Home Carbonyls (RS)-2-{4-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine

(RS)-2-{4-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine

CAS No.:
74191-85-8
Catalog Number:
AG019DK4
Molecular Formula:
C23H25N5O5
Molecular Weight:
451.4751
Pack Size
Purity
Availability
Location
Price(USD)
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Product Description
Catalog Number:
AG019DK4
Chemical Name:
(RS)-2-{4-[(2,3-Dihydro-1,4-benzodioxin-2-yl)carbonyl]piperazin-1-yl}-6,7-dimethoxyquinazolin-4-amine
CAS Number:
74191-85-8
Molecular Formula:
C23H25N5O5
Molecular Weight:
451.4751
MDL Number:
MFCD00800482
IUPAC Name:
[4-(4-amino-6,7-dimethoxyquinazolin-2-yl)piperazin-1-yl]-(2,3-dihydro-1,4-benzodioxin-3-yl)methanone
InChI:
InChI=1S/C23H25N5O5/c1-30-18-11-14-15(12-19(18)31-2)25-23(26-21(14)24)28-9-7-27(8-10-28)22(29)20-13-32-16-5-3-4-6-17(16)33-20/h3-6,11-12,20H,7-10,13H2,1-2H3,(H2,24,25,26)
InChI Key:
RUZYUOTYCVRMRZ-UHFFFAOYSA-N
SMILES:
COc1cc2nc(nc(c2cc1OC)N)N1CCN(CC1)C(=O)C1COc2c(O1)cccc2
EC Number:
616-059-6
Properties
Complexity:
678  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
451.186g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
9  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
451.483g/mol
Monoisotopic Mass:
451.186g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
112A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
2.5  
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Tamsulosin versus Alfuzosin in the Treatment of Patients with Distal Ureteral Stones: Prospective, Randomized, Comparative Study. Korean journal of urology 20100301
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Role of voiding and storage symptoms for the quality of life before and after treatment in men with voiding dysfunction. World journal of urology 20100201
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Add-on therapy with doxazosin in patients with hypertension influences arterial stiffness and albuterol-mediated arterial vasodilation. British journal of clinical pharmacology 20071201
Changes in self-monitored pulse pressure correlate with improvements in B-type natriuretic Peptide and urinary albumin in treated hypertensive patients. American journal of hypertension 20071201
Erectile dysfunction as the presenting symptom of a pheochromocytoma. European journal of internal medicine 20071201
Novel quinazoline-based compounds impair prostate tumorigenesis by targeting tumor vascularity. Cancer research 20071201
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Blood pressure control in Hispanics in the antihypertensive and lipid-lowering treatment to prevent heart attack trial. Hypertension (Dallas, Tex. : 1979) 20071101
The effect of doxazosin, finasteride and combination therapy on nocturia in men with benign prostatic hyperplasia. The Journal of urology 20071101
Effect of alpha1-adrenoceptor antagonist exposure on prostate cancer incidence: an observational cohort study. The Journal of urology 20071101
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New insights into the therapeutic management of morning hypertension with alpha1-adrenergic receptor blockers. Hypertension research : official journal of the Japanese Society of Hypertension 20071101
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A primary right atrium paraganglioma in a 15-year-old patient. Endocrine 20071001
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Comparative study of modified release alpha-blocker exposure in elderly patients with fractures. Pharmacoepidemiology and drug safety 20070801
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Usefulness of the alpha1-blocker doxazosin as a third-line antihypertensive drug. Hypertension research : official journal of the Japanese Society of Hypertension 20070401
Differential effects of urapidil and doxazosin on heart rate. European journal of clinical pharmacology 20070301
The effects of systemic alpha-1 adrenergic antagonists on pupil diameter in rats. Current eye research 20070301
Neuropsychiatric consequences of cardiovascular medications. Dialogues in clinical neuroscience 20070301
A review of combination therapy in patients with benign prostatic hyperplasia. Clinical therapeutics 20070301
Optimal timing for antihypertensive dosing: focus on valsartan. Therapeutics and clinical risk management 20070301
Outcomes and quality of life issues in the pharmacological management of benign prostatic hyperplasia (BPH). Therapeutics and clinical risk management 20070301
[Recurrent syncopes secondary to pheochromocytoma]. Medicina clinica 20070224
LC-MS determination and relative bioavailability of doxazosin mesylate tablets in healthy Chinese male volunteers. Journal of pharmaceutical and biomedical analysis 20070219
Doxazosin gastrointestinal therapeutic system versus tamsulosin for the treatment of benign prostatic hyperplasia: a study in Chinese patients. International journal of urology : official journal of the Japanese Urological Association 20070201
[Anesthetic management for off-pump coronary artery bypass grafting in a patient with a pheochromocytoma and followed by the resection of the pheochromocytoma]. Masui. The Japanese journal of anesthesiology 20070201
Separation, characterization, and quantitation of process-related substances of the anti-hypertensive drug doxazosin mesylate by reversed-phase LC with PDA and ESI-MS as detectors. Journal of chromatographic science 20070201
[Effects of doxazosin enantiomers on alpha-adrenoceptors of isolated rabbit blood vessels]. Yao xue xue bao = Acta pharmaceutica Sinica 20070201
Carvedilol in the treatment of chronic heart failure: lessons from the Carvedilol Or Metoprolol European Trial. Vascular health and risk management 20070201
Contractile responses of rabbit bladder neck to adrenaline, acetylcholine and papaverine after doxazosin treatment. International urology and nephrology 20070101
The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT) Heart Failure Validation Study: diagnosis and prognosis. American heart journal 20070101
Historical trends in survival of hospitalized heart failure patients: 2000 versus 1995. BMC cardiovascular disorders 20070101
Chronic prostatitis/chronic pelvic pain syndrome: role of alpha blocker therapy. Urologia internationalis 20070101
A review of the clinical efficacy and safety of 5alpha-reductase inhibitors for the enlarged prostate. Clinical therapeutics 20070101
Apoptosis induction by quinazoline-derived alpha1-blockers in prostate cancer cells: biomolecular implications and clinical relevance. European review for medical and pharmacological sciences 20070101
Effects of doxazosin and amlodipine on mean platelet volume and serum serotonin level in patients with metabolic syndrome: a randomised, controlled study. Clinical drug investigation 20070101
Identification of the patient with enlarged prostate: diagnosis and guidelines for management. Osteopathic medicine and primary care 20070101
Intraoperative floppy iris syndrome associated with terazosin. Indian journal of ophthalmology 20070101
Randomised controlled trials for evaluating the prescribing impact of information meetings led by pharmacists and of new information formats, in General Practice in Italy. BMC health services research 20070101
A patient with bilateral pheochromocytoma as part of a Von Hippel-Lindau (VHL) syndrome type 2C. World journal of surgical oncology 20070101
Serotonin induces a biphasic response in rabbit cavernosal smooth muscle: relevance to the erectile process. Urologia internationalis 20070101
Conflict of interest in biomedical publications. Indian journal of ophthalmology 20070101
Medicinal importance of grapefruit juice and its interaction with various drugs. Nutrition journal 20070101
Doxazosin-induced clusterin expression and apoptosis in prostate cancer cells. Urologic oncology 20070101
Targeting pituitary tumors. Hormone research 20070101
[Potentially inappropriate drugs for geriatric patients]. Przeglad lekarski 20070101
Alpha blockers for the treatment of benign prostatic hyperplasia. Reviews in urology 20070101
Laparoscopic resection of an interaortocaval paraganglioma: diagnosis following a needle biopsy. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20070101
Application of evidence-based urology in improving quality of care. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Clinical evaluation of a simple uroflowmeter for categorization of maximum urinary flow rate. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Search for new alpha1a-adrenoceptor-selective antagonist for treating lower urinary tract symptoms associated with benign prostatic hyperplasia. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Acute urinary retention in benign prostatic hyperplasia: Risk factors and current management. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Comorbid LUTS and erectile dysfunction: optimizing their management. Current medical research and opinion 20061201
Sexual function in hypertensive patients receiving treatment. Vascular health and risk management 20061201
Assessment of cognitive function in patients with essential hypertension treated with lercanidipine. Vascular health and risk management 20061201
Doxazosin in the treatment of benign prostatic hypertrophy: an update. Clinical interventions in aging 20061201
