Home Other Building Blocks Quinapril hydrochloride

Quinapril hydrochloride

CAS No.:
82586-55-8
Catalog Number:
AG01BD2N
Molecular Formula:
C25H31ClN2O5
Molecular Weight:
474.9770
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%(HPLC)
In Stock USA
United States
$46
- +
25mg
99%(HPLC)
In Stock USA
United States
$72
- +
100mg
99%(HPLC)
In Stock USA
United States
$151
- +
Product Description
Catalog Number:
AG01BD2N
Chemical Name:
Quinapril hydrochloride
CAS Number:
82586-55-8
Molecular Formula:
C25H31ClN2O5
Molecular Weight:
474.9770
MDL Number:
MFCD00889215
IUPAC Name:
(3S)-2-[(2S)-2-[[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino]propanoyl]-3,4-dihydro-1H-isoquinoline-3-carboxylic acid;hydrochloride
InChI:
InChI=1S/C25H30N2O5.ClH/c1-3-32-25(31)21(14-13-18-9-5-4-6-10-18)26-17(2)23(28)27-16-20-12-8-7-11-19(20)15-22(27)24(29)30;/h4-12,17,21-22,26H,3,13-16H2,1-2H3,(H,29,30);1H/t17-,21-,22-;/m0./s1
InChI Key:
IBBLRJGOOANPTQ-JKVLGAQCSA-N
SMILES:
CCOC(=O)[C@@H](N[C@H](C(=O)N1Cc2ccccc2C[C@H]1C(=O)O)C)CCc1ccccc1.Cl
UNII:
33067B3N2M
NSC Number:
758222
Properties
Complexity:
648  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
474.192g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
474.982g/mol
Monoisotopic Mass:
474.192g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
95.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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Plasma fibrin clot properties in arterial hypertension and their modification by antihypertensive medication. Thrombosis research 20120701
The impact of lipoic acid on endothelial function and proteinuria in quinapril-treated diabetic patients with stage I hypertension: results from the QUALITY study. Journal of cardiovascular pharmacology and therapeutics 20120601
In vivo kinetics of indoxyl sulfate in humans and its renal interaction with angiotensin-converting enzyme inhibitor quinapril in rats. The Journal of pharmacology and experimental therapeutics 20120601
Heart rate variability in conscious and anesthetized rats under the action of angiotensin converting enzyme inhibitors. Bulletin of experimental biology and medicine 20120301
[Advantages of quinapril therapy in patients with arterial hypertension and functional class III chronic heart failure with preserved left ventricular ejection fraction]. Kardiologiia 20120101
Sustained postoperative anaemia is associated with an impaired outcome after coronary artery bypass graft surgery: insights from the IMAGINE trial. Heart (British Cardiac Society) 20111001
Quantitation of quinapril in human plasma by matrix-assisted laser desorption ionization time-of-flight mass spectrometry with quinolone matrix additives. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110915
Meta-analysis of randomized controlled trials on effect of angiotensin-converting enzyme inhibitors on cancer risk. The American journal of cardiology 20110715
Ultra-thin-layer chromatography mass spectrometry and thin-layer chromatography mass spectrometry of single peptides of angiotensin-converting enzyme inhibitors. Journal of chromatography. A 20110520
Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia 20110301
The effect of quinapril treatment on insulin resistance, leptin and high sensitive C-reactive protein in hypertensive patients. Clinical and experimental hypertension (New York, N.Y. : 1993) 20110101
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Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Angioedema after nonsteroidal antiinflammatory drug initiation in a patient stable on an angiotensin-converting-enzyme inhibitor. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20100815
Solid-state surface acidity and pH-stability profiles of amorphous quinapril hydrochloride and silicate formulations. Journal of pharmaceutical sciences 20100601
Cardiovascular effects of inhibition of renin-angiotensin-aldosterone system components in hypertensive rats given salt excess. American journal of physiology. Heart and circulatory physiology 20100401
The endothelin receptor antagonist avosentan ameliorates nephropathy and atherosclerosis in diabetic apolipoprotein E knockout mice. Diabetologia 20100101
Effect of quinapril on in-stent restenosis and relation to plasma apoptosis signaling molecules. The American journal of cardiology 20100101
Influence of humidity and hydroxypropyl cellulose, hydroxypropylmethyl cellulose, glyceryl behenate or magnesium stearate on the degradation kinetics of quinapril hydrochloride in solid phase. Acta poloniae pharmaceutica 20100101
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Analysis of quinapril by two solvent-saving methods: application of capillary column high-performance liquid chromatography with ultraviolet absorbance detection and LDI-TOF-MS. Journal of AOAC International 20100101
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Effect of the pH grade of silicates on chemical stability of coground amorphous quinapril hydrochloride and its stabilization using pH-modifiers. Journal of pharmaceutical sciences 20090901
Renal organic anion transporter-mediated drug-drug interaction between gemcabene and quinapril. The Journal of pharmacology and experimental therapeutics 20090701
Determination of quinapril and quinaprilat in human plasma by ultraperformance liquid chromatography-electrospray ionization mass spectrometry. Biomedical chromatography : BMC 20090501
Sex-dependent impairment of cardiac action potential conduction in type 1 diabetic rats. American journal of physiology. Heart and circulatory physiology 20090501
