Home Sulfos Benzamide, N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-

Benzamide, N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-

CAS No.:
51012-32-9
Catalog Number:
AG00I951
Molecular Formula:
C15H24N2O4S
Molecular Weight:
328.4271
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
Product Description
Catalog Number:
AG00I951
Chemical Name:
Benzamide, N-[2-(diethylamino)ethyl]-2-methoxy-5-(methylsulfonyl)-
CAS Number:
51012-32-9
Molecular Formula:
C15H24N2O4S
Molecular Weight:
328.4271
MDL Number:
MFCD00242730
IUPAC Name:
N-[2-(diethylamino)ethyl]-2-methoxy-5-methylsulfonylbenzamide
InChI:
InChI=1S/C15H24N2O4S/c1-5-17(6-2)10-9-16-15(18)13-11-12(22(4,19)20)7-8-14(13)21-3/h7-8,11H,5-6,9-10H2,1-4H3,(H,16,18)
InChI Key:
JTVPZMFULRWINT-UHFFFAOYSA-N
SMILES:
CCN(CCNC(=O)c1cc(ccc1OC)S(=O)(=O)C)CC
EC Number:
256-907-9
UNII:
LAH70H9JPH
Properties
Complexity:
443  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
328.146g/mol
Formal Charge:
0
Heavy Atom Count:
22  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
328.427g/mol
Monoisotopic Mass:
328.146g/mol
Rotatable Bond Count:
8  
Topological Polar Surface Area:
84.1A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
0.9  
Literature
Title Journal
Neuroleptic malignant syndrome induced by combination therapy with tetrabenazine and tiapride in a Japanese patient with Huntington's disease at the terminal stage of recurrent breast cancer. Internal medicine (Tokyo, Japan) 20140101
Dopaminergic D2-like agonists produce yawning in the myelin mutant taiep and Sprague-Dawley rats. Pharmacology, biochemistry, and behavior 20120701
Efficacy and safety of pregabalin in the treatment of alcohol and benzodiazepine dependence. Expert opinion on investigational drugs 20120701
[Effects of Jing'an Oral Liquid on the central neurotransmitter of multiple tics children]. Zhongguo Zhong xi yi jie he za zhi Zhongguo Zhongxiyi jiehe zazhi = Chinese journal of integrated traditional and Western medicine 20120701
The D2/D3-receptor antagonist tiapride impairs concurrent but not sequential taste aversion learning. Brain research bulletin 20120210
Update on the role of antipsychotics in the treatment of Tourette syndrome. Neuropsychiatric disease and treatment 20120101
Altered monocyte activation markers in Tourette's syndrome: a case-control study. BMC psychiatry 20120101
High-performance liquid chromatographic determination of tiapride and its phase I metabolite in blood plasma using tandem UV photodiode-array and fluorescence detection. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20111215
Pharmacological agents for developmental stuttering in children and adolescents: a systematic review. Journal of clinical psychopharmacology 20111201
An International Survey-based Algorithm for the Pharmacologic Treatment of Chorea in Huntington's Disease. PLoS currents 20111011
An UPLC-MS/MS method for the determination of valproic acid in blood of a fatal intoxication case. Journal of forensic and legal medicine 20111001
[A multicenter controlled study on aripiprazole treatment for children with Tourette syndrome in China]. Zhonghua er ke za zhi = Chinese journal of pediatrics 20110801
A combination of levetiracetam and tiapride for outpatient alcohol detoxification: a case series. Journal of addiction medicine 20110601
European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. European child & adolescent psychiatry 20110401
Nitric Oxide-Soluble Guanylyl Cyclase-Cyclic GMP Signaling in the Striatum: New Targets for the Treatment of Parkinson's Disease? Frontiers in systems neuroscience 20110101
Pharmacological and physiological characterization of the tremulous jaw movement model of parkinsonian tremor: potential insights into the pathophysiology of tremor. Frontiers in systems neuroscience 20110101
Neuroacanthocytosis syndromes. Orphanet journal of rare diseases 20110101
Presynaptic dopaminergic agonists increased gripping-generated immobility episodes in the myelin-mutant taiep rat. Neuroscience letters 20101015
Response of i(kr) and HERG currents to the antipsychotics tiapride and sulpiride. The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology 20101001
[A control study of aripiprazole and tiapride treatment for tic disorders in children]. Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20100601
[Observation on therapeutic effect of tic disorders treated with local acupuncture]. Zhongguo zhen jiu = Chinese acupuncture & moxibustion 20100601
Gene expression of NMDA receptor subunits in the cerebellum of elderly patients with schizophrenia. European archives of psychiatry and clinical neuroscience 20100301
Pregabalin, tiapride and lorazepam in alcohol withdrawal syndrome: a multi-centre, randomized, single-blind comparison trial. Addiction (Abingdon, England) 20100201
Depression, extrapyramidal symptoms, dementia and an unexpected outcome: a case report. Cases journal 20100101
Medications acting on the dopaminergic system in the treatment of alcoholic patients. Current pharmaceutical design 20100101
[Application of near-infrared spectroscopy for differential detection of neuroleptics, derivatives of benzamides]. Sudebno-meditsinskaia ekspertiza 20100101
