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Nicardipine

CAS No.:
55985-32-5
Catalog Number:
AG019FS8
Molecular Formula:
C26H29N3O6-
Molecular Weight:
479.5250
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
250mg
95%
In Stock USA
United States
$63
- +
1g
95%
In Stock USA
United States
$113
- +
2g
95%
In Stock USA
United States
$200
- +
5g
95%
In Stock USA
United States
$450
- +
10g
95%
In Stock USA
United States
$788
- +
Product Description
Catalog Number:
AG019FS8
Chemical Name:
Nicardipine
CAS Number:
55985-32-5
Molecular Formula:
C26H29N3O6-
Molecular Weight:
479.5250
MDL Number:
MFCD00216027
IUPAC Name:
5-O-[2-[benzyl(methyl)amino]ethyl] 3-O-methyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate
InChI:
InChI=1S/C26H29N3O6/c1-17-22(25(30)34-4)24(20-11-8-12-21(15-20)29(32)33)23(18(2)27-17)26(31)35-14-13-28(3)16-19-9-6-5-7-10-19/h5-12,15,24,27H,13-14,16H2,1-4H3
InChI Key:
ZBBHBTPTTSWHBA-UHFFFAOYSA-N
SMILES:
COC(=O)C1=[C](C)(CCN(Cc2ccccc2)C)NC(=C(C1c1cccc(c1)[N+](=O)[O-])C(=O)[O-])C
EC Number:
259-932-3
Properties
Complexity:
856  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
479.206g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
479.533g/mol
Monoisotopic Mass:
479.206g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
114A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
3.8  
Literature
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Comparative effects of propofol, landiolol, and nicardipine on hemodynamic and bispectral index responses to endotracheal intubation: a prospective, randomized, double-blinded study. Journal of clinical anesthesia 20080601
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[6]-gingerol induces Ca2+ mobilization in Madin-Darby canine kidney cells. Journal of natural products 20080101
A comparison of nicardipine and labetalol for acute hypertension management following stroke. Neurocritical care 20080101
Effect of chemosensitizers on minimum inhibitory concentrations of fluconazole in Candida albicans. Medical principles and practice : international journal of the Kuwait University, Health Science Centre 20080101
Late and fatal deterioration of an intracerebral hemorrhage attributable to the onset of a high titer of acquired factor V inhibitor. European neurology 20080101
Nicardipine and adenosine 'flush cocktail' to prevent no-reflow during rotational atherectomy. Cardiovascular revascularization medicine : including molecular interventions 20080101
An investigation into the influence of counterion on the properties of some amorphous organic salts. Molecular pharmaceutics 20080101
Nicardipine versus salbutamol in the treatment of premature labor: comparison of their efficacy and side effects. La Tunisie medicale 20080101
New functional assay of P-glycoprotein activity using Hoechst 33342. Bioorganic & medicinal chemistry 20071201
Effect of anabasine on catecholamine secretion from the perfused rat adrenal medulla. Journal of cardiology 20071201
Calcium channel blockers increase the amount of nitrite production in rabbits without decreasing the responsiveness of platelets to collagen. Clinical and experimental medicine 20071201
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Properties of spontaneous Ca2+ transients recorded from interstitial cells of Cajal-like cells of the rabbit urethra in situ. The Journal of physiology 20070901
Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients. Neurologia medico-chirurgica 20070901
Assessment of the effects of L- and N-type Ca2+ channel blocking drugs using canine blood-perfused papillary muscle preparations. The Tohoku journal of experimental medicine 20070801
Symptomatic autoregulatory failure in acute ischemic stroke. Neurology 20070710
Quantitative structure--activity relationship analysis and molecular dynamics simulation to functionally validate nonsynonymous polymorphisms of human ABC transporter ABCB1 (P-glycoprotein/MDR1). Biochemistry 20070703
Calcium channel blocker prevents T helper type 2 cell-mediated airway inflammation. American journal of respiratory and critical care medicine 20070601
[Pulmonary edema during calcium-channel blockers therapy: role of predisposing or pharmacologic factors?]. Journal de gynecologie, obstetrique et biologie de la reproduction 20070601
Vasorelaxant effects of Acer nikoense extract and isolated coumarinolignans on rat aortic rings. Biological & pharmaceutical bulletin 20070601
Regulation of membrane excitability by intracellular pH (pHi) changers through Ca2+-activated K+ current (BK channel) in single smooth muscle cells from rabbit basilar artery. Pflugers Archiv : European journal of physiology 20070501
The mechanism and spread of pacemaker activity through myenteric interstitial cells of Cajal in human small intestine. Gastroenterology 20070501
Safety and feasibility of intra-arterial nicardipine for the treatment of subarachnoid hemorrhage-associated vasospasm: initial clinical experience with high-dose infusions. AJNR. American journal of neuroradiology 20070501
G1 cell cycle arrest by amlodipine, a dihydropyridine Ca2+ channel blocker, in human epidermoid carcinoma A431 cells. Biochemical pharmacology 20070401
Reversible cognitive and neurological symptoms during valproic acid therapy. Journal of the American Geriatrics Society 20070401
Anesthetic considerations of selective intra-arterial nicardipine injection for intracranial vasospasm: a case series. Journal of neurosurgical anesthesiology 20070401
Augmentation of cerebral blood flow and reversal of endothelin-1-induced vasospasm: a comparison of intracarotid nicardipine and verapamil. Neurosurgery 20070401
Azelnidipine attenuates cardiovascular and sympathetic responses to air-jet stress in genetically hypertensive rats. Hypertension research : official journal of the Japanese Society of Hypertension 20070401
The comparative effects of intravenous nicardipine and prostaglandin E1 on the cerebral pial arteriolar constriction seen after unclamping of an aortic cross-clamp in rabbits. Anesthesia and analgesia 20070301
Nicardipine in pre-eclamptic patients: placental transfer and disposition in breast milk. BJOG : an international journal of obstetrics and gynaecology 20070201
Effect of nicardipine prolonged-release implants on cerebral vasospasm and clinical outcome after severe aneurysmal subarachnoid hemorrhage: a prospective, randomized, double-blind phase IIa study. Stroke 20070201
L-type calcium current reactivation contributes to arrhythmogenesis associated with action potential triangulation. Journal of cardiovascular electrophysiology 20070201
'Pharmacologic' distal protection using prophylactic, intragraft nicardipine to prevent no-reflow and non-Q-wave myocardial infarction during elective saphenous vein graft intervention. The Journal of invasive cardiology 20070201
Comparison of nicardipine versus esmolol in attenuating the hemodynamic responses to anesthesia emergence and extubation. Journal of cardiothoracic and vascular anesthesia 20070201
Induction of hepatic cytochrome P450 isoforms by nicardipine at therapeutic doses in spontaneously hypertensive rats. The Journal of toxicological sciences 20070201
Action potential and QT prolongation not sufficient to cause Torsade de Pointes: role of action potential triangulation. Journal of cardiovascular electrophysiology 20070201
Predictors of hematoma enlargement in patients with intracerebral hemorrhage treated with rapid administration of antifibrinolytic agents and strict blood pressure control. Journal of neurosurgery 20070201
Ischemic colitis following colonoscopy in an elderly patient on cardiovascular medication. Endoscopy 20070201
Relative activation of human pregnane X receptor versus constitutive androstane receptor defines distinct classes of CYP2B6 and CYP3A4 inducers. The Journal of pharmacology and experimental therapeutics 20070101
Differential modulation of 7-ketocholesterol toxicity against PC12 cells by calmodulin antagonists and Ca2+ channel blockers. Neurochemical research 20070101
Autoantibody-mediated bladder dysfunction in type 1 diabetes. Scandinavian journal of immunology 20070101
Intravenously administered vasodilatory prostaglandins increase retinal and choroidal blood flow in rats. Journal of pharmacological sciences 20070101