Role of 5 alpha-reductase inhibitors in the management of prostate cancer. Clinical interventions in aging 20061201
Tadalafil in the treatment of erectile dysfunction; an overview of the clinical evidence. Clinical interventions in aging 20061201
High-performance liquid chromatographic determination of doxazosin in human plasma for bioequivalence study of controlled release doxazosin tablets. Biomedical chromatography : BMC 20061101
Chiral selective effects of doxazosin enantiomers on blood pressure and urinary bladder pressure in anesthetized rats. Acta pharmacologica Sinica 20061101
Effect of alpha1-adrenergic receptors in cardiac pathophysiology. American heart journal 20061101
Efficacy and safety of tamsulosin hydrochloride compared to doxazosin in the treatment of Indonesian patients with lower urinary tract symptoms due to benign prostatic hyperplasia. International journal of urology : official journal of the Japanese Urological Association 20061101
Adrenergic stimulation and blocking of hormonal secretion activity of cultured cow granulosa cells. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
The influence of alpha-adrenergic receptors stimulator and blockers and beta-blocker on the ovary and endocrinological activity in heifers during superovulation. Journal of physiology and pharmacology : an official journal of the Polish Physiological Society 20061101
Evaluation of short term clinical effects and presumptive mechanism of botulinum toxin type A as a treatment modality of benign prostatic hyperplasia. Yonsei medical journal 20061031
On-line simultaneous removal of human serum albumin and enrichment of doxazosin using a weak cation-exchange monolithic column. Journal of chromatography. A 20061006
A randomised, double-blind study comparing the efficacy and tolerability of controlled-release doxazosin and tamsulosin in the treatment of benign prostatic hyperplasia in Brazil. International journal of clinical practice 20061001
Myostatin expression in ventricular myocardium in a rat model of volume-overload heart failure. European journal of clinical investigation 20061001
Intraoperative floppy iris syndrome. Ophthalmology 20061001
Clinical spectrum of the osmotic-controlled release oral delivery system (OROS), an advanced oral delivery form. Current medical research and opinion 20061001
Development and validation of a reversed-phase HPLC method for monitoring of synthetic reactions during the manufacture of a key intermediate of an anti-hypertensive drug. Journal of separation science 20061001
[A novel microemulsion electrokinetic chromatography for measuring lipid-water partition coefficients of pharmaceuticals]. Yao xue xue bao = Acta pharmaceutica Sinica 20061001
The role of the alpha-1 adrenoceptor in modulating human mesangial cell matrix production. Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060901
Incidence and predictors of angioedema in elderly hypertensive patients at high risk for cardiovascular disease: a report from the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Journal of clinical hypertension (Greenwich, Conn.) 20060901
[Drug therapy for benign prostatic syndrome (BPS)]. Aktuelle Urologie 20060901
Validation and pharmacokinetic application of a method for determination of doxazosin in human plasma by high-performance liquid chromatography. Biomedical chromatography : BMC 20060801
alpha-blocker treatment of urolithiasis. European urology 20060801
UPLC-MS/MS determination of doxazosine in human plasma. Analytical and bioanalytical chemistry 20060801
Goals and guidelines for treating hypertension in a patient with heart failure. Current treatment options in cardiovascular medicine 20060801
Benign prostatic hyperplasia (BPH). Harvard men's health watch 20060801
Off-pump myocardial revascularizaton in a Jehovah's Witness patient with pheochromocytoma. Interactive cardiovascular and thoracic surgery 20060801
Doxazosin induces activation of GADD153 and cleavage of focal adhesion kinase in cardiomyocytes en route to apoptosis. Cardiovascular research 20060701
Survival benefits of different antiadrenergic interventions in pressure overload left ventricular hypertrophy/failure. Hypertension (Dallas, Tex. : 1979) 20060701
Enantiomeric resolution of doxazosin mesylate and its process-related substances on polysaccharide chiral stationary phases. Journal of pharmaceutical and biomedical analysis 20060607
Effect of doxazosin with and without rho-kinase inhibitor on human corpus cavernosum smooth muscle in the presence of bladder outlet obstruction. The Journal of urology 20060601
Anxiety-induced plasma norepinephrine augmentation increases reactive oxygen species formation by monocytes in essential hypertension. American journal of hypertension 20060601
Rational prescribing in primary care (RaPP): economic evaluation of an intervention to improve professional practice. PLoS medicine 20060601
[Efficacy of artificial urination in forecasting patient's ability to urinate after acute urinary retention]. Likars'ka sprava 20060601
Role of diuretics in the prevention of heart failure: the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial. Circulation 20060509
Preventing vascular events due to elevated blood pressure. Circulation 20060509
The role of noradrenaline in the generation of the preovulatory LH surge in the ewe. Domestic animal endocrinology 20060501
How should patients treated with alpha-blockers be followed? Insights from an ambulatory blood pressure monitoring database. Journal of hypertension 20060501
The effect of carvedilol on metabolic parameters in patients with metabolic syndrome. International heart journal 20060501
[One-year controlled therapy with doxazosin in patients with pulmonary hypertension due to chronic obstructive pulmonary disease]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20060501
Impact of medical treatments for benign prostatic hyperplasia on sexual function. BJU international 20060401
Baseline factors as predictors of clinical progression of benign prostatic hyperplasia in men treated with placebo. The Journal of urology 20060401
Antihypertensive pharmacobezoar. Journal of clinical hypertension (Greenwich, Conn.) 20060401
The management of phosphodiesterase-5 (PDE5) inhibitor failure. Current vascular pharmacology 20060401
BPH: epidemiology and comorbidities. The American journal of managed care 20060401
Treatment and pharmacologic management of BPH in the context of common comorbidities. The American journal of managed care 20060401
Effect of doxazosin on C-reactive protein plasma levels and on nitric oxide in patients with hypertension. Journal of cardiovascular pharmacology 20060401
Association of IFIS and vasodepressor medication. Journal of cataract and refractive surgery 20060401
Are all alpha-blockers created the same? European urology 20060301
Beneficial effects of extended-release doxazosin and doxazosin standard on sexual health. BJU international 20060301
Clinical efficacy and tolerability of alpha-blocker doxazosin as add-on therapy in patients with hypertension and impaired glucose metabolism. Nutrition, metabolism, and cardiovascular diseases : NMCD 20060301
Controlled-release doxazosin as combination therapy in hypertension: the GATES study. Journal of clinical hypertension (Greenwich, Conn.) 20060301
Doxazosin gastrointestinal therapeutic system: a clinical perspective. Journal of clinical hypertension (Greenwich, Conn.) 20060301
Comparison of doxazosin GITS and standard doxazosin in the treatment of high blood pressure. International journal of clinical pharmacology and therapeutics 20060301
[The objective of medical treatment: relieve the symptoms or stop the course?]. Annales d'urologie 20060301
The Japan Morning Surge-1 (JMS-1) study: protocol description. Hypertension research : official journal of the Japanese Society of Hypertension 20060301
Should patients with benign prostatic hypertrophy stop taking doxazosin in the light of the ALLHAT study? International journal of cardiology 20060215
Comparison of the protein profile of established and regressed hypertension-induced left ventricular hypertrophy. Journal of proteome research 20060201
In vivo studies on the effects of alpha1-adrenoceptor antagonists on pupil diameter and urethral tone in rabbits. Naunyn-Schmiedeberg's archives of pharmacology 20060201
Effect of doxazosin gastrointestinal therapeutic system on patients with uncontrolled hypertension: the ASOCIA Study. Journal of cardiovascular pharmacology 20060201
Effect of doxazosin on oxidative stress related proteins in essential hypertensive patients. Clinical and experimental hypertension (New York, N.Y. : 1993) 20060201
Antinociceptive and behavioral effects of ribavirin in mice. Pharmacology, biochemistry, and behavior 20060201
Effect of doxazosin gastrointestinal therapeutic system on platelet degranulation and platelet-leukocyte microaggregate formation induced by physiologic shear stress in hypertension. Thrombosis research 20060101
Long-term follow-up study to evaluate the efficacy and safety of the doxazosin gastrointestinal therapeutic system in patients with benign prostatic hyperplasia with or without concomitant hypertension. BJU international 20060101
Doxazosin induces apoptosis of benign and malignant prostate cells via a death receptor-mediated pathway. Cancer research 20060101
