Home Other Building Blocks Solifenacin

Solifenacin

CAS No.:
242478-37-1
Catalog Number:
AG019FSR
Molecular Formula:
C23H26N2O2
Molecular Weight:
362.4647
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
10mg
99%
1 week
United States
$126
- +
25mg
99%
1 week
United States
$182
- +
50mg
99%
1 week
United States
$223
- +
100mg
99%
1 week
United States
$321
- +
Product Description
Catalog Number:
AG019FSR
Chemical Name:
Solifenacin
CAS Number:
242478-37-1
Molecular Formula:
C23H26N2O2
Molecular Weight:
362.4647
MDL Number:
MFCD18910847
IUPAC Name:
[(3R)-1-azabicyclo[2.2.2]octan-3-yl] (1S)-1-phenyl-3,4-dihydro-1H-isoquinoline-2-carboxylate
InChI:
InChI=1S/C23H26N2O2/c26-23(27-21-16-24-13-10-18(21)11-14-24)25-15-12-17-6-4-5-9-20(17)22(25)19-7-2-1-3-8-19/h1-9,18,21-22H,10-16H2/t21-,22-/m0/s1
InChI Key:
FBOUYBDGKBSUES-VXKWHMMOSA-N
SMILES:
O=C(N1CCc2c(C1c1ccccc1)cccc2)O[C@H]1CN2CCC1CC2
UNII:
A8910SQJ1U
Properties
Complexity:
525  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
362.199g/mol
Formal Charge:
0
Heavy Atom Count:
27  
Hydrogen Bond Acceptor Count:
3  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
362.473g/mol
Monoisotopic Mass:
362.199g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
32.8A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4  
Literature
Title Journal
Pharmacokinetics and toxicity of antimuscarinic drugs for overactive bladder treatment in females. Expert opinion on drug metabolism & toxicology 20121101
ACP Journal Club. Review: drugs for urgency urinary incontinence improve continence in women. Annals of internal medicine 20121016
Are solifenacin and ramosetron really ideal to treat irritable bowel syndrome? Journal of neurogastroenterology and motility 20121001
Are Solifenacin and Ramosetron Really Ideal to Treat Irritable Bowel Syndrome?: Author's Reply. Journal of neurogastroenterology and motility 20121001
Efficacy and safety of solifenacin to treat overactive bladder symptoms in patients with idiopathic normal pressure hydrocephalus: an open-label, multicenter, prospective study. Neurourology and urodynamics 20120901
Characterization of bladder selectivity of antimuscarinic agents on the basis of in vivo drug-receptor binding. International neurourology journal 20120901
Solifenacin for overactive bladder: a systematic review and meta-analysis. International urogynecology journal 20120801
Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial. Journal of neurogastroenterology and motility 20120701
Benefits and harms of pharmacologic treatment for urinary incontinence in women: a systematic review. Annals of internal medicine 20120619
Urinary urgency: a review of its assessment as the key symptom of the overactive bladder syndrome. World journal of urology 20120601
Practical consensus guidelines for the management of enuresis. European journal of pediatrics 20120601
Has the cost of anti-muscarinic a key role in the success rate of patients diagnosed with overactive bladder syndrome? Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20120601
Solifenacin objectively decreases urinary sensation in women with overactive bladder syndrome. International urology and nephrology 20120401
Re: Tadalafil Versus Solifenacin for Persistent Storage Symptoms After Prostate Surgery in Patients With Erectile Dysfunction: A Prospective Randomized Study. The Journal of urology 20120401
Efficacy and safety of propiverine in children with overactive bladder. Korean journal of urology 20120401
Improvement of urinary dysfunction after kidney transplantation by administration of the antimuscarinic agent--prospective randomized controlled study. Transplantation 20120327
The Relations between Enuresis in Childhood and Nocturnal Polyuria Syndrome in Adult Life. International neurourology journal 20120301
The efficacy and safety of solifenacin in patients with overactive bladder syndrome. Collegium antropologicum 20120301
Which anticholinergic drug for overactive bladder symptoms in adults. The Cochrane database of systematic reviews 20120118
Microscopic binding of M5 muscarinic acetylcholine receptor with antagonists by homology modeling, molecular docking, and molecular dynamics simulation. The journal of physical chemistry. B 20120112
Neurogenic bladder. Advances in urology 20120101
Efficacy of solifenacin for overactive bladder symptoms, symptom bother, and health-related quality of life in patients by duration of self-reported symptoms: a secondary analysis of the VIBRANT study. Urologic nursing 20120101
Adding to the evidence base: efficacy of solifenacin for overactive bladder symptoms, symptom bother, and health-related quality of life in patients by duration of self-reported symptoms: a secondary analysis of the VIBRANT study. Urologic nursing 20120101
An investigation of the safety and pharmacokinetics of the novel TRPV1 antagonist XEN-D0501 in healthy subjects. British journal of clinical pharmacology 20111201
Co-administration of an α(1) -blocker improves the efficacy and safety of antimuscarinic agents in rats with detrusor overactivity. International journal of urology : official journal of the Japanese Urological Association 20111201
Urothelial/lamina propria spontaneous activity and the role of M3 muscarinic receptors in mediating rate responses to stretch and carbachol. Urology 20111201
Increased serum nerve growth factor levels in patients with overactive bladder syndrome refractory to antimuscarinic therapy. Neurourology and urodynamics 20111101
Antimuscarinic drugs: review of the cognitive impact when used to treat overactive bladder in elderly patients. Current urology reports 20111001
Influence of tissue integrity on pharmacological phenotypes of muscarinic acetylcholine receptors in the rat cerebral cortex. The Journal of pharmacology and experimental therapeutics 20111001