Effect of nicardipine on haemodynamic and bispectral index changes following endotracheal intubation. The Journal of international medical research 20070101
Effects of nicardipine-induced hypotension on cerebrovascular carbon dioxide reactivity in patients with diabetes mellitus under sevoflurane anesthesia. Journal of anesthesia 20070101
[Isolated severe neurologic disorders in post-partum: posterior reversible encephalopathy syndrome]. Annales francaises d'anesthesie et de reanimation 20070101
Preliminary experience with intra-arterial nicardipine in patients with acute ischemic stroke. Neurocritical care 20070101
[Vasorelaxant effect of sulfur dioxide derivatives on isolated aortic rings of rats and its mechanisms]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20061218
Pathophysiology and medical management of systemic hypertension in preeclampsia. Current hypertension reports 20061201
The suppressant effect of GEA3162 on spontaneous serotonin release from human colonic mucosa in vitro. European journal of pharmacology 20061121
Efficacy of intracoronary nicardipine in the treatment of no-reflow during percutaneous coronary intervention. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions 20061101
Improvement of donor myocardial function after treatment of autonomic storm during brain death. Transplantation 20061027
Role of calcium channels in cadmium-induced disruption of cortisol synthesis in rainbow trout (Oncorhynchus mykiss). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20061001
Blood pressure management in patients with intracerebral and subarachnoid hemorrhage. Neurosurgery clinics of North America 20060901
Evaluation of blood pressure measured by tail-cuff methods (without heating) in spontaneously hypertensive rats. Biological & pharmaceutical bulletin 20060801
The calcium channel blockers, 1,4-dihydropyridines, are substrates of the multidrug resistance-linked ABC drug transporter, ABCG2. Biochemistry 20060725
Treatment of acute hypertension in patients with intracerebral hemorrhage using American Heart Association guidelines. Critical care medicine 20060701
The visceromotor responses to colorectal distension and skin pinch are inhibited by simultaneous jejunal distension. Pain 20060701
Blood pressure control after intracerebral hemorrhage: have we reached the target? Critical care medicine 20060701
Differential involvement of intracellular Ca2+ in 1-methyl-4-phenylpyridinium- or 6-hydroxydopamine-induced cell viability loss in PC12 cells. Neurochemical research 20060701
Endogenous release of secretin from the hypothalamus. Annals of the New York Academy of Sciences 20060701
The cGMP/protein kinase G pathway contributes to dihydropyridine-sensitive calcium response and cytokine production in TH2 lymphocytes. The Journal of biological chemistry 20060505
Ca2+ channel activating action of maitotoxin in cultured brainstem neurons. European journal of pharmacology 20060501
Images in cardiovascular medicine. Coronary artery spasm. Circulation 20060411
Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage. Neurosurgery 20060401
Stretch-induced triphosphorylation of myosin light chain and myogenic tone in canine basilar artery. European journal of pharmacology 20060318
Expression of the neurokinin type 1 receptor in the human colon. Autonomic neuroscience : basic & clinical 20060130
Liquid chromatography-mass spectrometry method for the determination of nicardipine in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Deltamethrin, a pyrethroid insecticide, is a potent inducer for the activity-dependent gene expression of brain-derived neurotrophic factor in neurons. The Journal of pharmacology and experimental therapeutics 20060101
Vasorelaxant effects of methyl brevifolincarboxylate from the leaves of Phyllanthus niruri. Biological & pharmaceutical bulletin 20060101
[Tocolysis with nifedipine: its use in current practice. Gynecol Obstet Fertil 2005;33:483-7]. Gynecologie, obstetrique & fertilite 20060101
Managing emergency hypertension in aortic dissection and aortic aneurysm surgery. Journal of cardiac surgery 20060101
Determination of nifedipine in serum of women in preterm labor by high-performance liquid chromatography with diode array detection. Journal of AOAC International 20060101
Elevated plasma nitric oxide metabolites in hypertension: synergistic vasodepressor effects of a static magnetic field and nicardipine in spontaneously hypertensive rats. Clinical hemorheology and microcirculation 20060101
Analysis of responses to kava kava in the feline pulmonary vascular bed. Journal of medicinal food 20060101
Effects of indoxylsulfate on the in vitro hepatic metabolism of various compounds using human liver microsomes and hepatocytes. Nephron. Physiology 20060101
Intravenous nicardipine: its use in the short-term treatment of hypertension and various other indications. Drugs 20060101
A review of calcium channel antagonists in the treatment of pediatric hypertension. Paediatric drugs 20060101
Thermal stability of 1,4-dihydropyridine derivatives in solid state. Acta poloniae pharmaceutica 20060101
Exposure to a moderate intensity static magnetic field enhances the hypotensive effect of a calcium channel blocker in spontaneously hypertensive rats. Bioelectromagnetics 20051201
Intravenous use of the calcium-channel blocker nicardipine as second-line treatment in severe, early-onset pre-eclamptic patients. Journal of hypertension 20051201
[Acute pulmonary edema during preterm labor: role of nicardipine tocolysis (three cases)]. Journal de gynecologie, obstetrique et biologie de la reproduction 20051201
Long-term anti-hypertensive therapy with benidipine improves arterial stiffness over blood pressure lowering. Hypertension research : official journal of the Japanese Society of Hypertension 20051201
Rapid administration of antifibrinolytics and strict blood pressure control for intracerebral hemorrhage. Neurosurgery 20051101
Electrophysiological and molecular identification of voltage-gated sodium channels in murine vascular myocytes. The Journal of physiology 20051001
M(2) and M(3) muscarinic receptor-mediated contractions in longitudinal smooth muscle of the ileum studied with receptor knockout mice. British journal of pharmacology 20050901
Effects of neck exposure to 5.5 mT static magnetic field on pharmacologically modulated blood pressure in conscious rabbits. Bioelectromagnetics 20050901
[Acute pulmonary edema during nicardipine and salbutamol therapy for preterm labor in twin pregnancy]. Journal de gynecologie, obstetrique et biologie de la reproduction 20050901
Phenylephrine to increase blood flow in the radial artery used as a coronary bypass conduit. The Journal of thoracic and cardiovascular surgery 20050901
Automated screening with confirmation of mechanism-based inactivation of CYP3A4, CYP2C9, CYP2C19, CYP2D6, and CYP1A2 in pooled human liver microsomes. Drug metabolism and disposition: the biological fate of chemicals 20050801
Secretory phospholipases A2 induce neurite outgrowth in PC12 cells through lysophosphatidylcholine generation and activation of G2A receptor. The Journal of biological chemistry 20050729
The coupling mechanism of P-glycoprotein involves residue L339 in the sixth membrane spanning segment. FEBS letters 20050718
C-type natriuretic peptide inhibits L-type Ca2+ current in rat magnocellular neurosecretory cells by activating the NPR-C receptor. Journal of neurophysiology 20050701
Extrapolation of human pharmacokinetic parameters from rat, dog, and monkey data: Molecular properties associated with extrapolative success or failure. Journal of pharmaceutical sciences 20050701
Radix angelica elicits both nitric oxide-dependent and calcium influx-mediated relaxation in rat aorta. Journal of cardiovascular pharmacology 20050701
Anaphylactic shock: a form of distributive shock without inhibition of oxygen consumption. Anesthesiology 20050701
Endovascular treatment of cerebral vasospasm: transluminal balloon angioplasty, intra-arterial papaverine, and intra-arterial nicardipine. Neurosurgery clinics of North America 20050701
Prediction of genotoxicity of chemical compounds by statistical learning methods. Chemical research in toxicology 20050601
