Home Other Building Blocks Orphenadrine citrate

Orphenadrine citrate

CAS No.:
4682-36-4
Catalog Number:
AG019FSG
Molecular Formula:
C24H31NO8
Molecular Weight:
461.5048
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%(HPLC)
In Stock USA
United States
$73
- +
5g
98%(HPLC)
In Stock USA
United States
$155
- +
Product Description
Catalog Number:
AG019FSG
Chemical Name:
Orphenadrine citrate
CAS Number:
4682-36-4
Molecular Formula:
C24H31NO8
Molecular Weight:
461.5048
MDL Number:
MFCD00079197
IUPAC Name:
N,N-dimethyl-2-[(2-methylphenyl)-phenylmethoxy]ethanamine;2-hydroxypropane-1,2,3-tricarboxylic acid
InChI:
InChI=1S/C18H23NO.C6H8O7/c1-15-9-7-8-12-17(15)18(20-14-13-19(2)3)16-10-5-4-6-11-16;7-3(8)1-6(13,5(11)12)2-4(9)10/h4-12,18H,13-14H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)
InChI Key:
MMMNTDFSPSQXJP-UHFFFAOYSA-N
SMILES:
OC(=O)CC(C(=O)O)(CC(=O)O)O.CN(CCOC(c1ccccc1C)c1ccccc1)C
EC Number:
225-137-5
NSC Number:
757238
Properties
Complexity:
488  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
461.205g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
461.511g/mol
Monoisotopic Mass:
461.205g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
145A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Liver tumor promoting effect of orphenadrine in rats and its possible mechanism of action including CAR activation and oxidative stress. The Journal of toxicological sciences 20130101
Enhanced liver tumor promotion activity in rats subjected to combined administration of phenobarbital and orphenadrine. The Journal of toxicological sciences 20130101
Cu(II)-catalyzed asymmetric hydrosilylation of diaryl- and aryl heteroaryl ketones: application in the enantioselective synthesis of orphenadrine and neobenodine. Chemistry (Weinheim an der Bergstrasse, Germany) 20120611
[Interaction of drugs with the primary disease - when medicines exacerbate illnesses]. Praxis 20120314
Reduction of tinnitus severity by the centrally acting muscle relaxant cyclobenzaprine: an open-label pilot study. Audiology & neuro-otology 20120101
Validated stability-indicating reversed-phase-HPLC method for simultaneous determination of orphenadrine citrate, caffeine and aspirin. Chemical & pharmaceutical bulletin 20120101
Orphenadrine induces secondarily generalized convulsive status epilepticus in rats. Brain research bulletin 20110405
A predictive ligand-based Bayesian model for human drug-induced liver injury. Drug metabolism and disposition: the biological fate of chemicals 20101201
Full recovery from a potentially lethal dose of orphenadrine ingestion using conservative treatment: a case report. Human & experimental toxicology 20101101
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. Bioorganic & medicinal chemistry letters 20101101
Opiate sparing effect of fixed combination of diclophenac and orphenadrine after unilateral total hip arthroplasty: A double-blind, randomized, placebo-controlled, multi-centre clinical trial. Wiener medizinische Wochenschrift (1946) 20101101
Determination of orphenadrine plasma levels using HPLC with diode array detection and a novel solid-phase extraction procedure in psychiatric patients. Journal of pharmaceutical and biomedical analysis 20091015
The use of antipsychotic and anticholinergic antiparkinson drugs in Norway after the withdrawal of orphenadrine. British journal of clinical pharmacology 20090801
The first asymmetric halogen/metal-exchange reaction: desymmetrization of alcohols with enantiotopic bromoarene substituents. Chemistry (Weinheim an der Bergstrasse, Germany) 20090706
Involvement of voltage-gated sodium channels blockade in the analgesic effects of orphenadrine. Pain 20090401
The use and potential abuse of anticholinergic antiparkinson drugs in Norway: a pharmacoepidemiological study. British journal of clinical pharmacology 20090201
Effects of cytochrome P450 inducers and inhibitors on the pharmacokinetics of intravenous furosemide in rats: involvement of CYP2C11, 2E1, 3A1 and 3A2 in furosemide metabolism. The Journal of pharmacy and pharmacology 20090101
Influence of orphenadrine upon the protective activity of various antiepileptics in the maximal electroshock-induced convulsions in mice. Pharmacological reports : PR 20090101
Pharmacokinetic, metabolism and withdrawal time of orphenadrine in camels (Camelus dromedarius) after intravenous administration. Research in veterinary science 20081201
[Diclofenac/orphenadrine as a combined analgetic in post-operative relief of pain]. Orvosi hetilap 20080928
Effect of warnings in a medical journal on the use of orphenadrine. Journal of evaluation in clinical practice 20080801
Are there alternatives to the use of quinine to treat nocturnal leg cramps? The Consultant pharmacist : the journal of the American Society of Consultant Pharmacists 20080201
Effects of CYP inducers and inhibitors on the pharmacokinetics of intravenous theophylline in rats: involvement of CYP1A1/2 in the formation of 1,3-DMU. The Journal of pharmacy and pharmacology 20080101
Anticholinergic antiparkinson drug orphenadrine inhibits HERG channels: block attenuation by mutations of the pore residues Y652 or F656. Naunyn-Schmiedeberg's archives of pharmacology 20071201
Determination of paracetamol and orphenadrine citrate in pharmaceutical tablets by modeling of spectrophotometric data using partial least-squares and artificial neural networks. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071001
Evaluation of enantioselective binding of antihistamines to human serum albumin by ACE. Electrophoresis 20070801