Classification of drugs based on properties of sodium channel inhibition: a comparative automated patch-clamp study. PloS one 20100101
Central adrenal insufficiency and diabetes insipidus misdiagnosed as severe depression. Clinical medicine insights. Case reports 20100101
Rapid quantification of levosulpiride in human plasma using RP-HPLC-MS/MS for pharmacokinetic and bioequivalence study. Biomedical chromatography : BMC 20091201
Liquid chromatography/tandem mass spectrometry for the determination of changrolin in rat plasma: application to a bioavailability study. Journal of pharmaceutical and biomedical analysis 20090908
[Tiapride with the horn of saiga tatarica in the treatment of hemifacial spasm]. Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology, head, and neck surgery 20090801
Aripiprazole in the pharmacotherapy of Gilles de la Tourette syndrome in adult patients. The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 20090101
Development of membrane selective electrode for determination of the antipsychotic sulpiride in pharmaceuticals and urine. Sensors (Basel, Switzerland) 20090101
A thyrotoxicosis outbreak due to dietary pills in Paris. Therapeutics and clinical risk management 20081201
[D3 agonism: an augmentative treatment in tardive dyskinesia? A case report]. Psychiatrische Praxis 20081101
[Case of enzyme-linked immunoglobulin with persistent elevation of lactate dehydrogenase activity in serum by administration of an anti-psychotic drug]. Rinsho byori. The Japanese journal of clinical pathology 20080801
Successful treatment of tardive lingual dystonia with botulinum toxin: case report and review of the literature. Progress in neuro-psychopharmacology & biological psychiatry 20080701
Voluntary motor drive: possible reduction in Tourette syndrome. Journal of neural transmission (Vienna, Austria : 1996) 20080601
Relationship between obesity and antipsychotic drug use in the adult population: a longitudinal, retrospective claim database study in Primary Care settings. Neuropsychiatric disease and treatment 20080201
The efficacy of the dopamine D2/D3 antagonist tiapride in maintaining abstinence: a randomized, double-blind, placebo-controlled trial in 299 alcohol-dependent patients. The international journal of neuropsychopharmacology 20071001
Metoclopramide protection of diazinon-induced toxicosis in chickens. Journal of veterinary science 20070901
Membrane sensors for the selective determination of tiapride in presence of its degradation products. Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070801
Tourette's syndrome: clinical features, pathophysiology, and therapeutic approaches. Dialogues in clinical neuroscience 20070601
Anti-aggressive effects of GHB in OF.1 strain mice: involvement of dopamine D2 receptors. Progress in neuro-psychopharmacology & biological psychiatry 20070330
[The benzamides tiapride, sulpiride, and amisulpride in treatment for Tourette's syndrome]. Der Nervenarzt 20070301
Comparison of two pre-exposure treatment regimens in acute organophosphate (paraoxon) poisoning in rats: tiapride vs. pyridostigmine. Toxicology and applied pharmacology 20070301
Impaired cognition and attention in adults: pharmacological management strategies. Neuropsychiatric disease and treatment 20070201
[Carbamazepine intoxication. Complication of alcohol detoxification with combined carbamazepine and tiapride]. Der Nervenarzt 20070101
[The analysis of tiapride in cadaveric material]. Sudebno-meditsinskaia ekspertiza 20070101
[Toxicological characteristic of neuroleptics--substituted benzamides]. Sudebno-meditsinskaia ekspertiza 20070101
Stability-indicating methods for determination of tiapride in pure form, pharmaceutical preparation, and human plasma. Journal of AOAC International 20070101
Treatment of alcohol withdrawal syndrome with a combination of tiapride/carbamazepine: results of a pooled analysis in 540 patients. European archives of psychiatry and clinical neuroscience 20061001
[Efficacy and adverse reactions of antipsychotics for neuropsychiatric symptoms in dementia: a systematic review]. Nederlands tijdschrift voor geneeskunde 20060715
Simultaneous electrochemiluminescence determination of sulpiride and tiapride by capillary electrophoresis with cyclodextrin additives. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060501
Tiapride pre-treatment in acute exposure to paraoxon: comparison of effects of administration at different points-in-time in rats. Molecular and cellular biochemistry 20060401
Non-neuroleptic catecholaminergic drugs for neuroleptic-induced tardive dyskinesia. The Cochrane database of systematic reviews 20060125
Efficacy and safety of outpatient alcohol detoxification with a combination of tiapride/carbamazepine: additional evidence. Pharmacopsychiatry 20060101
[Identification of haloperidol and tiapride in the urine with thin layer chromatography]. Sudebno-meditsinskaia ekspertiza 20060101
Systematic review on the recurrence of postoperative nausea and vomiting after a first episode in the recovery room - implications for the treatment of PONV and related clinical trials. BMC anesthesiology 20060101
Pheochromocytoma unmasked by amisulpride and tiapride. The Annals of pharmacotherapy 20050501
