Home Halogens 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-aminophenylacetyl]amino]-3-chloro-8-oxo-, (6R,7R)-

5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-aminophenylacetyl]amino]-3-chloro-8-oxo-, (6R,7R)-

CAS No.:
53994-73-3
Catalog Number:
AG00I9MW
Molecular Formula:
C15H14ClN3O4S
Molecular Weight:
367.8074
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
500mg
96%
1 week
United States
$126
- +
1g
96%
1 week
United States
$157
- +
5g
96%
1 week
United States
$323
- +
Product Description
Catalog Number:
AG00I9MW
Chemical Name:
5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid,7-[[(2R)-aminophenylacetyl]amino]-3-chloro-8-oxo-, (6R,7R)-
CAS Number:
53994-73-3
Molecular Formula:
C15H14ClN3O4S
Molecular Weight:
367.8074
MDL Number:
MFCD00151471
IUPAC Name:
(6R,7R)-7-[[(2R)-2-amino-2-phenylacetyl]amino]-3-chloro-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
InChI:
InChI=1S/C15H14ClN3O4S/c16-8-6-24-14-10(13(21)19(14)11(8)15(22)23)18-12(20)9(17)7-4-2-1-3-5-7/h1-5,9-10,14H,6,17H2,(H,18,20)(H,22,23)/t9-,10-,14-/m1/s1
InChI Key:
QYIYFLOTGYLRGG-GPCCPHFNSA-N
SMILES:
N[C@H](c1ccccc1)C(=O)N[C@@H]1C(=O)N2[C@@H]1SCC(=C2C(=O)O)Cl
EC Number:
258-909-5
UNII:
3Z6FS3IK0K
NSC Number:
757422
Properties
Complexity:
606  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
367.039g/mol
Formal Charge:
0
Heavy Atom Count:
24  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
367.804g/mol
Monoisotopic Mass:
367.039g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
138A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-1.8  
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The vitro efficacy of beta-lactam and beta-lactamase inhibitors against multidrug resistant clinical strains of Mycobacterium tuberculosis. International journal of antimicrobial agents 20040401
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Modelling and analysing exchangeable binary data with random cluster sizes. Statistics in medicine 20030815
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Antibiotic prophylaxis by low-dose cefaclor in children with vesicoureteral reflux. Pediatric nephrology (Berlin, Germany) 20030501
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Natural antimicrobial susceptibilities of strains of 'unusual' Serratia species: S. ficaria, S. fonticola, S. odorifera, S. plymuthica and S. rubidaea. The Journal of antimicrobial chemotherapy 20030401
Drainage of liver abscess via laparoscopic trocar with local anesthesia. Surgical laparoscopy, endoscopy & percutaneous techniques 20030401
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Life-threatening infantile diarrhea from fluoroquinolone-resistant Salmonella enterica typhimurium with mutations in both gyrA and parC. Emerging infectious diseases 20030201
Low plasma cefaclor levels in cystectomized bladder cancer patients with various types of urinary diversion. European journal of clinical pharmacology 20030201
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beta-Lactam allergenic determinants: fine structural recognition of a cross-reacting determinant on benzylpenicillin and cephalothin. Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20021101
The Italian Epidemiological Survey 1997-1999. Antimicrobial susceptibility data of Haemophilus influenzae, Haemophilus parainfluenzae and Moraxella catarrhalis in Italy. International journal of antimicrobial agents 20021001
Mycobacterium bohemicum cervical lymphadenitis. The Pediatric infectious disease journal 20021001
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An evaluation of cefaclor in Pakistani children with pharyngotonsillitis. JPMA. The Journal of the Pakistan Medical Association 20021001
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Antimicrobial resistance amongst isolates of Streptococcus pyogenes and Staphylococcus aureus in the PROTEKT antimicrobial surveillance programme during 1999-2000. The Journal of antimicrobial chemotherapy 20020901
Natural antibiotic susceptibility of Enterobacter amnigenus, Enterobacter cancerogenus, Enterobacter gergoviae and Enterobacter sakazakii strains. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20020901
Immunoglobulin E binding determinants on beta-lactam drugs. Current opinion in allergy and clinical immunology 20020801
Antibacterial activity of oral antibiotics against community-acquired respiratory pathogens from three European countries. The Journal of antimicrobial chemotherapy 20020701