Intragraft nicardipine prophylaxis to prevent no-reflow in triple-vessel saphenous vein graft intervention. The Journal of invasive cardiology 20050601
Raynaud's phenomenon (primary). Clinical evidence 20050601
A novel neurotrophic role of secretory phospholipases A2 for cerebellar granule neurons. FEBS letters 20050509
Pheochromocytoma unmasked by amisulpride and tiapride. The Annals of pharmacotherapy 20050501
The effect of calcium channel blockers on outcome following the surgical treatment of phaeochromocytomas and paragangliomas. Anaesthesia 20050501
Application of nicardipine prolonged-release implants: analysis of 97 consecutive patients with acute subarachnoid hemorrhage. Neurosurgery 20050501
Inhibitory effects of nicardipine to cytochrome P450 (CYP) in human liver microsomes. Biological & pharmaceutical bulletin 20050501
Comment on the article 'Acute pulmonary oedema during nicardipine therapy for premature labour. Report of five cases' by Vaast P., et al. [Eur J Obstet Gynecol Reprod Biol 2004;113:98-9]. European journal of obstetrics, gynecology, and reproductive biology 20050501
Coronary blood flow responses are impaired independent of NO and endothelial function in conscious dogs with dilated cardiomyopathy. Journal of cardiac failure 20050501
Comparison of the direct negative dromotropic effect of a new calcium channel blocker, cilnidipine, with that of nicardipine. Heart and vessels 20050501
Nicardipine, a calcium antagonist, does not aggravate intracerebral haemorrhage in an intracerebral haemorrhage model in rats. The Journal of pharmacy and pharmacology 20050401
Cardiovascular effects and lethality of venom from nematocysts of the box-jellyfish Chiropsalmus quadrigatus (Habu-kurage) in anaesthetized rats. Toxicon : official journal of the International Society on Toxinology 20050315
Role of l-Ca(2+) channels in intestinal pacing in wild-type and W/W(V) mice. American journal of physiology. Gastrointestinal and liver physiology 20050301
Ionic mechanism for contractile response to hyposmotic challenge in canine basilar arteries. American journal of physiology. Cell physiology 20050301
Alteration of cyclopiazonic acid-mediated contracture of mouse diaphragm after denervation. Pharmacology 20050301
Responses of the sustained inward current to autonomic agonists in guinea-pig sino-atrial node pacemaker cells. British journal of pharmacology 20050301
Intubation without premedication may worsen outcome for unconsciousness patients with intracranial hemorrhage. The American journal of emergency medicine 20050301
Use of a bolus injection of nicardipine to prevent severe electroconvulsive therapy-induced bradycardia. Journal of clinical anesthesia 20050301
The difference between nicardipine and its enantiomers on inhibiting vasoconstriction of isolated rabbit thoracic artery. Archives of pharmacal research 20050301
The use of nicardipine for electroconvulsive therapy: a dose-ranging study. Anesthesia and analgesia 20050201
[Vasorelaxant effects of forsythiaside from the fruits of Forsythia suspensa]. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20050201
Optimization of pH-independent release of nicardipine hydrochloride extended-release matrix tablets using response surface methodology. International journal of pharmaceutics 20050131
Effect of nicardipine combined with esmolol on systemic and tissue oxygenation during off-pump coronary artery bypass grafting surgery. Chinese medical journal 20050120
[Antihypertensive management in acute cerebral stroke]. Medicina (Kaunas, Lithuania) 20050101
[Toxicological analysis of selected 1,4-dihydropyridine calcium channel blockers in the diagnosis of intoxications]. Archiwum medycyny sadowej i kryminologii 20050101
Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: correlation study with induction in vivo. Journal of pharmacological and toxicological methods 20050101
Nicardipine or labetalol as short-term treatment for severe hypertension of pregnancy. Current hypertension reports 20041201
Quantitative determination of amorphous nicardipine hydrochloride in long acting formula (NIC-LA) using light anhydrous silicic acid. Chemical & pharmaceutical bulletin 20041201
Raynaud's phenomenon (primary). Clinical evidence 20041201
Evaluation of photostability of solid-state nicardipine hydrochloride polymorphs by using Fourier-transformed reflection-absorption infrared spectroscopy - effect of grinding on the photostability of crystal form. International journal of pharmaceutics 20041122
P-glycoprotein retains function when reconstituted into a sphingolipid- and cholesterol-rich environment. Journal of lipid research 20041001
Differences in the inhibition of cytochromes P450 3A4 and 3A5 by metabolite-inhibitor complex-forming drugs. Drug metabolism and disposition: the biological fate of chemicals 20041001
High prevalence of right ventricular systolic dysfunction in early systemic sclerosis. The Journal of rheumatology 20041001
Clinical features and management of selected hypertensive emergencies. Journal of clinical hypertension (Greenwich, Conn.) 20041001
Factors affecting habituation of PC12 cells to ATP. European journal of biochemistry 20041001
Pulmonary edema induced by calcium-channel blockade for tocolysis. Anesthesia and analgesia 20040901
[Anesthetic management of a patient with acute idiopathic pandysautonomia]. Masui. The Japanese journal of anesthesiology 20040901
[Nicardipine-induced gingival hyperplasia: case report]. Revue de stomatologie et de chirurgie maxillo-faciale 20040901
Interactions of phospholipase D and cytochrome P450 protein stability. Biochemical pharmacology 20040801
Current applications for nicardipine in invasive and interventional cardiology. The Journal of invasive cardiology 20040801
Calcium influx pathways in rat CNS pericytes. Brain research. Molecular brain research 20040726
Induction of hepatic cyp2b and cyp3a subfamily enzymes by nicardipine and nifedipine in mice. Xenobiotica; the fate of foreign compounds in biological systems 20040701
Changes in calcium signalling, gravitropism, and statocyte ultrastructure in pea roots induced by calcium channel blockers. Journal of gravitational physiology : a journal of the International Society for Gravitational Physiology 20040701
Dihydropyridine receptors are selective markers of Th2 cells and can be targeted to prevent Th2-dependent immunopathological disorders. Journal of immunology (Baltimore, Md. : 1950) 20040501
Preliminary experience with intra-arterial nicardipine as a treatment for cerebral vasospasm. AJNR. American journal of neuroradiology 20040501
Treatment with nicardipine protects brain in an animal model of hypertension-induced damage. Clinical and experimental hypertension (New York, N.Y. : 1993) 20040501
Bioequivalence study of nicardipine solution versus nicardipine tablets. Clinical and experimental hypertension (New York, N.Y. : 1993) 20040501
Photostability studies on nicardipine-cyclodextrin complexes by capillary electrophoresis. Journal of pharmaceutical and biomedical analysis 20040416
ICC pacing mechanisms in intact mouse intestine differ from those in cultured or dissected intestine. American journal of physiology. Gastrointestinal and liver physiology 20040401
Sex difference in induction of hepatic CYP2B and CYP3A subfamily enzymes by nicardipine and nifedipine in rats. Toxicology and applied pharmacology 20040401
Acute pulmonary oedema during nicardipine therapy for premature labour; Report of five cases. European journal of obstetrics, gynecology, and reproductive biology 20040315
Verapamil increases the apolipoprotein-mediated release of cellular cholesterol by induction of ABCA1 expression via Liver X receptor-independent mechanism. Arteriosclerosis, thrombosis, and vascular biology 20040301
Vasodilation increases the threshold for bupivacaine-induced convulsions in rats. Anesthesia and analgesia 20040301
A new model of pacing in the mouse intestine. American journal of physiology. Gastrointestinal and liver physiology 20040201
Nicardipine versus nitroprusside for deliberate hypotension during idiopathic scoliosis repair. Journal of clinical anesthesia 20040201
[Migraine prophylaxis with calcium antagonists: a haemodynamic study using transcranial Doppler ultrasound]. Revista de neurologia 20040201
