L-Glutamic acid, N-[(5S)-5-amino-5-carboxypentyl]-
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Potential role for saccharopine reductase in swainsonine metabolism in endophytic fungus, Undifilum oxytropis. | Fungal biology 20120801 |
Supporting role of lysine 13 and glutamate 16 in the acid-base mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. | Archives of biochemistry and biophysics 20120601 |
Lysine catabolism in Haemonchus contortus and Teladorsagia circumcincta. | Experimental parasitology 20120501 |
Lysine degradation through the saccharopine pathway in bacteria: LKR and SDH in bacteria and its relationship to the plant and animal enzymes. | FEBS letters 20120323 |
Mutation of OsALDH7 causes a yellow-colored endosperm associated with accumulation of oryzamutaic acid A in rice. | Planta 20120201 |
Evidence in support of lysine 77 and histidine 96 as acid-base catalytic residues in saccharopine dehydrogenase from Saccharomyces cerevisiae. | Biochemistry 20120131 |
The proteome of cytosolic lipid droplets isolated from differentiated Caco-2/TC7 enterocytes reveals cell-specific characteristics. | Biology of the cell 20111101 |
A QM/MM-based computational investigation on the catalytic mechanism of saccharopine reductase. | Molecules (Basel, Switzerland) 20111012 |
Contribution of K99 and D319 to substrate binding and catalysis in the saccharopine dehydrogenase reaction. | Archives of biochemistry and biophysics 20111001 |
The oxidation state of active site thiols determines activity of saccharopine dehydrogenase at low pH. | Archives of biochemistry and biophysics 20110915 |
Lysine α-ketoglutarate reductase, but not saccharopine dehydrogenase, is subject to substrate inhibition in pig liver. | Nutrition research (New York, N.Y.) 20110701 |
Therapeutic modulation of cerebral L-lysine metabolism in a mouse model for glutaric aciduria type I. | Brain : a journal of neurology 20110101 |
Unexpected accumulation of ncm(5)U and ncm(5)S(2) (U) in a trm9 mutant suggests an additional step in the synthesis of mcm(5)U and mcm(5)S(2)U. | PloS one 20110101 |
Effects of abiotic stress on plants: a systems biology perspective. | BMC plant biology 20110101 |
Amino acids biosynthesis and nitrogen assimilation pathways: a great genomic deletion during eukaryotes evolution. | BMC genomics 20110101 |
Differences in transcriptional regulatory mechanisms functioning for free lysine content and seed storage protein accumulation in rice grain. | Plant & cell physiology 20101201 |
A molecular probe for Basidiomycota: the spermidine synthase-saccharopine dehydrogenase chimeric gene. | FEMS microbiology letters 20101101 |
Glutamates 78 and 122 in the active site of saccharopine dehydrogenase contribute to reactant binding and modulate the basicity of the acid-base catalysts. | The Journal of biological chemistry 20100702 |
Role of vimA in cell surface biogenesis in Porphyromonas gingivalis. | Microbiology (Reading, England) 20100701 |
Identification of the 2-hydroxyglutarate and isovaleryl-CoA dehydrogenases as alternative electron donors linking lysine catabolism to the electron transport chain of Arabidopsis mitochondria. | The Plant cell 20100501 |
First crystal structure of L-lysine 6-dehydrogenase as an NAD-dependent amine dehydrogenase. | The Journal of biological chemistry 20100312 |
Metabolism of lysine in alpha-aminoadipic semialdehyde dehydrogenase-deficient fibroblasts: evidence for an alternative pathway of pipecolic acid formation. | FEBS letters 20100104 |
Remobilization of Tol2 transposons in Xenopus tropicalis. | BMC developmental biology 20100101 |
Structural and transcriptional analysis of plant genes encoding the bifunctional lysine ketoglutarate reductase saccharopine dehydrogenase enzyme. | BMC plant biology 20100101 |
Proteomics of plant pathogenic fungi. | Journal of biomedicine & biotechnology 20100101 |
Predicted class-I aminoacyl tRNA synthetase-like proteins in non-ribosomal peptide synthesis. | Biology direct 20100101 |
