In vitro metabolism of piperaquine is primarily mediated by CYP3A4.

Xenobiotica; the fate of foreign compounds in biological systems 20121101

Arterolane maleate plus piperaquine phosphate for treatment of uncomplicated Plasmodium falciparum malaria: a comparative, multicenter, randomized clinical trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20120901

Pharmacokinetics of piperaquine in pregnant women in Sudan with uncomplicated Plasmodium falciparum malaria.

The American journal of tropical medicine and hygiene 20120701

Isothermal microcalorimetry, a new tool to monitor drug action against Trypanosoma brucei and Plasmodium falciparum.

PLoS neglected tropical diseases 20120601

Development of a generic micellar electrokinetic chromatography method for the separation of 15 antimalarial drugs as a tool to detect medicine counterfeiting.

Electrophoresis 20120601

Dihydroartemisinin/Piperaquine: a review of its use in the treatment of uncomplicated Plasmodium falciparum malaria.

Drugs 20120507

7-Chloro-4-(piperazin-1-yl)quinoline.

Acta crystallographica. Section E, Structure reports online 20120501

4,7-Dichloro-quinoline.

Acta crystallographica. Section E, Structure reports online 20120501

Reversed chloroquine molecules as a strategy to overcome resistance in malaria.

Current topics in medicinal chemistry 20120301

Population pharmacokinetics and pharmacodynamics of piperaquine in children with uncomplicated falciparum malaria.

Clinical pharmacology and therapeutics 20120301

[Immunological analysis of piperaquine-resistant murine model of Plasmodium berghei ANKA strain].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20120227

[In vitro sensitivity of Plasmodium falciparum isolates from China-Myanmar border region to chloroquine, piperaquine and pyronaridine].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20120227

Combination of probenecid-sulphadoxine-pyrimethamine for intermittent preventive treatment in pregnancy.

Malaria journal 20120101

Ex vivo activity of the ACT new components pyronaridine and piperaquine in comparison with conventional ACT drugs against isolates of Plasmodium falciparum.

Malaria journal 20120101

A high performance liquid chromatographic assay of mefloquine in saliva after a single oral dose in healthy adult Africans.

Malaria journal 20120101

P. falciparum in vitro killing rates allow to discriminate between different antimalarial mode-of-action.

PloS one 20120101

Genome wide adaptations of Plasmodium falciparum in response to lumefantrine selective drug pressure.

PloS one 20120101

Relationship between treatment-seeking behaviour and artemisinin drug quality in Ghana.

Malaria journal 20120101

Optimal designs for population pharmacokinetic studies of the partner drugs co-administered with artemisinin derivatives in patients with uncomplicated falciparum malaria.

Malaria journal 20120101

Efficacy and safety of artemisinin-naphthoquine versus dihydroartemisinin-piperaquine in adult patients with uncomplicated malaria: a multi-centre study in Indonesia.

Malaria journal 20120101

Optimising strategies for Plasmodium falciparum malaria elimination in Cambodia: primaquine, mass drug administration and artemisinin resistance.

PloS one 20120101

The efficacy and tolerability of artemisinin-piperaquine (Artequick®) versus artesunate-amodiaquine (Coarsucam™) for the treatment of uncomplicated Plasmodium falciparum malaria in south-central Vietnam.

Malaria journal 20120101

Therapeutic efficacy and safety of dihydroartemisinin-piperaquine versus artesunate-mefloquine in uncomplicated Plasmodium falciparum malaria in India.

Malaria journal 20120101

Effects of antimalarial drugs on movement of Plasmodium falciparum.

The Southeast Asian journal of tropical medicine and public health 20120101

Antimalarial efficacy of piperaquine-based antimalarial combination therapies: facts and uncertainties.

Tropical medicine & international health : TM & IH 20111201

The use of artemether-lumefantrine for the treatment of uncomplicated Plasmodium vivax malaria.

PLoS neglected tropical diseases 20111201

Highly effective therapy for maternal malaria associated with a lower risk of vertical transmission.