[Treatment for overactive bladder]. Der Urologe. Ausg. A 20111001
Solifenacin may improve sleep quality in patients with overactive bladder and sleep disturbance. Urology 20110901
In vivo bladder selectivity of imidafenacin, a novel antimuscarinic agent, assessed by using an effectiveness index for bladder capacity in rats. Naunyn-Schmiedeberg's archives of pharmacology 20110901
Montelukast for symptom control of interstitial cystitis. The Annals of pharmacotherapy 20110901
[Intravesical therapy of heparin and lidocaine for interstitial cystitis : a case report]. Hinyokika kiyo. Acta urologica Japonica 20110901
Korean version of the overactive bladder symptom score questionnaire: translation and linguistic validation. International neurourology journal 20110901
Efficacy of anticholinergics for chronic prostatitis/chronic pelvic pain syndrome in young and middle-aged patients: a single-blinded, prospective, multi-center study. International neurourology journal 20110901
α1-Adrenoceptors and muscarinic receptors in voiding function - binding characteristics of therapeutic agents in relation to the pharmacokinetics. British journal of clinical pharmacology 20110801
A comprehensive non-clinical evaluation of the CNS penetration potential of antimuscarinic agents for the treatment of overactive bladder. British journal of clinical pharmacology 20110801
The effect of solifenacin on urethral sphincter morphology. International urogynecology journal 20110801
Comparisons of urodynamic effects, therapeutic efficacy and safety of solifenacin versus tolterodine for female overactive bladder syndrome. The journal of obstetrics and gynaecology research 20110801
Species independence in brain tissue binding using brain homogenates. Drug metabolism and disposition: the biological fate of chemicals 20110701
A semiphysiological population model for prediction of the pharmacokinetics of drugs under liver and renal disease conditions. Drug metabolism and disposition: the biological fate of chemicals 20110701
Efficacy of solifenacin on nocturia in Japanese patients with overactive bladder: impact on sleep evaluated by bladder diary. The Journal of urology 20110701
Tadalafil versus solifenacin for persistent storage symptoms after prostate surgery in patients with erectile dysfunction: a prospective randomized study. International journal of urology : official journal of the Japanese Urological Association 20110701
Solifenacin as add-on therapy for overactive bladder symptoms in men treated for lower urinary tract symptoms--ASSIST, randomized controlled study. Urology 20110701
Systematic review and meta-analysis: do clinical trials testing antimuscarinic agents for overactive bladder adequately measure central nervous system adverse events? Journal of the American Geriatrics Society 20110701
Effects of tamsulosin, solifenacin, and combination therapy for the treatment of ureteral stent related discomforts. Korean journal of urology 20110701
Discovery of novel quaternary ammonium derivatives of (3R)-quinuclidinyl carbamates as potent and long acting muscarinic antagonists. Bioorganic & medicinal chemistry letters 20110601
Effect of desmopressin with anticholinergics in female patients with overactive bladder. Korean journal of urology 20110601
Antimuscarinics for treatment of storage lower urinary tract symptoms in men: a systematic review. International journal of clinical practice 20110401
Which single-item measures of overactive bladder symptom treatment correlate best with patient satisfaction? Neurourology and urodynamics 20110401
Efficacy and safety of low-dose propiverine in patients with lower urinary tract symptoms/benign prostatic hyperplasia with storage symptoms: a prospective, randomized, single-blinded and multicenter clinical trial. Korean journal of urology 20110401
Evaluation of brain anticholinergic activities of urinary spasmolytic drugs using a high-throughput radio receptor bioassay. Journal of the American Geriatrics Society 20110301
Tolerability of solifenacin and oxybutynin immediate release in older (> 65 years) and younger (≤ 65 years) patients with overactive bladder: sub-analysis from a Canadian, randomized, double-blind study. Current medical research and opinion 20110201
Relationships between symptoms, symptom bother, and health-related quality of life in patients with overactive bladder taking solifenacin or placebo in the VIBRANT study. International journal of clinical practice 20110201
[Treatment with solifenacin reduces urinary urgency and improves quality of life. Results of the non-interventional CAP-study]. MMW Fortschritte der Medizin 20110113
Overactive bladder drugs and constipation: a meta-analysis of randomized, placebo-controlled trials. Digestive diseases and sciences 20110101
Assessment of overactive bladder symptoms: comparison of 3-day bladder diary and the overactive bladder symptoms score. Urology 20110101
Efficacy and tolerability of solifenacin in patients aged ≥ 65 years with overactive bladder: post-hoc analysis of 2 open-label studies. Postgraduate medicine 20110101
Impact of lower urinary tract symptoms/benign prostatic hyperplasia treatment with tamsulosin and solifenacin combination therapy on erectile function. Korean journal of urology 20110101
Are antimuscarinic drugs effective against urinary frequency mediated by atropine-resistant contractions? Journal of pharmacological sciences 20110101
Adverse event assessment of antimuscarinics for treating overactive bladder: a network meta-analytic approach. PloS one 20110101
Cost-effectiveness analysis of antimuscarinics in the treatment of patients with overactive bladder in Spain: a decision-tree model. BMC urology 20110101
