 20080901 |
| MGlu5 antagonism impairs exploration and memory of spatial and non-spatial stimuli in rats. | Behavioural brain research 20080822 |
| Metabotropic glutamate 5 receptor (mGluR5) antagonists decrease nicotine seeking, but do not affect the reinforcement enhancing effects of nicotine. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20080801 |
| Wiring and volume transmission in rat amygdala. Implications for fear and anxiety. | Neurochemical research 20080801 |
| Pharmacological effects of the metabotropic glutamate receptor 1 antagonist compared with those of the metabotropic glutamate receptor 5 antagonist and metabotropic glutamate receptor 2/3 agonist in rodents: detailed investigations with a selective allosteric metabotropic glutamate receptor 1 antagonist, FTIDC [4-[1-(2-fluoropyridine-3-yl)-5-methyl-1H-1,2,3-triazol-4-yl]-N-isopropyl-N-methyl-3,6-dihydropyridine-1(2H)-carboxamide]. | The Journal of pharmacology and experimental therapeutics 20080801 |
| Endocannabinoid- and mGluR5-dependent short-term synaptic depression in an isolated neuron/bouton preparation from the hippocampal CA1 region. | Journal of neurophysiology 20080801 |
| Diversity synthesis of complex pyridines yields a probe of a neurotrophic signaling pathway. | Organic letters 20080703 |
| Rescue of behavioral phenotype and neuronal protrusion morphology in Fmr1 KO mice. | Neurobiology of disease 20080701 |
| Face-washing behavior induced by the group I metabotropic glutamate receptor agonist (S)-3,5-DHPG in mice is mediated by mGlu1 receptor. | European journal of pharmacology 20080531 |
| Inhibition of MPEP on the development of morphine antinociceptive tolerance and the biosynthesis of neuronal nitric oxide synthase in rat spinal cord. | Neuroscience letters 20080509 |
| Involvement of group I mGluRs in LTP induced by strong high frequency stimulation in the dentate gyrus in vitro. | Neuroscience letters 20080509 |
| Attenuation of ketamine-evoked behavioral responses by mGluR5 positive modulators in mice. | Psychopharmacology 20080501 |
| Effects of the mGluR2/3 agonist LY379268 and the mGluR5 antagonist MPEP on handling-induced convulsions during ethanol withdrawal in mice. | Alcohol (Fayetteville, N.Y.) 20080501 |
| Transcriptional profiling of the rat frontal cortex following administration of the mGlu5 receptor antagonists MPEP and MTEP. | European journal of pharmacology 20080428 |
| Metabotropic glutamate receptors regulate differentiation of embryonic stem cells into GABAergic neurons. | Cell death and differentiation 20080401 |
| Dopamine D1 receptors and group I metabotropic glutamate receptors contribute to the induction of long-term potentiation in the nucleus accumbens. | Neuropharmacology 20080401 |
| Identification of small molecules rescuing fragile X syndrome phenotypes in Drosophila. | Nature chemical biology 20080401 |
| Phenylethynyl-pyrrolo[1,2-a]pyrazine: a new potent and selective tool in the mGluR5 antagonists arena. | Bioorganic & medicinal chemistry letters 20080315 |
| Neuroprotective effect caused by MPEP, an antagonist of metabotropic glutamate receptor mGluR5, on seizures induced by pilocarpine in 21-day-old rats. | Brain research 20080310 |
| Additive neuroprotection by metabotropic glutamate receptor subtype-selective ligands in a rat Parkinson's model. | Neuroreport 20080305 |
| Metabotropic glutamate receptors subtype 5 are necessary for the enhancement of auditory evoked potentials in the lateral nucleus of the amygdala by tetanic stimulation of the auditory thalamus. | Neuroscience 20080303 |
| N-{4-Chloro-2-[(1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)methyl]phenyl}-2-hydroxybenzamide (CPPHA) acts through a novel site as a positive allosteric modulator of group 1 metabotropic glutamate receptors. | Molecular pharmacology 20080301 |
| Metabotropic glutamate receptor 1 (mGluR1) and 5 (mGluR5) regulate late phases of LTP and LTD in the hippocampal CA1 region in vitro. | The European journal of neuroscience 20080301 |
| Alcohol related changes in regulation of NMDA receptor functions. | Current neuropharmacology 20080301 |
| Analgesic activity of metabotropic glutamate receptor 1 antagonists on spontaneous post-operative pain in rats. | European journal of pharmacology 20080212 |
| Homer 1a suppresses neocortex long-term depression in a cortical layer-specific manner. | Journal of neurophysiology 20080201 |
| Regulation of motivation to self-administer ethanol by mGluR5 in alcohol-preferring (P) rats. | Alcoholism, clinical and experimental research 20080201 |
| Auditory fear conditioning modulates prepulse inhibition in socially reared rats and isolation-reared rats. | Behavioral neuroscience 20080201 |
| Inducible expression and pharmacological characterization of the mouse metabotropic glutamate 5b receptor. | European journal of pharmacology 20080128 |
| Glutamate spillover modulates GABAergic synaptic transmission in the rat midbrain periaqueductal grey via metabotropic glutamate receptors and endocannabinoid signaling. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20080123 |
| mGluR5 antagonists that block calcium mobilization in vitro also reverse (S)-3,5-DHPG-induced hyperalgesia and morphine antinociceptive tolerance in vivo. | Brain research 20080102 |
| Selective induction of metabotropic glutamate receptor 1- and metabotropic glutamate receptor 5-dependent chemical long-term potentiation at oriens/alveus interneuron synapses of mouse hippocampus. | Neuroscience 20080102 |
| Modulation of defensive responses and anxiety-like behaviors by group I metabotropic glutamate receptors located in the dorsolateral periaqueductal gray. | Progress in neuro-psychopharmacology & biological psychiatry 20080101 |
| Systemic administration of an mGluR5 antagonist, but not unilateral subthalamic lesion, counteracts l-DOPA-induced dyskinesias in a rodent model of Parkinson's disease. | Neurobiology of disease 20080101 |
| Differential modulation of ethanol-induced sedation and hypnosis by metabotropic glutamate receptor antagonists in C57BL/6J mice. | Alcoholism, clinical and experimental research 20080101 |
| Preferential binding of allosteric modulators to active and inactive conformational states of metabotropic glutamate receptors. | BMC bioinformatics 20080101 |
| Nucleotide sequence variation within the PI3K p85 alpha gene associates with alcohol risk drinking behaviour in adolescents. | PloS one 20080101 |
| MGluR5 mediates the interaction between late-LTP, network activity, and learning. | PloS one 20080101 |
| Cortical layer 1 and layer 2/3 astrocytes exhibit distinct calcium dynamics in vivo. | PloS one 20080101 |
| FMRP phosphorylation reveals an immediate-early signaling pathway triggered by group I mGluR and mediated by PP2A. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20071226 |
| Synthesis and preliminary biological evaluation of 3-[(18)F]fluoro-5-(2-pyridinylethynyl)benzonitrile as a PET radiotracer for imaging metabotropic glutamate receptor subtype 5. | Synapse (New York, N.Y.) 20071201 |
| Two-methyl-6-phenylethynyl-pyridine (MPEP), a metabotropic glutamate receptor 5 antagonist, with low doses of MK801 and diazepam: a novel approach for controlling status epilepticus. | Neuropharmacology 20071201 |
| Effect of 2-methyl-6-(phenylethynyl) pyridine on intravenous self-administration of ketamine and heroin in the rat. | Behavioural pharmacology 20071201 |