The Journal of infectious diseases 20111115

Dihydroartemisinin-piperaquine versus chloroquine in the treatment of Plasmodium vivax malaria in Thailand: a randomized controlled trial.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20111115

In vitro activity of antiretroviral drugs against Plasmodium falciparum.

Antimicrobial agents and chemotherapy 20111101

A head-to-head comparison of four artemisinin-based combinations for treating uncomplicated malaria in African children: a randomized trial.

PLoS medicine 20111101

Ultrastructural and real-time microscopic changes in P. falciparum-infected red blood cells following treatment with antimalarial drugs.

Ultrastructural pathology 20111001

Azithromycin plus chloroquine: combination therapy for protection against malaria and sexually transmitted infections in pregnancy.

Expert opinion on drug metabolism & toxicology 20110901

In vitro anti-malarial drug susceptibility of temperate Plasmodium vivax from central China.

The American journal of tropical medicine and hygiene 20110801

[Efficacy of compound dihydroartemisinin/piperaquine in treatment of uncomplicated falciparum malaria in Myanmar].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110801

Artemisinin-based combination therapy for treating uncomplicated Plasmodium vivax malaria.

The Cochrane database of systematic reviews 20110706

Orally formulated artemisinin in healthy fasting Vietnamese male subjects: a randomized, four-sequence, open-label, pharmacokinetic crossover study.

Clinical therapeutics 20110501

Identification and functional validation of the novel antimalarial resistance locus PF10_0355 in Plasmodium falciparum.

PLoS genetics 20110401

Plasmodium vivax recurrence following falciparum and mixed species malaria: risk factors and effect of antimalarial kinetics.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20110301

Cost-effectiveness of artemisinin combination therapy for uncomplicated malaria in children: data from Papua New Guinea.

Bulletin of the World Health Organization 20110301

Intermittent preventive treatment to reduce the burden of malaria in children: new evidence on integration and delivery.

PLoS medicine 20110201

Two strategies for the delivery of IPTc in an area of seasonal malaria transmission in the Gambia: a randomised controlled trial.

PLoS medicine 20110201

Intermittent preventive treatment of malaria provides substantial protection against malaria in children already protected by an insecticide-treated bednet in Burkina Faso: a randomised, double-blind, placebo-controlled trial.

PLoS medicine 20110201

Methotrexate is highly potent against pyrimethamine-resistant Plasmodium vivax.

The Journal of infectious diseases 20110115

Prevalence of resistance associated polymorphisms in Plasmodium falciparum field isolates from southern Pakistan.

Malaria journal 20110101

A research agenda for malaria eradication: drugs.

PLoS medicine 20110101

A systematic review and meta-analysis of the efficacy and safety of intermittent preventive treatment of malaria in children (IPTc).

PloS one 20110101

Safety and efficacy of dihydroartemisinin-piperaquine versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Zambian children.

Malaria journal 20110101

Effectiveness of artemether-lumefantrine provided by community health workers in under-five children with uncomplicated malaria in rural Tanzania: an open label prospective study.

Malaria journal 20110101

Determinants of the cost-effectiveness of intermittent preventive treatment for malaria in infants and children.

PloS one 20110101

Modelling the protective efficacy of alternative delivery schedules for intermittent preventive treatment of malaria in infants and children.

PloS one 20110101

Chloroquine resistant vivax malaria in a pregnant woman on the western border of Thailand.

Malaria journal 20110101

The potential contribution of mass treatment to the control of Plasmodium falciparum malaria.

PloS one 20110101

Acridine and acridinones: old and new structures with antimalarial activity.

The open medicinal chemistry journal 20110101

Comparative study of the efficacy and tolerability of dihydroartemisinin-piperaquine-trimethoprim versus artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in Cameroon, Ivory Coast and Senegal.

Malaria journal 20110101

Multicentric assessment of the efficacy and tolerability of dihydroartemisinin-piperaquine compared to artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria in sub-Saharan Africa.