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Trends in antimicrobial susceptibility of the Streptococcus milleri group. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020601
Susceptibility change to antibiotics of Staphylococcus aureus strains isolated from skin infections between July 1994 and November 2000. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020601
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[Urinary antimicrobial prophylaxis]. Archives de pediatrie : organe officiel de la Societe francaise de pediatrie 20020501
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Cefdinir: an advanced-generation, broad-spectrum oral cephalosporin. Clinical therapeutics 20020401
In vitro antibacterial activities of DQ-113, a potent quinolone, against clinical isolates. Antimicrobial agents and chemotherapy 20020301
The safety of azithromycin in the treatment of adults with community-acquired respiratory tract infections. International journal of antimicrobial agents 20020301
Differentiation of beta-lactamase-negative ampicillin-resistant Haemophilus influenzae from other H. influenzae strains by a disc method. Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 20020301
Comparative study of cefaclor AF vs. cefuroxime axetil in acute exacerbations of chronic bronchitis. Medical science monitor : international medical journal of experimental and clinical research 20020101
Cutaneous and systemic manifestations of drug-induced vasculitis. The Annals of pharmacotherapy 20020101
Probing substrate binding to metallo-beta-lactamase L1 from Stenotrophomonas maltophilia by using site-directed mutagenesis. BMC biochemistry 20020101
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Determination of antimicrobial activity of Cefaclor on common respiratory tract pathogens in Pakistan. JPMA. The Journal of the Pakistan Medical Association 20020101
Levofloxacin: an updated review of its use in the treatment of bacterial infections. Drugs 20020101
Review of the use of cephalosporins in children with anaphylactic reactions from penicillins. The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses 20020101
Desirable and undesirable immunotropic effects of antibiotics: immunomodulating properties of cefaclor. Journal of chemotherapy (Florence, Italy) 20011201
Upper respiratory tract infections. Indian journal of pediatrics 20011201
Antimicrobial susceptibilities of clinical isolates of Haemophilus influenzae and Moraxella catarrhalis collected during 1999-2000 from 13 countries. Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases 20011201
[Activity of different antimicrobial agents against penicillin-resistant Streptococcus pneumoniae]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20011201
Susceptibility of S. pneumoniae to various antibiotics aong strains isolated from patients and healthy carriers in different regions of Brazil(1999-2000). The Brazilian journal of infectious diseases : an official publication of the Brazilian Society of Infectious Diseases 20011201
Tolerability of 3-day, once-daily azithromycin suspension versus standard treatments for community-acquired paediatric infectious diseases. International journal of antimicrobial agents 20011101
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Release profile of antimicrobial agents from alpha-tricalcium phosphate cement. Biomaterials 20011001
High rates of multiple antibiotic resistance in Streptococcus pneumoniae from healthy children living in isolated rural communities: association with cephalosporin use and intrafamilial transmission. Pediatrics 20011001
Short-course therapy with cefaclor for treatment of streptococcal pharyngotonsillitis. International journal of antimicrobial agents 20011001
Antimicrobial susceptibility of nasopharyngeal isolates of Haemophilus influenzae from healthy children in day-care centres: results of multicentre study in Russia. International journal of antimicrobial agents 20011001
Novel mechanism of hydrolysis of therapeutic beta-lactams by Stenotrophomonas maltophilia L1 metallo-beta-lactamase. The Journal of biological chemistry 20010907
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[Susceptibility to penicillin and 13 antimicrobial agents in erythromycin-resistant viridans group streptococci isolated from blood cultures]. Revista espanola de quimioterapia : publicacion oficial de la Sociedad Espanola de Quimioterapia 20010901