An overview of the clinical use of antimuscarinics in the treatment of overactive bladder. Advances in urology 20110101
Solifenacin in multiple sclerosis patients with overactive bladder: a prospective study. Advances in urology 20110101
The efficacy and safety of propiverine hydrochloride in patients with overactive bladder symptoms who poorly responded to previous anticholinergic agents. Advances in urology 20110101
[Impact of overactive bladder on sexual function in women]. Urologia 20110101
Overactive bladder: the importance of tailoring treatment to the individual patient. Journal of multidisciplinary healthcare 20110101
Symptomatic therapy and rehabilitation in primary progressive multiple sclerosis. Neurology research international 20110101
Comparative Evaluation of the Safety and Efficacy of Long-Term Use of Imidafenacin and Solifenacin in Patients with Overactive Bladder: A Prospective, Open, Randomized, Parallel-Group Trial (the LIST Study). Advances in urology 20110101
Tolerance of bladder antispasmodics in children with urinary incontinence: An observational study from North India. Indian journal of pharmacology 20110101
Efficacy of Solifenacin on Overactive Bladder Symptoms, Symptom Bother, and Other Patient-Reported Outcomes in Subjects With or Without Incontinence: A Post Hoc Analysis of Data From VIBRANT. Female pelvic medicine & reconstructive surgery 20110101
Overactive bladder syndrome: what is the role of evidence of detrusor overactivity in the cystometric study? Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20101201
Determination of solifenacin in human plasma by liquid chromatography-tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20101201
Pregnancy in woman with spinal cord stimulator for complex regional pain syndrome: a case report and review of the literature. The Korean journal of pain 20101201
A validated rapid stability-indicating method for the determination of related substances in solifenacin succinate by ultra-fast liquid chromatography. Journal of chromatographic science 20101101
Efficacy of Solifenacin on Symptom Bother and Health-Related Quality of Life in Patients With Acute, Early Chronic, and Late Chronic Overactive Bladder: Secondary Analysis of Data From the VOLT Study. Female pelvic medicine & reconstructive surgery 20101101
Impact of solifenacin on diary-recorded and patient-reported urgency in patients with severe overactive bladder (OAB) symptoms. Current medical research and opinion 20101001
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis. Urology 20101001
Prospective open label study of solifenacin for overactive bladder in children. The Journal of urology 20101001
Solifenacin and tolterodine are equally effective in the treatment of overactive bladder symptoms. Journal of the Formosan Medical Association = Taiwan yi zhi 20101001
Urodynamic effects of solifenacin in untreated female patients with symptomatic overactive bladder. International journal of urology : official journal of the Japanese Urological Association 20100901
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20100901
The cost-effectiveness of solifenacin vs fesoterodine, oxybutynin immediate-release, propiverine, tolterodine extended-release and tolterodine immediate-release in the treatment of patients with overactive bladder in the UK National Health Service. BJU international 20100801
The cost-effectiveness of solifenacin vs fesoterodine, oxybutynin immediate-release, propiverine, tolterodine extended-release and tolterodine immediate-release in the treatment of patients with overactive bladder in the UK National Health Service. BJU international 20100801
Solifenacin for overactive bladder: secondary analysis of data from VENUS based on baseline continence status. International urogynecology journal 20100701
AE9C90CB: a novel, bladder-selective muscarinic receptor antagonist for the treatment of overactive bladder. British journal of pharmacology 20100701
New strategies for medical management of overactive bladder in children. Current opinion in urology 20100701
Solifenacin treatment in men with overactive bladder: effects on symptoms and patient-reported outcomes. The aging male : the official journal of the International Society for the Study of the Aging Male 20100601
Therapy: Solifenacin causes less dry mouth than oxybutynin in OAB. Nature reviews. Urology 20100601
Tolerability of 5 mg solifenacin once daily versus 5 mg oxybutynin immediate release 3 times daily: results of the VECTOR trial. The Journal of urology 20100501
Efficacy of simplified bladder training in patients with overactive bladder receiving a solifenacin flexible-dose regimen: results from a randomized study. BJU international 20100401
Solifenacin: scientific evidence in the treatment of overactive bladder. Archivos espanoles de urologia 20100401
Pediatrics: combining antimuscarinics shows promise for overactive bladder. Nature reviews. Urology 20100201
Antimuscarinics in men with lower urinary tract symptoms suggestive of bladder outlet obstruction due to benign prostatic hyperplasia. Current opinion in urology 20100101
The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: bladder selectivity based on in vivo drug-receptor binding characteristics of antimuscarinic agents for treatment of overactive bladder. Journal of pharmacological sciences 20100101
The forefront for novel therapeutic agents based on the pathophysiology of lower urinary tract dysfunction: ameliorative effect of solifenacin succinate (Vesicare), a bladder-selective antimuscarinic agent, on overactive bladder symptoms, especially urgency episodes. Journal of pharmacological sciences 20100101
Solifenacin pharmacology. Archivos espanoles de urologia 20100101