Malaria journal 20110101

In vivo efficacy of artemether-lumefantrine against uncomplicated Plasmodium falciparum malaria in Central Ethiopia.

Malaria journal 20110101

Radical curative efficacy of tafenoquine combination regimens in Plasmodium cynomolgi-infected Rhesus monkeys (Macaca mulatta).

Malaria journal 20110101

Randomized trials of artemisinin-piperaquine, dihydroartemisinin-piperaquine phosphate and artemether-lumefantrine for the treatment of multi-drug resistant falciparum malaria in Cambodia-Thailand border area.

Malaria journal 20110101

Saleability of anti-malarials in private drug shops in Muheza, Tanzania: a baseline study in an era of assumed artemisinin combination therapy (ACT).

Malaria journal 20110101

Plasmodium falciparum: differential selection of drug resistance alleles in contiguous urban and peri-urban areas of Brazzaville, Republic of Congo.

PloS one 20110101

Reduced in vitro susceptibility to artemisinin derivatives associated with multi-resistance in a traveller returning from South-East Asia.

Malaria journal 20110101

Cost analysis of school-based intermittent screening and treatment of malaria in Kenya.

Malaria journal 20110101

Case management of malaria fever in Cambodia: results from national anti-malarial outlet and household surveys.

Malaria journal 20110101

Coverage, adherence and costs of intermittent preventive treatment of malaria in children employing different delivery strategies in Jasikan, Ghana.

PloS one 20110101

Drugs for malaria: something old, something new, something borrowed.

F1000 biology reports 20110101

Declining responsiveness of Plasmodium falciparum infections to artemisinin-based combination treatments on the Kenyan coast.

PloS one 20110101

Poor quality vital anti-malarials in Africa - an urgent neglected public health priority.

Malaria journal 20110101

Prescription practices and availability of artemisinin monotherapy in India: where do we stand?

Malaria journal 20110101

Drug resistance associated genetic polymorphisms in Plasmodium falciparum and Plasmodium vivax collected in Honduras, Central America.

Malaria journal 20110101

Malaria treatment policy change and implementation: the case of Uganda.

Malaria research and treatment 20110101

A phase III, randomized, non-inferiority trial to assess the efficacy and safety of dihydroartemisinin-piperaquine in comparison with artesunate-mefloquine in patients with uncomplicated Plasmodium falciparum malaria in southern Laos.

The American journal of tropical medicine and hygiene 20101206

In vitro activity of pyronaridine against multidrug-resistant Plasmodium falciparum and Plasmodium vivax.

Antimicrobial agents and chemotherapy 20101201

Genetic structure of Plasmodium falciparum and elimination of malaria, Comoros archipelago.

Emerging infectious diseases 20101101

A molecular mechanism for eflornithine resistance in African trypanosomes.

PLoS pathogens 20101101

Increased risk of early vomiting among infants and young children treated with dihydroartemisinin-piperaquine compared with artemether-lumefantrine for uncomplicated malaria.

The American journal of tropical medicine and hygiene 20101005

Residual antimalarial concentrations before treatment in patients with malaria from Cambodia: indication of drug pressure.

The Journal of infectious diseases 20101001

Ultrafast and high-throughput mass spectrometric assay for therapeutic drug monitoring of antiretroviral drugs in pediatric HIV-1 infection applying dried blood spots.

Analytical and bioanalytical chemistry 20100901

Quinolines and structurally related heterocycles as antimalarials.

European journal of medicinal chemistry 20100801

Comparison of plasma, venous and capillary blood levels of piperaquine in patients with uncomplicated falciparum malaria.

European journal of clinical pharmacology 20100701

Dihydroartemisinin-piperaquine versus artemether-lumefantrine, in the treatment of uncomplicated Plasmodium falciparum malaria in central Sudan.

Annals of tropical medicine and parasitology 20100601

Selection of known Plasmodium falciparum resistance-mediating polymorphisms by artemether-lumefantrine and amodiaquine-sulfadoxine-pyrimethamine but not dihydroartemisinin-piperaquine in Burkina Faso.

