Home Aminos 2(1H)-Quinolinone,8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, hydrochloride,hydrate (2:2:1), rel-

2(1H)-Quinolinone,8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, hydrochloride,hydrate (2:2:1), rel-

CAS No.:
81262-93-3
Catalog Number:
AG01CBZA
Molecular Formula:
Molecular Weight:
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG01CBZA
Chemical Name:
2(1H)-Quinolinone,8-hydroxy-5-[(1R,2S)-1-hydroxy-2-[(1-methylethyl)amino]butyl]-, hydrochloride,hydrate (2:2:1), rel-
CAS Number:
81262-93-3
MDL Number:
MFCD04221378
IUPAC Name:
8-hydroxy-5-[1-hydroxy-2-(propan-2-ylamino)butyl]-1H-quinolin-2-one;hydrate;hydrochloride
InChI:
InChI=1S/C16H22N2O3.ClH.H2O/c1-4-12(17-9(2)3)16(21)11-5-7-13(19)15-10(11)6-8-14(20)18-15;;/h5-9,12,16-17,19,21H,4H2,1-3H3,(H,18,20);1H;1H2
InChI Key:
UIFLWWTUGCBILS-UHFFFAOYSA-N
Properties
Complexity:
397  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
344.15g/mol
Formal Charge:
0
Heavy Atom Count:
23  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
6  
Isotope Atom Count:
0
Molecular Weight:
344.836g/mol
Monoisotopic Mass:
344.15g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
82.6A^2
Undefined Atom Stereocenter Count:
2  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
The effect of β-2 adrenoreceptor agonist inhalation on lungs donated after cardiac death in a canine lung transplantation model. The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation 20120701
Capillary electrochromatography of three β2-agonists in human urine using a lauryl methacrylate-based monolithic column. Journal of separation science 20120501
Procaterol-stimulated increases in ciliary bend amplitude and ciliary beat frequency in mouse bronchioles. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20120101
The efficacy of nebulized procaterol versus nebulized salbutamol for the treatment of moderate acute asthma: a randomized, double-blind, parallel group study. International journal of clinical pharmacology and therapeutics 20111001
Suppressive effects of procaterol on expression of IP-10/CXCL 10 and RANTES/CCL 5 by bronchial epithelial cells. Inflammation 20110801
Adenosine activation of A(2B) receptor(s) is essential for stimulated epithelial ciliary motility and clearance. American journal of physiology. Lung cellular and molecular physiology 20110801
Role of G(i/o)-Src kinase-PI3K/Akt pathway and caveolin-1 in β₂-adrenoceptor coupling to endothelial NO synthase in mouse pulmonary artery. Cellular signalling 20110701
Structure and function of an irreversible agonist-β(2) adrenoceptor complex. Nature 20110113
Procaterol inhibits rhinovirus infection in primary cultures of human tracheal epithelial cells. European journal of pharmacology 20110110
Inhibitory effect of procaterol on exercise dynamic lung hyperinflation during the 6-min walk test in stable patients with chronic obstructive pulmonary disease. Arzneimittel-Forschung 20110101
Inhibition of eosinophil activation mediated by a Toll-like receptor 7 ligand with a combination of procaterol and budesonide. International archives of allergy and immunology 20110101
Pharmacokinetic study of the oral administration of procaterol hydrochloride hydrate 50 µg in healthy adult Japanese men. International journal of clinical pharmacology and therapeutics 20101101
Effect of procaterol on Th2-related chemokines production in human monocyte and bronchial epithelial cells. Pediatric pulmonology 20101001
Deterioration of asthma in a patient with diffuse panbronchiolitis (DPB) after macrolide therapy. The Journal of asthma : official journal of the Association for the Care of Asthma 20100501
Procaterol inhibits lung fibroblast migration. Inflammation 20091201
Overcoming dose-counting mechanisms on metered-dose inhalers for urgent treatment in the operating room. Anesthesia and analgesia 20091101
[Effect of proactive use of inhaled procaterol on dyspnea in daily activities and quality of life in patients with chronic obstructive pulmonary disease]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20090901
The investigation of photo-induced chemiluminescence on Co2+-doped TiO2 nanoparticles and its analytical application. The Analyst 20090701
Bronchoconstriction-triggered cough in conscious guinea pigs. Experimental lung research 20090501
Procaterol potentiates the anti-inflammatory activity of budesonide on eosinophil adhesion to lung fibroblasts. International archives of allergy and immunology 20090101
Bronchodilating effect and anabolic effect of inhaled procaterol. International journal of sports medicine 20081101