Functional role of cannabinoid receptors in urinary bladder. Indian journal of urology : IJU : journal of the Urological Society of India 20100101
Comparison of risk of neurovascular and cardiovascular side effects between tiotropium and other anticholinergic agents. Quality in primary care 20100101
Canadian cost-effectiveness analysis of solifenacin compared to oxybutynin immediate-release in patients with overactive bladder. Journal of medical economics 20100101
[Solifenacin in treatment of the overactive bladder syndrome--diagnosis, clinical management and results]. Akusherstvo i ginekologiia 20100101
Dose escalation improves therapeutic outcome: post hoc analysis of data from a 12-week, multicentre, double-blind, parallel-group trial of trospium chloride in patients with urinary urge incontinence. BMC urology 20100101
Tiotropium bromide inhibits TGF-β-induced MMP production from lung fibroblasts by interfering with Smad and MAPK pathways in vitro. International journal of chronic obstructive pulmonary disease 20100101
Medical management of overactive bladder. Indian journal of urology : IJU : journal of the Urological Society of India 20100101
[Treatment of overactive urinary bladder with imperative urinary incontinence in women]. Urologiia (Moscow, Russia : 1999) 20100101
The add-on effect of solifenacin for patients with remaining overactive bladder after treatment with tamsulosin for lower urinary tract symptoms suggestive of benign prostatic obstruction. Advances in urology 20100101
Etiopathogenesis and management of bladder dysfunction in patients with posterior urethral valves. Indian journal of urology : IJU : journal of the Urological Society of India 20100101
Bladder dysfunction in diabetes mellitus. Frontiers in pharmacology 20100101
Basic mechanisms of urgency: roles and benefits of pharmacotherapy. World journal of urology 20091201
Safety and tolerability of solifenacin add-on therapy to alpha-blocker treated men with residual urgency and frequency. The Journal of urology 20091201
Effects of solifenacin on overactive bladder symptoms, symptom bother and other patient-reported outcomes: results from VIBRANT - a double-blind, placebo-controlled trial. International journal of clinical practice 20091201
Treatment of dysautonomia associated with Parkinson's disease. Parkinsonism & related disorders 20091201
Impact of solifenacin on quality of life, medical care use, work productivity, and health utility in the elderly: an exploratory subgroup analysis. The American journal of geriatric pharmacotherapy 20091201
Anticholinergic drug use for overactive bladder in Sweden: a nationwide pharmacoepidemiological study. International urogynecology journal and pelvic floor dysfunction 20091101
Exploratory pilot study assessing the risk of cognitive impairment or sedation in the elderly following single doses of solifenacin 10 mg. Expert opinion on drug safety 20091101
Listening to the patient: a flexible approach to the use of antimuscarinic agents in overactive bladder syndrome. BJU international 20091001
Solifenacin for therapy resistant overactive bladder. The Journal of urology 20091001
Double anticholinergic therapy for refractory overactive bladder. The Journal of urology 20091001
Solifenacin for overactive bladder: patient-reported outcomes from a large placebo-controlled trial. Postgraduate medicine 20090901
Comparison of muscarinic receptor selectivity of solifenacin and oxybutynin in the bladder and submandibular gland of muscarinic receptor knockout mice. European journal of pharmacology 20090801
A systematic evaluation of factors associated with nocturia--the population-based FINNO study. American journal of epidemiology 20090801
Practical aspects of lifestyle modifications and behavioural interventions in the treatment of overactive bladder and urgency urinary incontinence. International journal of clinical practice 20090801
Tolterodine extended release is well tolerated in older subjects. International journal of clinical practice 20090801
Patient-reported most bothersome symptoms in OAB: post hoc analysis of data from a large, open-label trial of solifenacin. International urogynecology journal and pelvic floor dysfunction 20090601
Comparison of receptor binding characteristics of commonly used muscarinic antagonists in human bladder detrusor and mucosa. The Journal of pharmacology and experimental therapeutics 20090301
[Anticholinergic treatment of overactive bladder syndrome. Is it all the same?]. Der Urologe. Ausg. A 20090301
Pharmacological properties of TD-6301, a novel bladder selective muscarinic receptor antagonist. European journal of pharmacology 20090301
In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. British journal of pharmacology 20090301
Solifenacin succinate for the treatment of overactive bladder. Expert opinion on drug metabolism & toxicology 20090301
Solifenacin in the treatment of overactive bladder syndrome in Italian patients: pharmacoeconomic evaluation. Journal of medical economics 20090301
Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial. BJU international 20090201
Urodynamic parameters after solifenacin treatment in men with overactive bladder symptoms and detrusor underactivity. Neurourology and urodynamics 20090101
The cost utility of solifenacin in the treatment of overactive bladder. International urology and nephrology 20090101
Treatment with solifenacin increases warning time and improves symptoms of overactive bladder: results from VENUS, a randomized, double-blind, placebo-controlled trial. Urology 20090101
Muscarinic receptor antagonists for overactive bladder treatment: does one fit all? Current opinion in urology 20090101
Solifenacin for overactive bladder in women unsuccessfully treated with immediate release oxybutynin: a pilot study. Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology 20090101