| Behavioral expression of cocaine sensitization in rats is accompanied by a distinct pattern of modifications in the PKA/DARPP-32 signaling pathway. | Journal of neurochemistry 20071101 |
| Subtype selective antagonism of substantia nigra pars compacta Group I metabotropic glutamate receptors protects the nigrostriatal system against 6-hydroxydopamine toxicity in vivo. | Journal of neurochemistry 20071101 |
| Differential roles of hippocampal metabotropic glutamate receptors 1 and 5 in inhibitory avoidance learning. | Neurobiology of learning and memory 20071001 |
| Synthesis and SAR of 2-aryl pyrido[2,3-d]pyrimidines as potent mGlu5 receptor antagonists. | Bioorganic & medicinal chemistry letters 20071001 |
| Different effects of ionotropic and metabotropic glutamate receptor antagonists on attention and the attentional properties of nicotine. | Neuropharmacology 20070901 |
| Allosteric modulators for mGlu receptors. | Current neuropharmacology 20070901 |
| Allosteric modulators of GABA(B) receptors: mechanism of action and therapeutic perspective. | Current neuropharmacology 20070901 |
| Rational design of 7-arylquinolines as non-competitive metabotropic glutamate receptor subtype 5 antagonists. | Bioorganic & medicinal chemistry letters 20070815 |
| Blockade of metabotropic glutamate receptor 5 activation inhibits mechanical hypersensitivity following abdominal surgery. | European journal of pain (London, England) 20070801 |
| Stress-induced hyperthermia: effects of acute and repeated dosing of MPEP. | European journal of pharmacology 20070730 |
| Water T-maze, an improved method to assess spatial working memory in rats: Pharmacological validation. | Neuroscience letters 20070718 |
| Synthesis and pharmacological evaluation of phenylethynyl[1,2,4]methyltriazines as analogues of 3-methyl-6-(phenylethynyl)pyridine. | Journal of medicinal chemistry 20070712 |
| Involvement of AMPA/kainate, NMDA, and mGlu5 receptors in the nucleus accumbens core in cue-induced reinstatement of cocaine seeking in rats. | Psychopharmacology 20070701 |
| Differential activation of protein kinases in the dorsal horn in vitro of normal and inflamed rats by group I metabotropic glutamate receptor subtypes. | Neuropharmacology 20070701 |
| Modulation of dopaminergic and glutamatergic brain function: PET studies on parkinsonian rats. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20070701 |
| Role of spinal metabotropic glutamate receptor subtype 5 in the development of tolerance to morphine-induced antinociception in rat. | Neuroscience letters 20070613 |
| Persistent synaptic activity produces long-lasting enhancement of endocannabinoid modulation and alters long-term synaptic plasticity. | Journal of neurophysiology 20070601 |
| Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists. | Bioorganic & medicinal chemistry letters 20070601 |
| mGlu5 receptor and protein kinase C implicated in the development and induction of neuropathic pain following chronic ethanol consumption. | European journal of pharmacology 20070521 |
| Interaction of novel positive allosteric modulators of metabotropic glutamate receptor 5 with the negative allosteric antagonist site is required for potentiation of receptor responses. | Molecular pharmacology 20070501 |
| Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: receptor antagonism inhibits c-Fos expression in rat lumbosacral spinal cord at parturition. | Journal of neuroscience research 20070501 |
| mGluR5 is involved in dendrite differentiation and excitatory synaptic transmission in NTERA2 human embryonic carcinoma cell-derived neurons. | Neuropharmacology 20070501 |
| (+/-) Ketamine-induced prepulse inhibition deficits of an acoustic startle response in rats are not reversed by antipsychotics. | Journal of psychopharmacology (Oxford, England) 20070501 |
| Behavioral and neuropharmacological characterization of nicotine as a conditional stimulus. | European journal of pharmacology 20070430 |
| Peripheral metabotropic glutamate receptor 5 mediates mechanical hypersensitivity in craniofacial muscle via protein kinase C dependent mechanisms. | Neuroscience 20070425 |
| The peripheral role of group I metabotropic glutamate receptors on nociceptive behaviors in rats with knee joint inflammation. | Neuroscience letters 20070412 |
| Design and synthesis of novel heterobiaryl amides as metabotropic glutamate receptor subtype 5 antagonists. | Bioorganic & medicinal chemistry letters 20070401 |
| Effects of MPEP on avoidance learning in rats. | Methods and findings in experimental and clinical pharmacology 20070401 |
| Cocaine increases endoplasmic reticulum stress protein expression in striatal neurons. | Neuroscience 20070316 |
| Modulation of NMDA receptor current in layer V pyramidal neurons of the rat prefrontal cortex by P2Y receptor activation. | Cerebral cortex (New York, N.Y. : 1991) 20070301 |
| The effects of the mGluR5 antagonist MPEP and the mGluR2/3 antagonist LY341495 on rats' performance in the 5-choice serial reaction time task. | Neuropharmacology 20070301 |
| Stimulation of group I mGlu receptors in the ventrotegmental area enhances extracellular dopamine in the rat medial prefrontal cortex. | Journal of neurochemistry 20070301 |
| Synthesis and biological evaluation of fenobam analogs as mGlu5 receptor antagonists. | Bioorganic & medicinal chemistry letters 20070301 |
| Interleukin-18 mediated inhibition of LTP in the rat dentate gyrus is attenuated in the presence of mGluR antagonists. | Neuroscience letters 20070202 |
| Antidepressant-like effects of mGluR1 and mGluR5 antagonists in the rat forced swim and the mouse tail suspension tests. | European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology 20070201 |
| Metabotropic glutamate subtype 5 receptors modulate fear-conditioning induced enhancement of prepulse inhibition in rats. | Neuropharmacology 20070201 |
| Peripheral versus central modulation of gastric vagal pathways by metabotropic glutamate receptor 5. | American journal of physiology. Gastrointestinal and liver physiology 20070201 |
| ABP688, a novel selective and high affinity ligand for the labeling of mGlu5 receptors: identification, in vitro pharmacology, pharmacokinetic and biodistribution studies. | Bioorganic & medicinal chemistry 20070115 |
| Interactive effects of the mGlu5 receptor antagonist MPEP and the mGlu2/3 receptor antagonist LY341495 on nicotine self-administration and reward deficits associated with nicotine withdrawal in rats. | European journal of pharmacology 20070112 |
| Neuroprotective activity of selective mGlu1 and mGlu5 antagonists in vitro and in vivo. | European journal of pharmacology 20070105 |
| Metabotropic glutamate receptor antagonists: novel therapeutics for nicotine dependence and depression? | Biological psychiatry 20070101 |
| Effect of MPEP in Morris water maze in adult and old rats. | Pharmacological reports : PR 20070101 |
| Arthritis and pain. Future targets to control osteoarthritis pain. | Arthritis research & therapy 20070101 |
| Retrograde endocannabinoid inhibition of goldfish retinal cones is mediated by 2-arachidonoyl glycerol. | Visual neuroscience 20070101 |
| The binding site for neohesperidin dihydrochalcone at the human sweet taste receptor. | BMC structural biology 20070101 |
| Recent developments of the PET imaging agents for metabotropic glutamate receptor subtype 5. | Current topics in medicinal chemistry 20070101 |