Transcriptome of hypertension-induced left ventricular hypertrophy and its regression by antihypertensive therapies. Hypertension research : official journal of the Japanese Society of Hypertension 20090501
ACE inhibitors and plasma B-type natriuretic peptide levels in elderly patients with heart failure. Arquivos brasileiros de cardiologia 20090501
LC-MS/MS assay of quinapril and its metabolite quinaprilat for drug bioequivalence evaluation: prospective, concurrential and retrospective method validation. Bioanalysis 20090401
An experimental model of encapsulating peritoneal sclerosis. Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis 20090201
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[Combined antihypertensive therapy in patients with arterial hypertension and type 2 diabetes]. Klinicheskaia meditsina 20090101
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Transport of angiotensin-converting enzyme inhibitors by H+/peptide transporters revisited. The Journal of pharmacology and experimental therapeutics 20081101
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ADMA impairs nitric oxide-mediated arteriolar function due to increased superoxide production by angiotensin II-NAD(P)H oxidase pathway. Hypertension (Dallas, Tex. : 1979) 20081101
Simultaneous determination of hydrochlorothiazide, quinapril and quinaprilat in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080915
Comparison of the effects of quinapril and irbesartan on P-wave dispersion in hypertensive patients. Advances in therapy 20080801
Design and utilization of the drug-excipient chemical compatibility automated system. International journal of pharmaceutics 20080709
Electrochemical behavior of quinapril and its determination in pharmaceutical formulations by square-wave voltammetry at a mercury electrode. Die Pharmazie 20080601
Pharmacokinetics and bioequivalence study of the two 20-mg quinapril hydrochloride tablet formulations in healthy Thai male volunteers. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20080501
Angiotensin converting enzyme inhibition enhances collateral artery remodeling in rats with femoral artery occlusion. The American journal of the medical sciences 20080301
Effects of angiotensin-converting enzyme inhibition in low-risk patients early after coronary artery bypass surgery. Circulation 20080101
Early effects of treatment with nebivolol and quinapril on endothelial function in patients with hypertension. Endothelium : journal of endothelial cell research 20080101
Quinapril improves endothelial function in postmenopausal hypertensive patients. Kidney & blood pressure research 20080101
Effect of angiotensin-converting enzyme inhibition and angiotensin II type 1 receptor blockade on streptozotocin-induced diabetic nephropathy. Renal failure 20080101
Skeletal muscle capillary responses to insulin are abnormal in late-stage diabetes and are restored by angiotensin-converting enzyme inhibition. American journal of physiology. Endocrinology and metabolism 20071201
Comparison of selective AT1-receptor blockade versus ACE inhibition for restenosis prophylaxis in patients with peripheral occlusive arterial disease after stent angioplasty: a randomized, controlled, proof-of-concept study. Angiology 20071201
A randomized trial of a 6-week course of celecoxib on proteinuria in diabetic kidney disease. American journal of kidney diseases : the official journal of the National Kidney Foundation 20071201
Does blockade of the renin angiotensin system affect sympathetic and blood pressure responses to amlodipine in young hypertensive patients? American journal of hypertension 20071101
Prevention of vascular damage in scleroderma and autoimmune Raynaud's phenomenon: a multicenter, randomized, double-blind, placebo-controlled trial of the angiotensin-converting enzyme inhibitor quinapril. Arthritis and rheumatism 20071101
Aldosterone escape with diuretic or angiotensin-converting enzyme inhibitor/angiotensin II receptor blocker combination therapy in patients with mild to moderate hypertension. Journal of clinical hypertension (Greenwich, Conn.) 20071001
Acute effects of renin-angiotensin system blockade on arterial function in hypertensive patients. Journal of human hypertension 20070801
Therapeutic modulation of the nitric oxide: all ace inhibitors are not equivalent. Pharmacological research 20070701
Angiotensin receptor antagonist vs. angiotensin-converting enzyme inhibitor in Asian subjects with type 2 diabetes and albuminuria - a randomized crossover study. Diabetes, obesity & metabolism 20070701
Inhibition of matrix metalloproteinase activity by ACE inhibitors prevents left ventricular remodeling in a rat model of heart failure. American journal of physiology. Heart and circulatory physiology 20070601
Anti-inflammatory actions of quinapril. Cardiovascular drugs and therapy 20070601
Clearance of imidapril, an Angiotensin-converting enzyme inhibitor, during hemodialysis in hypertensive renal failure patients: comparison with quinapril and enalapril. Journal of clinical pharmacology 20070201
Amlodipine added to quinapril vs quinapril alone for the treatment of hypertension in diabetes: the Amlodipine in Diabetes (ANDI) trial. Journal of clinical hypertension (Greenwich, Conn.) 20070201
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Evaluation of a novel tablet splitter. Journal of the American Pharmacists Association : JAPhA 20070101
