4-Amino-7-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
| Title | Journal |
|---|---|
| Interaction of Rio1 kinase with toyocamycin reveals a conformational switch that controls oligomeric state and catalytic activity. | PloS one 20120101 |
| Revealing the quaternary structure of a heterogeneous noncovalent protein complex through surface-induced dissociation. | Analytical chemistry 20110415 |
| 7-Deazapurine biosynthesis: NMR study of toyocamycin biosynthesis in Streptomyces rimosus using 2-13C-7-15N-adenine. | Organic & biomolecular chemistry 20110407 |
| Susceptibility in vitro of clinically metronidazole-resistant Trichomonas vaginalis to nitazoxanide, toyocamycin, and 2-fluoro-2'-deoxyadenosine. | Parasitology research 20100901 |
| Cell cycle arrest and cytochrome c-mediated apoptotic induction in human lung cancer A549 cells by MCS-C2, an analogue of sangivamycin. | Journal of microbiology and biotechnology 20100201 |
| Hydrogenosomes of laboratory-induced metronidazole-resistant Trichomonas vaginalis lines are downsized while those from clinically metronidazole-resistant isolates are not. | The Journal of eukaryotic microbiology 20100101 |
| A toyocamycin analogue with the sugar moiety in a syn conformation. | Acta crystallographica. Section C, Crystal structure communications 20090901 |
| Studies on the glycosylation of pyrrolo[2,3-d] pyrimidines with 1-O-acetyl-2,3,5-tri-O-benzoyl-beta-D-ribofuranose: the formation of regioisomers during toyocamycin and 7-deazainosine syntheses. | Nucleosides, nucleotides & nucleic acids 20090501 |
| Light-activation of gene function in mammalian cells via ribozymes. | Chemical communications (Cambridge, England) 20090207 |
| Toyocamycin specifically inhibits auxin signaling mediated by SCFTIR1 pathway. | Phytochemistry 20090101 |
| Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors. | Journal of medicinal chemistry 20081113 |
| Deciphering deazapurine biosynthesis: pathway for pyrrolopyrimidine nucleosides toyocamycin and sangivamycin. | Chemistry & biology 20080825 |
| Functional expression of ribozymes in Apicomplexa: towards exogenous control of gene expression by inducible RNA-cleavage. | International journal for parasitology 20080501 |
| A CoMSIA study on the adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues. | Bioorganic & medicinal chemistry 20080501 |
| 7-deazainosine derivatives: synthesis and characterization of 7- and 7,8-substituted pyrrolo [2,3-d]pyrimidine ribonucleosides. | Nucleosides, nucleotides & nucleic acids 20080501 |
| Antineoplastic agents. 536. New sources of naturally occurring cancer cell growth inhibitors from marine organisms, terrestrial plants, and microorganisms(1a,). | Journal of natural products 20080301 |
| Synthesis of pyrrolo[2,3-d]pyrimidine nucleoside derivatives as potential anti-HCV agents. | Bioorganic chemistry 20070201 |
| Identification of inhibitors of ribozyme self-cleavage in mammalian cells via high-throughput screening of chemical libraries. | RNA (New York, N.Y.) 20060501 |
| Cell cycle arrest and apoptotic induction in LNCaP cells by MCS-C2, novel cyclin-dependent kinase inhibitor, through p53/p21WAF1/CIP1 pathway. | Cancer science 20060501 |
| Induction of apoptosis in human leukemia cells by MCS-C2 via caspase-dependent Bid cleavage and cytochrome c release. | Cancer letters 20050608 |
| Synthesis of 2'-beta-C-methyl toyocamycin and sangivamycin analogues as potential HCV inhibitors. | Bioorganic & medicinal chemistry letters 20050201 |
| Exogenous control of mammalian gene expression through modulation of RNA self-cleavage. | Nature 20040923 |