Diary and patient-reported outcomes in patients with severe overactive bladder switching from tolterodine extended release 4 mg/day to solifenacin treatment: An open-label, flexible-dosing, multicentre study. Clinical drug investigation 20090101
Cost-effectiveness analysis of solifenacin flexible dosing in patients with overactive bladder symptoms in four Nordic countries. Acta obstetricia et gynecologica Scandinavica 20090101
The safety and efficacy of tolterodine extended release in the treatment of overactive bladder in the elderly. Clinical interventions in aging 20090101
Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clinical pharmacokinetics 20090101
A meta-analysis of the placebo response in antimuscarinic drug trials for overactive bladder. BMC medical research methodology 20090101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20090101
Response to 'Suspected differential interactions of digoxin with imidafenacin and propantheline; some thoughts for introspection'. Drug metabolism and pharmacokinetics 20090101
Oxybutynin extended release for the management of overactive bladder: a clinical review. Drug design, development and therapy 20090101
Treatment success for overactive bladder with urinary urge incontinence refractory to oral antimuscarinics: a review of published evidence. BMC urology 20090101
Fesoterodine for the treatment of urinary incontinence and overactive bladder. Therapeutics and clinical risk management 20090101
Behavioral intervention versus pharmacotherapy or their combinations in the management of overactive bladder dysfunction. Advances in urology 20090101
The symptomatic management of multiple sclerosis. Annals of Indian Academy of Neurology 20090101
Highly sensitive and rapid LC-ESI-MS/MS method for the simultaneous quantification of uroselective alpha1-blocker, alfuzosin and an antimuscarinic agent, solifenacin in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081215
QT prolongation and torsade de pointes associated with solifenacin in an 81-year-old woman. British journal of clinical pharmacology 20081201
[Efficacy and safety of solifenacin in daily clinical practice--clinical study phase IV]. Ceska gynekologie 20081201
Suppressive activity of tiotropium bromide on matrix metalloproteinase production from lung fibroblasts in vitro. International journal of chronic obstructive pulmonary disease 20081201
Preserving cognitive function for patients with overactive bladder: evidence for a differential effect with darifenacin. International journal of clinical practice 20081101
Darifenacin treatment for overactive bladder in patients who expressed dissatisfaction with prior extended-release antimuscarinic therapy. International journal of clinical practice 20081101
Solifenacin in the treatment of urgency and other symptoms of overactive bladder: results from a randomized, double-blind, placebo-controlled, rising-dose trial. BJU international 20081101
Solifenacin at 3 years: a review of efficacy and safety. Commentary. Postgraduate medicine 20081101
[Economic impact of overactive bladder symptoms in Japan]. Nihon Hinyokika Gakkai zasshi. The japanese journal of urology 20081101
Efficacy and safety of solifenacin succinate in Korean patients with overactive bladder: a randomised, prospective, double-blind, multicentre study. International journal of clinical practice 20081101
Human urine with solifenacin intake but not tolterodine or darifenacin intake blocks detrusor overactivity. International urogynecology journal and pelvic floor dysfunction 20081001
Efficacy of solifenacin in patients previously treated with tolterodine extended release 4 mg: results of a 12-week, multicenter, open-label, flexible-dose study. Clinical therapeutics 20081001
The effects of antimuscarinic treatments in overactive bladder: an update of a systematic review and meta-analysis. European urology 20080901
Choice of antimuscarinic agents for overactive bladder in the older patient: focus on darifenacin. Clinical interventions in aging 20080901
Similarities and differences in the autonomic control of airway and urinary bladder smooth muscle. Naunyn-Schmiedeberg's archives of pharmacology 20080801
A cost-utility analysis of once daily solifenacin compared to tolterodine in the treatment of overactive bladder syndrome. Current medical research and opinion 20080801
[Urinary urgency]. MMW Fortschritte der Medizin 20080731
Solifenacin at 3 years: a review of efficacy and safety. Postgraduate medicine 20080701
In vivo quantitative autoradiographic analysis of brain muscarinic receptor occupancy by antimuscarinic agents for overactive bladder treatment. The Journal of pharmacology and experimental therapeutics 20080601
Impact of solifenacin on resource utilization, work productivity and health utility in overactive bladder patients switching from tolterodine ER. Current medical research and opinion 20080601
[Overactive bladder. When it's pressing, immediate help is indicated]. MMW Fortschritte der Medizin 20080515
Photodistributed lichenoid drug eruption secondary to solifenacin. Clinical and experimental dermatology 20080501
Urgency in overactive bladder: translating experimental data into clinical practice. Drugs of today (Barcelona, Spain : 1998) 20080501
Is solifenacin succinate safe and effective for the treatment of overactive bladder? Nature clinical practice. Urology 20080301
A simple validated scale to measure urgency. The Journal of urology 20080301
Solifenacin-induced small bowel pseudo-obstruction. Journal of hospital medicine 20080301
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20080301
A review of solifenacin in the treatment of urinary incontinence. Therapeutics and clinical risk management 20080201