Influence of preventive therapy with quinapril on IL-6 level in patients with chronic stable angina. Pharmacological reports : PR 20070101
Quinapril for treatment of hypertension in Turkey: dose titration and diuretic combination treatment strategies. Clinical drug investigation 20070101
Degradation mechanism for a trace impurity in quinapril drug by tandem mass and precursor ions studies. Rapid communications in mass spectrometry : RCM 20070101
Influence of enalapril, quinapril and losartan on lipopolysaccharide (LPS)-induced serum concentrations of TNF-alpha, IL-1 beta, IL-6 in spontaneously hypertensive rats (SHR). Pharmacological reports : PR 20070101
The role of quinapril in the presence of a weight loss regimen: endothelial function and markers of obesity in patients with the metabolic syndrome. Preventive cardiology 20070101
Cardiorenal protective effects of year-long antihypertensive therapy with an angiotensin-converting enzyme inhibitor or a calcium channel blocker in spontaneously hypertensive rats. American journal of hypertension 20061201
Effect of angiotensin converting enzyme inhibitors on 1.25-(OH)2 D levels of hypertensive patients. Relationship with ACE polymorphisms. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061201
Auto-intoxication with flecainide and quinapril: ECG-changes, symptoms and treatment. Acta cardiologica 20061201
Atorvastatin and quinapril inhibit blood coagulation in patients with coronary artery disease following 28 days of therapy. Journal of thrombosis and haemostasis : JTH 20061101
The effects of quinapril and atorvastatin on the responsiveness to sildenafil in men with erectile dysfunction. Vascular medicine (London, England) 20061101
Interaction of quinapril anion with cationic surfactant micelles of cetyltrimethylammonium bromide. Journal of colloid and interface science 20060915
Interleukin-6 (IL-6)-174 G/C polymorphism--lack of association with inflammatory and haemostatic variables in patients with coronary heart disease treated with atorvastatin and quinapril. International journal of cardiology 20060910
Estimation of intramolecular cyclization activation energies via isothermal gravimetric analysis: a technical note. AAPS PharmSciTech 20060901
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Antithrombotic effect of tissue and plasma type angiotensin converting enzyme inhibitors in experimental thrombosis in rats. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Statins, fenofibrate, and quinapril increase clot permeability and enhance fibrinolysis in patients with coronary artery disease. Journal of thrombosis and haemostasis : JTH 20060501
Effects of quinapril on left atrial structural remodeling and arterial stiffness. The American journal of cardiology 20060315
Progressive left ventricular hypertrophy after withdrawal of long-term ACE inhibition following experimental myocardial infarction. European journal of heart failure 20060301
Quinapril treatment increases insulin-stimulated endothelial function and adiponectin gene expression in patients with type 2 diabetes. The Journal of clinical endocrinology and metabolism 20060301
Inhibition of the renin angiotensin system decreases fibrogenic cytokine expression in tacrolimus nephrotoxicity in rats. Transplantation proceedings 20060301
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Long-term organ protection by doxazosin and/or quinapril as antihypertensive therapy. Journal of nephrology 20060101
Long-term treatment with an ACE inhibitor or an AT1 antagonist avoids hypertension-induced inflammation in the kidney. Journal of nephrology 20060101
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Beneficial effects of add-on hydrochlorothiazide in rats with myocardial infarction optimally treated with quinapril. European journal of heart failure 20051201
The development and stability assessment of extemporaneous pediatric formulations of Accupril. International journal of pharmaceutics 20051104
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Effects of Angiotensin-converting enzyme inhibition and statin treatment on inflammatory markers and endothelial functions in patients with longterm rheumatoid arthritis. The Journal of rheumatology 20051101
Post-infectious acute glomerulonephritis with predominant mesangial deposition of IgA. Clinical and experimental nephrology 20050901
The effects of quinapril and atorvastatin on artery structure and function in adult spontaneously hypertensive rats. European journal of pharmacology 20050822
The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease. Thrombosis and haemostasis 20050701
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High glucose levels abolish antiatherosclerotic benefits of ACE inhibition in alloxan-induced diabetes in rabbits. Journal of cardiovascular pharmacology 20050401
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The non-thiol angiotensin-converting enzyme inhibitor quinapril suppresses inflammatory arthritis. Rheumatology (Oxford, England) 20050101
ACE inhibitors improve nephrin expression in Zucker rats with glomerulosclerosis. Kidney international. Supplement 20050101
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A prospective open-label randomised trial of quinapril and/or amlodipine in progressive non-diabetic renal failure. Nephron. Clinical practice 20050101
Long-term blood pressure control prevents oxidative renal injury. Antioxidants & redox signaling 20050101
The influence of pharmaceutical excipients on quinapril hydrochloride stability. Acta poloniae pharmaceutica 20050101