| Metabotropic glutamate receptors differentially regulate GABAergic inhibition in thalamus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20061227 |
| Mechanisms of glutamate receptor induced proliferation of astrocytes. | Neuroreport 20061218 |
| Participation of peripheral group I and II metabotropic glutamate receptors in the development or maintenance of IL-1beta-induced mechanical allodynia in the orofacial area of conscious rats. | Neuroscience letters 20061206 |
| mGlu5 receptors are involved in the discriminative stimulus effects of self-administered ethanol in rats. | European journal of pharmacology 20061203 |
| Antiaggressive effects of MPEP, a selective antagonist of mGlu5 receptors, in agonistic interactions between male mice. | European journal of pharmacology 20061203 |
| Contribution of mGluR and Fmr1 functional pathways to neurite morphogenesis, craniofacial development and fragile X syndrome. | Human molecular genetics 20061201 |
| Behavioral and neurochemical interactions between Group 1 mGluR antagonists and ethanol: potential insight into their anti-addictive properties. | Drug and alcohol dependence 20061108 |
| Peripheral mGluR5 antagonist attenuated craniofacial muscle pain and inflammation but not mGluR1 antagonist in lightly anesthetized rats. | Brain research bulletin 20061016 |
| A combined marble burying-locomotor activity test in mice: a practical screening test with sensitivity to different classes of anxiolytics and antidepressants. | European journal of pharmacology 20061010 |
| Metabotropic glutamate 5 receptor antagonism is associated with antidepressant-like effects in mice. | The Journal of pharmacology and experimental therapeutics 20061001 |
| Endogenously activated mGlu5 metabotropic glutamate receptors sustain the increase in c-Myc expression induced by leukaemia inhibitory factor in cultured mouse embryonic stem cells. | Journal of neurochemistry 20061001 |
| Changes in mGlu5 receptor expression in the basal ganglia of reserpinised rats. | European journal of pharmacology 20060918 |
| A new series of pyridinyl-alkynes as antagonists of the metabotropic glutamate receptor 5 (mGluR5). | Bioorganic & medicinal chemistry letters 20060915 |
| Analgesic effects of mGlu1 and mGlu5 receptor antagonists in the rat formalin test. | Neuropharmacology 20060901 |
| Dynamic translational and proteasomal regulation of fragile X mental retardation protein controls mGluR-dependent long-term depression. | Neuron 20060817 |
| mGluR1/5 subtype-specific calcium signalling and induction of long-term potentiation in rat hippocampal oriens/alveus interneurones. | The Journal of physiology 20060815 |
| A novel class of positive allosteric modulators of metabotropic glutamate receptor subtype 1 interact with a site distinct from that of negative allosteric modulators. | Molecular pharmacology 20060801 |
| Comparison of the binding pockets of two chemically unrelated allosteric antagonists of the mGlu5 receptor and identification of crucial residues involved in the inverse agonism of MPEP. | Journal of neurochemistry 20060701 |
| Lowered brain stimulation reward thresholds in rats treated with a combination of caffeine and N-methyl-D-aspartate but not alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate or metabotropic glutamate receptor-5 receptor antagonists. | Behavioural pharmacology 20060601 |
| Regulation of nuclear factor kappaB in the hippocampus by group I metabotropic glutamate receptors. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060503 |
| Structure-activity relationship of thiopyrimidines as mGluR5 antagonists. | Bioorganic & medicinal chemistry letters 20060501 |
| Ketamine, but not propofol, anaesthesia is regulated by metabotropic glutamate 5 receptors. | British journal of anaesthesia 20060501 |
| The effect of mGlu5 receptor positive allosteric modulators on signaling molecules in brain slices. | European journal of pharmacology 20060501 |
| Spike-timing-dependent plasticity at resting and conditioned lateral perforant path synapses on granule cells in the dentate gyrus: different roles of N-methyl-D-aspartate and group I metabotropic glutamate receptors. | The European journal of neuroscience 20060501 |
| Anxiolytic-like effects of the selective metabotropic glutamate receptor 5 antagonist MPEP after its intra-amygdaloid microinjection in three different non-conditioned rat models of anxiety. | The European journal of neuroscience 20060501 |
| Ionotropic and metabotropic glutamate receptor antagonism attenuates cue-induced cocaine seeking. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20060401 |
| Prolonged blockade of NMDA or mGluR5 glutamate receptors reduces nigrostriatal degeneration while inducing selective metabolic changes in the basal ganglia circuitry in a rodent model of Parkinson's disease. | Neurobiology of disease 20060401 |
| Differential roles for group 1 mGluR subtypes in induction and expression of chemically induced hippocampal long-term depression. | Journal of neurophysiology 20060401 |
| Insulin secretion is controlled by mGlu5 metabotropic glutamate receptors. | Molecular pharmacology 20060401 |
| A temporally distinct role for group I and group II metabotropic glutamate receptors in object recognition memory. | Learning & memory (Cold Spring Harbor, N.Y.) 20060301 |
| Regulation of phosphorylation of NMDA receptor NR1 subunits in the rat neostriatum by group I metabotropic glutamate receptors in vivo. | Neuroscience letters 20060220 |
| Synthesis and structure-activity relationships of 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine analogues as potent, noncompetitive metabotropic glutamate receptor subtype 5 antagonists; search for cocaine medications. | Journal of medicinal chemistry 20060209 |
| Glutamate-based therapeutic approaches: allosteric modulators of metabotropic glutamate receptors. | Current opinion in pharmacology 20060201 |
| Loss of metabotropic glutamate receptor-mediated regulation of glutamate transport in chemically activated astrocytes in a rat model of amyotrophic lateral sclerosis. | Journal of neurochemistry 20060201 |
| Long-term depression of NMDA receptor-mediated synaptic transmission is dependent on activation of metabotropic glutamate receptors and is altered to long-term potentiation by low intracellular calcium buffering. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20060125 |
| Determination of key amino acids implicated in the actions of allosteric modulation by 3,3'-difluorobenzaldazine on rat mGlu5 receptors. | European journal of pharmacology 20060104 |
| Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors. | Cerebral cortex (New York, N.Y. : 1991) 20060101 |
| Nicotine has a permissive role on the activation of metabotropic glutamate 5 receptors coexisting with nicotinic receptors on rat hippocampal noradrenergic nerve terminals. | Neurochemistry international 20060101 |
| The metabotropic glutamate receptor subtype 5 antagonist MPEP and the Na+ channel blocker riluzole show different neuroprotective profiles in reversing behavioral deficits induced by excitotoxic prefrontal cortex lesions. | Neuroscience 20060101 |
| The mGluR5 antagonist MPEP selectively inhibits the onset and maintenance of ethanol self-administration in C57BL/6J mice. | Psychopharmacology 20060101 |