Effect of combination of dizocilpine with general antiepileptic drugs on amygdala kindling models in rats. Yao xue xue bao = Acta pharmaceutica Sinica 20040201
Study of drug effects of calcium channel blockers on retinal degeneration of rd mouse. Biochemical and biophysical research communications 20040123
Intravenous nicardipine for treatment of postcoarctectomy hypertension in children. Pediatric cardiology 20040101
Nicardipine versus nitroprusside infusion as antihypertensive therapy in hypertensive emergencies. The Journal of international medical research 20040101
[Comparison of three protocols in the control of cardiovascular response to suspended laryngoscopy in ENT surgery]. La Tunisie medicale 20040101
Comparison of the effects of nicardipine and sodium nitroprusside for control of increased blood pressure after coronary artery bypass graft surgery. The Journal of international medical research 20040101
Effect of erythropoietin on nitric oxide production in the rat hippocampus using in vivo brain microdialysis. Neuroscience 20040101
Pharmacokinetics of tocolytic agents. Clinical pharmacokinetics 20040101
Analysis of responses to St. John's Wort in the feline pulmonary vascular bed. Journal of herbal pharmacotherapy 20040101
Calcium mobilisation and CCK secretion induced by modified fatty acids and latex microspheres reveal dual receptor mechanisms for lipid stimulation of STC-1 cells. The Journal of physiology 20031215
Circumferential, not longitudinal, colonic stretch increases synaptic input to mouse prevertebral ganglion neurons. American journal of physiology. Gastrointestinal and liver physiology 20031201
The effect of intraoperative use of esmolol and nicardipine on recovery after ambulatory surgery. Anesthesia and analgesia 20031201
The role of calcium channels in substance P-induced contractile response in the rat iris. Peptides 20031201
Raynaud's (primary). Clinical evidence 20031201
Peroxynitrite-induced cardiac depression: role of myofilament desensitization and cGMP pathway. Cardiovascular research 20031101
Inhibitory effects of carvedilol on calcium channels in vascular smooth muscle cells. Japanese heart journal 20031101
Identification and prediction of promiscuous aggregating inhibitors among known drugs. Journal of medicinal chemistry 20031009
Inhibitory effects of potassium channel blockers on carbachol-induced contraction in rat detrusor muscle. Journal of Korean medical science 20031001
Nicardipine or nitroglycerin in patients with failed percutaneous coronary angioplasty: effect on myocardial diastolic function. Journal of cardiothoracic and vascular anesthesia 20031001
Effects of nicardipine and diltiazem on the bispectral index and 95% spectral edge frequency. European journal of anaesthesiology 20031001
Analysis of factors that determine the compliance of rat jejunum to distension in vivo. Neurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society 20030801
The in vitro effect of dual combinations of ritodrine, nicardipine and atosiban on contractility of pregnant rat myometrium. BJOG : an international journal of obstetrics and gynaecology 20030801
Role of calcium mobilization in sodium nitroprusside-induced increase of calcium-activated potassium currents in gastric antral circular myocytes of guinea pig. Acta pharmacologica Sinica 20030801
[A case report of the laryngeal edema and peripheral cyanosis after extubation of the tracheal tube]. Masui. The Japanese journal of anesthesiology 20030801
Pharmacological modulation of fatty acid desaturation and of cholesterol biosynthesis in THP-1 cells. Lipids 20030801
No major difference in inhibitory susceptibility between CYP2C9.1 and CYP2C9.3. European journal of clinical pharmacology 20030701
Effect of high concentration of glucose on dopamine release from pheochromocytoma-12 cells. Metabolism: clinical and experimental 20030701
Effects of diltiazem compared with nicardipine on diaphragmatic fatigability in vivo. European journal of anaesthesiology 20030701
New evidence on the mechanisms underlying bradykinin-mediated contraction of the pig iris sphincter in vitro. Peptides 20030701
Dihydropyridine Ca2+ channel antagonists and agonists block Kv4.2, Kv4.3 and Kv1.4 K+ channels expressed in HEK293 cells. British journal of pharmacology 20030601
Raynaud's phenomenon (primary). Clinical evidence 20030601
Effects of three different L-type Ca2+ entry blockers on airway constriction induced by muscarinic receptor stimulation. British journal of anaesthesia 20030501
Nicardipine to control neonatal hypertension during extracorporeal membrane oxygen support. The Annals of pharmacotherapy 20030501
Influence of menthol and pressure-sensitive adhesives on the in vivo performance of membrane-moderated transdermal therapeutic system of nicardipine hydrochloride in human volunteers. European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V 20030501
Comparison of in vitro P-glycoprotein screening assays: recommendations for their use in drug discovery. Journal of medicinal chemistry 20030424
High-affinity binding of [3H]DTZ323 to the diltiazem-binding site of L-type Ca2+ channels. European journal of pharmacology 20030411
The comparative effects of prostaglandin E1 and nicardipine on cerebral microcirculation in rabbits. Anesthesia and analgesia 20030401
Multimodal molecular encapsulation of nicardipine hydrochloride by beta-cyclodextrin, hydroxypropyl-beta-cyclodextrin and triacetyl-beta-cyclodextrin in solution. Structural studies by 1H NMR and ROESY experiments. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20030401
Substance P modulates localized calcium transients and membrane current responses in murine colonic myocytes. British journal of pharmacology 20030401
Ameliorative effect of NC-1900, a new AVP4-9 analog, through vasopressin V1A receptor on scopolamine-induced impairments of spatial memory in the eight-arm radial maze. Neuropharmacology 20030301
Effects of nicardipine on coronary, vertebral and renal arterial flows in patients with essential hypertension. Hypertension research : official journal of the Japanese Society of Hypertension 20030301
Inactivation of aconitase during the apoptosis of mouse cerebellar granule neurons induced by a deprivation of membrane depolarization. Journal of neuroscience research 20030215
Hydrophilic and hydrophobic cyclodextrins in a new sustained release oral formulation of nicardipine: in vitro evaluation and bioavailability studies in rabbits. Journal of controlled release : official journal of the Controlled Release Society 20030214
The vasodilatory effects of hydralazine, nicardipine, nitroglycerin, and fenoldopam in the human umbilical artery. Anesthesia and analgesia 20030201
Nicardipine augments local myocardial perfusion after coronary artery reperfusion in dogs. Journal of Korean medical science 20030201
Induction of hepatic cytochrome P450s responsible for the metabolism of xenobiotics by nicardipine and other calcium channel antagonists in the male rat. Xenobiotica; the fate of foreign compounds in biological systems 20030201
Enhanced percutaneous permeability of nicardipine hydrochloride by carvone across the rat abdominal skin. Drug development and industrial pharmacy 20030201
Decrease in plasma NOx concentration by isosorbide dinitrate, an organic nitrate ester. Journal of cardiovascular pharmacology 20030101
A simple method for nicardipine hydrochloride quantification in plasma using solid-phase extraction and reversed-phase high-performance liquid chromatography. Biomedical chromatography : BMC 20030101
Identification and characterization of Scp15, a protein from Streptomyces coelicolor A3(2) inducing neurites in PC12 cells. Bioscience, biotechnology, and biochemistry 20030101
Formulation and evaluation of sustained release floating capsules of nicardipine hydrochloride. Die Pharmazie 20030101
Formulation and in vivo evaluation of membrane-moderated transdermal therapeutic systems of nicardipine hydrochloride using carvone as a penetration enhancer. Drug delivery 20030101
[Therapeutics indications and prognosis of eclampsia at Dakar University Teaching Hospital]. Journal de gynecologie, obstetrique et biologie de la reproduction 20030101