[Combined therapy with quinapril, an ACE inhibitor, and valsartan, a type 1 angiotensin II receptors blocker, for moderate chronic cardiac failure may raise the degree of neurohormonal block and improve 24-h heart rate variability compared to the effect of monotherapy (data from the trial SADKO-CHF)]. Terapevticheskii arkhiv 20050101
Neurohormonal and circulatory effects of short-term treatment with enalapril and quinapril in dogs with asymptomatic mitral regurgitation. Journal of veterinary internal medicine 20050101
[Angiotensin converting enzyme inhibitors in patients with ischemic heart disease: in all cases or in high risk of complications]. Kardiologiia 20050101
Quinapril effects on resistance artery structure and function in hypertension. Naunyn-Schmiedeberg's archives of pharmacology 20041201
Class effect of angiotensin-converting enzyme inhibitors on prevention of myocardial infarction. The American journal of cardiology 20041101
The changing face of childhood nephrotic syndrome. Kidney international 20040901
Comparison of effects of quinapril versus enalapril on vasoactive substances following acute myocardial infarction. The American journal of cardiology 20040901
Vascular effects of quinapril completely depend on ACE insertion/deletion polymorphism. Journal of the renin-angiotensin-aldosterone system : JRAAS 20040901
Effect of quinapril on the attenuated heart rate recovery of type 2 diabetic subjects without known coronary artery disease. Clinical cardiology 20040801
Gender differences in ANG II levels and action on multiple K+ current modulation pathways in diabetic rats. American journal of physiology. Heart and circulatory physiology 20040701
Comparative effects of quinapril with enalapril in rats with heart failure. Pharmacology 20040701
Quinapril, an ACE inhibitor, reduces markers of oxidative stress in the metabolic syndrome. Diabetes care 20040701
Variability in response to antihypertensive drug treatment. Hypertension (Dallas, Tex. : 1979) 20040601
Determinants of blood pressure response to quinapril in black and white hypertensive patients: the Quinapril Titration Interval Management Evaluation trial. Hypertension (Dallas, Tex. : 1979) 20040601
Exploring the effects of ACE inhibitor tissue penetration on vascular inflammation following acute myocardial infarction. Coronary artery disease 20040601
Systemic photosensitivity to quinapril. Journal of the European Academy of Dermatology and Venereology : JEADV 20040501
Effect of amlodipine on vascular responses after coronary stenting compared with an angiotensin-converting enzyme inhibitor. Circulation journal : official journal of the Japanese Circulation Society 20040401
Long-term effects of quinapril with high affinity for tissue angiotensin-converting enzyme after coronary intervention in Japanese. American heart journal 20040401
Gender-dependent attenuation of cardiac potassium currents in type 2 diabetic db/db mice. The Journal of physiology 20040301
Tight blood pressure control decreases apoptosis during renal damage. Kidney international 20040301
Questioning a class effect: does ACE inhibitor tissue penetration influence the degree of fibrinolytic balance alteration following an acute myocardial infarction? Journal of clinical pharmacology 20040201
If it is not cough, it must be dysgeusia: differing adverse effects of angiotensin-converting enzyme inhibitors in the same individual. Journal of the American Medical Directors Association 20040101
Angiotension converting enzyme inhibition and calcium channel blockage improves cyclosporine induced glucose intolerance in rats. Transplantation proceedings 20040101
Systemic contact dermatitis due to captopril without cross-sensitivity to fosinopril, quinapril and benazepril. Acta dermato-venereologica 20040101
Application of derivative spectrophotometry for simultaneous determination of quinapril and hydrochlorothiazide in the combination tablets. Journal of AOAC International 20040101
[Thromboembolic chronic pulmonary hypertension--a fake primary pulmonary hypertension--case report]. Pneumologia (Bucharest, Romania) 20040101
Effects of angiotensin-converting enzyme inhibition on transient ischemia: the Quinapril Anti-Ischemia and Symptoms of Angina Reduction (QUASAR) trial. Journal of the American College of Cardiology 20031217
Synergistic effect of angiotensin-converting enzyme (ACE) and 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) reductase inhibition on inflammatory markers in atherosclerotic rabbits. Clinical science (London, England : 1979) 20031201
Effectiveness of angiotensin-converting enzyme inhibitor or angiotensin II receptor blocker on atrial natriuretic peptide. Circulation journal : official journal of the Japanese Circulation Society 20031201
Angiotensin II increases connective tissue growth factor in the kidney. The American journal of pathology 20031101
Effects of the ACE inhibitor quinapril on echocardiographic variables in horses with mitral valve insufficiency. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20031101
Anastrozole and quinapril can be safely coadministered to elderly women with breast cancer and hypertension: a pharmacokinetic study. Annals of oncology : official journal of the European Society for Medical Oncology 20031001
Long term angiotensin converting enzyme-inhibition in patients after coronary artery bypass grafting reduces levels of soluble intercellular cell adhesion molecule-1. European journal of vascular and endovascular surgery : the official journal of the European Society for Vascular Surgery 20031001
