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Astragaloside A

CAS No.:
83207-58-3
Catalog Number:
AG019FX4
Molecular Formula:
C41H68O14
Molecular Weight:
784.9702
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
95%
In Stock USA
United States
$116
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Product Description
Catalog Number:
AG019FX4
Chemical Name:
Astragaloside A
CAS Number:
83207-58-3
Molecular Formula:
C41H68O14
Molecular Weight:
784.9702
MDL Number:
MFCD16036240
IUPAC Name:
(2R,3R,4S,5S,6R)-2-[[(1S,3R,6S,8R,9S,11S,12S,14S,15R,16R)-14-hydroxy-15-[(2S,5R)-5-(2-hydroxypropan-2-yl)-2-methyloxolan-2-yl]-7,7,12,16-tetramethyl-6-[(2S,3R,4S,5R)-3,4,5-trihydroxyoxan-2-yl]oxy-9-pentacyclo[9.7.0.01,3.03,8.012,16]octadecanyl]oxy]-6-(hydroxymethyl)oxane-3,4,5-triol
InChI:
InChI=1S/C41H68O14/c1-35(2)24(54-33-29(48)26(45)20(44)17-51-33)9-11-41-18-40(41)13-12-37(5)31(39(7)10-8-25(55-39)36(3,4)50)19(43)15-38(37,6)23(40)14-21(32(35)41)52-34-30(49)28(47)27(46)22(16-42)53-34/h19-34,42-50H,8-18H2,1-7H3/t19-,20+,21-,22+,23-,24-,25+,26-,27+,28-,29+,30+,31-,32-,33-,34+,37+,38-,39-,40-,41+/m0/s1
InChI Key:
QMNWISYXSJWHRY-AUJDEUPOSA-N
SMILES:
OC[C@H]1O[C@@H](O[C@H]2C[C@@H]3[C@]4([C@@]5([C@@H]2C(C)(C)[C@H](CC5)O[C@@H]2OC[C@H]([C@@H]([C@H]2O)O)O)C4)CC[C@]2([C@@]3(C)C[C@@H]([C@@H]2[C@]2(C)CC[C@@H](O2)C(O)(C)C)O)C)[C@@H]([C@H]([C@@H]1O)O)O
UNII:
3A592W8XKE
Properties
Complexity:
1460  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
21  
Defined Bond Stereocenter Count:
0
Exact Mass:
784.461g/mol
Formal Charge:
0
Heavy Atom Count:
55  
Hydrogen Bond Acceptor Count:
14  
Hydrogen Bond Donor Count:
9  
Isotope Atom Count:
0
Molecular Weight:
784.981g/mol
Monoisotopic Mass:
784.461g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
228A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.3  
Literature
Title Journal
Astragaloside IV ameliorates acute pancreatitis in rats by inhibiting the activation of nuclear factor-κB. International journal of molecular medicine 20150301
Effects of Astragaloside IV combined with the active components of Panax notoginseng on oxidative stress injury and nuclear factor-erythroid 2-related factor 2/heme oxygenase-1 signaling pathway after cerebral ischemia-reperfusion in mice. Pharmacognosy magazine 20140101
Astragaloside IV attenuates Toll-like receptor 4 expression via NF-κB pathway under high glucose condition in mesenchymal stem cells. European journal of pharmacology 20121205
Chemical and biological assessment of Angelica herbal decoction: comparison of different preparations during historical applications. Phytomedicine : international journal of phytotherapy and phytopharmacology 20120815
Effects of astragaloside IV on eosinophil activation induced by house dust mite allergen. Molecular medicine reports 20120701
Astragaloside IV attenuates complement membranous attack complex induced podocyte injury through the MAPK pathway. Phytotherapy research : PTR 20120601
Astragaloside IV inhibits apoptotic cell death in the guinea pig cochlea exposed to impulse noise. Acta oto-laryngologica 20120501
Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production. Molecular and cellular biochemistry 20120501
Determination of astragalin and astragaloside content in Radix Astragali using high-performance liquid chromatography coupled with pulsed amperometric detection. Journal of chromatography. A 20120406
Synergistic protective effect of astragaloside IV-tetramethylpyrazine against cerebral ischemic-reperfusion injury induced by transient focal ischemia. Journal of ethnopharmacology 20120306
Topical astragaloside IV-releasing hydrogel improves healing of skin wounds in vivo. Biological & pharmaceutical bulletin 20120101
[Inhibitory effects of astragaloside IV on cytochrome P450 enzyme of rat liver microsomes]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20120101
Astragaloside IV, a novel antioxidant, prevents glucose-induced podocyte apoptosis in vitro and in vivo. PloS one 20120101