[Reversible posterior leukoencephalopathy syndrome]. Revue medicale de Liege 20030101
Interaction of Ginkgo biloba extract (GBE) with hypotensive agent, nicardipine, in rats. In vivo (Athens, Greece) 20030101
Spatial and temporal aspects of Ca2+ signaling mediated by P2Y receptors in cultured rat hippocampal astrocytes. Life sciences 20021220
Effects of four antihypertensive monotherapies on cardiac mass and function in hypertensive patients with left ventricular hypertrophy: randomized prospective study. Croatian medical journal 20021201
Combined use of esmolol and nicardipine to blunt the haemodynamic changes following laryngoscopy and tracheal intubation. Anaesthesia 20021201
Effect of the hydrophobic nature of triacetyl-beta-cyclodextrin on the complexation with nicardipine hydrochloride: physicochemical and dissolution properties of the kneaded and spray-dried complexes. Chemical & pharmaceutical bulletin 20021201
Effect of limonene on the in vitro permeation of nicardipine hydrochloride across the excised rat abdominal skin. Die Pharmazie 20021201
Effects of nicardipine and clonidine on cognitive functions and electroencephalography in hypertensive patients. Fundamental & clinical pharmacology 20021201
Randomized, comparative, double-blind study of amlodipine vs. nicardipine as a treatment of isolated systolic hypertension in the elderly. Fundamental & clinical pharmacology 20021201
Antioxidant effects and anti-elastase activity of the calcium antagonist nicardipine on activated human and rabbit neutrophils--a potential antiatherosclerotic property of calcium antagonists? Cardiovascular drugs and therapy 20021201
Detection of the calcium antagonist nicardipine and its metabolites by gas chromatography-mass spectrometry. Forensic science international 20021105
Involvement of T-type calcium channels in excitatory junction potentials in rat resistance mesenteric arteries. British journal of pharmacology 20021101
Intracellular calcium was involved in muscarinic currents increased by hypoosmotic membrane stretch in gastric myocytes of guinea pig. Acta pharmacologica Sinica 20021101
Influence of limonene on the bioavailability of nicardipine hydrochloride from membrane-moderated transdermal therapeutic systems in human volunteers. International journal of pharmaceutics 20021024
Effect of diaspirin cross-linked haemoglobin (DCLHb) on mean arterial pressure during cardiopulmonary bypass in swine. Transfusion medicine (Oxford, England) 20021001
[The effect of phosphodiesterase type 3 inhibitor on chorio-retinal blood flow in rabbits eyes]. Nippon Ganka Gakkai zasshi 20021001
Pituitary adenylate cyclase-activating polypeptide induces a sustained increase in intracellular free Ca(2+) concentration and catechol amine release by activating Ca(2+) influx via receptor-stimulated Ca(2+) entry, independent of store-operated Ca(2+) channels, and voltage-dependent Ca(2+) channels in bovine adrenal medullary chromaffin cells. The Journal of pharmacology and experimental therapeutics 20020901
Short-term treatment of severe hypertension of pregnancy: prospective comparison of nicardipine and labetalol. Intensive care medicine 20020901
Protection against ischemia and improvement of cerebral blood flow in genetically hypertensive rats by chronic pretreatment with an angiotensin II AT1 antagonist. Stroke 20020901
In vitro study of tocolytic effect of rofecoxib, a specific cyclo-oxygenase 2 inhibitor. Comparison and combination with other tocolytic agents. BJOG : an international journal of obstetrics and gynaecology 20020901
Relative effects of dihydropyridine L-type calcium channel antagonism on biliary, duodenal, and vascular tissues: an in vivo and in vitro analysis in Australian brush-tailed possum. Digestive diseases and sciences 20020901
Regulation of structural plasticity by different channel types in rod and cone photoreceptors. The Journal of neuroscience : the official journal of the Society for Neuroscience 20020815
Patterns of intracellular and intercellular Ca2+ waves in the longitudinal muscle layer of the murine large intestine in vitro. The Journal of physiology 20020815
Effects of 12 Ca2+ antagonists on multidrug resistance, MDR1-mediated transport and MDR1 mRNA expression. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020801
Profound sinus bradycardia after intravenous nicardipine. Anesthesia and analgesia 20020701
Influence of nicardipine and nifedipine on plasma carvedilol disposition after oral administration in rats. The Journal of pharmacy and pharmacology 20020601
Increased activity of calcium channels and Rho-associated kinase in the basilar artery during chronic hypertension in vivo. Journal of hypertension 20020501
Development of telemetry system in the common marmoset--cardiovascular effects of astemizole and nicardipine. The Journal of toxicological sciences 20020501
KCl activates mitogen-activated protein kinase in rabbit bailar artery. Biochemical and biophysical research communications 20020426
Feeding of Ginkgo biloba extract (GBE) enhances gene expression of hepatic cytochrome P-450 and attenuates the hypotensive effect of nicardipine in rats. Life sciences 20020426
A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein. Journal of medicinal chemistry 20020425
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Combined administration of diltiazem and nicardipine attenuates hypertensive responses to emergence and extubation. Journal of neurosurgical anesthesiology 20020401
Efficacy and safety of nicardipine prolonged-release implants for preventing vasospasm in humans. Stroke 20020401
Acute relaxant effects of 17-beta-estradiol through non-genomic mechanisms in rabbit carotid artery. Steroids 20020401
Therapeutic approaches to vasospasm in subarachnoid hemorrhage. Current opinion in critical care 20020401
Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles. Life sciences 20020322
Analysis of the effects of graded levels of hypoxia on noradrenaline-evoked contraction in the rat iliac artery in vitro. Experimental physiology 20020301
Homocysteine attenuates hemodynamic responses to nitric oxide in vivo. Atherosclerosis 20020301
Effect of manganese on guinea pig ventricle: initial depression and late augmentation of contractile force. Biological & pharmaceutical bulletin 20020301
[Comparison of nicardipine and isradipine in hypertension following coronary artery bypass graft]. Annales francaises d'anesthesie et de reanimation 20020301
Nitric oxide plays an insignificant role in direct vasodilator effects of calcium channel blockers in healthy humans. Heart and vessels 20020301
Interaction of digoxin with antihypertensive drugs via MDR1. Life sciences 20020215
Physicochemical characterization and in vitro dissolution behavior of nicardipine-cyclodextrins inclusion compounds. European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences 20020201
Long-term treatment with nicardipine for severe pre-eclampsia. International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics 20020201
Effect of the organotin compound triethyltin on Ca2+ handling in human prostate cancer cells. Life sciences 20020201
Accuracy of radial arterial pressure measurement during surgery under controlled hypotension. Acta anaesthesiologica Scandinavica 20020201
Insulin-like growth factor-induced hypertrophy of cultured adult rat cardiomyocytes is L-type calcium-channel-dependent. Molecular and cellular biochemistry 20020201
Effects of dihydropyridine-type Ca2+ antagonists on the renal arterial tree in spontaneously hypertensive rats. Journal of cardiovascular pharmacology 20020101
The influence of nicardipine-, nitroglycerin-, and prostaglandin E(1)-induced hypotension on cerebral pressure autoregulation in adult patients during propofol-fentanyl anesthesia. Anesthesia and analgesia 20020101
Protective effects of dihydropyridine Ca-blockers against endothelial cell oxidative injury due to combined nitric oxide and superoxide. Pharmacological research 20020101
Equinatoxin II-induced lysis Of the cultured endothelial cell line ECV-304. Cellular & molecular biology letters 20020101
Nicardipine diminished equinatoxin II-induced decrease of coronary flow in isolated rat and pig hearts. Cellular & molecular biology letters 20020101