Hydrochlorothiazide abolishes the anti-atherosclerotic effect of quinapril. Clinical and experimental pharmacology & physiology 20031001
Angiotensin II receptor blocker valsartan suppresses reactive oxygen species generation in leukocytes, nuclear factor-kappa B, in mononuclear cells of normal subjects: evidence of an antiinflammatory action. The Journal of clinical endocrinology and metabolism 20030901
Secretory dysfunction of vascular endothelium limits the effect of angiotensin converting enzyme inhibitor quinapril on aggregation of erythrocytes in experimental hypertension. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20030901
Quinapril inhibits progression of heart failure and fibrosis in rats with dilated cardiomyopathy after myocarditis. Molecular and cellular biochemistry 20030901
Interleukin-6 and tumor necrosis factor alpha in relation to myocardial infarct size and collagen formation. Journal of cardiac failure 20030801
Sex differences in the modulation of K+ currents in diabetic rat cardiac myocytes. The Journal of physiology 20030715
Angiotensin converting enzyme inhibitor induced cough: experience in Siriraj Hospital. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20030701
Mechanisms of angiotensin-converting enzyme inhibitor induced thrombolysis in Wistar rats. Thrombosis research 20030615
Effect of amlodipine, quinapril, and losartan on pulse wave velocity and plasma collagen markers in patients with mild-to-moderate arterial hypertension. American journal of hypertension 20030601
Effect of quinapril, quinapril-hydrochlorothiazide, and enalapril on the bone mass of hypertensive subjects: relationship with angiotensin converting enzyme polymorphisms. American journal of hypertension 20030601
Elimination kinetics of quinaprilat and perindoprilat in hypertensive patients with renal failure on haemodialysis. Biological & pharmaceutical bulletin 20030601
Usefulness of quinapril and irbesartan to improve the anti-inflammatory response of atorvastatin and aspirin in patients with coronary heart disease. The American journal of cardiology 20030501
Square wave voltammetric determination of the angiotensin-converting enzyme inhibitors cilazapril, quinapril and ramipril in pharmaceutical formulations. Farmaco (Societa chimica italiana : 1989) 20030501
Protective effects of quinaprilat and trandolaprilat, active metabolites of quinapril and trandolapril, on hemolysis induced by lysophosphatidylcholine in human erythrocytes. Biological & pharmaceutical bulletin 20030501
Long-term follow-up of ACE-inhibitor versus beta-blocker treatment and their effects on blood pressure and kidney function in renal transplant recipients. Transplant international : official journal of the European Society for Organ Transplantation 20030501
Genotype-dependent increase in plasma ACE activity after CABG is prevented by ACE inhibition. The Canadian journal of cardiology 20030501
Role of PKC in autocrine regulation of rat ventricular K+ currents by angiotensin and endothelin. American journal of physiology. Heart and circulatory physiology 20030401
Kinetics of degradation of quinapril hydrochloride in tablets. Die Pharmazie 20030401
Improvement of endothelial dysfunction by angiotensin II blockade accompanied by induction of vascular hepatocyte growth factor system in diabetic spontaneously hypertensive rats. Heart and vessels 20030301
The effect of quinapril on functional status of elderly patients with diastolic heart failure. Cardiovascular drugs and therapy 20030301
Effect of combination therapy with dipyridamole and quinapril in diabetic nephropathy. Diabetes research and clinical practice 20030201
Pharmacokinetics of quinapril in children: assessment during substitution for chronic angiotensin-converting enzyme inhibitor treatment. Journal of clinical pharmacology 20030201
Effects of angiotensin-converting enzyme inhibition and calcium channel blockade on cardiac apoptosis in rats with 2K1C (two-kidney/one-clip) renovascular hypertension. Clinical science (London, England : 1979) 20030101
Moexipril and quinapril inhibition of tissue angiotensin-converting enzyme activity in the rat: evidence for direct effects in heart, lung and kidney and stimulation of prostacyclin generation. Journal of endocrinological investigation 20030101
[Angiotensin-converting enzyme, quinapril, in treating chronic cardiac failure]. Terapevticheskii arkhiv 20030101
Comparative effects of angiotensin II receptor blockade (candesartan) with angiotensin-converting enzyme inhibitor (quinapril) in rats with dilated cardiomyopathy. Journal of cardiovascular pharmacology 20030101
[Russian study of efficacy and safety of an angiotensin converting enzyme inhibitor quinapril in patients with hypertension]. Kardiologiia 20030101
Comparative effect of clinidipine and quinapril on left ventricular mass in mild essential hypertension. Drugs under experimental and clinical research 20030101
The stability of quinapril hydrochloride--a mixture of amorphous and crystalline forms (QHCl-AC)--in solid phase. Acta poloniae pharmaceutica 20030101
Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney. Kidney international. Supplement 20021201
Effects of antihypertensive drugs in experimental type 2 diabetes-related nephropathy. Kidney international. Supplement 20021201
The ACE inhibitor, quinapril, ameliorates peritoneal fibrosis in an encapsulating peritoneal sclerosis model in mice. Pharmacological research 20021201