Astragaloside IV alleviates hypoxia/reoxygenation-induced neonatal rat cardiomyocyte injury via the protein kinase a pathway. Pharmacology 20120101
Therapeutic effects of astragaloside IV on myocardial injuries: multi-target identification and network analysis. PloS one 20120101
Ultrasonic-assisted liquid-liquid extraction and HILIC-ELSD analysis of ginsenoside Rb(1), astragaloside IV and dulcitol in sugar-free 'Fufangfufangteng Heji'. Journal of pharmaceutical and biomedical analysis 20111205
[Immunoregulatory mechanisms of an optimal Chinese herbal monomer compound in mice with allergic rhinitis]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20111201
Astragaloside IV regulates expression of ATP-sensitive potassium channel subunits after ischemia-reperfusion in rat ventricular cardiomyocytes. Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 20111201
[Effects of astragaloside IV on the expressions of transforming growth factor-β1 and thymic stromal lymphopoietin in a murine model of asthma]. Zhonghua yi xue za zhi 20111129
Astragaloside IV attenuates impulse noise-induced trauma in guinea pig. Acta oto-laryngologica 20110801
Astragaloside IV stimulates angiogenesis and increases hypoxia-inducible factor-1α accumulation via phosphatidylinositol 3-kinase/Akt pathway. The Journal of pharmacology and experimental therapeutics 20110801
Effect comparison of different formulation of Dang-Gui-Bu-Xu-Tang on myelosuppression mouse. Asian Pacific journal of tropical medicine 20110701
[Determination of astragaloside IV of eight area in Astragali Radix is by HPLC-ELSD internal standard method]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110701
Chuanxiongzine-astragaloside IV decreases IL-1β and Caspase-3 gene expressions in rat brain damaged by cerebral ischemia/reperfusion: a study of real-time quantitative PCR assay. Sheng li xue bao : [Acta physiologica Sinica] 20110625
Astragaloside IV protects against ischemia reperfusion in a murine model of orthotopic liver transplantation. Transplantation proceedings 20110601
[Effect of astragaloside against the oxidative damage on endothelial cells]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20110601
Astragaloside IV improves metabolic syndrome and endothelium dysfunction in fructose-fed rats. Molecules (Basel, Switzerland) 20110510
The known immunologically active components of Astragalus account for only a small proportion of the immunological adjuvant activity when combined with conjugate vaccines. Planta medica 20110501
Astragaloside IV synergizes with ferulic acid to inhibit renal tubulointerstitial fibrosis in rats with obstructive nephropathy. British journal of pharmacology 20110401
[Simultaneous determination of five glycosides in Aidi injection by RP-HPLC-ELSD]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20110301
The osteogenetic effect of astragaloside IV with centrifugating pressure on the OCT-1 cells. Die Pharmazie 20110101
[Protective effect of astragalosides on anoxia/reoxygenation injury of hippocampal neuron]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20101101
Cigarette smoke enhances {beta}-defensin 2 expression in rat airways via nuclear factor-{kappa}B activation. The European respiratory journal 20100901
[Morphological investigation of the protective effect of astragaloside preconditioning against ischemia-reperfusion lung injury in rats]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100801
Effects of cycloartane saponins from hairy roots of Astragalus membranaceus Bge., on human tumor cell targets. Fitoterapia 20100701
Ligustilide suppresses the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composed of radix astragali and radix angelica sinensis. Planta medica 20100301
[Study on preventative and curative effects of astragaloside (AST) on mice memory impairment and expression of amyloid precursor protein and beta secretase mRNA induced by dexamethasone]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20100301