Nicardipine hydrochloride injectable phase IV open-label clinical trial: study on the anti-hypertensive effect and safety of nicardipine for acute aortic dissection. The Journal of international medical research 20020101
Effect of the solvent system on the in vitro permeability of nicardipine hydrochloride through excised rat epidermis. Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques 20020101
Penetration enhancing effect of menthol on the percutaneous flux of nicardipine hydrochloride through excised rat epidermis from hydroxypropyl cellulose gels. Pharmaceutical development and technology 20020101
Neuronal populations of rat cerebral cortex and hippocampus expressed a higher density of L-type Ca 2+ channel than corresponding cerebral vessels. Clinical and experimental hypertension (New York, N.Y. : 1993) 20020101
Neuroprotective effect of treatment with calcium antagonists on hypertensive retina. Clinical and experimental hypertension (New York, N.Y. : 1993) 20020101
Quantitative image analysis of choroid and retinal vasculature in SHR: a model of cerebrovascular hypertensive changes? Clinical and experimental hypertension (New York, N.Y. : 1993) 20020101
TNP-470 combined with nicardipine suppresses in vivo growth of PC-3, a human prostate cancer cell line. Urologic oncology 20020101
Transdermal delivery of nicardipine: an approach to in vitro permeation enhancement. Drug delivery 20020101
Sodium nitroprusside-induced rat fundus relaxation is ryanodine-sensitive and involves L-type Ca2+ channel and small conductance Ca(2+)-sensitive K+ channel components. Autonomic & autacoid pharmacology 20020101
Sevoflurane and nitrous oxide anaesthesia suppresses heart rate variabilities during deliberate hypotension. European journal of anaesthesiology 20011201
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein. British journal of pharmacology 20011201
Comparison of nicardipine versus placebo to control hemodynamic responses during emergence and extubation. Journal of cardiothoracic and vascular anesthesia 20011201
Intrathecal administration of nicardipine hydrochloride to prevent vasospasm in patients with subarachnoid hemorrhage. Neurosurgical review 20011201
Origin of Ca2+ necessary for carbachol-induced contraction in longitudinal muscle of the proximal colon of rats. Japanese journal of pharmacology 20011201
Rhythmic spontaneous contractions in the rat proximal colon. The Japanese journal of physiology 20011201
Comparative study of calcium-channel blockers on cell proliferation, DNA and collagen syntheses, and EGF receptors of cultured gingival fibroblasts derived from human nifedipine, nicardipine and nisoldipine responders. Journal of oral science 20011201
Enalaprilat blunts reflexive increases in cardiac interstitial norepinephrine in conscious rats. Journal of hypertension 20011101
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Polyvalent cation-sensing mechanism increased Na(+)-independent Mg(2+) transport in renal epithelial cells. Biochemical and biophysical research communications 20010928
Glutamate-mediated extrasynaptic inhibition: direct coupling of NMDA receptors to Ca(2+)-activated K+ channels. Neuron 20010927
Ameliorative effect of vasopressin-(4-9) through vasopressin V(1A) receptor on scopolamine-induced impairments of rat spatial memory in the eight-arm radial maze. European journal of pharmacology 20010907
Modulatory effects of static magnetic fields on blood pressure in rabbits. Bioelectromagnetics 20010901
Evidences of cyclodextrin-mediated enantioselective photodegradation of rac-nicardipine by capillary electrophoresis. Electrophoresis 20010901
Tolerability and safety of a calcium channel blocker in comparison with a diuretic in the treatment of elderly patients with hypertension: secondary analysis of the NICS-EH. Hypertension research : official journal of the Japanese Society of Hypertension 20010901
Growth inhibition of epidermal growth factor-stimulated human glioblastoma cells by nicardipine in vitro. Journal of neurosurgical sciences 20010901
Reversal of preexisting vasospasm in coronary artery conduits. The Annals of thoracic surgery 20010801
Synthesis of hexahydroquinoline derivatives possessing calcium antagonistic activity. Die Pharmazie 20010801
Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage. Neurology 20010710
Intraganglionic laminar endings are mechano-transduction sites of vagal tension receptors in the guinea-pig stomach. The Journal of physiology 20010701
The use of short-acting nifedipine in children with hypertension: another example of the need for comprehensive drug testing in children. The Journal of pediatrics 20010701
Intravenous nicardipine for treatment of severe hypertension in children. The Journal of pediatrics 20010701
Searching for balanced hybrid NO-donor 1,4-dihydropyridines with basic properties. Pharmaceutical research 20010701
Development of hollow microspheres as floating controlled-release systems for cardiovascular drugs: preparation and release characteristics. Drug development and industrial pharmacy 20010701
[Growth inhibition of epidermal growth factor-stimulated human glioblastoma cells by nicardipine in vito]. Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University 20010628
Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. Cell calcium 20010601
Novel voltage-dependent non-selective cation conductance in murine colonic myocytes. The Journal of physiology 20010601
Modulation of glycine responses by dihydropyridines and verapamil in rat spinal neurons. The European journal of neuroscience 20010601
Evaluation of a floating dosage form of nicardipine hydrochloride and hydroxypropylmethylcellulose acetate succinate prepared using a twin-screw extruder. International journal of pharmaceutics 20010507
The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells. British journal of pharmacology 20010501
Haemodynamic changes during retroperitoneoscopic adrenalectomy for phaeochromocytoma. British journal of anaesthesia 20010501
[Studies on in-vivo process of the enantiomers of nicardipine in rabbit by coupled chiral and achiral HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica 20010501
Modulation of drug release from hydrogels by using cyclodextrins: the case of nicardipine/beta-cyclodextrin system in crosslinked polyethylenglycol. Journal of controlled release : official journal of the Controlled Release Society 20010428
Relaxant effects of 17-beta-estradiol in cerebral arteries through Ca(2+) entry inhibition. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010401
The involvement of calcium mobilization in the calcium-activated potassium currents activated by hyposmotic swelling in gastric antral circular myocytes of the guinea-pig. The Japanese journal of physiology 20010401
Inhibition of nicardipine on amygdala kindling in rats. Acta pharmacologica Sinica 20010401
Increased levels of hypothalamic neuronal nitric oxide synthase and vasopressin in salt-loaded Dahl rat. Autonomic neuroscience : basic & clinical 20010323
Requirement of neural activity for the maintenance of dopaminergic neurons in rat midbrain slice cultures. Neuroscience letters 20010316
Inhibition by nifedipine of adherence- and activated macrophage-induced death of human gingival fibroblasts. European journal of pharmacology 20010309
Dihydropyridine calcium channel blockers inhibit ascorbic acid accumulation in human intestinal Caco-2 cells. Life sciences 20010302
Nicardipine improves the antidepressant action of ECT but does not improve cognition. The journal of ECT 20010301
Pharmacological properties of excitation-contraction mechanisms in isolated mouse left atria. Pharmacology 20010201
[Intravenous nicardipine: a new calcium antagonist for perioperative use]. Revista espanola de anestesiologia y reanimacion 20010201
Nicardipine versus nitroprusside for breakthrough hypertension following carotid endarterectomy. Journal of clinical anesthesia 20010201
Synthesis and structure--activity analysis of novel dihydropyridine derivatives to overcome multidrug resistance. Bioorganic & medicinal chemistry letters 20010122