Effect of doxazosin on oxidative stress-related proteins in benign prostatic hyperplasia. Urologia internationalis 20060101
Combination therapy with doxazosin and finasteride for benign prostatic hyperplasia in patients with lower urinary tract symptoms and a baseline total prostate volume of 25 ml or greater. The Journal of urology 20060101
Combination regimen in the treatment of chronic prostatitis. Archives of andrology 20060101
Cytoplasmic free calcium mobilization in platelets, expression of P-selectin, phosphatidylserine, and microparticle formation, measured by whole blood flow cytometry, in hypertensive patients. Effect of doxazosin GITS. Thrombosis research 20060101
Treatment of lower urinary tract symptoms in benign prostatic hyperplasia and its impact on sexual function. Clinical therapeutics 20060101
Effects of alpha(1)-adrenoceptor antagonists on male sexual function. Drugs 20060101
Analysis of proliferative activity in oral gingival epithelium in immunosuppressive medication induced gingival overgrowth. Head & face medicine 20060101
Doxazosin and serotonin (5-HT) receptor (1A, 2A, and 4) antagonists inhibit 5-HT-mediated human cavernosal contraction. Journal of andrology 20060101
Pharmacologic expulsive treatment of ureteral calculi. The Annals of pharmacotherapy 20060101
[The comparative study on selective alpha1-blocker and behavioural therapy in the treatment of discoordinated voiding in children]. Przeglad lekarski 20060101
[The system of management nocturnal enuresis based on functional classification]. Przeglad lekarski 20060101
Risk of acute myocardial infarction with nonselective non-steroidal anti-inflammatory drugs: a meta-analysis. Arthritis research & therapy 20060101
Treatment of benign prostatic hyperplasia in patients with cardiovascular disease. Drugs & aging 20060101
[Alpha-adrenergic blockers as a support in the treatment of acute urinary retention]. Lijecnicki vjesnik 20060101
Potentially inappropriate medication prescribing for elderly outpatients in Emilia Romagna, Italy: a population-based cohort study. Drugs & aging 20060101
Treatment of detrusor sphincter dyssynergia with baclofen and doxazosin. International urology and nephrology 20060101
Long-term organ protection by doxazosin and/or quinapril as antihypertensive therapy. Journal of nephrology 20060101
Pheochromocytomas and secreting paragangliomas. Orphanet journal of rare diseases 20060101
Linguistic adaptation and validation of the Spanish version of the Benign Prostatic Hyperplasia-Patient Impact Measure (BPH-PIM). Clinical drug investigation 20060101
Synergistic effect of doxazosin and acarbose in improving metabolic control in patients with impaired glucose tolerance. Clinical drug investigation 20060101
Dropout in a longitudinal, cohort study of urologic disease in community men. BMC medical research methodology 20060101
The evolution of alpha-blockers for the treatment of benign prostatic hyperplasia. Reviews in urology 20060101
[Using doxasosine and finasteride combination in the treatment of prostate adenoma]. Urologiia (Moscow, Russia : 1999) 20060101
Alpha1-adrenergic receptor antagonists: novel therapy for pituitary adenomas. Molecular endocrinology (Baltimore, Md.) 20051201
Doxazosin induces apoptosis in LNCaP prostate cancer cell line through DNA binding and DNA-dependent protein kinase down-regulation. International journal of oncology 20051201
Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate cancer cell apoptosis and proliferation. Journal of medicinal chemistry 20051201
Bioequivalence evaluation of two formulations of doxazosin tablet in healthy thai male volunteers. Drug development and industrial pharmacy 20051201
Alpha1-adrenergic antagonists and floppy iris syndrome: tip of the iceberg? Ophthalmology 20051201
Alpha1-adrenergic blockers: current usage considerations. Journal of clinical hypertension (Greenwich, Conn.) 20051201
Sympathectomy or doxazosin, but not propranolol, blunt myocardial interstitial fibrosis in pressure-overload hypertrophy. Hypertension (Dallas, Tex. : 1979) 20051101
The effects of alpha-adrenoceptor antagonists on the urethral perfusion pressure of the female rat. BJU international 20051101
Efficacy of the combination of an alpha1-blocker with an anticholinergic agent in the treatment of lower urinary tract symptoms associated with bladder outlet obstruction. Expert opinion on pharmacotherapy 20051101
Combination treatment with propiverine hydrochloride plus doxazosin controlled release gastrointestinal therapeutic system formulation for overactive bladder and coexisting benign prostatic obstruction: a prospective, randomized, controlled multicenter study. The Journal of urology 20051001
Efficacy of extended-release doxazosin and doxazosin standard in patients with concomitant benign prostatic hyperplasia and sexual dysfunction. The Journal of urology 20051001
Can alpha-blocker therapy be an alternative to biofeedback for dysfunctional voiding and urinary retention? A prospective study. The Journal of urology 20051001
Hemodynamic effects of alpha1-adrenoceptor antagonist, doxazosin, in patients with chronic congestive heart failure. Journal of cardiovascular pharmacology 20051001
Effects of doxazosin on ambulatory blood pressure and sympathetic nervous activity in hypertensive Type 2 diabetic patients with overt nephropathy. Diabetic medicine : a journal of the British Diabetic Association 20051001
[ASCOT-BPLA Study raises new questions regarding: which is the best initial antihypertensive drug?]. MMW Fortschritte der Medizin 20050929
Oral treatment of the TRAMP mice with doxazosin suppresses prostate tumor growth and metastasis. The Prostate 20050901
A double-blind placebo-controlled study evaluating the onset of action of doxazosin gastrointestinal therapeutic system in the treatment of benign prostatic hyperplasia. European urology 20050901
Administration-time-dependent effects of antihypertensive treatment on the circadian pattern of blood pressure. Current opinion in nephrology and hypertension 20050901
One drug fits all. BJU international 20050901
Maspin sensitizes prostate cancer cells to doxazosin-induced apoptosis. Oncogene 20050811
Benign prostatic hyperplasia cell line viability and modulation of jm-27 by doxazosin and Ibuprofen. The Journal of urology 20050701
Perioperative management of a child with severe hypertension from a catecholamine secreting neuroblastoma. Paediatric anaesthesia 20050701
Pharmacogenetic association of the angiotensin-converting enzyme insertion/deletion polymorphism on blood pressure and cardiovascular risk in relation to antihypertensive treatment: the Genetics of Hypertension-Associated Treatment (GenHAT) study. Circulation 20050628
[Inhibitory effect of doxazosin on the growth of transplanted tumor of prostate cancer cell PC-3 in nude mice]. Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences 20050618
Molecular classification of doxazosin-induced alterations in the rat prostate using gene expression profiling. Life sciences 20050610
Lower urinary tract symptoms suggestive of benign prostatic hyperplasia: latest update on alpha-adrenoceptor antagonists. BJU international 20050601
The comparison and efficacy of 3 different alpha1-adrenergic blockers for distal ureteral stones. The Journal of urology 20050601
Double-blind placebo controlled study of alpha-adrenergic receptor antagonists (doxazosin) for treatment of voiding dysfunction in the pediatric population. The Journal of urology 20050601
Effects of doxazosin and irbesartan on blood pressure and metabolic control in patients with type 2 diabetes and hypertension. Journal of cardiovascular pharmacology 20050601
Sexual dysfunction and lower urinary tract symptoms (LUTS) associated with benign prostatic hyperplasia (BPH). European urology 20050601
[Therapeutic strategy for morning blood pressure elevation in elderly hypertensives]. Nihon rinsho. Japanese journal of clinical medicine 20050601
[Severe hypotension after induction of general anesthesia in a patient receiving an angiotensin II receptor antagonist and an alpha-blocker]. Masui. The Japanese journal of anesthesiology 20050601
Doxazosin versus bendrofluazide: a comparison of the metabolic effects in British South Asians with hypertension. The British journal of general practice : the journal of the Royal College of General Practitioners 20050601
Acute intoxication with doxazosin. Human & experimental toxicology 20050601
[Effects of doxazosin mosylate and phenoxybenzamine in preoperative volume expansion of pheochromocytoma: a comparative study in 38 cases]. Zhonghua yi xue za zhi 20050601
Polymorphism of doxazosin mesylate. Archives of pharmacal research 20050601
Monotherapy versus combination drug therapy for the treatment of benign prostatic hyperplasia. The American journal of geriatric pharmacotherapy 20050601
Doxazosin GITS versus standard doxazosin in mild to moderate hypertension. International journal of cardiology 20050511
Sympathetic modulation by carvedilol and losartan reduces angiotensin II-mediated lipolysis in subcutaneous and visceral fat. The Journal of clinical endocrinology and metabolism 20050501
Potentiation of L-NAME-induced systemic and renal vasoconstrictor responses by alpha1-adrenoceptor antagonism. Journal of hypertension 20050501
Comparison of doxazosin with or without tolterodine in men with symptomatic bladder outlet obstruction and an overactive bladder. BJU international 20050501