Antimicrobial agents and chemotherapy 20100501

Identification of a mutant PfCRT-mediated chloroquine tolerance phenotype in Plasmodium falciparum.

PLoS pathogens 20100501

Investigation of reproductive toxicity of piperaquine in mice.

Reproductive toxicology (Elmsford, N.Y.) 20100401

Severe congenital malaria acquired in utero.

The American journal of tropical medicine and hygiene 20100401

Chloroquine and its derivatives exacerbate B19V-associated anemia by promoting viral replication.

PLoS neglected tropical diseases 20100401

In vitro selection of Plasmodium falciparum drug-resistant parasite lines.

The Journal of antimicrobial chemotherapy 20100301

In vitro sensitivities of Plasmodium falciparum to different antimalarial drugs in Uganda.

Antimicrobial agents and chemotherapy 20100301

In vitro sensitivity of Plasmodium falciparum to conventional and novel antimalarial drugs in Papua New Guinea.

Tropical medicine & international health : TM & IH 20100301

Continued cytoadherence of Plasmodium falciparum infected red blood cells after antimalarial treatment.

Molecular and biochemical parasitology 20100201

Gel versus capillary electrophoresis genotyping for categorizing treatment outcomes in two anti-malarial trials in Uganda.

Malaria journal 20100101

Treatment of asymptomatic carriers with artemether-lumefantrine: an opportunity to reduce the burden of malaria?

Malaria journal 20100101

Compliance with a three-day course of artesunate-mefloquine combination and baseline anti-malarial treatment in an area of Thailand with highly multidrug resistant falciparum malaria.

Malaria journal 20100101

Evaluation of chloroquine therapy for vivax and falciparum malaria in southern Sumatra, western Indonesia.

Malaria journal 20100101

Efficacy of non-artemisinin- and artemisinin-based combination therapies for uncomplicated falciparum malaria in Cameroon.

Malaria journal 20100101

Rapid and effective malaria control in Cambodia through mass administration of artemisinin-piperaquine.

Malaria journal 20100101

Dihydroartemisinin-piperaquine versus chloroquine to treat vivax malaria in Afghanistan: an open randomized, non-inferiority, trial.

Malaria journal 20100101

Development of and access to products for neglected diseases.

PloS one 20100101

Monitoring for Plasmodium falciparum drug resistance to artemisinin and artesunate in Binh Phuoc Province, Vietnam: 1998-2009.

Malaria journal 20100101

A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children.

PloS one 20100101

An open-label, randomised study of dihydroartemisinin-piperaquine versus artesunate-mefloquine for falciparum malaria in Asia.

PloS one 20100101

Cost effectiveness of seasonal intermittent preventive treatment using amodiaquine & artesunate or sulphadoxine-pyrimethamine in Ghanaian children.

PloS one 20100101

Efficacy, safety, and tolerability of three regimens for prevention of malaria: a randomized, placebo-controlled trial in Ugandan schoolchildren.

PloS one 20100101

Absence of association between pyronaridine in vitro responses and polymorphisms in genes involved in quinoline resistance in Plasmodium falciparum.

Malaria journal 20100101

Anti-malarial drugs and the prevention of malaria in the population of malaria endemic areas.

Malaria journal 20100101

Immunological consequences of intermittent preventive treatment against malaria in Senegalese preschool children.

Malaria journal 20100101

Progress in the development of piperaquine combinations for the treatment of malaria.

Current opinion in infectious diseases 20091201

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for falciparum malaria: a longitudinal, randomized trial in young Ugandan children.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091201

Artemisinin combination therapy for malaria: beyond good efficacy.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20091201

Artemisinin-based combination therapy for treating uncomplicated malaria.

The Cochrane database of systematic reviews 20090708

Plasmodium berghei ANKA: selection of resistance to piperaquine and lumefantrine in a mouse model.

Experimental parasitology 20090701

Antimalarial drug susceptibility of Plasmodium vivax in the Republic of Korea.

