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Dirithromycin

CAS No.:
62013-04-1
Catalog Number:
AG019FVM
Molecular Formula:
C42H78N2O14
Molecular Weight:
835.0737
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
95%
In Stock USA
United States
$87
- +
1g
95%
In Stock USA
United States
$172
- +
5g
95%
In Stock USA
United States
$630
- +
Product Description
Catalog Number:
AG019FVM
Chemical Name:
Dirithromycin
CAS Number:
62013-04-1
Molecular Formula:
C42H78N2O14
Molecular Weight:
835.0737
MDL Number:
MFCD00865041
IUPAC Name:
(1R,2R,3R,6R,7S,8S,9R,10R,12R,13S,15R,17S)-9-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-3-ethyl-2,10-dihydroxy-7-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-15-(2-methoxyethoxymethyl)-2,6,8,10,12,17-hexamethyl-4,16-dioxa-14-azabicyclo[11.3.1]heptadecan-5-one
InChI:
InChI=1S/C42H78N2O14/c1-15-29-42(10,49)37-24(4)32(43-30(56-37)21-52-17-16-50-13)22(2)19-40(8,48)36(58-39-33(45)28(44(11)12)18-23(3)53-39)25(5)34(26(6)38(47)55-29)57-31-20-41(9,51-14)35(46)27(7)54-31/h22-37,39,43,45-46,48-49H,15-21H2,1-14H3/t22-,23-,24+,25+,26-,27+,28+,29-,30-,31+,32+,33-,34+,35+,36-,37-,39+,40-,41-,42-/m1/s1
InChI Key:
WLOHNSSYAXHWNR-DWIOZXRMSA-N
SMILES:
COCCOC[C@@H]1N[C@H]2[C@H](C)C[C@@](C)(O)[C@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3O)N(C)C)[C@@H](C)[C@@H]([C@H](C(=O)O[C@@H]([C@@]([C@H](O1)[C@H]2C)(C)O)CC)C)O[C@@H]1O[C@@H](C)[C@@H]([C@](C1)(C)OC)O
UNII:
1801D76STL
Properties
Complexity:
1300  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
20  
Defined Bond Stereocenter Count:
0
Exact Mass:
834.545g/mol
Formal Charge:
0
Heavy Atom Count:
58  
Hydrogen Bond Acceptor Count:
16  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
835.086g/mol
Monoisotopic Mass:
834.545g/mol
Rotatable Bond Count:
12  
Topological Polar Surface Area:
196A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.2  
Literature
Title Journal
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Long-acting erythromycins: assessing their role in treating outpatient odontogenic infections. Texas dental journal 20090401
Quantitative determination of erythromycylamine in human plasma by liquid chromatography-mass spectrometry and its application in a bioequivalence study of dirithromycin. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080315
Characterization of impurities in dirithromycin by liquid chromatography/ion trap mass spectrometry. Journal of chromatography. A 20060825
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
In vitro activity of azithromycin and dirithromycin against axenic Entamoeba histolytica. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20041201
A computational approach to the synthesis of dirithromycin. Journal of molecular modeling 20040401
Efficacy of oral levofloxacin and dirithromycin alone and in combination with rifampicin in the treatment of experimental murine Brucella abortus infection. International journal of antimicrobial agents 20040201
Actual therapeutic management of allergic and hyperreactive nasal disorders. GMS current topics in otorhinolaryngology, head and neck surgery 20040101
A comparison of 5-day courses of dirithromycin and azithromycin in the treatment of acute exacerbations of chronic obstructive pulmonary disease. Clinical therapeutics 20030201
Macrolides in dermatology. Clinics in dermatology 20030101
From the Centers for Disease Control and Prevention. Sudden death in a traveler following halofantrine administration--Togo, 2000. JAMA 20010411
Comparative study of dirithromycin and azithromycin in the treatment of acute bacterial exacerbations of chronic bronchitis. Journal of chemotherapy (Florence, Italy) 19990401
Dirithromycin: a new macrolide. The Annals of pharmacotherapy 19961001
[Extra and intracellular activity of dirithromycin against Mycobacterium avium]. Pathologie-biologie 19950401
Dirithromycin. A review of its antimicrobial activity, pharmacokinetic properties and therapeutic efficacy. Drugs 19941001
Pharmacokinetics of dirithromycin. The Journal of antimicrobial chemotherapy 19930301
Properties