Rapid analysis of clenbuterol, salbutamol, procaterol, and fenoterol in pharmaceuticals and human urine by capillary electrophoresis. Talanta 20080915
[A case of smoking-induced chest pain improved with beta2-stimulant]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20080701
[Flow-injection chemiluminescence determination of procaterol hydrochloride]. Guang pu xue yu guang pu fen xi = Guang pu 20080201
[Case of chest pain variant asthma]. Arerugi = [Allergy] 20080101
Long-term effect of the beta2-receptor agonist procaterol on daily life performance and exercise capacity in patients with stable chronic obstructive pulmonary disease. Clinical study with special reference to health-related quality of life and activities of daily living. Arzneimittel-Forschung 20080101
Single dose of inhaled procaterol has a prolonged effect on exercise performance of patients with COPD. Physiotherapy theory and practice 20080101
[Therapy with nebulized beta2 agonists (procaterol) in asthmatic children: pulmonary function and plasma levels after inhalation]. Arerugi = [Allergy] 20071101
Effect of procaterol, a beta(2) selective adrenergic receptor agonist, on airway inflammation and hyperresponsiveness. Allergology international : official journal of the Japanese Society of Allergology 20070901
Inhalation and incubation with procaterol increases diaphragm muscle contractility in mice. Allergology international : official journal of the Japanese Society of Allergology 20070901
[Bronchial asthma attack with lactic acidosis and hypokalemia in a case receiving high dose inhalation of procaterol hydrochloride]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20070401
Cathine, an amphetamine-related compound, acts on mammalian spermatozoa via beta1- and alpha2A-adrenergic receptors in a capacitation state-dependent manner. Human reproduction (Oxford, England) 20070301
Prednisolone oral solution plus inhaled procaterol for acute asthma in children: a double-blind randomized controlled trial. Acta paediatrica Taiwanica = Taiwan er ke yi xue hui za zhi 20070101
Effects of KP-496, a novel dual antagonist for leukotriene D4 and thromboxane A2 receptors, on contractions induced by various agonists in the guinea pig trachea. Allergology international : official journal of the Japanese Society of Allergology 20061201
Production of an extremly low dose procaterol HCl preparation by fluidized-bed coating method: in vitro and in vivo evaluation. Drug development and industrial pharmacy 20060701
Safety and usefulness of a novel eMotion electric mesh nebulizer in children with asthma. Allergology international : official journal of the Japanese Society of Allergology 20060601
Differential effects of short-acting beta2-agonists on human granulocyte functions. International archives of allergy and immunology 20060101
Preferable inotropic action of procaterol, a potent bronchodilator, on impaired diaphragmatic contractility in an intraabdominal septic model. Journal of anesthesia 20060101
Procaterol upregulates peroxisome proliferator-activated receptor-gamma expression in human eosinophils. International archives of allergy and immunology 20060101
Relaxant effects of beta-adrenergic agonists on porcine and human detrusor muscle. Acta physiologica Scandinavica 20051001
Pharmacodynamic equivalence study of CFC-free and CFC-containing procaterol hydrochloride metered-dose inhalers. Methods and findings in experimental and clinical pharmacology 20051001
Adrenal influences on the inhibitory effects of procaterol, a selective Beta-two-adrenoceptor agonist, on antigen-induced airway microvascular leakage and bronchoconstriction in Guinea pigs. Pharmacology 20050301
Propranolol modulates trigeminovascular responses in thalamic ventroposteromedial nucleus: a role in migraine? Brain : a journal of neurology 20050101
Beta2-adrenoceptor agonists induce the mammalian clock gene, hPer1, mRNA in cultured human bronchial epithelium cells in vitro. Chronobiology international 20050101
Pharmacodynamic study of procaterol hydrochloride dry powder inhaler: evaluation of pharmacodynamic equivalence between procaterol hydrochloride dry powder inhaler and procaterol hydrochloride metered-dose inhaler in asthma patients in a randomized, double-dummy, double-blind crossover manner. Methods and findings in experimental and clinical pharmacology 20050101
A guinea pig model for cough variant asthma and role of tachykinins. Experimental lung research 20041201