The American journal of tropical medicine and hygiene 20090601

A randomized, controlled trial of artemisinin-piperaquine vs dihydroartemisinin-piperaquine phosphate in treatment of falciparum malaria.

Chinese journal of integrative medicine 20090601

Discovery of dual function acridones as a new antimalarial chemotype.

Nature 20090514

Open label randomized comparison of dihydroartemisinin-piperaquine and artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria in central Vietnam.

Tropical medicine & international health : TM & IH 20090501

Quantification of artemisinin in human plasma using liquid chromatography coupled to tandem mass spectrometry.

Journal of pharmaceutical and biomedical analysis 20090405

A single LC-tandem mass spectrometry method for the simultaneous determination of 14 antimalarial drugs and their metabolites in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20090401

Disruption of a Plasmodium falciparum multidrug resistance-associated protein (PfMRP) alters its fitness and transport of antimalarial drugs and glutathione.

The Journal of biological chemistry 20090320

Antimalarial therapies in children from Papua New Guinea.

The New England journal of medicine 20090319

Does artesunate prolong the electrocardiograph QT interval in patients with severe malaria?

The American journal of tropical medicine and hygiene 20090101

Loss of population levels of immunity to malaria as a result of exposure-reducing interventions: consequences for interpretation of disease trends.

PloS one 20090101

The last man standing is the most resistant: eliminating artemisinin-resistant malaria in Cambodia.

Malaria journal 20090101

Mefloquine pharmacokinetics and mefloquine-artesunate effectiveness in Peruvian patients with uncomplicated Plasmodium falciparum malaria.

Malaria journal 20090101

A systematic review and meta-analysis of evidence for correlation between molecular markers of parasite resistance and treatment outcome in falciparum malaria.

Malaria journal 20090101

Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.

BMJ (Clinical research ed.) 20090101

Safety and efficacy of dihydroartemisinin-piperaquine in falciparum malaria: a prospective multi-centre individual patient data analysis.

PloS one 20090101

Randomized trial of piperaquine with sulfadoxine-pyrimethamine or dihydroartemisinin for malaria intermittent preventive treatment in children.

PloS one 20090101

Ongoing challenges in the management of malaria.

Malaria journal 20090101

Coartem: the journey to the clinic.

Malaria journal 20090101

The clinical efficacy of artemether/lumefantrine (Coartem).

Malaria journal 20090101

A new double-antibody sandwich ELISA targeting Plasmodium falciparum aldolase to evaluate anti-malarial drug sensitivity.

Malaria journal 20090101

Artemether-lumefantrine in the treatment of uncomplicated Plasmodium falciparum malaria.

Therapeutics and clinical risk management 20090101

Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance.

Malaria journal 20090101

Dihydroartemisinin-piperaquine and artemether-lumefantrine for treating uncomplicated malaria in African children: a randomised, non-inferiority trial.

PloS one 20090101

Safety and tolerability of artemether-lumefantrine versus dihydroartemisinin-piperaquine for malaria in young HIV-infected and uninfected children.

Malaria journal 20090101

Residual antimalarials in malaria patients from Tanzania--implications on drug efficacy assessment and spread of parasite resistance.

PloS one 20090101

A Multidisciplinary Investigation to Determine the Structure and Source of Dimeric Impurities in AMG 517 Drug Substance.

International journal of analytical chemistry 20090101

A trial of combination antimalarial therapies in children from Papua New Guinea.

The New England journal of medicine 20081211

In vitro assessment of the pharmacodynamic properties of DB75, piperaquine, OZ277 and OZ401 in cultures of Plasmodium falciparum.

The Journal of antimicrobial chemotherapy 20081101

Revisiting the design of phase III clinical trials of antimalarial drugs for uncomplicated Plasmodium falciparum malaria.

PLoS medicine 20081101

Two years after the Fourth External Review: TDR moves forward with a new vision and strategy.