| A TOPS-MODE approach to predict adenosine kinase inhibition. | Bioorganic & medicinal chemistry letters 20040621 |
| An improved total synthesis of triciribine: a tricyclic nucleoside with antineoplastic and antiviral properties. | Nucleosides, nucleotides & nucleic acids 20040101 |
| Induction of p16/INK4a gene expression and cellular senescence by toyocamycin. | Biological & pharmaceutical bulletin 20021001 |
| Inhibition of cyclin-dependent kinase 1 by purines and pyrrolo[2,3-d]pyrimidines does not correlate with antiviral activity. | Antimicrobial agents and chemotherapy 20020801 |
| QSAR study on adenosine kinase inhibition of pyrrolo[2,3-d]pyrimidine nucleoside analogues using the hansch approach. | Bioorganic & medicinal chemistry letters 20020325 |
| Drug-induced translocation of nucleolar proteins fused to green fluorescent protein. | Methods in molecular biology (Clifton, N.J.) 20020101 |
| Synthesis of pyrrolo[2,1-f][1,2,4]triazine C-nucleosides. Isosteres of sangivamycin, tubercidin, and toyocamycin. | Carbohydrate research 20010309 |
| Synthesis and cytotoxicity of 4'-C- and 5'-C-substituted toyocamycins. | Bioorganic & medicinal chemistry 20010101 |
| Synthesis of carbocyclic analogs of 2',3'-dideoxysangivamycin, 2',3'-dideoxytoyocamycin, and 2',3'-dideoxytriciribine. | Nucleosides, nucleotides & nucleic acids 20010101 |
| Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and thiosangivamycin: the effect of certain 4- and 4,6-substituents on the antiviral activity of pyrrolo[2,3-d]pyrimidines. | Journal of medicinal chemistry 19960830 |
| Synthesis of non-nucleoside analogs of toyocamycin, sangivamycin, and ++thiosangivamycin: influence of various 7-substituents on antiviral activity. | Journal of medicinal chemistry 19960216 |
| Synthesis and antiproliferative and antiviral activity of 2'-deoxy-2'-fluoroarabinofuranosyl analogs of the nucleoside antibiotics toyocamycin and sangivamycin. | Journal of medicinal chemistry 19950929 |
| Synthesis and evaluation of certain thiosangivamycin analogs as potential inhibitors of cell proliferation and human cytomegalovirus. | Journal of medicinal chemistry 19950929 |
| Design, synthesis, and studies on the structure activity relationships of certain pyrrolo[2,3-d]pyrimidine nucleosides and structurally related analogs as potential antineoplastic and antiviral agents. | Farmaco (Societa chimica italiana : 1989) 19910101 |
| Arabinofuranosylpyrrolo[2,3-d]pyrimidines as potential agents for human cytomegalovirus infections. | Journal of medicinal chemistry 19901201 |
| Synthesis and antiviral activity of some 7-[(2-hydroxyethoxy)methyl]pyrazolo[3,4-d]pyrimidine analogues of sangivamycin and toyocamycin. | Journal of medicinal chemistry 19900701 |
| Broad-spectrum antiviral activities of neplanocin A, 3-deazaneplanocin A, and their 5'-nor derivatives. | Antimicrobial agents and chemotherapy 19890801 |
| Synthesis, cytotoxicity, and antiviral activity of certain 7-[(2-hydroxyethoxy)methyl]pyrrolo[2,3-d]pyrimidine nucleosides related to toyocamycin and sangivamycin. | Journal of medicinal chemistry 19890701 |
| Pyrrolo[2,3-d]pyrimidine nucleosides as inhibitors of human cytomegalovirus. | Antimicrobial agents and chemotherapy 19870401 |
| Nucleic acid related compounds. 51. Synthesis and biological properties of sugar-modified analogues of the nucleoside antibiotics tubercidin, toyocamycin, sangivamycin, and formycin. | Journal of medicinal chemistry 19870301 |
| Xylotubercidin against herpes simplex virus type 2 in mice. | Antimicrobial agents and chemotherapy 19861101 |
| Antiviral activity of C-5 substituted tubercidin analogues. | Journal of medicinal chemistry 19840301 |