Effect of astragaloside IV on hepatic glucose-regulating enzymes in diabetic mice induced by a high-fat diet and streptozotocin. Phytotherapy research : PTR 20100201
Astragaloside IV improves homocysteine-induced acute phase endothelial dysfunction via antioxidation. Biological & pharmaceutical bulletin 20100101
Protective effect of astragaloside on focal cerebral ischemia/reperfusion injury in rats. The American journal of Chinese medicine 20100101
[Effects of Astragalus injection and its ingredients on proliferation and Akt phosphorylation of breast cancer cell lines]. Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine 20091201
[Inhibitory effect on activated renin-angiotensin system by astragaloside IV in rats with pressure-overload induced cardiac hypertrophy]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20091201
Neuroprotective effects of Astragaloside IV in 6-hydroxydopamine-treated primary nigral cell culture. Neurochemistry international 20091101
Astragalosides isolated from the root of astragalus radix inhibit the formation of advanced glycation end products. Journal of agricultural and food chemistry 20090909
Protective effects of astragaloside IV on porcine-serum-induced hepatic fibrosis in rats and in vitro effects on hepatic stellate cells. Journal of ethnopharmacology 20090421
Astragaloside IV attenuates hypoxia-induced cardiomyocyte damage in rats by upregulating superoxide dismutase-1 levels. Clinical and experimental pharmacology & physiology 20090401
[Study on the determination method of the astragaloside IV in health food]. Wei sheng yan jiu = Journal of hygiene research 20090301
Anti-hepatitis B virus activities of astragaloside IV isolated from radix Astragali. Biological & pharmaceutical bulletin 20090101
Astragaloside IV improves high glucose-induced podocyte adhesion dysfunction via alpha3beta1 integrin upregulation and integrin-linked kinase inhibition. Biochemical pharmacology 20080915
Astragaloside IV inhibits proliferation and promotes apoptosis in rat vascular smooth muscle cells under high glucose concentration in vitro. Planta medica 20080801
Inhibitory effects of astragaloside IV on ovalbumin-induced chronic experimental asthma. Canadian journal of physiology and pharmacology 20080701
[Study on absorption kinetics of astragaloside IV in rats intestines]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20080701
Simultaneous determination of calycosin-7-O-beta-D-glucoside, ononin, astragaloside IV, astragaloside I and ferulic acid in rat plasma after oral administration of Danggui Buxue Tang extract for their pharmacokinetic studies by liquid chromatography-mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080401
Aqueous extract of Astragali Radix induces human natriuresis through enhancement of renal response to atrial natriuretic peptide. Journal of ethnopharmacology 20080328
Astragaloside IV inhibits spontaneous synaptic transmission and synchronized Ca2+ oscillations on hippocampal neurons. Acta pharmacologica Sinica 20080101
Astragaloside IV improved intracellular calcium handling in hypoxia-reoxygenated cardiomyocytes via the sarcoplasmic reticulum Ca-ATPase. Pharmacology 20080101
[Effects of AST and ASI on metabolism of free radical in senescent rats treated by HC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20071201
[Investigation on one-pot extraction of active ingredient group from Yupingfeng powder by HPLC]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20070901
Modification of alterations in cardiac function and sarcoplasmic reticulum by astragaloside IV in myocardial injury in vivo. European journal of pharmacology 20070730
[Protective effects of Astragaloside and Quercetin on rat myocardial cells after hypoxia]. Zhonghua shao shang za zhi = Zhonghua shaoshang zazhi = Chinese journal of burns 20070601
Mechanisms underlying vasorelaxant action of astragaloside IV in isolated rat aortic rings. Clinical and experimental pharmacology & physiology 20070101