PLoS neglected tropical diseases 20081101

Modelling the impact of artemisinin combination therapy and long-acting treatments on malaria transmission intensity.

PLoS medicine 20081101

Pharmacokinetics of the antimalarial drug piperaquine in healthy Vietnamese subjects.

The American journal of tropical medicine and hygiene 20081001

Drug metabolism and pharmacokinetics.

Indian journal of pharmacology 20081001

Pharmacokinetics and metabolism of the antimalarial piperaquine after intravenous and oral single doses to the rat.

Journal of pharmaceutical sciences 20080801

The influence of food on the pharmacokinetics of piperaquine in healthy Vietnamese volunteers.

Acta tropica 20080801

Clinical development of new prophylactic antimalarial drugs after the 5th Amendment to the Declaration of Helsinki.

Therapeutics and clinical risk management 20080801

Toxicology and pharmacokinetics of piperaquine in mice.

Toxicology 20080710

Quality control of piperaquine in pharmaceutical formulations by capillary zone electrophoresis.

Talanta 20080630

Effect of folate derivatives on the activity of antifolate drugs used against malaria and cancer.

Parasitology research 20080501

Quantification of the antimalarial piperaquine in plasma.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20080501

Adverse pregnancy outcomes in an area where multidrug-resistant plasmodium vivax and Plasmodium falciparum infections are endemic.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20080501

Dihydroartemisinin-piperaquine rescue treatment of multidrug-resistant Plasmodium falciparum malaria in pregnancy: a preliminary report.

The American journal of tropical medicine and hygiene 20080401

Antimalarial dual drugs based on potent inhibitors of glutathione reductase from Plasmodium falciparum.

Journal of medicinal chemistry 20080313

[Efficacy of dihydroartemisinin-piperaquine and artemether-lumefantrine in the treatment of uncomplicated falciparum malaria in Hainan, China].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20080227

Development and validation of a liquid chromatographic-tandem mass spectrometric method for determination of piperaquine in plasma stable isotope labeled internal standard does not always compensate for matrix effects.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20080201

Safety, tolerability, and single- and multiple-dose pharmacokinetics of piperaquine phosphate in healthy subjects.

Journal of clinical pharmacology 20080201

How antimalarial drug resistance affects post-treatment prophylaxis.

Malaria journal 20080101

Sulfadoxine-pyrimethamine-based combinations for malaria: a randomised blinded trial to compare efficacy, safety and selection of resistance in Malawi.

PloS one 20080101

Plasmodium vivax trophozoites insensitive to chloroquine.

Malaria journal 20080101

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treating uncomplicated malaria: a randomized trial to guide policy in Uganda.

PloS one 20080101

Efficacy of Artequick versus artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.

The Southeast Asian journal of tropical medicine and public health 20080101

No PfATPase6 S769N mutation found in Plasmodium falciparum isolates from China.

Malaria journal 20080101

Antimalarial therapy selection for quinolone resistance among Escherichia coli in the absence of quinolone exposure, in tropical South America.

PloS one 20080101

Spread of anti-malarial drug resistance: mathematical model with implications for ACT drug policies.

Malaria journal 20080101

A randomized trial to monitor the efficacy and effectiveness by QT-NASBA of artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment and transmission control of uncomplicated Plasmodium falciparum malaria in western Kenya.

Malaria journal 20080101

Azithromycin-chloroquine and the intermittent preventive treatment of malaria in pregnancy.

Malaria journal 20080101

The role of anti-malarial drugs in eliminating malaria.

Malaria journal 20080101

Randomized comparison of amodiaquine plus sulfadoxine-pyrimethamine, artemether-lumefantrine, and dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in Burkina Faso.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20071201

Sensitive and rapid liquid chromatography/tandem mass spectrometric assay for the quantification of piperaquine in human plasma.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20071101

Dose ranging studies of new artemisinin-piperaquine fixed combinations compared to standard regimens of artemisisnin combination therapies for acute uncomplicated falciparum malaria.