Time-effect profile of antihypertensive agents assessed with trough/peak ratio, smoothness index and dose omission: an ambulatory blood pressure monitoring study with trandolapril vs. quinapril. Fundamental & clinical pharmacology 20021201
Effect of losartan on nocturnal blood pressure in patients with stroke: comparison with angiotensin converting enzyme inhibitor. American journal of hypertension 20021101
Ischemia Management with Accupril post bypass Graft via Inhibition of angiotensin coNverting enzyme (IMAGINE): a multicentre randomized trial - design and rationale. The Canadian journal of cardiology 20021101
Captopril and quinapril reduce reactive oxygen species. European journal of clinical investigation 20021001
Prevention of vascular damage in scleroderma with angiotensin-converting enzyme (ACE) inhibition. Rheumatology (Oxford, England) 20020901
Enalapril and quinapril improve endothelial vasodilator function and aortic eNOS gene expression in L-NAME-treated rats. European journal of pharmacology 20020816
Circulating intercellular cell adhesion molecule-1, endothelin-1 and von Willebrand factor-markers of endothelial dysfunction in uncomplicated essential hypertension: the effect of treatment with ACE inhibitors. Journal of human hypertension 20020801
AT1 receptor blockade increases cardiac bradykinin via neutral endopeptidase after induction of myocardial infarction in rats. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20020801
Influence of antihypertensive drugs on renal microcirculation and renal hemodynamics in cyclosporine A-treated rats. Transplantation proceedings 20020801
Using ACE inhibitors appropriately. American family physician 20020801
[Is mild essential hypertension without obvious organ complications and risk factors associated with increased levels of circulating markers of endothelial dysfunction? Effect of ACE inhibitor therapy]. Vnitrni lekarstvi 20020801
Subacute and chronic effects of quinapril on cardiac cytokine expression, remodeling, and function after myocardial infarction in the rat. Journal of cardiovascular pharmacology 20020601
The mechanism of the angiotensin-converting enzyme inhibitor quinapril is not related to bradykinin level in heart tissue. Peptides 20020601
Pretreatment with angiotensin-converting enzyme inhibitors attenuates ischemia-reperfusion injury. The Annals of thoracic surgery 20020501
Inhibition of left ventricular fibrosis by tranilast in rats with renovascular hypertension. Journal of hypertension 20020401
Quinapril prevents restenosis after coronary stenting in patients with angiotensin-converting enzyme D allele. Circulation journal : official journal of the Japanese Circulation Society 20020401
Effects of chronic administration of sarpogrelate on systolic blood pressure of spontaneously hypertensive rats: comparison with quinapril. Pharmacology 20020201
Influence of angiotensinogen M253T gene polymorphism and an angiotensin converting enzyme inhibitor on restenosis after percutaneous coronary intervention. Atherosclerosis 20020201
Simultaneous determination of quinapril and its active metabolite quinaprilat in human plasma using high-performance liquid chromatography with ultraviolet detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020125
The solid-state stability of amorphous quinapril in the presence of beta-cyclodextrins. Journal of pharmaceutical sciences 20020101
Oxidative stress and nitric oxide synthase in rat diabetic nephropathy: effects of ACEI and ARB. Kidney international 20020101
Effects of losartan and its combination with quinapril on the cardiac sympathetic nervous system and neurohormonal status in essential hypertension. Journal of hypertension 20020101
Quinapril: a further update of its pharmacology and therapeutic use in cardiovascular disorders. Drugs 20020101
Determination of the angiotensin-converting enzyme inhibitor quinapril and its metabolite quinaprilat in pharmaceuticals and urine by capillary zone electrophoresis and solid-phase extraction. Electrophoresis 20020101
Effects of a citrate buffer system on the solid-state chemical stability of lyophilized quinapril preparations. Pharmaceutical research 20020101
Ventricular remodeling after myocardial infarction and effects of ACE inhibition on hemodynamics and scar formation in SHR. Cardiovascular pathology : the official journal of the Society for Cardiovascular Pathology 20020101
Quinapril treatment restores the vasodilator action of insulin in fructose-hypertensive rats. Clinical and experimental pharmacology & physiology 20020101
Effects of quinapril on myocardial function, ventricular remodeling and cardiac cytokine expression in congestive heart failure in the rat. Cardiovascular drugs and therapy 20020101
Angiotensin II as an inflammatory mediator: evolving concepts in the role of the renin angiotensin system in the failing heart. Cardiovascular drugs and therapy 20020101
Effects of a long-term pharmacological interruption of the renin-angiotensin system on the fibrinolytic system in essential hypertension. Pathophysiology of haemostasis and thrombosis 20020101
[Some new data concerning effectiveness of amlodipine, atorvastatine and quinaprile for heart diseases]. Kardiologiia 20020101
Isoproterenol-induced cardiac hypertrophy: role of circulatory versus cardiac renin-angiotensin system. American journal of physiology. Heart and circulatory physiology 20011201
Quinapril ischemic event trial. The American journal of cardiology 20011201