| Blockade of mGluR glutamate receptors in the subthalamic nucleus ameliorates motor asymmetry in an animal model of Parkinson's disease. | The European journal of neuroscience 20060101 |
| The role of group I metabotropic glutamate receptors in memory consolidation and reconsolidation in the passive avoidance task in 1-day-old chicks. | Neurochemistry international 20060101 |
| Effect of MPEP treatment on brain-derived neurotrophic factor gene expression. | Pharmacological reports : PR 20060101 |
| Metabotropic glutamate receptor subtype 5 antagonists MPEP and MTEP. | CNS drug reviews 20060101 |
| Effect of metabotropic glutamate receptor subtype 5 antagonist, 2-methyl-6-(phenylethynyl)-pyridine on mechanosensory afferents innervating rat hind paw following inflammation. | Neuroscience letters 20051230 |
| Suppression of two major Fragile X Syndrome mouse model phenotypes by the mGluR5 antagonist MPEP. | Neuropharmacology 20051201 |
| A close structural analog of 2-methyl-6-(phenylethynyl)-pyridine acts as a neutral allosteric site ligand on metabotropic glutamate receptor subtype 5 and blocks the effects of multiple allosteric modulators. | Molecular pharmacology 20051201 |
| The inhibition of glycogen synthase kinase 3beta by a metabotropic glutamate receptor 5 mediated pathway confers neuroprotection to Abeta peptides. | Journal of neurochemistry 20051201 |
| Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20051109 |
| The metabotropic glutamate receptor, mGluR5, is a key determinant of good and bad spatial learning performance and hippocampal synaptic plasticity. | Cerebral cortex (New York, N.Y. : 1991) 20051101 |
| Fenobam: a clinically validated nonbenzodiazepine anxiolytic is a potent, selective, and noncompetitive mGlu5 receptor antagonist with inverse agonist activity. | The Journal of pharmacology and experimental therapeutics 20051101 |
| Adenosine A2A receptors and metabotropic glutamate 5 receptors are co-localized and functionally interact in the hippocampus: a possible key mechanism in the modulation of N-methyl-D-aspartate effects. | Journal of neurochemistry 20051101 |
| Neuroprotective effects of metabotropic glutamate receptor ligands in a 6-hydroxydopamine rodent model of Parkinson's disease. | The European journal of neuroscience 20051001 |
| Cochlear dopamine release is modulated by group II metabotropic glutamate receptors via GABAergic neurotransmission. | Neuroscience letters 20050909 |
| Transient lower esophageal sphincter relaxations in dogs are inhibited by a metabotropic glutamate receptor 5 antagonist. | European journal of pharmacology 20050905 |
| Involvement of spinal metabotropic glutamate receptor 5 in the development of tolerance to morphine-induced antinociception. | Journal of neurochemistry 20050901 |
| Effects of MPEP on expression of food-, MDMA- or amphetamine-conditioned place preference in rats. | Addiction biology 20050901 |
| Inhibition of transient lower esophageal sphincter relaxation and gastroesophageal reflux by metabotropic glutamate receptor ligands. | Gastroenterology 20050901 |
| Glutamatergic neurotransmission and protein kinase C play a role in neuron-glia communication during the development of methamphetamine-induced psychological dependence. | The European journal of neuroscience 20050901 |
| Methoxyphenylethynyl, methoxypyridylethynyl and phenylethynyl derivatives of pyridine: synthesis, radiolabeling and evaluation of new PET ligands for metabotropic glutamate subtype 5 receptors. | Nuclear medicine and biology 20050801 |
| Activation of group I metabotropic glutamate receptors depresses recurrent inhibition of motoneurons in the neonatal rat spinal cord in vitro. | Experimental brain research 20050701 |
| Retrograde endocannabinoid signaling in a postsynaptic neuron/synaptic bouton preparation from basolateral amygdala. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20050629 |
| Neuroprotective activity of the mGluR5 antagonists MPEP and MTEP against acute excitotoxicity differs and does not reflect actions at mGluR5 receptors. | British journal of pharmacology 20050601 |
| Chronic treatment with the mGlu5R antagonist MPEP reduces the functional effects of the mGlu5R agonist CHPG in the striatum of 6-hydroxydopamine-lesioned rats: possible relevance to the effects of mGlu5R blockade in Parkinson's disease. | Journal of neuroscience research 20050601 |
| Essential roles of Homer-1a in homeostatic regulation of pyramidal cell excitability: a possible link to clinical benefits of electroconvulsive shock. | The European journal of neuroscience 20050601 |
| Behavioral sensitization due to social defeat stress in mice: antagonism at mGluR5 and NMDA receptors. | Psychopharmacology 20050401 |
| Pharmacological and anatomical evidence for an interaction between mGluR5- and GABA(A) alpha1-containing receptors in the discriminative stimulus effects of ethanol. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20050401 |
| Metabotropic glutamate 5 receptor blockade may attenuate cocaine self-administration by decreasing brain reward function in rats. | Psychopharmacology 20050401 |
| A novel selective positive allosteric modulator of metabotropic glutamate receptor subtype 5 has in vivo activity and antipsychotic-like effects in rat behavioral models. | The Journal of pharmacology and experimental therapeutics 20050401 |
| The metabotropic glutamate receptor 5 antagonist MPEP decreased break points for nicotine, cocaine and food in rats. | Psychopharmacology 20050401 |
| The antinociceptive and anxiolytic-like effects of the metabotropic glutamate receptor 5 (mGluR5) antagonists, MPEP and MTEP, and the mGluR1 antagonist, LY456236, in rodents: a comparison of efficacy and side-effect profiles. | Psychopharmacology 20050401 |
| Drug discrimination analysis of NMDA receptor channel blockers as nicotinic receptor antagonists in rats. | Psychopharmacology 20050401 |
| The mGluR5 antagonist MPEP decreases operant ethanol self-administration during maintenance and after repeated alcohol deprivations in alcohol-preferring (P) rats. | Psychopharmacology 20050401 |
| Blockade of the mGlu5 receptor decreases basal and stress-induced cortical norepinephrine in rodents. | Psychopharmacology 20050401 |
| Functional interaction between mGlu 5 and NMDA receptors in a rat model of Parkinson's disease. | Psychopharmacology 20050401 |
| The effect of the mGlu5 receptor antagonist MPEP in rodent tests of anxiety and cognition: a comparison. | Psychopharmacology 20050401 |
| New allosteric modulators of metabotropic glutamate receptor 5 (mGluR5) found by ligand-based virtual screening. | Chembiochem : a European journal of chemical biology 20050401 |
| Characterization of long-term potentiation of primary afferent transmission at trigeminal synapses of juvenile rats: essential role of subtype 5 metabotropic glutamate receptors. | Pain 20050401 |
| Modulation of aspartate release by ascorbic acid and endobain E, an endogenous Na+, K+ -ATPase inhibitor. | Neurochemical research 20050401 |
| Attenuation of behavioral effects of cocaine by the Metabotropic Glutamate Receptor 5 Antagonist 2-Methyl-6-(phenylethynyl)-pyridine in squirrel monkeys: comparison with dizocilpine. | The Journal of pharmacology and experimental therapeutics 20050301 |
| mGlu and NMDA receptor contributions to capsaicin-induced thermal and mechanical hypersensitivity. | Neuropharmacology 20050301 |
| Role of central and peripheral mGluR5 receptors in post-operative pain in rats. | Pain 20050301 |