[Enzyme kinetics of schizandrin metabolism and sex differences in rat liver microsomes]. Yao xue xue bao = Acta pharmaceutica Sinica 20070701
Anticholinergic drug-induced delirium in an elderly Alzheimer's dementia patient. Archives of gerontology and geriatrics 20070101
Propofol metabolism is enhanced after repetitive ketamine administration in rats: the role of cytochrome P-450 2B induction. British journal of anaesthesia 20060901
Acute adverse cutaneous reaction after the concomitant use of venlafaxine and orphenadrine citrate plus paracetamol in a depressed patient. Journal of the European Academy of Dermatology and Venereology : JEADV 20060901
Efficacy and safety of combined piroxicam, dexamethasone, orphenadrine, and cyanocobalamin treatment in mandibular molar surgery. Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 20060901
Pharmacokinetic study of orphenadrine using high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060724
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Torsades de pointes in congenital long QT syndrome following low-dose orphenadrine. International journal of clinical practice 20060501
Catanionic mixtures involving a drug: a rather general concept that can be utilized for prolonged drug release from gels. Journal of pharmaceutical sciences 20060401
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes. Life sciences 20050701
Comparison of the analgesic effects of a fixed-dose combination of orphenadrine and diclofenac (Neodolpasse) with its single active ingredients diclofenac and orphenadrine: a placebo-controlled study using laser-induced somatosensory-evoked potentials from capsaicin-induced hyperalgesic human skin. Drugs in R&D 20050101
Rhythm-specific pharmacological modulation of subthalamic activity in Parkinson's disease. Experimental neurology 20041001
Objective high-frequency tinnitus of middle-ear myoclonus. The Journal of laryngology and otology 20040301
[Diclofenac 75mg. and 30 mg. orfenadine (Neodolpasse) versus placebo and piroxicam in postoperative analgesia after arthroscopy]. Acta chirurgiae orthopaedicae et traumatologiae Cechoslovaca 20040101
Analgesic effects of low-dose intravenous orphenadrine in the state of capsaicin hyperalgesia. A randomised, placebo-controlled, double-blind cross-over study using laser somatosensory evoked potentials obtained from capsaicin-irritated skin in healthy volunteers. Arzneimittel-Forschung 20040101
Upregulation of cytochromes P450 2B in rat liver by orphenadrine. British journal of pharmacology 20030601
Neuronal sensitization and its behavioral correlates in a rat model of neuropathy are prevented by a cyclic analog of orphenadrine. Journal of neurotrauma 20030601
Therapeutic response of benzodiazepine, orphenadrine citrate and occlusal splint association in TMD pain. Cranio : the journal of craniomandibular practice 20030401
Affinity and specificity of N-methyl- D-aspartate channel blockers affect their ability to disrupt prepulse inhibition of acoustic startle in rats. Psychopharmacology 20030201
Spectrophotometric determination of phenylephrine HCl and orphenadrine citrate in pure and in dosage forms. Journal of pharmaceutical and biomedical analysis 20021107
Nefopam, an analogue of orphenadrine, protects against both NMDA receptor-dependent and independent veratridine-induced neurotoxicity. Amino acids 20020101
Acute intoxication with orphenadrine and clozapine. Forensic science international 20011115
Non-sustained ventricular tachycardia due to low-dose orphenadrine. The American journal of medicine 20011001
Cytochrome P4502B6 and 2C9 do not metabolize midazolam: kinetic analysis and inhibition study with monoclonal antibodies. British journal of anaesthesia 20010401
Orphenadrine prevents 3-nitropropionic acid-induced neurotoxicity in vitro and in vivo. British journal of pharmacology 20010201
[Experience gained with the drug amizon in the treatment of patients with mumps, with special reference to its effects on some biochemical markers]. Likars'ka sprava 20010101
[Diagnostic image (17). Acute dystonia induced by prochlorperazine]. Nederlands tijdschrift voor geneeskunde 20001223
Examination of purported probes of human CYP2B6. Pharmacogenetics 19970601
Reversal of orphenadrine-induced ventricular tachycardia with physostigmine. The Journal of emergency medicine 19910101
Mental impairment in Parkinson's disease. The role of anticholinergic drugs. Acta psychiatrica Belgica 19840101
[Orphenadrine poisoning]. Ugeskrift for laeger 19810316
An extrapyramidal syndrome after lithium therapy. The British journal of psychiatry : the journal of mental science 19800201
A comparative trial of orphenadrine and tofenacin in the control of depression and extrapyramidal side-effects associated with fluphenazine decanoate therapy. The Journal of international medical research 19760101
Visual hallucinations and delirium during treatment with amantadine (Symmetrel). Journal of the American Geriatrics Society 19750501
[Pilot study on the effects of an antiparkinson anticholinergic agent during depressive conditions]. L'Encephale 19750101
Abnormal involuntary movements induced by anticholinergic therapy. Acta neurologica Scandinavica 19740101
Fluphenazine enanthate and fluphenazine decanoate: a comparison of their duration of action and motor side effects. The American journal of psychiatry 19730701
Haloperidol-desipramine interaction in mice, rats and man. Chemico-biological interactions 19700801
A controlled trial of anti-Parkinson drugs in drug-induced Parkinsonism. The British journal of psychiatry : the journal of mental science 19660601
Properties