Beneficial effect of quinapril in patients with angiotensin-converting enzyme D allele after coronary stenting. Atherosclerosis 20011201
Inhibition of the formation or action of angiotensin II reverses attenuated K+ currents in type 1 and type 2 diabetes. The Journal of physiology 20011115
Modulation of incipient glomerular lesions in experimental diabetic nephropathy by hypotensive and subhypotensive dosages of an ACE inhibitor. Diabetes 20011101
Potentiation of bradykinin-induced tissue plasminogen activator release by angiotensin-converting enzyme inhibition. Journal of the American College of Cardiology 20011101
Renal tubulointerstitial damage caused by persistent proteinuria is attenuated in AT1-deficient mice: role of endothelin-1. The American journal of pathology 20011101
Myocardial contractile responsiveness to endothelin-1 in the post-infarction rat model of heart failure: effects of chronic quinapril. Journal of molecular and cellular cardiology 20011101
[Quality of life and psychosocial factors during treatment with antihypertensive drugs. A comparison of captopril and quinapril in geriatric patients]. Herz 20011101
Vitamin C and quinapril abrogate LVH and endothelial dysfunction in aortic-banded guinea pigs. American journal of physiology. Heart and circulatory physiology 20011001
Aminophylline reversal of antihypertensive agent toxicity. Veterinary and human toxicology 20011001
Inhibition of progression of heart failure and expression of TGF-beta 1 mRNA in rats with heart failure by the ACE inhibitor quinapril. Journal of cardiovascular pharmacology 20011001
Restenotic process and DD genotype after angiotensin-converting enzyme inhibitor treatment. Lancet (London, England) 20010901
Hyperkalemia, renal failure, and converting-enzyme inhibition: an overrated connection. Hypertension (Dallas, Tex. : 1979) 20010901
[Effects of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): double-blind randomized trial]. Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology 20010901
[Hypertensive patients with signs of coronary heart disease. An ACE inhibitor improves endothelial function]. MMW Fortschritte der Medizin 20010823
A single (investigator)-blind randomised control trial comparing the effects of quinapril and nifedipine on platelet function in patients with mild to moderate hypertension. Platelets 20010801
Angiotensin converting enzyme inhibitors and restenosis: let's stop teasing ourselves. Cardiovascular drugs and therapy 20010701
Quinapril with high affinity to tissue angiotensin-converting enzyme reduces restenosis after percutaneous transcatheter coronary intervention. Cardiovascular drugs and therapy 20010701
Effect of quinapril versus nitrendipine on endothelial dysfunction in patients with systemic hypertension. The American journal of cardiology 20010615
The QUinapril Ischemic Event Trial (QUIET): evaluation of chronic ACE inhibitor therapy in patients with ischemic heart disease and preserved left ventricular function. The American journal of cardiology 20010501
Quinapril and its metabolite quinaprilat in human milk. British journal of clinical pharmacology 20010501
Effect of ACE inhibitors on angiographic restenosis after coronary stenting (PARIS): a randomised, double-blind, placebo-controlled trial. Lancet (London, England) 20010428
ACE inhibitors for hypertension--again. The New Zealand medical journal 20010427
Solid-phase extraction and high-performance liquid chromatography applied to the determination of quinapril and its metabolite quinaprilat in urine. Journal of chromatographic science 20010401
Effects of quinapril on expression of eNOS, ACE, and AT1 receptor in deoxycorticosterone acetate-salt hypertensive rats. American journal of hypertension 20010401
Comparative effects of ACE inhibitors and an angiotensin receptor blocker on atherosclerosis and vascular function. Journal of cardiovascular pharmacology and therapeutics 20010401
Ace-inhibition with quinapril modulates the nitric oxide pathway in normotensive rats. Journal of molecular and cellular cardiology 20010301
Effects of quinapril on clinical outcome after coronary artery bypass grafting (The QUO VADIS Study). QUinapril on Vascular Ace and Determinants of Ischemia. The American journal of cardiology 20010301
What are 'tissue ACE inhibitors,' and should they be used instead of other ACE inhibitors? Cleveland Clinic journal of medicine 20010301
The influence of angiotensin-converting enzyme inhibitors on the aorta elastin metabolism in diet-induced hypercholesterolaemia in rabbits. Journal of the renin-angiotensin-aldosterone system : JRAAS 20010301
ACE inhibitors for hypertension. The New Zealand medical journal 20010223
Effect of quinapril on intimal hyperplasia after coronary stenting as assessed by intravascular ultrasound. The American journal of cardiology 20010215
Effect of short-term treatment with bumetanide, quinapril and low-sodium diet on dogs with moderate congestive heart failure. Australian veterinary journal 20010201
ACE inhibitors for hypertension. The New Zealand medical journal 20010126
Effects of dehydroepiandrosterone and quinapril on nephropathy in obese Zucker rats. Kidney international 20010101
Quinapril treatment enhances vascular sensitivity to insulin. Journal of hypertension 20010101
Significance of endothelial prostacyclin and nitric oxide in peripheral and pulmonary circulation. Medical science monitor : international medical journal of experimental and clinical research 20010101