Solifenacin treatment for overactive bladder in Hispanic patients: patient-reported symptom bother and quality of life outcomes from the VESIcare Open-Label Trial. International journal of clinical practice 20080101
Pharmacological analysis of the interaction of antimuscarinic drugs at M(2) and M(3) muscarinic receptors in vivo using the pithed rat assay. Naunyn-Schmiedeberg's archives of pharmacology 20080101
[Anticholinergic drugs in overactive bladder]. Gynecologie, obstetrique & fertilite 20080101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20080101
Pharmacological effects of solifenacin on human isolated urinary bladder. Pharmacology 20080101
Cardiovascular safety and overall tolerability of solifenacin in routine clinical use: a 12-week, open-label, post-marketing surveillance study. Drug safety 20080101
Gateways to clinical trials. July-August 2008. Methods and findings in experimental and clinical pharmacology 20080101
[Assessment of symptoms severity in patients with overactive bladder]. Urologiia (Moscow, Russia : 1999) 20080101
Practical management of nocturia in urology. Indian journal of urology : IJU : journal of the Urological Society of India 20080101
Effects of intravenously and orally administered solifenacin succinate (YM905) on carbachol-induced intravesical pressure elevation and salivary secretion in mice. Biological & pharmaceutical bulletin 20071201
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20071201
Determination of solifenacin succinate, a novel muscarinic receptor antagonist, and its major metabolite in rat plasma by semi-micro high performance liquid chromatography. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071115
Muscarinic receptor antagonists for overactive bladder. BJU international 20071101
Comparative in vivo uroselectivity profiles of anticholinergics, tested in a novel anesthetized rabbit model. European journal of pharmacology 20071031
An unusual cause of postoperative detrusor overactivity. International urogynecology journal and pelvic floor dysfunction 20071001
Treatment outcomes in the STAR study: a subanalysis of solifenacin 5 mg and tolterodine ER 4 mg. European urology 20071001
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20071001
Comparison of the efficacy and tolerability of solifenacin succinate with or without previous use of trospium chloride. International urogynecology journal and pelvic floor dysfunction 20070901
Randomized, double-blind, placebo- and propiverine-controlled trial of the once-daily antimuscarinic agent solifenacin in Japanese patients with overactive bladder. BJU international 20070901
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20070901
Pharmacologic management of overactive bladder. Clinical interventions in aging 20070901
Number of daytime micturitions and volume voided per micturition in the evaluation of efficacy of drugs for overactive bladder: findings from randomized clinical trials. European urology 20070801
Nocturnal polyuria and nocturia relief in patients treated with solifenacin for overactive bladder symptoms. International urogynecology journal and pelvic floor dysfunction 20070701
Overactive bladder treatments in early phase clinical trials. Expert opinion on investigational drugs 20070701
Agents for treatment of overactive bladder: a therapeutic class review. Proceedings (Baylor University. Medical Center) 20070701
Maximizing anticholinergic therapy for overactive bladder: has the ceiling been reached? BJU international 20070601
Update on drugs for overactive bladder syndrome. Drug and therapeutics bulletin 20070601
Treatment of overactive bladder: selective use of anticholinergic agents with low drug-drug interaction potential. Geriatrics 20070501
[How do medications used to treat urinary incontinence affect the cerebral function of the elderly?]. Der Urologe. Ausg. A 20070401
[Comment on the STAR study: Comparison of the efficacy and tolerance of solifenacin and tolterodine retard in the treatment of overactive bladder]. Der Urologe. Ausg. A 20070401
Solifenacin treatment for overactive bladder in black patients: patient-reported symptom bother and health-related quality of life outcomes. Current medical research and opinion 20070401
Solifenacin for overactive bladder with incontinence: symptom bother and health-related quality of life outcomes. The Annals of pharmacotherapy 20070301
Effect of antimuscarinic drugs used for overactive bladder on learning in a rat passive avoidance response test. European journal of pharmacology 20070227
Pharmacological characterization of a new antimuscarinic agent, solifenacin succinate, in comparison with other antimuscarinic agents. Biological & pharmaceutical bulletin 20070101
Redefining response in overactive bladder syndrome. BJU international 20070101
Pharmacokinetics, safety, and tolerability of solifenacin in patients with renal insufficiency. Journal of pharmacological sciences 20070101
Identification of the patient with enlarged prostate: diagnosis and guidelines for management. Osteopathic medicine and primary care 20070101
[Solifenacin in the treatment of patients with hyperactive urinary bladder]. Urologiia (Moscow, Russia : 1999) 20070101
[A placebo-controlled, double-blind, randomized trial of single daily dose of anti-muscarinic drug solifenacin succinate in patients with overactive bladder]. Akusherstvo i ginekologiia 20070101
Application of evidence-based urology in improving quality of care. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Newer agents for the management of overactive bladder. American family physician 20061215
Solifenacin provides effective antimuscarinic therapy for the complete management of overactive bladder. Expert opinion on pharmacotherapy 20061201
