Home Aminos 2-Furancarboxamide,N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-

2-Furancarboxamide,N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-

CAS No.:
81403-80-7
Catalog Number:
AG00IKK8
Molecular Formula:
C19H27N5O4
Molecular Weight:
389.4488
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
In Stock USA
United States
$46
- +
25mg
98%
In Stock USA
United States
$73
- +
100mg
98%
In Stock USA
United States
$155
- +
1g
98%
In Stock USA
United States
$433
- +
Product Description
Catalog Number:
AG00IKK8
Chemical Name:
2-Furancarboxamide,N-[3-[(4-amino-6,7-dimethoxy-2-quinazolinyl)methylamino]propyl]tetrahydro-
CAS Number:
81403-80-7
Molecular Formula:
C19H27N5O4
Molecular Weight:
389.4488
MDL Number:
MFCD00865792
IUPAC Name:
N-[3-[(4-amino-6,7-dimethoxyquinazolin-2-yl)-methylamino]propyl]oxolane-2-carboxamide
InChI:
InChI=1S/C19H27N5O4/c1-24(8-5-7-21-18(25)14-6-4-9-28-14)19-22-13-11-16(27-3)15(26-2)10-12(13)17(20)23-19/h10-11,14H,4-9H2,1-3H3,(H,21,25)(H2,20,22,23)
InChI Key:
WNMJYKCGWZFFKR-UHFFFAOYSA-N
SMILES:
COc1cc2nc(nc(c2cc1OC)N)N(CCCNC(=O)C1CCCO1)C
EC Number:
617-230-8
NSC Number:
760065
Properties
Complexity:
511  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
389.206g/mol
Formal Charge:
0
Heavy Atom Count:
28  
Hydrogen Bond Acceptor Count:
8  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
389.456g/mol
Monoisotopic Mass:
389.206g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
112A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
1.7  
Literature
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Current treatment options in the management of chronic prostatitis. Therapeutics and clinical risk management 20070801
Intraoperative floppy-iris syndrome associated with alpha1-adrenoreceptors: comparison of tamsulosin and alfuzosin. Journal of cataract and refractive surgery 20070701
Selective sample treatment using molecularly imprinted polymers. Journal of chromatography. A 20070608
Combination of alfuzosin and sildenafil is superior to monotherapy in treating lower urinary tract symptoms and erectile dysfunction. European urology 20070601
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Reduction of PSA values by combination pharmacological therapy in patients with chronic prostatitis: implications for prostate cancer detection. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20070601
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Computational approach to the basicity of a series of alpha1-adrenoceptor ligands in aqueous solution. Bioorganic & medicinal chemistry 20070415
Re: Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers: W. J. Hellstrom and S. C. Sikka. J Urol 2006; 176: 1529-1533. The Journal of urology 20070401
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A review of combination therapy in patients with benign prostatic hyperplasia. Clinical therapeutics 20070301
Update on the use of dutasteride in the management of benign prostatic hypertrophy. Clinical interventions in aging 20070301
Outcomes and quality of life issues in the pharmacological management of benign prostatic hyperplasia (BPH). Therapeutics and clinical risk management 20070301
Rapid onset of action with alfuzosin 10 mg once daily in men with benign prostatic hyperplasia: a randomized, placebo-controlled trial. Prostate cancer and prostatic diseases 20070101
Re: Alfuzosin 10 mg once daily prevents overall clinical progression of benign prostatic hyperplasia but not acute urinary retention: results of a 2-year placebo-controlled study. European urology 20070101
Identification of the patient with enlarged prostate: diagnosis and guidelines for management. Osteopathic medicine and primary care 20070101
Intraoperative floppy iris syndrome associated with terazosin. Indian journal of ophthalmology 20070101
Effects of alfuzosin 10 mg once daily on sexual function in men treated for symptomatic benign prostatic hyperplasia. International journal of impotence research 20070101
In vitro controlled release of alfuzosin hydrochloride using HPMC-based matrix tablets and its comparison with marketed product. Pharmaceutical development and technology 20070101
Alpha blockers for the treatment of benign prostatic hyperplasia. Reviews in urology 20070101
[The experience in postoperative administration of alpha-adrenoblockers]. Urologiia (Moscow, Russia : 1999) 20070101
Acute urinary retention in benign prostatic hyperplasia: Risk factors and current management. Indian journal of urology : IJU : journal of the Urological Society of India 20070101
Intraoperative floppy iris syndrome in a patient taking alfuzosin for benign prostatic hypertrophy. Eye (London, England) 20061201
Alfuzosin (10 mg) does not affect blood pressure in young healthy men. European urology 20061201
Molecularly imprinted polymers for the clean-up of a basic drug from environmental and biological samples. Journal of chromatography. A 20061201
Comorbid LUTS and erectile dysfunction: optimizing their management. Current medical research and opinion 20061201
Validated HPLC and HPTLC stability-indicating methods for determination of alfuzosin hydrochloride in bulk powder and pharmaceutical formulations. Journal of separation science 20061201