Chronic effects of ACE-inhibition (quinapril) and angiotensin-II-type-1 receptor blockade (losartan) on atrial natriuretic peptide in brain nuclei of rats with experimental myocardial infarction. Basic research in cardiology 20010101
Preservation of cardiac function and energy reserve by the angiotensin-converting enzyme inhibitor quinapril during postmyocardial infarction remodeling in the rat. Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance 20010101
[Does quinapril improve coronary vasoconstriction in vasospastic angina?]. Journal of cardiology 20001201
Acute onset of auditory hallucinations after initiation of celecoxib therapy. The American journal of psychiatry 20000601
Ventricular adrenomedullin levels correlate with the extent of cardiac hypertrophy in rats. Hypertension (Dallas, Tex. : 1979) 19990501
[Conversion from oral ACE inhibitor to intravenous quinaprilat administration in mild to moderate essential hypertension]. Medizinische Klinik (Munich, Germany : 1983) 19981215
Dissociation of blood pressure reduction from end-organ damage in TGR(mREN2)27 transgenic hypertensive rats. Journal of hypertension 19981201
Serotonin syndrome following the administration of tramadol with paroxetine. International journal of geriatric psychiatry 19980501
Interaction of the renin-angiotensin system and the endothelin system in cardiac hypertrophy. Journal of cardiovascular pharmacology 19980101
Arterial function in mineralocorticoid-NaCl hypertension: influence of angiotensin-converting enzyme inhibition. Pharmacology & toxicology 19971001
Reduced proteinuria after cessation of long-acting, osmotic release nifedipine GITS in diabetic nephropathy. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 19970801
Relation of functional improvement in congestive heart failure after quinapril therapy to peripheral limitation. The American journal of cardiology 19970301
Quinapril ACE-inhibition effects on adrenergic parameters in moderate essential hypertension. Kidney international. Supplement 19960601
Early genes induction in spontaneously hypertensive rats left ventricle with angiotensin-converting enzyme inhibitors but not hydralazine. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.) 19951201
Plasma digoxin immunoreactivity and arterial potassium relaxation after quinapril therapy in hypertensive rats. The Journal of pharmacology and experimental therapeutics 19951101
Controlled multicenter study with quinapril, hydrochlorothiazide, and combination in patients with moderate to severe hypertension. Journal of cardiovascular pharmacology 19950701
Comparative trial of quinapril versus captopril in mild to moderate congestive heart failure. Quinapril/Captopril Congestive Heart Failure Study Group. Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19940701
Effects of ANG-converting enzyme and alpha 1-adrenoceptor inhibition on intrarenal hemodynamics in SHR. The American journal of physiology 19940501
Quinapril and hydrochlorothiazide combination for control of hypertension: assessment by factorial design. Quinapril Investigator Group. Journal of human hypertension 19940301
Clinical consequences of angiotensin-converting enzyme inhibitor withdrawal in chronic heart failure: a double-blind, placebo-controlled study of quinapril. The Quinapril Heart Failure Trial Investigators. Journal of the American College of Cardiology 19931115
Quinapril prevents stroke both during and after the treatment period in stroke-prone spontaneously hypertensive rats. American journal of hypertension 19931101
[Antihypertensive activity of the angiotensin converting enzyme inhibitor quinapril HCl: (S)-2-[(S)-N-[(S)-1-ethoxycarbonyl-3-phenylpropyl) alanyl]-1,2,3,4- tetrahydro-3-isoquinolinecarboxylic acid monohydrochloride in various hypertensive animal models]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 19930701
Comparison of quinapril and atenolol as single drugs or in combination with hydrochlorothiazide in moderate to severe hypertensives, using automated ambulatory monitoring. British journal of clinical pharmacology 19930201
Time course of stimulation of renal renin messenger RNA by furosemide. Hypertension (Dallas, Tex. : 1979) 19930101
Angio-oedema in relation to treatment with angiotensin converting enzyme inhibitors. BMJ (Clinical research ed.) 19920411
Hemodynamic and morphological effects of quinapril during genetic hypertension development. Journal of cardiovascular pharmacology 19911001
Molecular and crystal structures of MDL27,467A hydrochloride and quinapril hydrochloride, two ester derivatives of potent angiotensin converting enzyme inhibitors. Journal of medicinal chemistry 19910201
Digoxin, converting-enzyme inhibition (quinapril), and the combination in patients with congestive heart failure functional class II and sinus rhythm. Journal of cardiovascular pharmacology 19900701
The treatment of moderate to severe hypertension with ACE inhibitors. Journal of cardiovascular pharmacology 19900101
The safety and tolerability of quinapril. Journal of cardiovascular pharmacology 19900101
[A comparative study of the effects of lisinopril and quinapril administered once a day in essential hypertension]. Minerva medica 19900101
Quinapril reduces arterial blood pressure and improves metabolic control in elderly hypertensive diabetic patients. Diabete & metabolisme 19900101
CI-906 and CI-907: new orally active nonsulfhydryl angiotensin-converting enzyme inhibitors. Federation proceedings 19840401
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