Pharmacoeconomic evaluation of antimuscarinic agents for the treatment of overactive bladder. Pharmacotherapy 20061201
[Pharmacological and clinical profile of solifenacin succinate (Vesicare) developed as a new therapeutic agent for overactive bladder]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20061201
Open-label study of the safety and pharmacokinetics of solifenacin in subjects with hepatic impairment. Journal of pharmacological sciences 20061201
Solifenacin succinate (VESIcare): overactive bladder therapy. Urologic nursing 20061201
New developments in the treatment of urinary incontinence. Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20061201
Treatment of overactive bladder in the aging population: focus on darifenacin. Clinical interventions in aging 20061201
Solifenacin. The Urologic clinics of North America 20061101
Treatment of the overactive bladder syndrome with muscarinic receptor antagonists: a matter of metabolites? Naunyn-Schmiedeberg's archives of pharmacology 20061101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20061101
Symptom bother and health-related quality of life outcomes following solifenacin treatment for overactive bladder: the VESIcare Open-Label Trial (VOLT). Clinical therapeutics 20061101
Anticholinergic drugs versus placebo for overactive bladder syndrome in adults. The Cochrane database of systematic reviews 20061018
Reductions in overactive bladder-related incontinence from pooled analysis of phase III trials evaluating treatment with solifenacin. International urogynecology journal and pelvic floor dysfunction 20060901
Solifenacin succinate for the treatment of symptoms of overactive bladder. Clinical therapeutics 20060901
Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: A pooled analysis. The American journal of geriatric pharmacotherapy 20060901
Multiple doses of the antimuscarinic agent solifenacin do not affect the pharmacodynamics or pharmacokinetics of warfarin or the steady-state pharmacokinetics of digoxin in healthy subjects. British journal of clinical pharmacology 20060801
Solifenacin significantly improves all symptoms of overactive bladder syndrome. International journal of clinical practice 20060801
Patient-reported outcomes in overactive bladder: importance for determining clinical effectiveness of treatment. Urology 20060801
[Oral anticholinergics in overactive bladder]. Der Urologe. Ausg. A 20060701
[Comment on the STAR study: Comparison of the efficacy and tolerance of solifenacin and tolterodine retard in the treatment of overactive bladder]. Der Urologe. Ausg. A 20060701
Comparative evaluation of exocrine muscarinic receptor binding characteristics and inhibition of salivation of solifenacin in mice. Biological & pharmaceutical bulletin 20060701
Pharmacokinetic effect of ketoconazole on solifenacin in healthy volunteers. Basic & clinical pharmacology & toxicology 20060701
Solifenacin: as effective in mixed urinary incontinence as in urge urinary incontinence. International urogynecology journal and pelvic floor dysfunction 20060601
Short- and long-term efficacy of solifenacin treatment in patients with symptoms of mixed urinary incontinence. BJU international 20060601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060501
The causes and consequences of overactive bladder. Journal of women's health (2002) 20060401
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060401
Using anticholinergics to treat overactive bladder: the issue of treatment tolerability. The American journal of medicine 20060301
Pharmacologic management of overactive bladder: practical options for the primary care physician. The American journal of medicine 20060301
Management of overactive bladder and urge urinary incontinence in the elderly patient. The American journal of medicine 20060301
The emergence of new drugs for overactive bladder. Expert opinion on emerging drugs 20060301
Efficacy and tolerability of solifenacin in elderly subjects with overactive bladder syndrome: a pooled analysis. The American journal of geriatric pharmacotherapy 20060301
New drugs 06, part I. Nursing 20060201
Muscarinic receptors in the bladder: from basic research to therapeutics. British journal of pharmacology 20060201
Re: Chapple CR, Martinez-Garcia R, Selvaggi L, Toozs-Hobson P, Warnack W, Drogendijk T, Wright DM, Bolodeoku J. A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial. Eur Urol 2005;48:464-70. European urology 20060101
Efficacy of solifenacin in patients with severe symptoms of overactive bladder: a pooled analysis. Current medical research and opinion 20060101
Solifenacin in overactive bladder syndrome. Drugs 20060101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20060101
Solifenacin versus tolterodine--a head-to-head study: finally! But not final? Current urology reports 20051101
The Q-T interval and antimuscarinic drugs. Current urology reports 20051101
[Drug discovery in the fields of urology: tamsulosin and solifenacin]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20051101
Synthesis and antimuscarinic properties of quinuclidin-3-yl 1,2,3,4-tetrahydroisoquinoline-2-carboxylate derivatives as novel muscarinic receptor antagonists. Journal of medicinal chemistry 20051020
Solifenacin in the management of the overactive bladder syndrome. International journal of clinical practice 20051001
A comparison of the efficacy and tolerability of solifenacin succinate and extended release tolterodine at treating overactive bladder syndrome: results of the STAR trial. European urology 20050901
Solifenacin is effective for the treatment of OAB dry patients: a pooled analysis. European urology 20050901
Role of muscarinic receptor antagonists in urgency and nocturia. BJU international 20050901