Doxazosin in the treatment of benign prostatic hypertrophy: an update. Clinical interventions in aging 20061201
Urethral syndrome: response to alpha-adrenergic blocking agents. International urogynecology journal and pelvic floor dysfunction 20061101
Comparison between tamsulosin and alfuzosin on the expulsion phase of ejaculation in rats. BJU international 20061001
A randomised, double-blind study comparing the efficacy and tolerability of controlled-release doxazosin and tamsulosin in the treatment of benign prostatic hyperplasia in Brazil. International journal of clinical practice 20061001
Effects of acute treatment with tamsulosin versus alfuzosin on ejaculatory function in normal volunteers. The Journal of urology 20061001
Stuttering priapism after ingestion of alfuzosin. Urology 20061001
Development and validation of a reversed-phase HPLC method for monitoring of synthetic reactions during the manufacture of a key intermediate of an anti-hypertensive drug. Journal of separation science 20061001
Response to daily 10 mg alfuzosin predicts acute urinary retention and benign prostatic hyperplasia related surgery in men with lower urinary tract symptoms. The Journal of urology 20060901
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Toxic epidermal necrolysis caused by alfuzosin, an alpha1-adrenoceptor antagonist. Archives of dermatology 20060701
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The beneficial effect of alfuzosin 10 mg once daily in 'real-life' practice on lower urinary tract symptoms (LUTS), quality of life and sexual dysfunction in men with LUTS and painful ejaculation. BJU international 20060601
Hemodynamic interaction study between the alpha1-blocker alfuzosin and the phosphodiesterase-5 inhibitor tadalafil in middle-aged healthy male subjects. Urology 20060601
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Definition of at-risk patients: dynamic variables. BJU international 20060401
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Combination of phosphodiesterase-5 inhibitors and alpha-blockers in patients with benign prostatic hyperplasia: treatments of lower urinary tract symptoms, erectile dysfunction, or both? BJU international 20060401
Tablet induced dysphagia in oesophageal cancer. Gut 20060401
The management of acute urinary retention in France: a cross-sectional survey in 2618 men with benign prostatic hyperplasia. BJU international 20060401
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BPH: epidemiology and comorbidities. The American journal of managed care 20060401
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Placebo controlled, randomised, double blind study of the effects of botulinum A toxin on detrusor sphincter dyssynergia in multiple sclerosis patients. Journal of neurology, neurosurgery, and psychiatry 20051201
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Symptom deterioration during treatment and history of AUR are the strongest predictors for AUR and BPH-related surgery in men with LUTS treated with alfuzosin 10 mg once daily. Urology 20050801
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Lower urinary tract symptoms suggestive of benign prostatic hyperplasia: latest update on alpha-adrenoceptor antagonists. BJU international 20050601
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Efficacy and safety of two doses (10 and 15 mg) of alfuzosin or tamsulosin (0.4 mg) once daily for treating symptomatic benign prostatic hyperplasia. BJU international 20050501
Clinical assessment of drug-induced QT prolongation in association with heart rate changes. Clinical pharmacology and therapeutics 20050401
The clinical efficacy and tolerability of doxazosin standard and gastrointestinal therapeutic system for benign prostatic hyperplasia. BJU international 20050301
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The vasodilatory effect of alfuzosin and tamsulosin in passive orthostasis: a randomised, double-blind, placebo-controlled study. European urology 20050301
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A pharmacoepidemiological approach to investigating inappropriate physician prescribing in a managed care setting in Israel. The American journal of managed care 20050201
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Role of the newer alpha, -adrenergic-receptor antagonists in the treatment of benign prostatic hyperplasia-related lower urinary tract symptoms. Clinical therapeutics 20041101
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On call. My doctor gave me a prescription for Uroxatral to treat my enlarged prostate. I tried to look up this medicine in your Harvard Medical School Guide to Men's Health, but I couldn't find it. What can you tell me about Uroxatral? Harvard men's health watch 20040601
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Comparative efficacy of two alpha-adrenoreceptor antagonists, doxazosin and alfuzosin, in patients with lower urinary tract symptoms from benign prostatic enlargement. BJU international 20040401
Priapism as a possible acute side effect of radical radiotherapy for prostate cancer. The Canadian journal of urology 20040401
Alpha1-adrenergic receptors and their inhibitors in lower urinary tract symptoms and benign prostatic hyperplasia. The Journal of urology 20040301
