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Pinaverium bromide

CAS No.:
53251-94-8
Catalog Number:
AG00I9I8
Molecular Formula:
C26H41Br2NO4
Molecular Weight:
591.4160
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
25mg
>98%(HPLC)
In Stock USA
United States
$73
- +
100mg
>98%(HPLC)
In Stock USA
United States
$155
- +
1g
>98%(HPLC)
In Stock USA
United States
$483
- +
Product Description
Catalog Number:
AG00I9I8
Chemical Name:
Pinaverium bromide
CAS Number:
53251-94-8
Molecular Formula:
C26H41Br2NO4
Molecular Weight:
591.4160
MDL Number:
MFCD01713435
IUPAC Name:
4-[(2-bromo-4,5-dimethoxyphenyl)methyl]-4-[2-[2-(6,6-dimethyl-2-bicyclo[3.1.1]heptanyl)ethoxy]ethyl]morpholin-4-ium;bromide
InChI:
InChI=1S/C26H41BrNO4.BrH/c1-26(2)21-6-5-19(22(26)16-21)7-11-31-12-8-28(9-13-32-14-10-28)18-20-15-24(29-3)25(30-4)17-23(20)27;/h15,17,19,21-22H,5-14,16,18H2,1-4H3;1H/q+1;/p-1
InChI Key:
IKGXLCMLVINENI-UHFFFAOYSA-M
SMILES:
COc1cc(C[N+]2(CCOCCC3CCC4CC3C4(C)C)CCOCC2)c(cc1OC)Br.[Br-]
EC Number:
258-450-0
Properties
Complexity:
596  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
591.138g/mol
Formal Charge:
0
Heavy Atom Count:
33  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
591.425g/mol
Monoisotopic Mass:
589.14g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
36.9A^2
Undefined Atom Stereocenter Count:
3  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Pinaverium Reduces Symptoms of Irritable Bowel Syndrome in a Multicenter, Randomized, Controlled Trial. Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association 20150701
[Comparative observation on therapeutic effects between acupuncture and western medication for diarrhea-predominant irritable bowel syndrome]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20120801
Exfoliative erythrodermia induced by pantoprazole. Allergologia et immunopathologia 20120101
A sensitive and specific liquid chromatography/tandem mass spectrometry method for determination of pinaverium bromide in human plasma: application to a pharmacokinetic study in healthy volunteers. Biomedical chromatography : BMC 20111201
Translating clinical findings into knowledge in drug safety evaluation--drug induced liver injury prediction system (DILIps). PLoS computational biology 20111201
The stapled hemorrhoidopexy syndrome: a new clinical entity? Techniques in coloproctology 20111001
[Effect of jianpi tiaogan wenshen recipe in treating diarrhea-predominant irritable bowel syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20100101
Effect of four medications associated with gastrointestinal motility on Oddi sphincter in the rabbit. Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 20090101
[Pinaverium bromide-induced esophageal ulcerations]. Therapie 20080101
[Drug treatment of irritable bowel syndrome: an unmet need]. Gastroenterologia y hepatologia 20070301
[New approaches to diagnosing and treating hyperkinetic biliary dyskinesia associated with chronic acalculous cholecystitis]. Klinicheskaia meditsina 20040101
Quaternary ammonium derivatives as spasmolytics for irritable bowel syndrome. Current pharmaceutical design 20040101
[Randomized controlled clinical study on effect of Chinese compound changjitai in treating diarrheic irritable bowel syndrome]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20031101
Effect of pinaverium bromide on stress-induced colonic smooth muscle contractility disorder in rats. World journal of gastroenterology 20030315
[Effects of dicetel on gastrointestinal motility and vegetative dysfunction in patients with duodenal ulcer]. Klinicheskaia meditsina 20030101
Contraction of human colonic circular smooth muscle cells is inhibited by the calcium channel blocker pinaverium bromide. Cell calcium 20010601
[Current approaches to the diagnosis and treatment of irritable bowel syndrome]. Likars'ka sprava 20010101
Irritable bowel syndrome treatment using pinaverium bromide as a calcium channel blocker. A randomized double-blind placebo-controlled trial. Acta gastroenterologica Latinoamericana 19950101
Effect of pinaverium and other calcium channel blockers on contraction of isolated gastric antral smooth muscle cells caused by gastrointestinal hormones. Life sciences 19940101
Interaction of pinaverium (a quaternary ammonium compound) with 1,4-dihydropyridine binding sites in rat ileum smooth muscle. British journal of pharmacology 19920201
Action of pinaverium bromide, a calcium-antagonist, on gastrointestinal motility disorders. General pharmacology 19900101
Effects of pinaverium bromide and verapamil on the motility of the rat isolated colon. British journal of pharmacology 19850901
Inhibitory effect of pinaverium bromide on gastrointestinal contractile activity in conscious dogs. Arzneimittel-Forschung 19810101
Properties