Pharmacokinetic interaction of solifenacin with an oral contraceptive containing ethinyl estradiol and levonorgestrel in healthy women: a double-blind, placebo-controlled study. Clinical therapeutics 20050901
Solifenacin and darifenacin for overactive bladder. Obstetrics and gynecology 20050801
Darifenacin in the treatment of overactive bladder. International journal of clinical practice 20050701
New treatment options for overactive bladder. South Dakota journal of medicine 20050601
Trospium chloride: an update on a quaternary anticholinergic for treatment of urge urinary incontinence. Therapeutics and clinical risk management 20050601
Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice. British journal of pharmacology 20050501
Effect of age on the pharmacokinetics of solifenacin in men and women. International journal of clinical pharmacology and therapeutics 20050501
Effects of solifenacin succinate (YM905) on detrusor overactivity in conscious cerebral infarcted rats. European journal of pharmacology 20050404
Solifenacin and darifenacin for overactive bladder. The Medical letter on drugs and therapeutics 20050314
Long-term open-label solifenacin treatment associated with persistence with therapy in patients with overactive bladder syndrome. European urology 20050301
[Medical therapy of urinary incontinence]. Der Internist 20050101
Improved quality of life in patients with overactive bladder symptoms treated with solifenacin. BJU international 20050101
New molecular entity: Vesicare, Yamanouchi/GlaxoSmithKline solifenacin. Geriatrics 20050101
New drugs: acamprosate calcium and solifenacin succinate. Journal of the American Pharmacists Association : JAPhA 20050101
Recent developments in the management of overactive bladder: focus on the efficacy and tolerability of once daily solifenacin succinate 5 mg. Current medical research and opinion 20050101
Improving the tolerability of anticholinergic agents in the treatment of overactive bladder. Drug safety 20050101
[Neurological aspect of the hyperactive urinary bladder syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101
Overactive bladder in the elderly: a guide to pharmacological management. Drugs & aging 20050101
Solifenacin in overactive bladder syndrome. Drugs & aging 20050101
Solifenacin in overactive bladder syndrome: a viewpoint by Scott Serels. Drugs & aging 20050101
Solifenacin in overactive bladder: a viewpoint by Hashim Hashim. Drugs & aging 20050101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20041201
Randomized, double-blind placebo controlled trial of the once daily antimuscarinic agent solifenacin succinate in patients with overactive bladder. The Journal of urology 20041101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20041101
The emerging role of solifenacin in the treatment of overactive bladder. Expert opinion on investigational drugs 20041001
Preview of new drugs for overactive bladder and incontinence: darifenacin, solifenacin, trospium, and duloxetine. Current urology reports 20041001
Elevating our therapeutic expectations in overactive bladder. Journal of the American Academy of Nurse Practitioners 20041001
Pharmacokinetics and safety of solifenacin succinate in healthy young men. Journal of clinical pharmacology 20040901
[Overactive bladder. New anticholinergic drug controls urinary urge]. MMW Fortschritte der Medizin 20040708
Food does not affect the pharmacokinetics of solifenacin, a new muscarinic receptor antagonist: results of a randomized crossover trial. British journal of clinical pharmacology 20040701
[In overactive bladder, above all urgency is stressful. The patients know the site of each toilet]. MMW Fortschritte der Medizin 20040527
In vitro and in vivo tissue selectivity profile of solifenacin succinate (YM905) for urinary bladder over salivary gland in rats. European journal of pharmacology 20040525
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20040501
Drug forecast--solifenacin: an investigational anticholinergic for overactive bladder. The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20040501
Solifenacin: treatment of overactive bladder. Drugs of today (Barcelona, Spain : 1998) 20040401
Role of antimuscarinics in the treatment of nonneurogenic daytime urinary incontinence in children. Urology 20040301
Randomized, double-blind placebo- and tolterodine-controlled trial of the once-daily antimuscarinic agent solifenacin in patients with symptomatic overactive bladder. BJU international 20040201
Comparison of in vitro selectivity profiles of solifenacin succinate (YM905) and current antimuscarinic drugs in bladder and salivary glands: a Ca2+ mobilization study in monkey cells. Life sciences 20040102
Solifenacin appears effective and well tolerated in patients with symptomatic idiopathic detrusor overactivity in a placebo- and tolterodine-controlled phase 2 dose-finding study. BJU international 20040101
Drug treatment of overactive bladder: efficacy, cost and quality-of-life considerations. Drugs 20040101
Solifenacin demonstrates high absolute bioavailability in healthy men. Drugs in R&D 20040101
[Urinary incontinence: anticholinergic treatment]. Revista de medicina de la Universidad de Navarra 20040101
[Urinary incontinence: new pharmacologic therapies]. Revista de medicina de la Universidad de Navarra 20040101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20031101
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20030601
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20030101
M(3) receptor antagonism by the novel antimuscarinic agent solifenacin in the urinary bladder and salivary gland. Naunyn-Schmiedeberg's archives of pharmacology 20020801
Effects of YM905, a novel muscarinic M3-receptor antagonist, on experimental models of bowel dysfunction in vivo. Japanese journal of pharmacology 20010701
Properties