| Functionalization at position 3 of the phenyl ring of the potent mGluR5 noncompetitive antagonists MPEP. | Bioorganic & medicinal chemistry letters 20050215 |
| Effects of metabotropic glutamate receptor 5 on latent inhibition in conditioned taste aversion. | Behavioural brain research 20050210 |
| Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. | The EMBO journal 20050209 |
| Protection but maintained dysfunction of nigral dopaminergic nerve cell bodies and striatal dopaminergic terminals in MPTP-lesioned mice after acute treatment with the mGluR5 antagonist MPEP. | Brain research 20050208 |
| The mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine decreases ethanol consumption via a protein kinase C epsilon-dependent mechanism. | Molecular pharmacology 20050201 |
| The mGlu5 receptor antagonists MPEP and MTEP attenuate behavioral signs of morphine withdrawal and morphine-withdrawal-induced activation of locus coeruleus neurons in rats. | Neuropharmacology 20050201 |
| Reversal of hippocampal LTP by spontaneous seizure-like activity: role of group I mGluR and cell depolarization. | Journal of neurophysiology 20050101 |
| mGluR1 and mGluR5 antagonists in the amygdala inhibit different components of audible and ultrasonic vocalizations in a model of arthritic pain. | Pain 20050101 |
| Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells. | The European journal of neuroscience 20050101 |
| Chronic exposure to ammonia alters the modulation of phosphorylation of microtubule-associated protein 2 by metabotropic glutamate receptors 1 and 5 in cerebellar neurons in culture. | Neuroscience 20050101 |
| Anticonvulsant action of an antagonist of metabotropic glutamate receptors mGluR5 MPEP in immature rats. | Neuropharmacology 20050101 |
| Periaqueductal grey CB1 cannabinoid and metabotropic glutamate subtype 5 receptors modulate changes in rostral ventromedial medulla neuronal activities induced by subcutaneous formalin in the rat. | Neuroscience 20050101 |
| Repeated administration of group I mGluR antagonists prevents seizure-induced long-term aberrations in hippocampal synaptic plasticity. | Neuropharmacology 20050101 |
| Endogenous activation of mGlu5 metabotropic glutamate receptors supports self-renewal of cultured mouse embryonic stem cells. | Neuropharmacology 20050101 |
| Group I metabotropic glutamate receptors stimulate the activity of poly(ADP-ribose) polymerase in mammalian mGlu1-transfected cells and in cortical cell cultures. | Neuropharmacology 20050101 |
| Metabotropic glutamate receptor (mGluR5) antagonist MPEP attenuated cue- and schedule-induced reinstatement of nicotine self-administration behavior in rats. | Neuropharmacology 20050101 |
| Screening cascade and development of potential Positron Emission Tomography radiotracers for mGluR5: in vitro and in vivo characterization. | Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging 20050101 |
| Effects of a metabotropic, mglu5, glutamate receptor antagonist on ethanol consumption by genetic drinking rats. | Alcohol and alcoholism (Oxford, Oxfordshire) 20050101 |
| The role of metabotropic glutamate receptor 5 in learning and memory processes. | Drug news & perspectives 20050101 |
| Non-competitive metabotropic glutamate subtype 5 receptor antagonist (SIB-1893) decreases body temperature in rats. | Pharmacological reports : PR 20050101 |
| Application of magnetic resonance diffusion anisotropy imaging for the assessment neuroprotecting effects of MPEP, a selective mGluR5 antagonist, on the rat spinal cord injury in vivo. | Pharmacological reports : PR 20050101 |
| Assessing the role of metabotropic glutamate receptor 5 in multiple nociceptive modalities. | European journal of pharmacology 20041215 |
| Effects of MPEP on locomotion, sensitization and conditioned reward induced by cocaine or morphine. | Neuropharmacology 20041201 |
| Calcium dynamics in cortical astrocytes and arterioles during neurovascular coupling. | Circulation research 20041112 |
| The behavioral profile of the potent and selective mGlu5 receptor antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine (MTEP) in rodent models of anxiety. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20041101 |
| Group I metabotropic glutamate receptor NMDA receptor coupling and signaling cascade mediate spinal dorsal horn NMDA receptor 2B tyrosine phosphorylation associated with inflammatory hyperalgesia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20041013 |
| The metabotropic glutamate receptor 5 is necessary for late-phase long-term potentiation in the hippocampal CA1 region. | Brain research 20041001 |
| Antagonism at metabotropic glutamate 5 receptors inhibits nicotine- and cocaine-taking behaviours and prevents nicotine-triggered relapse to nicotine-seeking. | European journal of pharmacology 20040919 |
| The metabotropic glutamate receptor 5 antagonist MPEP and the mGluR2 agonist LY379268 modify disease progression in a transgenic mouse model of Huntington's disease. | Brain research 20040903 |
| The mGluR5 antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) potentiates PCP-induced cognitive deficits in rats. | Psychopharmacology 20040901 |
| Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum. | Journal of neurochemistry 20040901 |
| Activation of group I metabotropic glutamate receptors enhances efficacy of glutamatergic inputs to neonatal rat hypoglossal motoneurons in vitro. | The European journal of neuroscience 20040901 |
| Metabotropic glutamate receptor 5 localized in the limbic forebrain is critical for the development of morphine-induced rewarding effect in mice. | The European journal of neuroscience 20040901 |
| Opposite influence of MPEP, an mGluR5 antagonist, on the locomotor hyperactivity induced by PCP and amphetamine. | Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20040901 |
| Mouse hepatocytes lacking mGlu5 metabotropic glutamate receptors are less sensitive to hypoxic damage. | European journal of pharmacology 20040816 |
| 5-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-2,3'-bipyridine: a highly potent, orally active metabotropic glutamate subtype 5 (mGlu5) receptor antagonist with anxiolytic activity. | Bioorganic & medicinal chemistry letters 20040802 |
| Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040801 |
| Activation of the phosphoinositide 3-kinase-Akt-mammalian target of rapamycin signaling pathway is required for metabotropic glutamate receptor-dependent long-term depression. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040714 |
| Inhibition of human hepatic CYP isoforms by mGluR5 antagonists. | Life sciences 20040709 |
| Effect of the mGluR5 antagonist 6-methyl-2-(phenylethynyl)pyridine (MPEP) on the acute locomotor stimulant properties of cocaine, D-amphetamine, and the dopamine reuptake inhibitor GBR12909 in mice. | Psychopharmacology 20040701 |
| Functional Interaction Between NMDA and mGlu5 Receptors: Effects on Working Memory, Instrumental Learning, Motor Behaviors, and Dopamine Release. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040701 |
| Group I metabotropic glutamate receptors interfere in different ways with pentylenetetrazole seizures, kindling, and kindling-related learning deficits. | Naunyn-Schmiedeberg's archives of pharmacology 20040701 |