Insights into the mechanism of ligand binding to octopine dehydrogenase from Pecten maximus by NMR and crystallography. | PloS one 20100101 |
Cytoplasmic- and extracellular-proteome analysis of Diplodia seriata: a phytopathogenic fungus involved in grapevine decline. | Proteome science 20100101 |
Proteomic analysis of fungal host factors differentially expressed by Fusarium graminearum infected with Fusarium graminearum virus-DK21. | Virus research 20090901 |
Ustilago maydis spermidine synthase is encoded by a chimeric gene, required for morphogenesis, and indispensable for survival in the host. | FEMS yeast research 20090901 |
Chemical mechanism of saccharopine reductase from Saccharomyces cerevisiae. | Biochemistry 20090630 |
Characterization of the ABA-regulated global responses to dehydration in Arabidopsis by metabolomics. | The Plant journal : for cell and molecular biology 20090301 |
Genetic manipulation of lysine catabolism in maize kernels. | Plant molecular biology 20090101 |
A pathway-specific microarray analysis highlights the complex and co-ordinated transcriptional networks of the developing grain of field-grown barley. | Journal of experimental botany 20090101 |
Understanding the regulation of aspartate metabolism using a model based on measured kinetic parameters. | Molecular systems biology 20090101 |
Structural motifs recurring in different folds recognize the same ligand fragments. | BMC bioinformatics 20090101 |
Multiple horizontal gene transfer events and domain fusions have created novel regulatory and metabolic networks in the oomycete genome. | PloS one 20090101 |
LKR/SDH plays important roles throughout the tick life cycle including a long starvation period. | PloS one 20090101 |
Recent amplification and impact of MITEs on the genome of grapevine (Vitis vinifera L.). | Genome biology and evolution 20090101 |
Protein-induced alterations in murine hepatic alpha-aminoadipate delta-semialdehyde synthase activity are mediated posttranslationally. | Nutrition research (New York, N.Y.) 20081201 |
Supply of nitrogen can reverse senescence processes and affect expression of genes coding for plastidic glutamine synthetase and lysine-ketoglutarate reductase/saccharopine dehydrogenase. | Plant biology (Stuttgart, Germany) 20080901 |
Overall kinetic mechanism of saccharopine dehydrogenase (L-glutamate forming) from Saccharomyces cerevisiae. | Biochemistry 20080513 |
Modifying lysine biosynthesis and catabolism in corn with a single bifunctional expression/silencing transgene cassette. | Plant biotechnology journal 20080101 |
The hidden universal distribution of amino acid biosynthetic networks: a genomic perspective on their origins and evolution. | Genome biology 20080101 |
Histoplasma capsulatum proteome response to decreased iron availability. | Proteome science 20080101 |
Crystal structures of ligand-bound saccharopine dehydrogenase from Saccharomyces cerevisiae. | Biochemistry 20071106 |
Structural studies of the final enzyme in the alpha-aminoadipate pathway-saccharopine dehydrogenase from Saccharomyces cerevisiae. | Journal of molecular biology 20071026 |
High-lysine corn generated by endosperm-specific suppression of lysine catabolism using RNAi. | Plant biotechnology journal 20070901 |
Ongoing genome reduction in Mycobacterium ulcerans. | Emerging infectious diseases 20070701 |
Determinants of substrate specificity for saccharopine dehydrogenase from Saccharomyces cerevisiae. | Biochemistry 20070626 |
A proposed proton shuttle mechanism for saccharopine dehydrogenase from Saccharomyces cerevisiae. | Biochemistry 20070123 |
Reactome: a knowledge base of biologic pathways and processes. | Genome biology 20070101 |
A semi-quantitative GeLC-MS analysis of temporal proteome expression in the emerging nosocomial pathogen Ochrobactrum anthropi. | Genome biology 20070101 |
Unbiased characterization of genotype-dependent metabolic regulations by metabolomic approach in Arabidopsis thaliana. | BMC systems biology 20070101 |