Heterogeneous beta2-adrenoceptor expression and dilation in coronary arterioles across the left ventricular wall. Circulation 20041026
[Acute effect of inhaled beta(2)-agonists with different type of intrinsic activity on airway resistance in healthy volunteers]. Arerugi = [Allergy] 20040401
Role of adenylate and guanylate cyclases in beta1-, beta2-, and beta3-adrenoceptor-mediated relaxation of internal anal sphincter smooth muscle. The Journal of pharmacology and experimental therapeutics 20040301
[Beta 2-adrenoceptor polymorphism and effects of inhaled beta 2-stimulant (procaterol) and an anti-cholinergic drug (oxitropium) on the airway resistance]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20040301
3,3',4,4',5-Pentachlorobiphenyl (PCB 126) impacts hepatic lipid peroxidation, membrane fluidity and beta-adrenoceptor kinetics in chick embryos. Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20040101
Functional characterization of beta-adrenoceptor subtypes in the canine and rat lower urinary tract. The Journal of urology 20030801
Beta2-adrenergic receptor antagonist accelerates skin barrier recovery and reduces epidermal hyperplasia induced by barrier disruption. The Journal of investigative dermatology 20030701
Functional and molecular characterization of beta-adrenoceptors in the internal anal sphincter. The Journal of pharmacology and experimental therapeutics 20030501
Inhibition by fenoterol of human eosinophil functions including beta2-adrenoceptor-independent actions. Clinical and experimental immunology 20021201
Airway responsiveness and airway remodeling after chronic exposure to procaterol and fenoterol in guinea pigs in vivo. International archives of allergy and immunology 20021201
Functional beta1- and beta2-adrenoceptors in the left and right atrium of pre-hypertensive rats. The Journal of pharmacy and pharmacology 20021001
Effects of selective beta2 and beta3-adrenoceptor agonists on detrusor hyperreflexia in conscious cerebral infarcted rats. The Journal of urology 20020901
Different effects of beta-adrenoceptor desensitization on inhibitory actions in guinea-pig trachealis. Clinical and experimental pharmacology & physiology 20020801
[beta 2-adrenoceptor polymorphism and effect of inhaled beta 2-stimulant (procaterol) on airway resistance measured by body plethysmography in healthy volunteers]. Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 20020801
Fenoterol inhibits superoxide anion generation by human polymorphonuclear leukocytes via beta-adrenoceptor-dependent and -independent mechanisms. Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology 20020501
Effects of Y-27632, a Rho/Rho kinase inhibitor, on leukotriene D(4)- and histamine-induced airflow obstruction and airway microvascular leakage in guinea pigs in vivo. Pharmacology 20020401
Synergistic effect of theophylline and procaterol on interleukin-5-induced degranulation from human eosinophils. The Journal of asthma : official journal of the Association for the Care of Asthma 20020201
Effects of beta(3)-adrenoceptor stimulation on prostaglandin E(2)-induced bladder hyperactivity and on the cardiovascular system in conscious rats. Neurourology and urodynamics 20020101
Beta2-adrenergic receptor genotype-related changes in cAMP levels in peripheral blood mononuclear cells after multiple-dose oral procaterol. Pharmaceutical research 20011201
Exhaled nitric oxide decreases during exercise-induced bronchoconstriction in children with asthma. American journal of respiratory and critical care medicine 20011115
beta(2)-adrenergic receptor overexpression increases alveolar fluid clearance and responsiveness to endogenous catecholamines in rats. Circulation research 20011109
Vascular responses to beta-adrenoceptor subtype-selective agonists with and without endothelium in rat common carotid arteries. Journal of autonomic pharmacology 20010201
Clinical characteristics of asthmatic patients prescribed various beta-agonist metered-dose inhalers at Yamagata University Hospital. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20010101
Binding pockets of the beta(1)- and beta(2)-adrenergic receptors for subtype-selective agonists. Molecular pharmacology 19991101
Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. Journal of investigational allergology & clinical immunology 19960101
A comparison of oral procaterol and albuterol in reversible airflow obstruction. The American review of respiratory disease 19881201
Procaterol and terbutaline in bronchial asthma. A double-blind, placebo-controlled, cross-over study. Allergy 19851001
Properties