Ca(2+) mobilization, tyrosine hydroxylase activity, and signaling mechanisms in cultured porcine adrenal medullary chromaffin cells: effects of leptin. Endocrinology 20010101
Effect of isoflurane versus nicardipine on blood flow of lumbar paraspinal muscles during controlled hypotension for spinal surgery. Spine 20010101
Effect of nicardipine and magnesiumon cerebral infarction - brain surface perfusion technique. Cerebrovascular diseases (Basel, Switzerland) 20010101
[The effects of intravenous nicardipine on jugular venous oxygen saturation]. Masui. The Japanese journal of anesthesiology 20010101
[Continuous intrathecal administration of nicardipine using a portable infusion pump system for management of vasospasm after subarachnoid hemorrhage]. No shinkei geka. Neurological surgery 20010101
Occupancy by oral administration of nicardipine of L-type calcium channels in rat brain. Clinical and experimental hypertension (New York, N.Y. : 1993) 20010101
Effect of nicardipine treatment on the expression of neurofilament 200 KDa immunoreactivity in the brain of spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20010101
Protective effect of treatment with nicardipine on cerebrovascular tree of spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20010101
Effect of antihypertensive treatment on peripheral nerve vasculature in spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 20010101
Nicardipine to control mean arterial pressure after cardiothoracic surgery in infants and children. American journal of therapeutics 20010101
Preliminary bioequivalence testing of two nicardipine HCl sustained-release formulations with in vitro/in vivo correlations. European journal of drug metabolism and pharmacokinetics 20010101
Development of nicardipine prolonged-release implants for preventing vasospasm. Acta neurochirurgica. Supplement 20010101
Nicardipine dose dependently reduces the effect of equinatoxin II on coronary flow in isolated rat heart. Pflugers Archiv : European journal of physiology 20010101
Nicardipine protocol for CABG using the radial artery clinical and angiographic data. Acta chirurgica Belgica 20010101
AM-404 elevates renal intracellular Ca(2+), questioning its selectivity as a pharmacological tool for investigating the anandamide transporter. Journal of pharmacological and toxicological methods 20010101
Studies on calcium antagonist activities of 2-ethyl-3-carbmethoxy-4-aryl- 5-oxo-6,6-dimethyl-1,4,5,6,7,8-hexahydroquinoline derivatives. Arzneimittel-Forschung 20010101
Calmodulin kinases II and IV and calcineurin are involved in leukemia inhibitory factor-induced cardiac hypertrophy in rats. Circulation research 20001110
A comparative study between a calcium channel blocker (Nicardipine) and a combined alpha-beta-blocker (Labetalol) for the control of emergence hypertension during craniotomy for tumor surgery. Anesthesia and analgesia 20001001
Nephroprotective effect of treatment with calcium channel blockers in spontaneously hypertensive rats. The Journal of pharmacology and experimental therapeutics 20000901
The effects of nicardipine on dynamic cerebral autoregulation in patients anesthetized with propofol and fentanyl. Anesthesia and analgesia 20000901
Inhibition of human cytochrome P450 enzymes by 1,4-dihydropyridine calcium antagonists: prediction of in vivo drug-drug interactions. European journal of clinical pharmacology 20000101
[Effects of calcium antagonists on atherosclerosis progression and intima media thickness]. Drugs 20000101
Effects of nicardipine-, nitroglycerin-, and prostaglandin E1-induced hypotension on human cerebrovascular carbon dioxide reactivity during propofol-fentanyl anesthesia. Journal of clinical anesthesia 19991101
Neuroprotective action of a novel compound--M50463--in primary cultured neurons. Brain research 19990102
[Angioedema associated with the use of dihydropyridines]. Therapie 19990101
Haemodynamic effects of hypotension induced by KRN2391 and nicardipine in isoflurane anaesthetized dogs. Canadian journal of anaesthesia = Journal canadien d'anesthesie 19970901
Determining the optimum dose for the intravenous administration of nicardipine in the treatment of acute heart failure--a multicenter study. The Nicardipine Heart Failure Study Group. Japanese circulation journal 19970501
Epileptogenic activity induced by combined treatment with antiinflammatory drugs and enoxacin and its inhibition by a calcium antagonist, nicardipine. Methods and findings in experimental and clinical pharmacology 19961101
Vascular and neuronal hypertensive brain damage: protective effect of treatment with nicardipine. Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19961001
Interaction of 1,4-dihydropyridine and pyridine derivatives with adenosine receptors: selectivity for A3 receptors. Journal of medicinal chemistry 19960719
Metabolic alkalosis and myoclonus from antacid ingestion. Internal medicine (Tokyo, Japan) 19960601
Influence of long-term treatment with the dihydropyridine-type calcium antagonist nicardipine on renal microanatomical changes in spontaneously hypertensive rats. Clinical and experimental pharmacology & physiology. Supplement 19951201
Differential microcirculation dynamics during deliberate hypotension induced by nicardipine, PGE1 and trimethaphan in rat mesentery. Canadian journal of anaesthesia = Journal canadien d'anesthesie 19951101
Coronary vasomotion during dynamic exercise: influence of intravenous and intracoronary nicardipine. Journal of the American College of Cardiology 19950901
Nicardipine: applications in anesthesia practice. Journal of clinical anesthesia 19950901
[Nationwide drug surveillance project on slow-release nicardipine in the short-term therapy of light/moderate arterial hypertension]. Minerva cardioangiologica 19950901
Renoprotective effect of enalapril in uninephrectomized spontaneously hypertensive rats with neonatal streptozotocin-induced diabetes. Diabetes research and clinical practice 19950901
Protective effect of nicardipine treatment on renal microanatomical changes in spontaneously hypertensive rats. Clinical and experimental hypertension (New York, N.Y. : 1993) 19940701
Effects of a novel dihydropyridine calcium antagonist on venous capacitance in Wistar-Kyoto rats. Drugs under experimental and clinical research 19940101
Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones. Life sciences 19940101
Profile of capsaicin-induced mouse ear oedema as neurogenic inflammatory model: comparison with arachidonic acid-induced ear oedema. British journal of pharmacology 19931201
Effects of dihydropyridines on cerebral blood vessels. Journal of hypertension. Supplement : official journal of the International Society of Hypertension 19931201
Nifedipine and nicardipine potentiate glucagon-stimulated glycogenolysis in primary cultures of rat hepatocytes. Biological & pharmaceutical bulletin 19930901
Intravenous nicardipine in hypertensive children. European journal of pediatrics 19930901
Protection by nicorandil against the dysfunction of the central vagal baroreflex system following transient global cerebral ischaemia in dogs. British journal of pharmacology 19930801
[Acute effects of nicardipine on the vascular reactivity of oxygen in patients with respiratory insufficiency and pulmonary hypertension]. Archives des maladies du coeur et des vaisseaux 19930601
Effect of nicardipine treatment on carbohydrate and lipoprotein metabolism in patients with hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993) 19930501
Cardiovascular effects of OPC-13340, a potent, long-acting 1,4-dihydropyridine calcium channel blocker, in dogs. Archives internationales de pharmacodynamie et de therapie 19930101
The acute effect of nicardipine on the renin-angiotensin-aldosterone system in salt-sensitive essential hypertension. Clinical and experimental hypertension (New York, N.Y. : 1993) 19930101
Hemodynamic effects of nicardipine-induced hypotension during enflurane/nitrous oxide anesthesia in man. Journal of anesthesia 19921001
Nicardipine in the prevention of spasm-induced neurological deficits after subarachnoid hemorrhage: a dose-ranging study. Surgical neurology 19920701
Effects of nicardipine on the metabolic responses to food and exercise. Journal of human hypertension 19920401