Reconstruction and flux analysis of coupling between metabolic pathways of astrocytes and neurons: application to cerebral hypoxia. | Theoretical biology & medical modelling 20070101 |
Overall kinetic mechanism of saccharopine dehydrogenase from Saccharomyces cerevisiae. | Biochemistry 20061003 |
Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum. | Fungal genetics and biology : FG & B 20060901 |
Novel lysine biosynthetic gene sequences (LYS1 and LYS5) used as PCR targets for the detection of the pathogenic Candida yeast. | Applied microbiology and biotechnology 20060901 |
Lysine catabolism, an effective versatile regulator of lysine level in plants. | Amino acids 20060301 |
Functional analysis through site-directed mutations and phylogeny of the Candida albicans LYS1-encoded saccharopine dehydrogenase. | Molecular genetics and genomics : MGG 20060101 |
Origin and evolution of the peroxisomal proteome. | Biology direct 20060101 |
Crystal structure of the his-tagged saccharopine reductase from Saccharomyces cerevisiae at 1.7-A resolution. | Cell biochemistry and biophysics 20060101 |
The alpha-aminoadipate pathway for lysine biosynthesis in fungi. | Cell biochemistry and biophysics 20060101 |
The lysine-ketoglutarate reductase-saccharopine dehydrogenase is involved in the osmo-induced synthesis of pipecolic acid in rapeseed leaf tissues. | Plant physiology and biochemistry : PPB 20060101 |
Lysine is catabolized to 2-aminoadipic acid in Penicillium chrysogenum by an omega-aminotransferase and to saccharopine by a lysine 2-ketoglutarate reductase. Characterization of the omega-aminotransferase. | Molecular genetics and genomics : MGG 20051001 |
Isolation and characterization of enzymes involved in lysine catabolism from sorghum seeds. | Journal of agricultural and food chemistry 20050309 |
Regulation of lysine catabolism in Arabidopsis through concertedly regulated synthesis of the two distinct gene products of the composite AtLKR/SDH locus. | Journal of experimental botany 20050201 |
Novel chimeric spermidine synthase-saccharopine dehydrogenase gene (SPE3-LYS9) in the human pathogen Cryptococcus neoformans. | Eukaryotic cell 20040601 |
Regulation of maize lysine metabolism and endosperm protein synthesis by opaque and floury mutations. | European journal of biochemistry 20031201 |
Synthesis of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is concertedly regulated by metabolic and stress-associated signals. | Plant physiology 20031101 |
Interdomain communications in bifunctional enzymes: how are different activities coordinated? | IUBMB life 20030801 |
Nutritional biochemistry: A new redox-cofactor vitamin for mammals. | Nature 20030424 |
Impact of the cross-pathway control on the regulation of lysine and penicillin biosynthesis in Aspergillus nidulans. | Current genetics 20030101 |
Isolation of the bifunctional enzyme lysine 2-oxoglutarate reductase-saccharopine dehydrogenase from Phaseolus vulgaris. | Amino acids 20030101 |
The activity of the Arabidopsis bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase enzyme of lysine catabolism is regulated by functional interaction between its two enzyme domains. | The Journal of biological chemistry 20021220 |
The bifunctional LKR/SDH locus of plants also encodes a highly active monofunctional lysine-ketoglutarate reductase using a polyadenylation signal located within an intron. | Plant physiology 20020901 |
Analysis of the aspartic acid metabolic pathway using mutant genes. | Amino acids 20020101 |
A T-DNA insertion knockout of the bifunctional lysine-ketoglutarate reductase/saccharopine dehydrogenase gene elevates lysine levels in Arabidopsis seeds. | Plant physiology 20010801 |
Lysine catabolism: a stress and development super-regulated metabolic pathway. | Current opinion in plant biology 20010601 |
The essential amino acid lysine acts as precursor of glutamate in the mammalian central nervous system. | FEBS letters 20010112 |
Lysine metabolism in higher plants. | Amino acids 20010101 |