Home Halogens 1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrochloride

1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrochloride

CAS No.:
84485-00-7
Catalog Number:
AG00JOEP
Molecular Formula:
C17H27Cl2N
Molecular Weight:
316.3090
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
≥98%
1 week
United States
$161
- +
5mg
≥98%
1 week
United States
$318
- +
Product Description
Catalog Number:
AG00JOEP
Chemical Name:
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine hydrochloride
CAS Number:
84485-00-7
Molecular Formula:
C17H27Cl2N
Molecular Weight:
316.3090
MDL Number:
MFCD04039806
IUPAC Name:
1-[1-(4-chlorophenyl)cyclobutyl]-N,N,3-trimethylbutan-1-amine;hydrochloride
InChI:
InChI=1S/C17H26ClN.ClH/c1-13(2)12-16(19(3)4)17(10-5-11-17)14-6-8-15(18)9-7-14;/h6-9,13,16H,5,10-12H2,1-4H3;1H
InChI Key:
UWAOJIWUVCMBAZ-UHFFFAOYSA-N
SMILES:
CC(CC(C1(CCC1)c1ccc(cc1)Cl)N(C)C)C.Cl
NSC Number:
758928
Properties
Complexity:
275  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
315.152g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
1  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
316.31g/mol
Monoisotopic Mass:
315.152g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
3.2A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
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Effect of sibutramine on Na+, K+ ATPase activity and tryptophan levels on male and female rat brain. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090501
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5-HT(1A) activation counteracts cardiovascular but not hypophagic effects of sibutramine in rats. Obesity (Silver Spring, Md.) 20090301
The anorexic agents, sibutramine and fenfluramine, depress GABA(B)-induced inhibitory postsynaptic potentials in rat mesencephalic dopaminergic cells. British journal of pharmacology 20090301
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Chinese slimming capsules containing sibutramine sold over the Internet: a case series. Deutsches Arzteblatt international 20090301
Bonghan system as mesenchymal stem cell niches and pathways of macrophages in adipose tissues. Journal of acupuncture and meridian studies 20090301
Demo-experiments of Bonghan ducts in Beijing. Journal of acupuncture and meridian studies 20090301
Comparison of methods for delivering a lifestyle modification program for obese patients: a randomized trial. Annals of internal medicine 20090217
Characterization of metabolites of sibutramine in primary cultures of rat hepatocytes by liquid chromatography-ion trap mass spectrometry. Analytical and bioanalytical chemistry 20090201
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Effect of sibutramine HCl on cardiac hERG K+ channel. Molecular and cellular biochemistry 20090101
Pharmacotherapy for eating disorders and obesity. Child and adolescent psychiatric clinics of North America 20090101
Recent advances in obesity pharmacotherapy. Current clinical pharmacology 20090101
Pioglitazone metabolic effect in metformin-intolerant obese patients treated with sibutramine. Internal medicine (Tokyo, Japan) 20090101
Predictors and correlates for weight changes in patients co-treated with olanzapine and weight mitigating agents; a post-hoc analysis. BMC psychiatry 20090101
Development and validation of a column high-performance liquid chromatographic method for determination of sibutramine in capsules. Journal of AOAC International 20090101
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What extent of weight loss can benefit the health-related quality of life in motivated obese Chinese? Asia Pacific journal of clinical nutrition 20090101
Comparison of rimonabant and sibutramine treatment effects on food compulsion in rats. Acta cirurgica brasileira 20090101
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A double-blind, placebo-controlled trial of sibutramine for clozapine-associated weight gain. Acta psychiatrica Scandinavica 20070201
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Detection of sibutramine, its two metabolites and one analogue in a herbal product for weight loss by liquid chromatography triple quadrupole mass spectrometry and time-of-flight mass spectrometry. Rapid communications in mass spectrometry : RCM 20070101
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Comparison of the effects of sibutramine and orlistat on obese, poorly-controlled type 2 diabetic patients. Chang Gung medical journal 20070101
Comparison of lipid lowering effect of sibutramine in patients treated or not treated with statins--3 month follow-up. Prague medical report 20070101
Assessment of clinical and economic benefits of weight management with sibutramine in general practice in Germany. The European journal of health economics : HEPAC : health economics in prevention and care 20061201
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The sibutramine metabolite M2 improves muscle glucose uptake and reduces hepatic glucose output: preliminary data. Diabetes & vascular disease research 20061201
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Tolerability and effectiveness of fluoxetine, metformin and sibutramine in reducing anthropometric and metabolic parameters in obese patients. Arquivos brasileiros de endocrinologia e metabologia 20061201
Comparison of orlistat and sibutramine in an obesity management program: efficacy, compliance, and weight regain after noncompliance. Eating and weight disorders : EWD 20061201
Locomotor and peripheral effects of sibutramine modulated by 5-HT2 receptors. Canadian journal of physiology and pharmacology 20061201
Reduced left ventricular mass after treatment of obese patients with sibutramine: An echocardiographic multicentre study. Diabetes, obesity & metabolism 20061101
Baseline serum folate level may be a predictive factor of weight loss in a morbid-obesity-management programme. The British journal of nutrition 20061101
The primary amine metabolite of sibutramine stimulates lipolysis in adipocytes isolated from lean and obese mice and in isolated human adipocytes. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20061101
Serotonin and norepinephrine reuptake inhibition and eating behavior. Annals of the New York Academy of Sciences 20061101
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Identification of a sibutramine-metabolite in patient urine after intake of a 'pure herbal' Chinese slimming product. Therapeutic drug monitoring 20061001
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Chronic 5-HT6 receptor modulation by E-6837 induces hypophagia and sustained weight loss in diet-induced obese rats. British journal of pharmacology 20060801
Norepinephrine transporter inhibition prevents tilt-induced pre-syncope. Journal of the American College of Cardiology 20060801
Weight loss medications--where do they fit in? Australian family physician 20060801
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Peripheral mechanisms of sibutramine involving proximal gastric motility in dogs. Obesity (Silver Spring, Md.) 20060801
Summaries for patients. Effects of drug treatment for obesity in adolescence. Annals of internal medicine 20060718
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Use of lifestyle changes treatment plans and drug therapy in controlling cardiovascular and metabolic risk factors. Obesity (Silver Spring, Md.) 20060601
Influence of weight reduction by sibutramine on female sexual function. International journal of obesity (2005) 20060501
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
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QT interval prolongation associated with sibutramine treatment. British journal of clinical pharmacology 20060401
Locomotion is the major determinant of sibutramine-induced increase in energy expenditure. Pharmacology, biochemistry, and behavior 20060401
Keeping weight-loss drugs in perspective. If you're dangerously overweight, diet pills may help--but not without major lifestyle changes. Harvard women's health watch 20060401
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Clinical trial issues in weight-loss therapy. American heart journal 20060301
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Determination of N-desmethyl- and N-bisdesmethyl metabolites of Sibutramine in doping control analysis using liquid chromatography-tandem mass spectrometry. European journal of mass spectrometry (Chichester, England) 20060101
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Valuable lessons from research on drugs for adolescent obesity in Mexico. Advances in therapy 20060101
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Rapid treatment of posttraumatic stress disorder with sibutramine. Epilepsy & behavior : E&B 20051101
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A double-blind, placebo-controlled trial of sibutramine for olanzapine-associated weight gain. The American journal of psychiatry 20050501
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