Combined treatment with MK-801 and nicardipine reduces global ischemic damage in the gerbil. Stroke 19920101
[Effects of nicardipine on the functional state of the liver in patients with ischemic heart disease]. Klinicheskaia meditsina 19911001
Deliberate hypotension with nicardipine or nitroprusside during total hip arthroplasty. Anesthesia and analgesia 19910901
Nicardipine protects against chronic ethanol- or haloperidol-induced supersensitivity to apomorphine-induced aggression. Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 19910801
[A comparison of the endocrine effects of hypotension induced by nicardipine with those by sodium nitroprusside in dogs]. Masui. The Japanese journal of anesthesiology 19910701
Nicardipine and vascular hypertrophy. American heart journal 19910701
Heterogeneous interference of nicardipine, verapamil, and diltiazem with forearm arteriolar responsiveness to adrenergic stimulation in hypertensive patients. American heart journal 19910701
Co-suppression by nicardipine, a calcium antagonist, of induction of microsomal lauric acid hydroxylation with peroxisome proliferation in clofibrate-treated rat liver. Chemical & pharmaceutical bulletin 19910501
Adverse drug reactions leading to hospital admission. Drug safety 19910101
[A nicardipine-isoflurane combination in the microsurgery of the middle ear]. Cahiers d'anesthesiologie 19910101
Long-term effects of enalapril and nicardipine on urinary albumin excretion in patients with chronic renal insufficiency: a 1-year follow-up. American journal of nephrology 19910101
[The hemodynamics of oral nicardipine determined by radioisotope ventriculography in patients with ischemic cardiopathy]. Archivos del Instituto de Cardiologia de Mexico 19910101
[Blood pressure monitoring in aged hypertensive patients treated with sustained-release nicardipine or nifedipine]. Schweizerische medizinische Wochenschrift 19901208
[Hemodynamic features of hypotension induced by nicardipine in dogs]. Masui. The Japanese journal of anesthesiology 19901201
Nicardipine reduces the cardio-respiratory toxicity of intravenously administered bupivacaine in rats. Canadian journal of anaesthesia = Journal canadien d'anesthesie 19901101
Inhibitory effects of diltiazem, verapamil, nifedipine, and nicardipine on sympathetic tachycardia in decentralized hearts of anesthetized dogs. Journal of cardiovascular pharmacology 19901001
Twenty-four hour ambulatory blood pressure profile of a new, sustained-release preparation of nicardipine. Cardiovascular drugs and therapy 19900401
Oxytocin-induced penile erection and yawning: role of calcium and prostaglandins. Pharmacology, biochemistry, and behavior 19900301
Acute antianginal hemodynamic effects of nicardipine in coronary artery disease. American heart journal 19900201
Randomized double-blind comparison of side effects of nicardipine and nifedipine in angina pectoris. The Nicardipine Investigators Group. American heart journal 19900201
The influence of nicardipine on left ventricular hemodynamics and compliance in patients with coronary heart disease. Journal of cardiovascular pharmacology 19900101
Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. British journal of pharmacology 19891201
Intravenous nicardipine for the treatment of severe hypertension. A double-blind, placebo-controlled multicenter trial. Archives of internal medicine 19891201
Nicardipine decreases blood pressure and heart rate at nucleus tractus solitarii of spontaneously hypertensive rats. Journal of cardiovascular pharmacology 19891101
Inotropic effect of nicardipine in patients with heart failure: assessment by left ventricular end-systolic pressure-volume analysis. Journal of the American College of Cardiology 19891101
Calcium channel inhibitors prevent apomorphine- and oxytocin-induced penile erection and yawning in male rats. European journal of pharmacology 19890803
Erythromelalgia induced by nicardipine. BMJ (Clinical research ed.) 19890729
[Calcium intestinal absorption in normotensive and essential hypertensive subjects before and after nicardipine]. Archives des maladies du coeur et des vaisseaux 19890701
Erythromelalgia induced by nicardipine. BMJ (Clinical research ed.) 19890610
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Haemodynamic responses to nicardipine in humans anaesthetised with halothane. Anaesthesia 19890501
[Antihypertensive effect and tolerability of slow-release nicardipine]. Cardiologia (Rome, Italy) 19890201
Endogenous opiate system and dihydropyridine-induced central regulation of sympathetic tone in rats. European journal of pharmacology 19881206
Serum lipid changes in patients with mild to moderate essential hypertension taking nicardipine and propranolol. The British journal of clinical practice 19881201
Antihypertensive activity of a new calcium channel blocker LF 2.0254, in spontaneously hypertensive rats: a comparison with nifedipine and nicardipine. Archives internationales de pharmacodynamie et de therapie 19880101
Hemodynamic and cardiac metabolic changes during nicardipine-induced myocardial ischemia. Catheterization and cardiovascular diagnosis 19880101
Nicardipine and urinary retention. JAMA 19871218
Central interactions between dihydropyridines and cholinergic systems in the control of blood pressure in rat. Brain research 19871201
An evaluation of the pharmacodynamics and pharmacokinetics of nicardipine combined with enalapril in essential hypertension. Journal of cardiovascular pharmacology 19871201
Nicardipine causes sympathetic activation that does not involve baroreceptor reflex tachycardia in conscious sinoaortic-denervated dogs. European journal of pharmacology 19871006
Nicardipine for systemic hypertension: effects on blood pressure and target organ function. The American journal of cardiology 19870630
The potential beneficial effect of nicardipine in a rat model of transient forebrain ischemia. Neurology 19870501
Nicardipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in the treatment of angina pectoris, hypertension and related cardiovascular disorders. Drugs 19870401
Metabolic and hemodynamic effects of nicardipine during pacing-induced angina pectoris. The American journal of cardiology 19870201
Comparative effects of prolonged therapy with four calcium ion antagonists (diltiazem, nicardipine, tiapamil and verapamil) in patients with chronic stable angina pectoris. Cardiovascular drugs and therapy 19870101
Nicardipine in the treatment of essential hypertension controlled 6-month-study comparing nicardipine with propranolol at rest and during exercise. European journal of clinical pharmacology 19870101
Effects of calcium entry blockers on blood pressure and heart rate in neurogenic hypertensive dogs. Fundamental & clinical pharmacology 19870101
A comparison of nine calcium ion antagonists and propranolol: exercise tolerance, heart rate and ST-segment changes in patients with chronic stable angina pectoris. European journal of clinical pharmacology 19870101
Efficacy and safety of nicardipine for chronic, stable angina pectoris: a multicenter randomized trial. The American journal of cardiology 19861001
Effects of nicardipine on left ventricular function and energetics in man. International journal of cardiology 19860301
The calcium entry blockers: anti-manic drugs? Progress in neuro-psychopharmacology & biological psychiatry 19860101
Haemodynamic analysis of the effects of nicardipine and metoprolol alone and in combination in coronary artery disease. European heart journal 19851101
The calcium antagonist, nicardipine, inhibits antigen-stimulated and anti-IgE-induced histamine release from basophilic leucocytes of atopic asthmatics. Acta medica Okayama 19850801
Inhibition of histamine release from dispersed human lung and tonsillar mast cells by nicardipine and nifedipine. British journal of clinical pharmacology 19850501
Myocardial ischemia during intravenous nicardipine administration. The American journal of cardiology 19850301
[Treatment of arterial hypertension in the aged with a calcium antagonist: nicardipine]. Archives des maladies du coeur et des vaisseaux 19841001
Antihypertensive and renal effects of nicardipine. British journal of clinical pharmacology 19840701
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