[Anti-apoptosis effect of astragaloside on adriamycin induced rat's cardiotoxicity]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20061101
[The effect of icariin and astragalosid I on the proliferation and differentiation of bone marrow stromal cells]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20061001
Astragaloside IV improved barrier dysfunction induced by acute high glucose in human umbilical vein endothelial cells. Life sciences 20060815
Simultaneous analysis of seven astragalosides in Radix Astragali and related preparations by liquid chromatography coupled with electrospray ionization time-of-flight mass spectrometry. Journal of separation science 20060801
[Determination of three constituents in Radix Astragali by HPLC-MS]. Yao xue xue bao = Acta pharmaceutica Sinica 20060801
Astragaloside IV dilates aortic vessels from normal and spontaneously hypertensive rats through endothelium-dependent and endothelium-independent ways. Planta medica 20060601
Inhibitory effects of astragaloside IV on diabetic peripheral neuropathy in rats. Canadian journal of physiology and pharmacology 20060601
[Study on fingerprints of astragalosides injection by HPLC-ELSD]. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 20060501
Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties. Journal of agricultural and food chemistry 20060405
Sensitive and selective liquid chromatography-electrospray ionisation-mass spectrometry analysis of astragaloside-IV in rat plasma. Journal of pharmaceutical and biomedical analysis 20060224
Effects of astragaloside IV on pathogenesis of metabolic syndrome in vitro. Acta pharmacologica Sinica 20060201
Astragaloside IV from Astragalus membranaceus shows cardioprotection during myocardial ischemia in vivo and in vitro. Planta medica 20060101
Absorption enhancement study of astragaloside IV based on its transport mechanism in caco-2 cells. European journal of drug metabolism and pharmacokinetics 20060101
Quantitation of astragaloside IV in rat plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925
Gastroprotective effect of Astragaloside IV: role of prostaglandins, sulfhydryls and nitric oxide. The Journal of pharmacy and pharmacology 20050801
[Study on new extraction technology of astragaloside IV]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20050801
Separation of compounds interacting with liposome membrane in combined prescription of traditional Chinese medicines with immobilized liposome chromatography. Journal of pharmaceutical and biomedical analysis 20050615
Effect of astragalosides on intracellular calcium overload in cultured cardiac myocytes of neonatal rats. The American journal of Chinese medicine 20050101
[Studies on chromatography fingerprint of huangqi by HPLC]. Zhong yao cai = Zhongyaocai = Journal of Chinese medicinal materials 20041101
[Effect of astrgaloside IV on the long-term consequences of renal ischemia-reperfusion injury in rat]. Zhonghua yi xue za zhi 20040902
Astragaloside IV protects against ischemic brain injury in a murine model of transient focal ischemia. Neuroscience letters 20040617
Antiinflammatory activity of astragaloside IV is mediated by inhibition of NF-kappaB activation and adhesion molecule expression. Thrombosis and haemostasis 20031101
Determination of serum astragaloside in rats fed with Buyanghuanwu dicoction using solidphase extraction, chemical derivatization and fluorospectrophotometry. Di 1 jun yi da xue xue bao = Academic journal of the first medical college of PLA 20030401
Effects of astragaloside IV on myocardial calcium transport and cardiac function in ischemic rats. Acta pharmacologica Sinica 20021001
Determination of astragaloside IV in Radix astragali (Astragalus membranaceus var. monghulicus) using high-performance liquid chromatography with evaporative light-scattering detection. Journal of chromatographic science 20011101
Antinociceptive effect of astragalosides and its mechanism of action. Acta pharmacologica Sinica 20010901
Properties