A comparison of the effects of tamsulosin and alfuzosin on neurally evoked increases in bladder neck and seminal vesicle pressure in rats. BJU international 20040301
The role of alpha-blockers in the management of acute urinary retention caused by benign prostatic obstruction. European urology 20040301
Patients with bladder outlet obstruction who refuse treatment show no clinical and urodynamic change after long-term follow-up. Archivio italiano di urologia, andrologia : organo ufficiale [di] Societa italiana di ecografia urologica e nefrologica 20040301
Extended-release alfuzosin hydrochloride: a new alpha-adrenergic receptor antagonist for symptomatic benign prostatic hyperplasia. The American journal of geriatric pharmacotherapy 20040301
Drug approval highlights for 2003. The Nurse practitioner 20040201
A current review of medical therapy for benign prostatic hyperplasia. The Journal of the American Osteopathic Association 20040201
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Alfuzosin improves penile erection triggered by apomorphine in spontaneous hypertensive rats. European urology 20040101
Real life practice in the management of benign prostatic hyperplasia. Current opinion in urology 20040101
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A comparison of four different alpha1-blockers in benign prostatic hyperplasia patients with and without diabetes. Scandinavian journal of urology and nephrology 20040101
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Use of alpha-blockers and the risk of hip/femur fractures. Journal of internal medicine 20031201
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First dose efficacy of alfuzosin once daily in men with symptomatic benign prostatic hyperplasia. Urology 20031101
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Alfuzosin treatment for chronic prostatitis/chronic pelvic pain syndrome: a prospective, randomized, double-blind, placebo-controlled, pilot study. Urology 20030901
The Finnish version of The National Institutes Of Health Chronic Prostatitis Symptom Index correlates well with the visual pain scale: translation and results of a modified linguistic validation study. BJU international 20030801
Safety and efficacy of alfuzosin 10 mg once-daily in the treatment of lower urinary tract symptoms and clinical benign prostatic hyperplasia: a pooled analysis of three double-blind, placebo-controlled studies. BJU international 20030801
Alfuzosin hydrochloride for the treatment of benign prostatic hyperplasia. American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20030715
Prostatic tissual distribution of alfuzosin in patients with benign prostatic hyperplasia following repeated oral administration. European urology 20030701
Proceedings of the 99th meeting of the Food and Drug Administration Cardiovascular and Renal Drugs Advisory Committee. May 29th and 30th, 2003. Circulation 20030617
Comparison of the relaxant effects of alfuzosin, phentolamine and sildenafil on rabbit isolated corpus cavernosum. BJU international 20030601
Selective, sensitive and rapid liquid chromatography-tandem mass spectrometry method for the determination of alfuzosin in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030525
Current treatment options for benign prostatic hyperplasia and their impact on sexual function. Urology 20030401
The evolution of detrusor overactivity after watchful waiting, medical therapy and surgery in patients with bladder outlet obstruction. The Journal of urology 20030201
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Estimated costs of treatment of benign prostate hyperplasia in Brazil. International braz j urol : official journal of the Brazilian Society of Urology 20030101
Pharmacokinetics and safety of a single oral dose of once-daily alfuzosin, 10 mg, in male subjects with mild to severe renal impairment. Journal of clinical pharmacology 20021201
Alfuzosin in the treatment of high leak-point pressure in children with neurogenic bladder. BJU international 20021101
Randomised, placebo controlled, double blind study of alfuzosin SR in patients undergoing trial without catheter following acute urinary retention. European urology 20021001
Gateways to clinical trials. Methods and findings in experimental and clinical pharmacology 20021001
[Drug therapy of benign prostatic hyperplasia syndrome with alpha 1-receptor blockers. Basic principles and clinical results]. Der Urologe. Ausg. A 20020901
[alpha 1-receptor blockade in therapy of benign prostatic hyperplasia syndrome. Correct dosing for optimal effectiveness]. Der Urologe. Ausg. A 20020901
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Alfuzosin, an alpha1-adrenoceptor antagonist for the treatment of benign prostatic hyperplasia: once daily versus 3 times daily dosing in healthy subjects. International journal of clinical pharmacology and therapeutics 20020701
[Chiral separation and preparation of three new antagonists of alpha 1-adrenoceptors by chiral mobile phase HPLC]. Yao xue xue bao = Acta pharmaceutica Sinica 20020601
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
Long-term risk of re-treatment of patients using alpha-blockers for lower urinary tract symptoms. The Journal of urology 20020401