| Neuroprotective effects of the mGlu5R antagonist MPEP towards quinolinic acid-induced striatal toxicity: involvement of pre- and post-synaptic mechanisms and lack of direct NMDA blocking activity. | Journal of neurochemistry 20040601 |
| MGLuR5 activation reduces beta-amyloid-induced cell death in primary neuronal cultures and attenuates translocation of cytochrome c and apoptosis-inducing factor. | Journal of neurochemistry 20040601 |
| MPEP, an antagonist of metabotropic glutamate receptors, exhibits anticonvulsant action in immature rats without a serious impairment of motor performance. | Epilepsy research 20040601 |
| Effects of mGlu1 and mGlu5 metabotropic glutamate antagonists to reverse morphine tolerance in mice. | European journal of pharmacology 20040525 |
| Metabotropic glutamate receptor 5 and dorsal raphe serotonin release in inflammatory pain in rat. | European journal of pharmacology 20040525 |
| Activation of presynaptic group I metabotropic glutamate receptors enhances glutamate release in the rat spinal cord substantia gelatinosa. | Neuroscience letters 20040506 |
| mGluR5 antagonist MPEP reduces ethanol-seeking and relapse behavior. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040501 |
| A novel selective allosteric modulator potentiates the activity of native metabotropic glutamate receptor subtype 5 in rat forebrain. | The Journal of pharmacology and experimental therapeutics 20040501 |
| mGlu5 receptor antagonists: a novel class of anxiolytics? | Drug news & perspectives 20040501 |
| Block of long-term potentiation by naturally secreted and synthetic amyloid beta-peptide in hippocampal slices is mediated via activation of the kinases c-Jun N-terminal kinase, cyclin-dependent kinase 5, and p38 mitogen-activated protein kinase as well as metabotropic glutamate receptor type 5. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040331 |
| mGluR5-dependent increases in immediate early gene expression in the rat striatum following acute administration of amphetamine. | Brain research. Molecular brain research 20040330 |
| Metabotropic glutamate receptor activation regulates fragile x mental retardation protein and FMR1 mRNA localization differentially in dendrites and at synapses. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040317 |
| In the amygdala anxiolytic action of mGlu5 receptors antagonist MPEP involves neuropeptide Y but not GABAA signaling. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040301 |
| Blockade of glutamate mGlu5 receptors in a rat model of neuropathic pain prevents early over-expression of pro-apoptotic genes and morphological changes in dorsal horn lamina II. | Neuropharmacology 20040301 |
| In vivo modulation of extracellular hippocampal glutamate and GABA levels and limbic seizures by group I and II metabotropic glutamate receptor ligands. | Journal of neurochemistry 20040301 |
| Regulation by metabotropic glutamate receptor 5 of LTP in the dentate gyrus of freely moving rats: relevance for learning and memory formation. | Cerebral cortex (New York, N.Y. : 1991) 20040201 |
| Modulation of rhythmic patterns and cumulative depolarization by group I metabotropic glutamate receptors in the neonatal rat spinal cord in vitro. | The European journal of neuroscience 20040201 |
| Endogenous activation of mGlu5 metabotropic glutamate receptors contributes to the development of nigro-striatal damage induced by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in mice. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040128 |
| Intracellular astrocyte calcium waves in situ increase the frequency of spontaneous AMPA receptor currents in CA1 pyramidal neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20040121 |
| Differential roles of mGluR1 and mGluR5 in brief and prolonged nociceptive processing in central amygdala neurons. | Journal of neurophysiology 20040101 |
| Overwhelmingly asynchronous firing of rat subthalamic nucleus neurones in brain slices provides little evidence for intrinsic interconnectivity. | Neuroscience 20040101 |
| Interactions of the mGluR5 gene with breeding and maternal factors on startle and prepulse inhibition in mice. | Neurotoxicity research 20040101 |
| Effect of MPEP, a selective mGluR5 antagonist, on the antielectroshock activity of conventional antiepileptic drugs. | Polish journal of pharmacology 20040101 |
| MPEP, mGlu5 receptor antagonist, regulates NPYmRNA expression in hippocampal and amygdalar neurons. | Polish journal of pharmacology 20040101 |
| Evidence that the metabotropic glutamate receptor 5 antagonist MPEP may act as an inhibitor of the norepinephrine transporter in vitro and in vivo. | Synapse (New York, N.Y.) 20031215 |
| Developmental shift from long-term depression to long-term potentiation in the rat medial vestibular nuclei: role of group I metabotropic glutamate receptors. | The Journal of physiology 20031201 |
| Blockade of excitatory amino acid transporters in the rat hippocampus results in enhanced activation of group I and group III metabotropic glutamate receptors. | Neuropharmacology 20031201 |
| Presynaptic group I metabotropic glutamate receptors modulate synaptic transmission in the rat superior colliculus via 4-AP sensitive K(+) channels. | British journal of pharmacology 20031201 |
| Hippocampal mGluR1 and consolidation of contextual fear conditioning. | Brain research bulletin 20031115 |
| PI3 kinase enhancer-Homer complex couples mGluRI to PI3 kinase, preventing neuronal apoptosis. | Nature neuroscience 20031101 |
| Contribution of spinal glutamatergic mechanisms in heterosegmental antinociception induced by noxious stimulation. | Pain 20031101 |
| Metabotropic glutamate 5 receptor antagonist MPEP decreased nicotine and cocaine self-administration but not nicotine and cocaine-induced facilitation of brain reward function in rats. | Annals of the New York Academy of Sciences 20031101 |
| mGluR1, but not mGluR5, mediates depolarization of spinal cord neurons by blocking a leak current. | Journal of neurophysiology 20031001 |
| Mutational analysis and molecular modeling of the binding pocket of the metabotropic glutamate 5 receptor negative modulator 2-methyl-6-(phenylethynyl)-pyridine. | Molecular pharmacology 20031001 |
| Neuroprotection against NMDA excitotoxicity by group I metabotropic glutamate receptors is associated with reduction of NMDA stimulated currents. | Experimental neurology 20031001 |
| Metabotropic glutamate 5 receptor blockade alleviates akinesia by normalizing activity of selective basal-ganglia structures in parkinsonian rats. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030910 |
| Group II metabotropic and alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA)/kainate glutamate receptors regulate the deficit in brain reward function associated with nicotine withdrawal in rats. | The Journal of pharmacology and experimental therapeutics 20030901 |
| Neuroprotective action of MPEP, a selective mGluR5 antagonist, in methamphetamine-induced dopaminergic neurotoxicity is associated with a decrease in dopamine outflow and inhibition of hyperthermia in rats. | Neuropharmacology 20030901 |
| A family of highly selective allosteric modulators of the metabotropic glutamate receptor subtype 5. | Molecular pharmacology 20030901 |
| Characterisation of the actions of group I metabotropic glutamate receptor subtype selective ligands on excitatory amino acid release and sodium-dependent re-uptake in rat cerebrocortical minislices. | Journal of neurochemistry 20030901 |