The bedtime administration of doxazosin controls morning hypertension and albuminuria in patients with type-2 diabetes: evaluation using home-based blood pressure measurements. Clinical and experimental hypertension (New York, N.Y. : 1993) 20050501
[Antihypertensive therapy and congestive heart failure]. Medicina clinica 20050409
The perioperative management of a patient with complex single ventricle physiology and pheochromocytoma. Anesthesia and analgesia 20050401
First-line first? Trends in thiazide prescribing for hypertensive seniors. PLoS medicine 20050401
Molecular targets of doxazosin in human prostatic stromal cells. The Prostate 20050301
Clarithromycin-nifedipine interaction as possible cause of vasodilatory shock. The Annals of pharmacotherapy 20050301
The clinical efficacy and tolerability of doxazosin standard and gastrointestinal therapeutic system for benign prostatic hyperplasia. BJU international 20050301
Finasteride with doxazosin to reduce BPH progression. The Nurse practitioner 20050301
[Alfa-blockade with doxazosin vs tamsulozin in combination of intermittent androgen blockade in patients with prostate cancer]. Georgian medical news 20050301
[Impact of 30 day therapy with doxazosin--alpha1 adrenergic blocker on pulmonary hemodynamics in patients with secondary pulmonary hypertension due to chronic obstructive pulmonary disease]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20050301
Simon Campbell on the ups and downs of drug discovery and development. Interview by Jayne Carey and Samantha Barton. Drug discovery today 20050215
Doxazosin inhibits human vascular endothelial cell adhesion, migration, and invasion. Journal of cellular biochemistry 20050201
The vascular effects of doxazosin in hypertension complicated by metabolic syndrome. Coronary artery disease 20050201
pH-mediated acid stacking with reverse pressure for the analysis of cationic pharmaceuticals in capillary electrophoresis. Electrophoresis 20050201
Doxazosin for benign prostatic hyperplasia: an open-label, baseline-controlled study in Korean general practice. International journal of urology : official journal of the Japanese Urological Association 20050201
Re: an economic evaluation of doxazosin, finasteride and combination therapy in the treatment of benign prostatic hyperplasia. The Canadian journal of urology 20050201
Improvement of doxazosin determination in human plasma using high-performance liquid chromatography with fluorescence detection. Journal of chromatographic science 20050201
Unresolved priapism secondary to tamsulosin. International journal of impotence research 20050101
Primary bladder neck dysfunction in children and adolescents II: results of treatment with alpha-adrenergic antagonists. The Journal of urology 20050101
alpha1-Adrenergic receptor antagonists induce production of IL-18 and expression of ICAM-1 and CD40 in human monocytes. Journal of immunotherapy (Hagerstown, Md. : 1997) 20050101
Efficacy of extended-release doxazosin and doxazosin standard in patients with concomitant benign prostatic hyperplasia and sexual dysfunction. BJU international 20050101
Clinical ease of using doxazosin in BPH patients with and without hypertension. Prostate cancer and prostatic diseases 20050101
International variation in prescribing antihypertensive drugs: its extent and possible explanations. BMC health services research 20050101
Carvedilol prevents cardiac hypertrophy and overexpression of hypoxia-inducible factor-1alpha and vascular endothelial growth factor in pressure-overloaded rat heart. Journal of biomedical science 20050101
Different effects on inhibition of cardiac hypertrophy in spontaneously hypertensive rats by monotherapy and combination therapy of adrenergic receptor antagonists and/or the angiotensin II type 1 receptor blocker under comparable blood pressure reduction. Hypertension research : official journal of the Japanese Society of Hypertension 20050101
Littoral cell angioma of the spleen treated by laparoscopic splenectomy. JSLS : Journal of the Society of Laparoendoscopic Surgeons 20050101
Noninvasive management of lower urinary tract symptoms and sexual dysfunction associated with benign prostatic hyperplasia in the primary care setting. Comprehensive therapy 20050101
Doxazosin gastrointestinal therapeutic system: a review of its use in benign prostatic hyperplasia. Drugs 20050101
Controlled-release doxazosin in the treatment of benign prostatic hyperplasia. Prostate cancer and prostatic diseases 20050101
Growth inhibitory effect of doxazosin on prostate and bladder cancer cells. Is the serotonin receptor pathway involved? Anticancer research 20050101
[Refractory hypertention in a female patient with renal failure]. Giornale italiano di nefrologia : organo ufficiale della Societa italiana di nefrologia 20050101
[Doxazosine associated to renin-angiotensin blockers and calcioantagonists in chronic renal failure patients]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20050101
Successful alpha-1 receptor blockade therapy in a toddler with infrequent and difficult voiding. Advances in therapy 20050101
Hypertension guidelines and their effects on the health system. GMS health technology assessment 20050101
Dutasteride: an evidence-based review of its clinical impact in the treatment of benign prostatic hyperplasia. Core evidence 20050101
Eliciting preferences for drug treatment of lower urinary tract symptoms associated with benign prostatic hyperplasia. The Journal of urology 20041201
Effects of chronic administration of doxazosin on alpha1-adrenoceptors in the rat prostate. The Journal of urology 20041201
Recent developments in the therapy of phaeochromocytoma. Expert opinion on investigational drugs 20041201
Doxazosin for treating lower urinary tract symptoms compatible with benign prostatic obstruction: a systematic review of efficacy and adverse effects. BJU international 20041201
Blood pressure and urologists: like oil and water? BJU international 20041201
Interaction between the phosphodiesterase 5 inhibitor, tadalafil and 2 alpha-blockers, doxazosin and tamsulosin in healthy normotensive men. The Journal of urology 20041101
MTOPS: conclusions about invasive therapy for BPH should be interpreted with caution. BJU international 20041101
[Anesthetic management for removal of pheochromocytoma in a patient after repair of tetralogy of Fallot]. Masui. The Japanese journal of anesthesiology 20041101
Parameters of cell energy metabolism during stress in laboratory animals and energotropic effect of alpha1-adrenoblocker doxazosin. Bulletin of experimental biology and medicine 20041101
Doxazosin treatment causes differential alterations of alpha 1-adrenoceptor subtypes in the rat kidney, heart and aorta. Life sciences 20041008
Inhibition of mitogenic signaling and induction of apoptosis in human bladder smooth muscle cells treated with doxazosin. The Journal of urology 20041001
Comparison of doxazosin with or without tolterodine in men with symptomatic bladder outlet obstruction and an overactive bladder. BJU international 20041001
Doxazosin-induced up-regulation of alpha 1A-adrenoceptor mRNA in the rat lower urinary tract. Canadian journal of physiology and pharmacology 20041001
[Effect of modified liberation doxazosin on blood pressure, insulin resistance, and catecholamine secretion in patients with true resistant hypertension]. Medicina clinica 20040911
Importance of antioxidant and antiapoptotic effects of beta-receptor blockers in heart failure therapy. American journal of physiology. Heart and circulatory physiology 20040901
Chronotherapy of hypertension. Current opinion in nephrology and hypertension 20040901
After ALLHAT: doxazosin for the treatment of benign prostatic hyperplasia. Expert opinion on pharmacotherapy 20040901
[Therapy of benign prostatic hyperplasia with finasteride and doxazosin -- long-term studies support the combination]. Aktuelle Urologie 20040901
Doxazosin in the sigmoid. Lancet (London, England) 20040901
Long-term efficacy of doxazosin plus atenolol in the management of severe and sustained arterial hypertension and reversibility of the cardiac damage induced by chronic cathecolamine excess. A case report in a young girl with recurrent, functioning paraganglioma. Journal of endocrinological investigation 20040901
Pharmacological exploitation of the alpha1-adrenoreceptor antagonist doxazosin to develop a novel class of antitumor agents that block intracellular protein kinase B/Akt activation. Journal of medicinal chemistry 20040826
Induction of anoikis by doxazosin in prostate cancer cells is associated with activation of caspase-3 and a reduction of focal adhesion kinase. Urological research 20040801
Morning blood pressure surge and hypertensive cerebrovascular disease: role of the alpha adrenergic sympathetic nervous system. American journal of hypertension 20040801
An economic evaluation of doxazosin, finasteride and combination therapy in the treatment of benign prostatic hyperplasia. The Canadian journal of urology 20040801
Doxazosin effects on cholinergic and adrenergic responses in rat isolated detrusor smooth muscle preparations from obstructed bladder. Journal of pharmacological sciences 20040701