Antimicrobial prescribing patterns at a rural hospital in Trinidad: evidence for intervention measures. African journal of medicine and medical sciences 20010901
Spectrophotometric determination of selected cephalosporins in drug formulations using flow injection analysis. Journal of pharmaceutical and biomedical analysis 20010701
Etiologies of the urinary tract infections in a Yemeni City. Saudi medical journal 20010701
Susceptibility of Canadian isolates of Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pneumoniae to oral antimicrobial agents. International journal of antimicrobial agents 20010601
Evaluation of oral antimicrobial agent levels in tooth extraction sites. Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics 20010601
Serum sickness-like reaction to cefaclor. Journal of paediatrics and child health 20010601
Competition of IL-1 and IL-1ra determines lymphocyte response to delayed stimulation with PHA. Mediators of inflammation 20010601
[Comparative studies on activities of antimicrobial agents against causative organisms isolated from patients with urinary tract infections (1999). I. Susceptibility distribution]. The Japanese journal of antibiotics 20010501
Recurrent temporal petrositis. The Journal of laryngology and otology 20010401
Immunopharmacology of antibiotics: direct and indirect immunomodulation of defence mechanisms. Journal of chemotherapy (Florence, Italy) 20010401
Bioequivalence evaluation of two brands of cefaclor 500 mg capsules: quantification of cefaclor using solid phase extraction technique. Journal of clinical pharmacy and therapeutics 20010401
[Murine typhus infected in Oku-etsu area, Fukui Prefecture]. Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases 20010401
Tests for 2 x K contingency tables with clustered ordered categorical data. Statistics in medicine 20010315
What have we learned from pharmacokinetic and pharmacodynamic theories? Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20010315
Death from multi-resistant shigellosis in Fiji Islands. Pacific health dialog 20010301
The near fatal lick. Australian family physician 20010101
Antibiotic susceptibilities among recent clinical isolates of Haemophilus influenzae and Moraxella catarrhalis from fifteen countries. European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology 20010101
Cefpodoxime proxetil: a review of its use in the management of bacterial infections in paediatric patients. Paediatric drugs 20010101
In vitro and in vivo antibacterial activity and pharmacokinetics of SC-002 and its derivative, SC-004: new oral cephalosporins. Chemotherapy 20010101
Drug resistant Haemophilus influenzae from respiratory tract infection in a tertiary care hospital in north India. The Indian journal of chest diseases & allied sciences 20010101
Encouraging good antimicrobial prescribing practice: a review of antibiotic prescribing policies used in the South East Region of England. BMC public health 20010101
A comparative study of cefaclor vs. amoxicillin/clavulanate in tonsillopharyngitis. Medical science monitor : international medical journal of experimental and clinical research 20010101
Clinical and pro-host effects of cefaclor in prophylaxis of recurrent otitis media in HIV-infected children. The Journal of international medical research 20010101
Cefditoren in vitro activity and spectrum: a review of international studies using reference methods. Diagnostic microbiology and infectious disease 20010101
Enterococcal urinary tract infections: eight years experience at a regional hospital in Trinidad, West Indies. Chinese medical journal 20010101
Oral pharmacokinetics of cefaclor in Mexican subjects. Proceedings of the Western Pharmacology Society 20010101
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beta-Lactam drug allergens: fine structural recognition patterns of cephalosporin-reactive IgE antibodies. Journal of molecular recognition : JMR 19960101
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Loracarbef (LY163892) versus cefaclor in the treatment of bacterial skin and skin-structure infections in an adult population. The American journal of medicine 19920622
Loracarbef (LY163892) versus cefaclor and norfloxacin in the treatment of uncomplicated pyelonephritis. The American journal of medicine 19920622
The in-vitro activity of two new quinolones: rufloxacin and MF 961. The Journal of antimicrobial chemotherapy 19920601
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