| Glutamate metabotropic receptors as targets for drug therapy in epilepsy. | European journal of pharmacology 20030822 |
| The human immunodeficiency virus-1 protein Tat and its discrete fragments evoke selective release of acetylcholine from human and rat cerebrocortical terminals through species-specific mechanisms. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030730 |
| In vivo receptor occupancy of mGlu5 receptor antagonists using the novel radioligand [3H]3-methoxy-5-(pyridin-2-ylethynyl)pyridine). | European journal of pharmacology 20030718 |
| Metabotropic glutamate subtype 5 receptors modulate locomotor activity and sensorimotor gating in rodents. | The Journal of pharmacology and experimental therapeutics 20030701 |
| In vitro characterization of [3H]MethoxyPyEP, an mGluR5 selective radioligand. | Life sciences 20030606 |
| Role of metabotropic glutamate receptor subtype 5 (mGluR5) in the maintenance of cold hypersensitivity following a peripheral mononeuropathy in the rat. | Neuropharmacology 20030601 |
| The mGluR5 selective antagonist 6-methyl-2-(phenylethynyl)-pyridine reduces the spinal neuron pain-related activity in mononeuropathic rats. | Neuroscience letters 20030515 |
| MPEP, a selective metabotropic glutamate receptor 5 antagonist, attenuates conditioned taste aversion in rats. | Behavioural brain research 20030515 |
| The mGluR5 antagonist MPEP decreased nicotine self-administration in rats and mice. | Psychopharmacology 20030501 |
| Metabotropic glutamate receptor 5 antagonist-induced stimulation of hypothalamic-pituitary-adrenal axis activity: interaction with serotonergic systems. | Neuropharmacology 20030401 |
| Preproenkephalin mRNA expression in rat dorsal striatum induced by selective activation of metabotropic glutamate receptor subtype-5. | Synapse (New York, N.Y.) 20030315 |
| The mGluR5 antagonist MPEP reduces the conditioned rewarding effects of cocaine but not other drugs of abuse. | Synapse (New York, N.Y.) 20030301 |
| Functional metabotropic glutamate receptors are expressed in oligodendrocyte progenitor cells. | Journal of neurochemistry 20030301 |
| Acute activation of the spinal cord metabotropic glutamate subtype-5 receptor leads to cold hypersensitivity in the rat. | Neuropharmacology 20030301 |
| Positive allosteric modulation of the human metabotropic glutamate receptor 4 (hmGluR4) by SIB-1893 and MPEP. | British journal of pharmacology 20030301 |
| Group I metabotropic glutamate receptors modulate glutamate and gamma-aminobutyric acid release in the periaqueductal grey of rats. | European journal of pharmacology 20030221 |
| [3H]-methoxymethyl-MTEP and [3H]-methoxy-PEPy: potent and selective radioligands for the metabotropic glutamate subtype 5 (mGlu5) receptor. | Bioorganic & medicinal chemistry letters 20030210 |
| Selective blockade of mGlu5 metabotropic glutamate receptors is protective against acetaminophen hepatotoxicity in mice. | Journal of hepatology 20030201 |
| Determination of group I metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR1 and mGluR5 mutant mice. | Neuropharmacology 20030201 |
| mGlu5 receptor antagonist decreases Fos expression in spinal neurons after noxious visceral stimulation. | Brain research 20030117 |
| 3-[(2-Methyl-1,3-thiazol-4-yl)ethynyl]-pyridine: a potent and highly selective metabotropic glutamate subtype 5 receptor antagonist with anxiolytic activity. | Journal of medicinal chemistry 20030116 |
| Inhibitory effects of MPEP, an mGluR5 antagonist, and memantine, an N-methyl-D-aspartate receptor antagonist, on morphine antinociceptive tolerance in mice. | Psychopharmacology 20030101 |
| Distinct functional roles of the metabotropic glutamate receptors 1 and 5 in the rat globus pallidus. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20030101 |
| Phosphorylation of cAMP response element-binding protein in cultured striatal neurons by metabotropic glutamate receptor subtype 5. | Journal of neurochemistry 20030101 |
| Corticostriatal LTP requires combined mGluR1 and mGluR5 activation. | Neuropharmacology 20030101 |
| Actions of Group I and Group II metabotropic glutamate receptor ligands on 5-hydroxytryptamine release in the rat cerebral cortex in vivo: differential roles in the regulation of central serotonergic neurotransmission. | Neuroscience 20030101 |
| [3H]Methoxymethyl-3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine binding to metabotropic glutamate receptor subtype 5 in rodent brain: in vitro and in vivo characterization. | The Journal of pharmacology and experimental therapeutics 20021201 |
| The mGluR5 antagonist MPEP, but not the mGluR2/3 agonist LY314582, augments PCP effects on prepulse inhibition and locomotor activity. | Neuropharmacology 20021201 |
| Morphine conditioned reward is inhibited by MPEP, the mGluR5 antagonist. | Neuropharmacology 20021201 |
| Signal discrimination in the semicircular canals: a role for group I metabotropic glutamate receptors. | Neuroreport 20021007 |
| Role of synaptic metabotropic glutamate receptors in epileptiform discharges in hippocampal slices. | Journal of neurophysiology 20021001 |
| Amphetamine increases phosphorylation of extracellular signal-regulated kinase and transcription factors in the rat striatum via group I metabotropic glutamate receptors. | Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20021001 |
| Different metabotropic glutamate receptors play opposite roles in synaptic plasticity of the rat medial vestibular nuclei. | The Journal of physiology 20020915 |
| Anxiolytic-like activity of the mGluR5 antagonist MPEP: a comparison with diazepam and buspirone. | Pharmacology, biochemistry, and behavior 20020901 |
| Inhibition of mGluR5 blocks hippocampal LTP in vivo and spatial learning in rats. | Pharmacology, biochemistry, and behavior 20020901 |
| Differential effects of mGluR1 and mGlur5 antagonism on spatial learning in rats. | Pharmacology, biochemistry, and behavior 20020901 |
| Antinociceptive effects following intrathecal pretreatment with selective metabotropic glutamate receptor compounds in a rat model of neuropathic pain. | Pharmacology, biochemistry, and behavior 20020901 |
| Activation of mGlu1 but not mGlu5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo. | Pharmacology, biochemistry, and behavior 20020901 |
| Group I mGluRs modulate the pattern of non-synaptic epileptiform activity in the hippocampus. | Neuropharmacology 20020801 |
| Multiple MPEP administrations evoke anxiolytic- and antidepressant-like effects in rats. | Neuropharmacology 20020801 |
| Activation of spinal group I metabotropic glutamate receptors in rats evokes local glutamate release and spontaneous nociceptive behaviors: effects of 2-methyl-6-(phenylethynyl)-pyridine pretreatment. | Neuroscience letters 20020726 |
| Group I mGluRs increase excitability of hippocampal CA1 pyramidal neurons by a PLC-independent mechanism. | Journal of neurophysiology 20020701 |
| Metabotropic glutamate receptor 1-induced upregulation of NMDA receptor current: mediation through the Pyk2/Src-family kinase pathway in cortical neurons. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020701 |
| Chronic but not acute treatment with a metabotropic glutamate 5 receptor antagonist reverses the akinetic deficits in a rat model of parkinsonism. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020701 |