Renoprotective effect of angiotensin-converting enzyme inhibitor combined with alpha1-adrenergic antagonist in spontaneously hypertensive rats with renal ablation. Hypertension research : official journal of the Japanese Society of Hypertension 20040701
[Postoperative hypoglycemia after resection of pheochromocytoma: a case report]. Hinyokika kiyo. Acta urologica Japonica 20040701
The role of alpha-blockers in the management of prostate cancer. Expert opinion on pharmacotherapy 20040601
Ambulatory blood pressure monitoring in renal transplant patients: modifiable parameters after active antihypertensive treatment. Transplantation proceedings 20040601
5-Alpha reductase inhibition provides superior benefits to alpha blockade by preventing AUR and BPH-related surgery. European urology 20040501
Inhibition of human ether-a-go-go-related gene potassium channels by alpha 1-adrenoceptor antagonists prazosin, doxazosin, and terazosin. Naunyn-Schmiedeberg's archives of pharmacology 20040501
Two-drug therapy is best for symptomatic prostate enlargement: could a combination of doxazosin and finasteride change clinical practice? BJU international 20040501
Combination of finasteride and doxazosin for the treatment of benign prostatic hyperplasia. Expert opinion on pharmacotherapy 20040501
Apoptotic impact of alpha1-blockers on prostate cancer growth: a myth or an inviting reality? The Prostate 20040401
Comparative efficacy of two alpha-adrenoreceptor antagonists, doxazosin and alfuzosin, in patients with lower urinary tract symptoms from benign prostatic enlargement. BJU international 20040401
Successful treatment of pain in two patients with cutaneous leiomyomata with the oral alpha-1 adrenoceptor antagonist, doxazosin. The British journal of dermatology 20040401
[Estimation of the cost in the medical treatment of benign prostatic hyperplasia in Navarre, Spain]. Actas urologicas espanolas 20040401
[Treatment with Doxazosin in 3347 patients with lower urinary tract symptoms. Impact on sexual function. The impros study]. Actas urologicas espanolas 20040401
Finasteride in benign prostatic hyperplasia. The New England journal of medicine 20040325
Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. The Journal of urology 20040301
Cardiovascular outcomes using doxazosin vs. chlorthalidone for the treatment of hypertension in older adults with and without glucose disorders: a report from the ALLHAT study. Journal of clinical hypertension (Greenwich, Conn.) 20040301
[Alpha blocker for protection against hypertensive target-organ damage]. Nihon rinsho. Japanese journal of clinical medicine 20040301
[ALLHAT trial--antithesis to the overuse of vasodilating antihypertensive drugs]. Nihon rinsho. Japanese journal of clinical medicine 20040301
Administration-time-dependent effects of doxazosin GITS on ambulatory blood pressure of hypertensive subjects. Chronobiology international 20040301
Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia. The American journal of geriatric pharmacotherapy 20040301
Male breast cancer during finasteride therapy. Journal of the National Cancer Institute 20040218
Prostate apoptosis after doxazosin treatment in the spontaneous hypertensive rat model. BJU international 20040201
Herbal and vitamin supplement use in a prostate cancer screening population. Urology 20040201
Patients with uncontrolled hypertension or concomitant hypertension and benign prostatic hyperplasia. Clinical cardiology 20040201
Drug combo stalls BPH progression. Health news (Waltham, Mass.) 20040201
A current review of medical therapy for benign prostatic hyperplasia. The Journal of the American Osteopathic Association 20040201
Validated specific HPLC methods for determination of prazosin, terazosin and doxazosin in the presence of degradation products formed under ICH-recommended stress conditions. Journal of pharmaceutical and biomedical analysis 20040127
[ALLHAT--remaining questions await answers]. Lakartidningen 20040115
[Choice of antihypertensive agent--insignificant role of doxazosin (Alfadil). How are evidence-based recommendations implemented?]. Lakartidningen 20040115
Impact of clinical trial results on national trends in alpha-blocker prescribing, 1996-2002. JAMA 20040107
Guidelines for antihypertensive treatment: an update after the ALLHAT study. Journal of the American Society of Nephrology : JASN 20040101
Clinical application of wave intensity for the treatment of essential hypertension. Heart and vessels 20040101
Doxazosin controlled release vs tamsulosin in the management of benign prostatic hyperplasia: an efficacy analysis. International journal of clinical practice 20040101
[Doxazosin in the gastrointestinal therapeutic system (GITS) formulation and trial without catheter after acute urinary retention due to BPH. Dose increase action on recovery effect]. Actas urologicas espanolas 20040101
Relationship between body mass index and anti-hypertensive efficacy of doxazosin according to a survey of Japanese patients. The Journal of international medical research 20040101
Clinical usefulness of doxazosin in patients with type 2 diabetes complicated by hypertension: effects on glucose and lipid metabolism. The Journal of international medical research 20040101
Elevated sympathetic activity may promote insulin resistance syndrome by activating alpha-1 adrenergic receptors on adipocytes. Medical hypotheses 20040101
Benign prostatic hyperplasia progression and its impact on treatment. Current opinion in urology 20040101
Therapy of ED: PDE-5 Inhibitors. Endocrine 20040101
[Interstitial pneumonitis associated with sirolimus administration in a renal transplantation patient: a clinical case]. Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia 20040101
Cardiovascular parameter changes in patients with erectile dysfunction using pde-5 inhibitors: a study with sildenafil and vardenafil. Journal of andrology 20040101
Doxazosin plus finasteride reduced clinical progression of benign prostatic hyperplasia more than either drug used alone. ACP journal club 20040101
[Epidemiology of lower urinary tract symptoms and use of doxazosin in the treatment of early stages of benign prostate hyperplasia]. Likars'ka sprava 20040101
Terazosin and doxazosin in the treatment of BPH: results of a randomized study with crossover in non-responders. Urologia internationalis 20040101
Long-term treatment with doxazosin in men with benign prostatic hyperplasia: 10-year follow-up. International urology and nephrology 20040101
Cost-effectiveness of tamsulosin, doxazosin, and terazosin in the treatment of benign prostatic hyperplasia. Journal of managed care pharmacy : JMCP 20040101
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Pheochromocytoma. Scandinavian journal of surgery : SJS : official organ for the Finnish Surgical Society and the Scandinavian Surgical Society 20040101
A comparison of four different alpha1-blockers in benign prostatic hyperplasia patients with and without diabetes. Scandinavian journal of urology and nephrology 20040101
[LUTS in women and possible therapeutic effects of alfa1-adrenoblockers]. Khirurgiia 20040101
[Particular features of the treatment of ulcer recurrence in patients with myocardial infarction]. Eksperimental'naia i klinicheskaia gastroenterologiia = Experimental & clinical gastroenterology 20040101
The long-term effect of doxazosin, finasteride, and combination therapy on the clinical progression of benign prostatic hyperplasia. The New England journal of medicine 20031218
[Doxazosin and heart failure: a clinical conclusion is wanted]. Lakartidningen 20031218
[Alfadil--positive documentation when it comes to safety is missing]. Lakartidningen 20031218
[Alfadil and heart failure--clinical conclusions do exist!]. Lakartidningen 20031204
Protonation site and hydrogen bonding in anhydrous and hydrated crystalline forms of doxazosin mesylate from powder data. Acta crystallographica. Section B, Structural science 20031201
Use of alpha-blockers and the risk of hip/femur fractures. Journal of internal medicine 20031201
Relapse of Graves' disease in a patient with pheochromocytoma. Endocrine journal 20031201
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[Treatment of hypertension in a clinical trial. Depot alpha 1 blocker simplifies dosing]. MMW Fortschritte der Medizin 20031120
[Two drugs have a better outcome. Finasteride plus alpha blocker improves urine flow]. MMW Fortschritte der Medizin 20031120
Altered pharmacokinetics and excessive hypotensive effect of candesartan in a patient with the CYP2C91/3 genotype. Clinical pharmacology and therapeutics 20031101
Short-term subjective efficacy of doxazosin in predicting probability of prostatectomy in the management of benign prostatic hyperplasia in patients with severe symptoms. International journal of urology : official journal of the Japanese Urological Association 20031101
The effects of alpha and beta blockade on ventilatory responses to exercise in chronic heart failure. Heart (British Cardiac Society) 20031001
Alpha blocker therapy for children with dysfunctional voiding and urinary retention. The Journal of urology 20031001
Doxazosin, an alpha-1 antagonist, prevents further progression of the advanced atherosclerotic lesion in hypercholesterolemic hamsters. Metabolism: clinical and experimental 20031001
[Benign prostatic syndrome. 3-step plan for the treatment]. MMW Fortschritte der Medizin 20030925
