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PF-670462

CAS No.:
950912-80-8
Catalog Number:
AG01CC2S
Molecular Formula:
C19H22Cl2FN5
Molecular Weight:
410.3159
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$223
- +
50mg
99%
1 week
United States
$682
- +
Product Description
Catalog Number:
AG01CC2S
Chemical Name:
PF-670462
CAS Number:
950912-80-8
Molecular Formula:
C19H22Cl2FN5
Molecular Weight:
410.3159
MDL Number:
MFCD12828759
IUPAC Name:
4-[3-cyclohexyl-5-(4-fluorophenyl)imidazol-4-yl]pyrimidin-2-amine;dihydrochloride
InChI:
InChI=1S/C19H20FN5.2ClH/c20-14-8-6-13(7-9-14)17-18(16-10-11-22-19(21)24-16)25(12-23-17)15-4-2-1-3-5-15;;/h6-12,15H,1-5H2,(H2,21,22,24);2*1H
InChI Key:
PSNKGVAXBSAHCH-UHFFFAOYSA-N
SMILES:
Nc1nccc(n1)c1n(cnc1c1ccc(cc1)F)C1CCCCC1.Cl.Cl
UNII:
D68ANS5I8B
Properties
Complexity:
422  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
409.124g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
410.318g/mol
Monoisotopic Mass:
409.124g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
69.6A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Inhibition of αENaC expression and ENaC activity following blockade of the circadian clock-regulatory kinases CK1δ/ε. American journal of physiology. Renal physiology 20121001
Inhibition of the casein-kinase-1-ε/δ/ prevents relapse-like alcohol drinking. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20120801
IC261 induces cell cycle arrest and apoptosis of human cancer cells via CK1δ/ɛ and Wnt/β-catenin independent inhibition of mitotic spindle formation. Oncogene 20110602
Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. The Journal of pharmacology and experimental therapeutics 20090801
A role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology 20090501
An inhibitor of casein kinase I epsilon induces phase delays in circadian rhythms under free-running and entrained conditions. The Journal of pharmacology and experimental therapeutics 20070801
Properties