Alfuzosin: a clinically uroselective alpha1-blocker. World journal of urology 20020401
The use of alpha-adrenoceptor antagonists in lower urinary tract disease. Expert opinion on pharmacotherapy 20020201
Tamsulosin: an update of its role in the management of lower urinary tract symptoms. Drugs 20020101
[Comparative evaluation of the effectiveness and safety of combined drug therapy of patients with benign prostatic hyperplasia with finasteride and alfuzozine]. Urologiia (Moscow, Russia : 1999) 20020101
Alfuzosin: a review of the therapeutic use of the prolonged-release formulation given once daily in the management of benign prostatic hyperplasia. Drugs 20020101
Tamsulosin: a review of its pharmacology and therapeutic efficacy in the management of lower urinary tract symptoms. Drugs & aging 20020101
Long-term safety and efficacy of a once-daily formulation of alfuzosin 10 mg in patients with symptomatic benign prostatic hyperplasia: open-label extension study. European urology 20020101
Finasteride in the treatment of clinical benign prostatic hyperplasia: a systematic review of randomised trials. BMC urology 20020101
Efficacy and safety of once-daily alfuzosin in the treatment of lower urinary tract symptoms and clinical benign prostatic hyperplasia: a randomized, placebo-controlled trial. Urology 20011201
Alfuzosin: overview of pharmacokinetics, safety, and efficacy of a clinically uroselective alpha-blocker. Urology 20011201
Worldwide experience with alfuzosin and tamsulosin. Urology 20011001
Structure-activity studies for a novel series of bicyclic substituted hexahydrobenz[e]isoindole alpha1A adrenoceptor antagonists as potential agents for the symptomatic treatment of benign prostatic hyperplasia. Journal of medicinal chemistry 20010607
Evaluating adverse cardiovascular effects of drug treatment for benign prostatic hyperplasia (BPH): methodological considerations. Journal of clinical epidemiology 20010501
Postvoid residual urine in patients with lower urinary tract symptoms suggestive of benign prostatic hyperplasia: pooled analysis of eleven controlled studies with alfuzosin. Urology 20010301
Does acute urinary retention respond to alpha-blockers alone? European urology 20010301
Do alpha-blockers prevent the occurrence of acute urinary retention? European urology 20010301
The efficacy and safety of a new once-a-day formulation of an alpha-blocker. European urology 20010301
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alpha-Blockade improves symptoms suggestive of bladder outlet obstruction but fails to relieve it. The Journal of urology 20010101
A quantitative analysis of antagonism and inverse agonism at wild-type and constitutively active hamster alpha1B-adrenoceptors. Naunyn-Schmiedeberg's archives of pharmacology 20010101
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Efficacy and tolerability of drugs for treatment of benign prostatic hyperplasia. International urology and nephrology 20010101
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Initial choices and final outcomes in lower urinary tract symptoms. European urology 20010101
Clinical significance of alpha1-adrenoceptor selectivity in the management of benign prostatic hyperplasia. International urology and nephrology 20010101
The efficacy of alfuzosin treatment in patients with prostatism. International urology and nephrology 20010101
Adrenoceptor subclassification: an approach to improved cardiovascular therapeutics. Pharmaceutica acta Helvetiae 20000301
A meta-analysis on the efficacy and tolerability of alpha1-adrenoceptor antagonists in patients with lower urinary tract symptoms suggestive of benign prostatic obstruction. European urology 19990101
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Comparison of tamsulosin with alfuzosin in the treatment of patients with lower urinary tract symptoms suggestive of bladder outlet obstruction (symptomatic benign prostatic hyperplasia). The European Tamsulosin Study Group. British journal of urology 19971001
Prostatic alpha 1-adrenoceptors and uroselectivity. The Prostate 19970215
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Effect of alpha 1 adrenoceptor antagonists on prostatic pressure and blood pressure in the anesthetized dog. Urology 19940701
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The effect of cimetidine on the pharmacokinetics of single oral doses of alfuzosin. International journal of clinical pharmacology, therapy, and toxicology 19931101
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Research in 'prostatitis syndromes': the use of alfuzosin (a new alpha 1-receptor-blocking agent) in patients mainly presenting with micturition complaints of an irritative nature and confirmed urodynamic abnormalities. European urology 19920101
Peripubertal changes in the nature of the GnRH response to alpha-adrenoceptor stimulation in vitro and their modulation by testosterone. Neuroendocrinology 19900701
A comparison of the effects of doxazosin and alfuzosin with those of urapidil on preganglionic sympathetic nerve activity in anaesthetised cats. European journal of pharmacology 19861007
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