[Pharmacologic treatment of benign prostatic hyperplasia]. Orvosi hetilap 20030914
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Effect of the alpha-adrenergic blocker, doxazosin, on endothelial function and insulin action. Metabolism: clinical and experimental 20030901
Effect of doxazosin on insulin resistance in hypertensive patients with obesity. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20030901
Chronic ischemia increases prostatic smooth muscle contraction in the rabbit. The Journal of urology 20030801
Doxazosin for the symptomatic treatment of benign prostatic hyperplasia. Current urology reports 20030801
The role of combination therapy for lower urinary tract symptoms secondary to benign prostatic hyperplasia. Current urology reports 20030801
Pharmaceutical review. BJU international 20030801
Effects of preweaning doxazosin treatment on adult pressure in the spontaneously hypertensive rat. Clinical and experimental pharmacology & physiology 20030801
Efficacy and safety of doxazosin GITS in hypertensive renal transplant patients: comparison of 8 and 4 mg. Transplantation proceedings 20030801
Doxazosin GITS trough to peak ratio and 24-hour blood pressure monitoring in the management of hypertension in renal transplant patients. Transplantation proceedings 20030801
Effectiveness of alpha1-adrenergic blockers in boys with low urinary flow rate and urinary incontinence. Journal of the Formosan Medical Association = Taiwan yi zhi 20030801
[5-alpha reductase inhibitors plus alpha blockers. A combination therapy keeps a common disease checked]. MMW Fortschritte der Medizin 20030710
Pharmacological characterization of unique prazosin-binding sites in human kidney. Naunyn-Schmiedeberg's archives of pharmacology 20030701
Doxazosin as combination therapy for patients with stage 1 and stage 2 hypertension. Journal of cardiovascular pharmacology 20030601
Effect of doxazosin GITS on 24-hour blood pressure profile in patients with stage 1 to stage 2 primary hypertension. Blood pressure monitoring 20030601
Flow cytometric analysis of platelet activation in hypertensive patients. Effect of doxazosin. Thrombosis research 20030601
Quinazoline-based alpha 1-adrenoceptor antagonists induce prostate cancer cell apoptosis via TGF-beta signalling and I kappa B alpha induction. British journal of cancer 20030519
Doxazosin and finasteride alone or in combination: the PREDICT study. BJU international 20030501
Safety and effectiveness of replacing standard doxazosin with doxazosin in the gastrointestinal therapeutic system (GITS) formulation in elderly hypertensive patients. International journal of clinical practice 20030501
Effect of doxazosin GITS on blood pressure in hypertensive and normotensive patients: a review of hypertension and BPH studies. Blood pressure. Supplement 20030501
Two cases of pheochromocytoma associated with tetralogy of Fallot. Hypertension research : official journal of the Japanese Society of Hypertension 20030501
Doxazosin and terazosin suppress prostate growth by inducing apoptosis: clinical significance. The Journal of urology 20030401
Diuretics: older, cheaper, better. The Johns Hopkins medical letter health after 50 20030401
By the way, doctor. I'm 77 and have an enlarged prostate. I take Proscar once a day and saw palmetto three times a day. Yet I still have to get up two to seven times a night to urinate. What can I do to reduce the frequency of urination? Harvard health letter 20030401
[ALLHAT: Old Hat Hits All? On selection of the optimal antihypertensive drug]. Wiener klinische Wochenschrift 20030331
The ICH guidance in practice: stress decomposition studies on three piperazinyl quinazoline adrenergic receptor-blocking agents and comparison of their degradation behaviour. Journal of pharmaceutical and biomedical analysis 20030326
Anoikis induction by quinazoline based alpha 1-adrenoceptor antagonists in prostate cancer cells: antagonistic effect of bcl-2. The Journal of urology 20030301
The ALLHAT Trial. Diuretics are still the preferred initial drugs for high blood pressure. Cleveland Clinic journal of medicine 20030301
Benign prostatic hyperplasia. Hospital medicine (London, England : 1998) 20030201
Medical treatment for urinary retention in rehabilitating elderly women: is it necessary? Aging clinical and experimental research 20030201
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[Misleading advertising claims about the indication of doxazosin (Cardura) for type 2 diabetes mellitus and hypertension]. Nederlands tijdschrift voor geneeskunde 20030118
[Established blood pressure drug wins out in a comparative study. In hypertension, a diuretic first!]. MMW Fortschritte der Medizin 20030116
Doxazosin induces apoptosis in cardiomyocytes cultured in vitro by a mechanism that is independent of alpha1-adrenergic blockade. Circulation 20030107
Stromal/epithelial interactions of murine prostatic cell lines in vivo: a model for benign prostatic hyperplasia and the effect of doxazosin on tissue size. The Prostate 20030101
Efficacy and tolerability of doxazosin and finasteride, alone or in combination, in treatment of symptomatic benign prostatic hyperplasia: the Prospective European Doxazosin and Combination Therapy (PREDICT) trial. Urology 20030101
A randomized, double-blind crossover study of tamsulosin and controlled-release doxazosin in patients with benign prostatic hyperplasia. BJU international 20030101
[The incidence, features of the course, and treatment of arterial hypertension in patients with prostate hyperplasia]. Likars'ka sprava 20030101
ALLHAT. Is it all hat? The Journal of the Louisiana State Medical Society : official organ of the Louisiana State Medical Society 20030101
[Tonocardin (doxazosin) in treating lower urinary tract symptoms]. Urologiia (Moscow, Russia : 1999) 20030101
[The new (old) knowledge in primary prevention of stroke. It depends on lowering of blood pressure]. MMW Fortschritte der Medizin 20030101
[Primary prevention of stroke. What helps--what does not help? The guidelines of the German Society of Neurology briefly summarized]. MMW Fortschritte der Medizin 20030101
The potential savings of using thiazides as the first choice antihypertensive drug: cost-minimisation analysis. BMC health services research 20030101
[Dynamics of immunologic indices in patients with ischemic heart disease on a course of doxazosin therapy]. Likars'ka sprava 20030101
[Efficacy and safety in the use of doxazosin (cardura) in the treatment of patients with benign prostatic hypertrophy (bph)]. Urologiia (Moscow, Russia : 1999) 20030101
[Possibility of predicting the use of doxazosin in the treatment of arterial hypertension]. Klinicheskaia meditsina 20030101
What ALLHAT tells us about treating high-risk patients with hypertension and hyperlipidemia. The Journal of cardiovascular nursing 20030101
Characteristics and lipid distribution of a large, high-risk, hypertensive population: the lipid-lowering component of the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Journal of clinical hypertension (Greenwich, Conn.) 20030101
[Effects of monotherapy with an alpha1-adrenoblocker doxazosin and its combination with beta1-adrenoblocker atenolol on hemodynamics, reversible myocardial ischemia in postmyocardial infarction patients with arterial hypertension]. Klinicheskaia meditsina 20030101
Back to thiazide-diuretics for hypertension: reflections after a decade of irrational prescribing. BMC family practice 20030101
Estimated costs of treatment of benign prostate hyperplasia in Brazil. International braz j urol : official journal of the Brazilian Society of Urology 20030101
Benign prostatic hyperplasia: does prostate size matter? Reviews in urology 20030101
Landmark studies impacting the medical management of benign prostatic hyperplasia. Reviews in urology 20030101
Landmark studies impacting the medical management of benign prostatic hyperplasia. Reviews in urology 20030101
Drug effects on aldosterone/plasma renin activity ratio in primary aldosteronism. Hypertension (Dallas, Tex. : 1979) 20021201
Effects of doxazosin and propranolol on A2A adenosine receptors in essential hypertension. Hypertension (Dallas, Tex. : 1979) 20021201
Doxazosin, but not amlodipine decreases insulin resistance in patients with chronic renal failure: a prospective, randomized-controlled study. Clinical nephrology 20021201
Second opinion. I have benign prostatic hyperplasia. The drug my doctor prescribed has helped somewhat, but I'm still making a lot of trips to the bathroom at night. Short of surgery, are there any new approaches to managing this condition that might be more helpful? Mayo Clinic health letter (English ed.) 20021201
[Misleading advertising claims about the indication of doxazosin (Cardura) for type 2 diabetes mellitus and hypertension]. Nederlands tijdschrift voor geneeskunde 20021102
Influence of drugs and gender on the arterial pulse wave and natriuretic peptide secretion in untreated patients with essential hypertension. Clinical science (London, England : 1979) 20021101
[5-alpha reductase inhibitors or alpha blockers? The combination brakes best prostatic hyperplasia]. MMW Fortschritte der Medizin 20021031
[Management of hypertensive patients with left ventricular hypertrophy]. Presse medicale (Paris, France : 1983) 20021001
Effect of doxazosin on arterial elasticity: functional versus structural changes. Journal of clinical pharmacology 20021001