Tiapride may accelerate lung cancer in older people: a case report. Journal of the American Geriatrics Society 20050401
Treatment of alcohol withdrawal syndrome with combined carbamazepine and tiapride in a patient with probable sleep apnoe syndrome. Pharmacopsychiatry 20050301
Protective drugs in acute large-dose exposure to organophosphates: a comparison of metoclopramide and tiapride with pralidoxime in rats. Anesthesia and analgesia 20050201
A randomized, observer-blind, controlled trial of the traditional Chinese medicine Yi-Gan San for improvement of behavioral and psychological symptoms and activities of daily living in dementia patients. The Journal of clinical psychiatry 20050201
[Iatrogenic neurological disorders in old people: a review]. Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 20050101
Weak inhibitors protect cholinesterases from stronger inhibitors (dichlorvos): in vitro effect of tiapride. International journal of toxicology 20050101
Weak inhibitors protect cholinesterases from strong inhibitors (paraoxon): in vitro effect of tiapride. Journal of applied toxicology : JAT 20050101
[Autonomic cardiovascular regulation in patients with tics and Tourette syndrome]. Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova 20050101
Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the determination of levosulpiride in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20041005
Determination of tiapride in human plasma using hydrophilic interaction liquid chromatography-tandem mass spectrometry. Archives of pharmacal research 20040901
Tourette syndrome: efficient treatment with ziprasidone and normalization of body weight in a patient with excessive weight gain under tiapride. Movement disorders : official journal of the Movement Disorder Society 20040801
Early administration of tiapride to young rats without long-lasting changes in the development of the dopaminergic system. Pharmacopsychiatry 20040701
[A case of hemichorea with hyperglycemia presenting with low signal intensity in the striatum on T2*-weighted gradient-echo magnetic resonance imaging]. Rinsho shinkeigaku = Clinical neurology 20040201
Influence of tiapride on platelet counts in healthy volunteers and patients with movement disorders. Progress in neuro-psychopharmacology & biological psychiatry 20030601
Direct determination of benzamides in serum by column-switching high-performance liquid chromatography. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry 20030501
Successful therapy of tardive dyskinesia in a 71-year-old woman with a combination of tetrabenazine, olanzapine and tiapride. International journal of clinical practice 20030301
Conventional and atypical antipsychotics in the elderly : a review. Clinical drug investigation 20030101
A combination of carbamazepine/tiapride in outpatient alcohol detoxification. Results from an open clinical study. European archives of psychiatry and clinical neuroscience 20021001
The treatment of Tourette's syndrome: current opinions. Expert opinion on pharmacotherapy 20020701
Sustained ER Ca2+ depletion suppresses protein synthesis and induces activation-enhanced cell death in mast cells. The Journal of biological chemistry 20020419
[Models of drug treatment in the attention deficit disorder with hyperactivity]. Revista de neurologia 20020201
Coadministration of L-NOARG and tiapride: effects on catalepsy in male mice. Progress in neuro-psychopharmacology & biological psychiatry 20020101
Use of neuroleptics in a general hospital. BMC geriatrics 20020101
Influence of the dopamine D2 receptor (DRD2) exon 8 genotype on efficacy of tiapride and clinical outcome of alcohol withdrawal. Pharmacogenetics 20011101
Treatment of alcohol withdrawal: tiapride and carbamazepine versus clomethiazole. A pilot study. European archives of psychiatry and clinical neuroscience 20010801
ElogD(oct): a tool for lipophilicity determination in drug discovery. 2. Basic and neutral compounds. Journal of medicinal chemistry 20010719
Psychosis in children: diagnosis and treatment. Dialogues in clinical neuroscience 20010601
Flow-injection chemiluminometric analysis of some benzamides by their sensitizing effect on the cerium-sulphite reaction. Talanta 20010530
Tiapride in gerontopsychiatry. European psychiatry : the journal of the Association of European Psychiatrists 20010101
The preclinical pharmacologic profile of tiapride. European psychiatry : the journal of the Association of European Psychiatrists 20010101
Clinical management of agitation in the elderly with tiapride. European psychiatry : the journal of the Association of European Psychiatrists 20010101
Pharmacological options for the treatment of Tourette's disorder. Drugs 20010101
The benzamide tiapride: treatment of extrapyramidal motor and other clinical syndromes. Pharmacopsychiatry 20000101
Tiapride. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic potential in geriatric agitation. Drugs & aging 19930101
Single oral dose pharmacokinetics of tiapride in patients with Huntington's disease. European journal of clinical pharmacology 19870101
Septo-hippocampal system: target for substituted benzamides. European journal of pharmacology 19820423
Properties