| The group I metabotropic glutamate receptor mGluR5 is required for fear memory formation and long-term potentiation in the lateral amygdala. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615 |
| Interaction of group I mGlu and NMDA receptor agonists within the dorsal horn of the spinal cord of the juvenile rat. | British journal of pharmacology 20020501 |
| Metabotropic glutamate receptors are involved in amygdaloid plasticity. | The European journal of neuroscience 20020501 |
| Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. | The Journal of biological chemistry 20020419 |
| Metabotropic glutamate receptor 5 upregulation in A-fibers after spinal nerve injury: 2-methyl-6-(phenylethynyl)-pyridine (MPEP) reverses the induced thermal hyperalgesia. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020401 |
| Interaction between vanilloid and glutamate receptors in the central modulation of nociception. | European journal of pharmacology 20020329 |
| Selective blockade of mGlu5 metabotropic glutamate receptors is protective against methamphetamine neurotoxicity. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020315 |
| Signaling mechanisms of metabotropic glutamate receptor 5 subtype and its endogenous role in a locomotor network. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20020301 |
| [(3)H]-M-MPEP, a potent, subtype-selective radioligand for the metabotropic glutamate receptor subtype 5. | Bioorganic & medicinal chemistry letters 20020211 |
| Nicotine potentiation of brain stimulation reward reversed by DH beta E and SCH 23390, but not by eticlopride, LY 314582 or MPEP in rats. | Psychopharmacology 20020201 |
| Pharmacological and endocrinological characterisation of stress-induced hyperthermia in singly housed mice using classical and candidate anxiolytics (LY314582, MPEP and NKP608). | European journal of pharmacology 20020125 |
| Differential roles for mGluR1 and mGluR5 in the persistent prolongation of epileptiform bursts. | Journal of neurophysiology 20020101 |
| Group I metabotropic glutamate receptors in spinal cord injury: roles in neuroprotection and the development of chronic central pain. | Journal of neurotrauma 20020101 |
| Behavioral effects of the selective blockade of metabotropic glutamate receptor subtype 5 in experimental hypoxia. | Polish journal of pharmacology 20020101 |
| The role of striatal metabotropic glutamate receptors in Parkinson's disease. | Amino acids 20020101 |
| In vitro and in vivo characterization of MPEP, an allosteric modulator of the metabotropic glutamate receptor subtype 5: review article. | Amino acids 20020101 |
| Antidepressant-like effect of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist in the olfactory bulbectomized rats. | Amino acids 20020101 |
| Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons. | Neuroscience 20020101 |
| Selective mGluR5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. | Brain research 20011220 |
| Interaction between metabotropic and NMDA glutamate receptors in the periaqueductal grey pain modulatory system. | Naunyn-Schmiedeberg's archives of pharmacology 20011101 |
| Endogenous activation of group-I metabotropic glutamate receptors is required for differentiation and survival of cerebellar Purkinje cells. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20011001 |
| Presynaptic group I and II metabotropic glutamate receptors oppositely modulate striatal acetylcholine release. | The European journal of neuroscience 20011001 |
| Metabotropic glutamate receptor subtypes as targets for neuroprotective drugs. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010901 |
| Blockade of the metabotropic glutamate receptor subtype 5 (mGluR5) produces antiparkinsonian-like effects in rats. | Neuropharmacology 20010901 |
| Glutamate release inhibiting properties of the novel mGlu(5) receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP): complementary in vitro and in vivo evidence. | Neuropharmacology 20010901 |
| Characterization of a metabotropic glutamate receptor type 5-green fluorescent protein chimera (mGluR5-GFP): pharmacology, surface expression, and differential effects of Homer-1a and Homer-1c. | Molecular and cellular neurosciences 20010901 |
| Metabotropic glutamate receptors 1 and 5 differentially regulate CA1 pyramidal cell function. | The Journal of neuroscience : the official journal of the Society for Neuroscience 20010815 |
| Changes in rat serum corticosterone after treatment with metabotropic glutamate receptor agonists or antagonists. | Journal of neuroendocrinology 20010801 |
| Novel allosteric antagonists shed light on mglu(5) receptors and CNS disorders. | Trends in pharmacological sciences 20010701 |
| The metabotropic glutamate receptor antagonist 2-methyl-6-(phenylethynyl)-pyridine (MPEP) blocks fear conditioning in rats. | Neuropharmacology 20010701 |
| Endogenous sulphur-containing amino acids: potent agonists at presynaptic metabotropic glutamate autoreceptors in the rat central nervous system. | British journal of pharmacology 20010701 |
| Selective involvement of mGlu1 receptors in corticostriatal LTD. | Neuropharmacology 20010601 |
| Zinc inhibition of group I mGluR-mediated calcium homeostasis in auditory neurons. | Journal of the Association for Research in Otolaryngology : JARO 20010601 |
| The metabotropic glutamate receptor agonist 1S,3R-ACPD stimulates and modulates NMDA receptor mediated excitotoxicity in organotypic hippocampal slice cultures. | Brain research 20010413 |
| Potential anxiolytic- and antidepressant-like effects of MPEP, a potent, selective and systemically active mGlu5 receptor antagonist. | British journal of pharmacology 20010401 |
| Peripheral group I metabotropic glutamate receptors modulate nociception in mice. | Nature neuroscience 20010401 |
| Actions of the systemically active metabotropic glutamate antagonist MPEP on sensory responses of thalamic neurones. | Neuropharmacology 20010401 |
| Modulation of the neuronal dopamine transporter activity by the metabotropic glutamate receptor mGluR5 in rat striatal synaptosomes through phosphorylation mediated processes. | Journal of neurochemistry 20010301 |
| Activation of type 5 metabotropic glutamate receptors enhances NMDA responses in mice cortical wedges. | British journal of pharmacology 20010201 |
| Metabotropic glutamate receptor subtype 5 (mGlu5) and nociceptive function. I. Selective blockade of mGlu5 receptors in models of acute, persistent and chronic pain. | Neuropharmacology 20010101 |
| mGlu5 receptors and nociceptive function II. mGlu5 receptors functionally expressed on peripheral sensory neurones mediate inflammatory hyperalgesia. | Neuropharmacology 20010101 |
| mGluR5 antagonists 2-methyl-6-(phenylethynyl)-pyridine and (E)-2-methyl-6-(2-phenylethenyl)-pyridine reduce traumatic neuronal injury in vitro and in vivo by antagonizing N-methyl-D-aspartate receptors. | The Journal of pharmacology and experimental therapeutics 20010101 |
| Metabotropic glutamate receptor 5 mediates the potentiation of N-methyl-D-aspartate responses in medium spiny striatal neurons. | Neuroscience 20010101 |
| Anticonvulsant activity of two metabotropic glutamate group I antagonists selective for the mGlu5 receptor: 2-methyl-6-(phenylethynyl)-pyridine (MPEP), and (E)-6-methyl-2-styryl-pyridine (SIB 1893). | Neuropharmacology 20000710 |
| 2-Methyl-6-(phenylethynyl)-pyridine (MPEP), a potent, selective and systemically active mGlu5 receptor antagonist. | Neuropharmacology 19991001 |