Effects of distension of urinary bladder on coronary conduit and resistance vessels in hyperlipidemic patients. Clinical cardiology 20021001
Prophylactic versus therapeutic alpha-blockers after permanent prostate brachytherapy. Urology 20021001
Prevention of heart failure. Journal of cardiac failure 20021001
[Doxazosin and urinary incontinence]. Anales de medicina interna (Madrid, Spain : 1984) 20021001
Doxazosin and hydrochlorothiazide equally affect arterial wall thickness in hypertensive males with hypercholesterolaemia (the DAPHNE study). Doxazosin Atherosclerosis Progression Study in Hypertensives in the Netherlands. The Netherlands journal of medicine 20021001
Relationship of antihypertensive treatment regimens and change in blood pressure to risk for heart failure in hypertensive patients randomly assigned to doxazosin or chlorthalidone: further analyses from the Antihypertensive and Lipid-Lowering treatment to prevent Heart Attack Trial. Annals of internal medicine 20020903
Summaries for patients. Blood pressure drugs and heart failure. Annals of internal medicine 20020903
Doxazosin and ALLHAT trial: a response. American journal of hypertension 20020901
The effect of doxazosin on sexual function in patients with benign prostatic hyperplasia, hypertension, or both. International journal of clinical practice 20020901
Effects of acute administration of doxazosin on fasting and postprandial haemodynamics and lipid metabolism in healthy subjects. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20020901
[Drug therapy of benign prostatic hyperplasia syndrome with alpha 1-receptor blockers. Basic principles and clinical results]. Der Urologe. Ausg. A 20020901
[alpha 1-receptor blockade in therapy of benign prostatic hyperplasia syndrome. Correct dosing for optimal effectiveness]. Der Urologe. Ausg. A 20020901
Microalbuminuria reduction with valsartan in patients with type 2 diabetes mellitus: a blood pressure-independent effect. Circulation 20020806
alpha1-Adrenergic blockers in young men with primary bladder neck obstruction. The Journal of urology 20020801
Critical evaluation of the problem of chronic urinary retention after orthotopic bladder substitution in women. The Journal of urology 20020801
Effect of doxazosin on stretch-activated adenosine triphosphate release in bladder urothelial cells from patients with benign prostatic hyperplasia. Urology 20020801
Medical therapy for benign prostatic hyperplasia progression. Current urology reports 20020801
Two-drug therapy is best for symptomatic prostate enlargement: combination should change clinical practice. Journal of the American College of Surgeons 20020801
Efficacy and safety of doxazosin for perioperative management of patients with pheochromocytoma. World journal of surgery 20020801
The potential of pill splitting to achieve cost savings. The American journal of managed care 20020801
Successful blood pressure control in the African American Study of Kidney Disease and Hypertension. Archives of internal medicine 20020722
alpha-Adrenoceptor antagonists in the treatment of benign prostate hyperplasia. Pharmacology 20020701
Managing benign prostatic hyperplasia. American family physician 20020701
[Hypertension and metabolic syndrome in population of one company. Monotherapy with amlodipine and doxazosin]. Polski merkuriusz lekarski : organ Polskiego Towarzystwa Lekarskiego 20020701
Doxazosin, an inferior antihypertensive agent? Journal of human hypertension 20020601
[Chiral separation and preparation of three new antagonists of alpha 1-adrenoceptors by chiral mobile phase HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica 20020601
A postmarketing, open-label study to evaluate the tolerability and effectiveness of replacing standard-formulation doxazosin with doxazosin in the gastrointestinal therapeutic system formulation in adult patients with hypertension. Clinical therapeutics 20020501
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Double-blind, placebo-controlled crossover comparison of five classes of antihypertensive drugs. Journal of hypertension 20020401
[Doxazosin, of modified liberation, in hemodialyzed patients]. Anales de medicina interna (Madrid, Spain : 1984) 20020401
Reduction of the soluble cyclic GMP vasorelaxing system in the vascular wall of stroke-prone spontaneously hypertensive rats: effect of the alpha1 -receptor blocker doxazosin. Journal of hypertension 20020301
Interaction of digoxin with antihypertensive drugs via MDR1. Life sciences 20020215
Modeling of relationships between pharmacokinetics and blockade of agonist-induced elevation of intraurethral pressure and mean arterial pressure in conscious dogs treated with alpha(1)-adrenoceptor antagonists. The Journal of pharmacology and experimental therapeutics 20020201
Stability-indicating methods for the determination of doxazosin mezylate and celecoxib. Journal of pharmaceutical and biomedical analysis 20020201
Flow injection analysis of doxazosin mesylate using UV-detection. Journal of pharmaceutical and biomedical analysis 20020201
The use of alpha-adrenoceptor antagonists in lower urinary tract disease. Expert opinion on pharmacotherapy 20020201
Combined oral therapy with sildenafil and doxazosin for the treatment of non-organic erectile dysfunction refractory to sildenafil monotherapy. International journal of impotence research 20020201
Double-blind, crossover, comparative study of doxazosin and enalapril in the treatment of hypertension in renal transplant patients under cyclosporine immunosuppression. Transplantation proceedings 20020201
Quinazoline-derived alpha1-adrenoceptor antagonists induce prostate cancer cell apoptosis via an alpha1-adrenoceptor-independent action. Cancer research 20020115
Relationship between arterial distensibility and low-frequency power spectrum of blood pressure in spontaneously hypertensive rats. Journal of cardiovascular pharmacology 20020101
Treatment of hypertension in the elderly. The American journal of geriatric cardiology 20020101
Acute effects of serotonin on rat bladder contractility. Urologia internationalis 20020101
Psychological characteristics and responses to antihypertensive drug therapy. Journal of clinical hypertension (Greenwich, Conn.) 20020101
Influence of the alpha-1-adrenergic receptor blocker doxazosin on exercise-induced hyperkalemia in hemodialysis patients. Kidney & blood pressure research 20020101
Observational multicentric trial performed with doxazosin: evaluation of sexual effects on patients with diagnosed benign prostatic hyperplasia. Urologia internationalis 20020101
Stroke associated with alpha blocker therapy for benign prostatic hypertrophy. Journal of the National Medical Association 20020101
Effect of doxazosin on rat urinary bladder function after partial outlet obstruction. Neurourology and urodynamics 20020101
Low-dose doxazosin improved aortic stiffness and endothelial dysfunction as measured by noninvasive evaluation. Hypertension research : official journal of the Japanese Society of Hypertension 20020101
The choice of antihypertensive drugs in patients with erectile dysfunction. Current medical research and opinion 20020101
Premature termination of clinical trials--lessons learned. Journal of clinical hypertension (Greenwich, Conn.) 20020101
Doxazosin and congestive heart failure. Congestive heart failure (Greenwich, Conn.) 20020101
Alpha1-adrenoceptor antagonists radiosensitize prostate cancer cells via apoptosis induction. Anticancer research 20020101
Differential actions of naftopidil, doxazosin and nifedipine on platelet thromboxane generation and platelet-derived growth factor efflux in vitro. Platelets 20020101
Alpha blockade in preoperative preparation of patients with pheochromocytomas. International surgery 20020101
[Policy of antihypertensive therapy in arterial hypertension in the elderly. II]. Klinicheskaia meditsina 20020101
Apoptotic and proliferative index after Alpha-1-adrenoceptor antagonist and/or finasteride treatment in benign prostatic hyperplasia. Urologia internationalis 20020101
Success and predictors of blood pressure control in diverse North American settings: the antihypertensive and lipid-lowering treatment to prevent heart attack trial (ALLHAT). Journal of clinical hypertension (Greenwich, Conn.) 20020101
Induction of prostate apoptosis by alpha1-adrenoceptor antagonists: mechanistic significance of the quinazoline component. Prostate cancer and prostatic diseases 20020101
[Tonocardin in complex treatment of diabetes mellitus concurrent with hypertension]. Terapevticheskii arkhiv 20020101
[Drug therapy of spastic disorder of urine outflow in patients with spinal injury and spinal cord injury]. Likars'ka sprava 20020101
Lower urinary tract symptoms, pain and quality of life assessment in chronic non-bacterial prostatitis patients treated with alpha-blocking agent doxazosin; versus placebo. International urology and nephrology 20020101
Clinical Implications of Recent Findings from the Antihypertensive and Lipid-Lowering Treatment To Prevent Heart Attack Trial (ALLHAT) and Other Studies of Hypertension. Annals of internal medicine 20011218
Participant recruitment in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Controlled clinical trials 20011201
Tamsulosin: current clinical experience. Urology 20011201
Terazosin, doxazosin, and prazosin: current clinical experience. Urology 20011201
5alpha-reductase inhibitors: what role should they play? Urology 20011201
Meta-analysis of studies using selective alpha1-blockers in patients with hypertension and type 2 diabetes. International journal of clinical practice 20011201
Effects of blood pressure lowering with amlodipine or lisinopril on vascular structure of the common carotid artery. Clinical science (London, England : 1979) 20011101
Doxazosin and congestive heart failure. Journal of the American College of Cardiology 20011101
Doxazosin for the management of hypertension: implications of the findings of the ALLHAT trial. American journal of hypertension 20011101
Effects of antihypertensive agents on blood pressure during exercise. Hypertension research : official journal of the Japanese Society of Hypertension 20011101
Cardiovascular protection and blood pressure reduction: a meta-analysis. Lancet (London, England) 20011020
Warning for antihypertensive drug? Lancet (London, England) 20011006
A random comparison of fosinopril and nifedipine GITS in patients with primary renal disease. Journal of hypertension 20011001
Ventricular production of natriuretic peptides and ventricular structural remodeling in hypertensive heart failure. Journal of hypertension 20011001
[Effect of doxazosin on postural changes in blood pressure using a multibiomedical recorder]. Nihon Jinzo Gakkai shi 20011001
Heart lines. Cardura update. Harvard heart letter : from Harvard Medical School 20010901
Doxazosin reduces prevalence of small dense low density lipoprotein and remnant-like particle cholesterol levels in nondiabetic and diabetic hypertensive patients. American journal of hypertension 20010901
Lessons learned from prematurely terminated clinical trials. Current hypertension reports 20010801
Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin in men with lower urinary tract symptoms and clinical evidence of benign prostatic hyperplasia. Urology 20010801
Apoptotic activity of doxazosin on prostate stroma in vitro is mediated through an autocrine expression of TGF-beta1. The Prostate 20010801
Reduction of human prostate tumor vascularity by the alpha1-adrenoceptor antagonist terazosin. The Prostate 20010701
Role of alpha1-blockade in congenital long QT syndrome: investigation by exercise stress test. Japanese circulation journal 20010701
[Doxazosin and soluble guanylate cyclase in a rat model of hypertension]. Revista espanola de cardiologia 20010701
Antihypertensive effect of alpha- and beta-adrenergic blockade in obese and lean hypertensive subjects. American journal of hypertension 20010701
Safety and availability of doxazosin in treating hypertensive patients with chronic renal failure. Hypertension research : official journal of the Japanese Society of Hypertension 20010701
On call. I'm a 76-year-old man with an enlarged prostate. I've been taking Cardura and it's helped a lot, but my doctor stopped it because he said a study found the drug could cause heart failure. Now I'm getting up three or four times a night again. Is Cadura safe? Harvard men's health watch 20010701
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia. Journal of medicinal chemistry 20010607
US FDA weighs options for warning on antihypertensive drug. Lancet (London, England) 20010602
Voltammetric determination of doxazosin in tablets using rotating platinum electrode. Journal of pharmaceutical and biomedical analysis 20010601
Low-dose alpha/beta blockade in the treatment of essential hypertension. American journal of hypertension 20010601
[Alpha-blockers in therapy of arterial hypertension. No longer the drug of first choice]. MMW Fortschritte der Medizin 20010531
The role of alpha(1)-adrenoceptors and 5-HT(1A) receptors in the control of the micturition reflex in male anaesthetized rats. British journal of pharmacology 20010501
Doxazosin inhibits monocyte chemotactic protein 1-directed migration of human monocytes. Journal of cardiovascular pharmacology 20010501
Effect of antihypertensive therapy on renal artery structure in type 2 diabetic rats with hypertension. Hypertension (Dallas, Tex. : 1979) 20010501
Initiation of nonselective alpha1-antagonist therapy and occurrence of hypotension-related adverse events among men with benign prostatic hyperplasia: a retrospective cohort study. Clinical therapeutics 20010501
Update in pharmacologic treatment of hypertension. Cardiology clinics 20010501
Recent clinical trial highlights in hypertension. Current hypertension reports 20010401
Baseline characteristics of the diabetic participants in the Antihypertensive and Lipid-Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Diabetes care 20010401
Reduced heat shock proteins: a mechanism to explain higher cardiovascular events associated with doxazosin. Journal of human hypertension 20010401
Doxazosin, an alpha1-adrenergic antihypertensive agent, decreases serum oxidized LDL. American journal of hypertension 20010301
Doxazosin, an alpha1-adrenoceptor antagonist, inhibits serotonin-induced shape change in human platelets. Journal of human hypertension 20010301
Reduced heat shock proteins--a mechanism to explain higher cardiovascular events associated with doxazosin. Journal of human hypertension 20010301
The cost-effectiveness of doxazosin for the treatment of hypertension in type II diabetic patients in the UK and Italy. International journal of clinical practice 20010301
The release of the substrate for xanthine oxidase in hypertensive patients was suppressed by angiotensin converting enzyme inhibitors and alpha1-blockers. Journal of hypertension 20010301
Apoptotic regression of prostatic tissue induced by short-term doxazosin treatment in benign prostatic hyperplasia. Archivos espanoles de urologia 20010301
[Long-term therapy of benign prostatic hyperplasia. Our experience]. Minerva urologica e nefrologica = The Italian journal of urology and nephrology 20010301
Operational aspects of terminating the doxazosin arm of The Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). Controlled clinical trials 20010201
A combined analysis of double-blind trials of the efficacy and tolerability of doxazosin-gastrointestinal therapeutic system, doxazosin standard and placebo in patients with benign prostatic hyperplasia. BJU international 20010201
Renal hemodynamic effects of captopril and doxazosin during slight physical activity in hypertensive patients with type-1 diabetes mellitus. Kidney & blood pressure research 20010101
A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology 20010101
pH-mediated field-amplified sample stacking of pharmaceutical cations in high-ionic strength samples. Electrophoresis 20010101
Discontinuation of alpha-blockade after initial treatment with finasteride and doxazosin for bladder outlet obstruction. Urologia internationalis 20010101
[The best in 2000 on arterial hypertension]. Archives des maladies du coeur et des vaisseaux 20010101
[Bilateral pheochromocytoma: laparoscopic surgery in 2 cases]. Revista medica de Chile 20010101
Lower urinary tract symptoms suggestive of benign prostatic obstruction--Triumph: the role of general practice databases. European urology 20010101
Reversible renal impairment induced by treatment with the angiotensin II receptor antagonist candesartan in a patient with bilateral renal artery stenosis. BMC nephrology 20010101
Low-dose ACE with alpha- or beta-adrenergic receptor inhibitors have beneficial SHR cardiovascular effects. Journal of cardiovascular pharmacology and therapeutics 20010101
Doxazosin added to single-drug therapy in hypertensive patients with benign prostatic hypertrophy. Journal of clinical hypertension (Greenwich, Conn.) 20010101
[Doksazozin 'Cardura' in acute urinary retention caused by benign prostatic hyperplasia]. Urologiia (Moscow, Russia : 1999) 20010101
A comparison of selected antihypertensives and the use of conventional vs ambulatory blood pressure in the detection and treatment of hypertension. Cardiology 20010101
Is postural hypotension a real problem with antihypertensive medication? Cardiology 20010101
Effects of two atypical neuroleptics, olanzapine and risperidone, on the function of the urinary bladder and the external urethral sphincter in anesthetized rats. BMC pharmacology 20010101
Efficacy and tolerability of drugs for treatment of benign prostatic hyperplasia. International urology and nephrology 20010101
Quality-of-life assessment in patients with benign prostatic hyperplasia: effects of various interventions. PharmacoEconomics 20010101
Clinical significance of alpha1-adrenoceptor selectivity in the management of benign prostatic hyperplasia. International urology and nephrology 20010101
Suppression of human prostate cancer cell growth by alpha1-adrenoceptor antagonists doxazosin and terazosin via induction of apoptosis. Cancer research 20000815
Alpha-blockers and congestive heart failure: early termination of an arm of the ALLHAT trial. Cleveland Clinic journal of medicine 20000601
Characterization of human recombinant alpha(2A)-adrenoceptors expressed in Chinese hamster lung cells using intracellular Ca(2+) changes: evidence for cross-talk between recombinant alpha(2A)- and native alpha(1)-adrenoceptors. British journal of pharmacology 20000401
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