The Southeast Asian journal of tropical medicine and public health 20071101

Pharmacokinetics of piperaquine after single and multiple oral administrations in healthy volunteers.

Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20071001

Efficacy and safety of dihydroartemisinin-piperaquine.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20070901

Gene encoding a deubiquitinating enzyme is mutated in artesunate- and chloroquine-resistant rodent malaria parasites.

Molecular microbiology 20070701

Activity of piperaquine and other 4-aminoquinoline antiplasmodial drugs against chloroquine-sensitive and resistant blood-stages of Plasmodium falciparum. Role of beta-haematin inhibition and drug concentration in vacuolar water- and lipid-phases.

Biochemical pharmacology 20070615

Artemether-lumefantrine versus dihydroartemisinin-piperaquine for treatment of malaria: a randomized trial.

PLoS clinical trials 20070501

Dihydroartemisinin-piperaquine versus artesunate-amodiaquine: superior efficacy and posttreatment prophylaxis against multidrug-resistant Plasmodium falciparum and Plasmodium vivax malaria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20070415

Two fixed-dose artemisinin combinations for drug-resistant falciparum and vivax malaria in Papua, Indonesia: an open-label randomised comparison.

Lancet (London, England) 20070303

In vitro and in vivo interaction of synthetic peroxide RBx11160 (OZ277) with piperaquine in Plasmodium models.

Experimental parasitology 20070301

A randomized open study to assess the efficacy and tolerability of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Cambodia.

Tropical medicine & international health : TM & IH 20070201

Characterization and quantitative determination of impurities in piperaquine phosphate by HPLC and LC/MS/MS.

Journal of pharmaceutical and biomedical analysis 20070104

Overestimating resistance in field testing of malaria parasites: simple methods for estimating high EC50 values using a Bayesian approach.

Malaria journal 20070101

Intermittent preventive treatment for malaria in pregnancy in Africa: what's new, what's needed?

Malaria journal 20070101

Large-scale malaria survey in Cambodia: novel insights on species distribution and risk factors.

Malaria journal 20070101

In vitro activity of ferroquine (SSR 97193) against Plasmodium falciparum isolates from the Thai-Burmese border.

Malaria journal 20070101

World Antimalarial Resistance Network (WARN) II: in vitro antimalarial drug susceptibility.

Malaria journal 20070101

World Antimalarial Resistance Network (WARN) III: molecular markers for drug resistant malaria.

Malaria journal 20070101

World Antimalarial Resistance Network (WARN) IV: clinical pharmacology.

Malaria journal 20070101

A randomised controlled trial to assess the efficacy of dihydroartemisinin-piperaquine for the treatment of uncomplicated falciparum malaria in Peru.

PloS one 20070101

Intermittent preventive treatment for the prevention of malaria during pregnancy in high transmission areas.

Malaria journal 20070101

Safety and efficacy of dihydroartemisinin/piperaquine (Artekin) for the treatment of uncomplicated Plasmodium falciparum malaria in Rwandan children.

Transactions of the Royal Society of Tropical Medicine and Hygiene 20061201

Characterization of human urinary metabolites of the antimalarial piperaquine.

Drug metabolism and disposition: the biological fate of chemicals 20061201

Identification of an isomer impurity in piperaquine drug substance.

Journal of chromatography. A 20061201

An open, randomized comparison of artesunate plus mefloquine vs. dihydroartemisinin-piperaquine for the treatment of uncomplicated Plasmodium falciparum malaria in the Lao People's Democratic Republic (Laos).

Tropical medicine & international health : TM & IH 20060801

Artemisinin combination therapies.

Lancet (London, England) 20060624

Efficacy and effectiveness of dihydroartemisinin-piperaquine versus artesunate-mefloquine in falciparum malaria: an open-label randomised comparison.

Lancet (London, England) 20060624

Pharmacokinetics of piperaquine after repeated oral administration of the antimalarial combination CV8 in 12 healthy male subjects.

European journal of clinical pharmacology 20060501

Modelling malaria control.

PLoS medicine 20060501

Development and validation of an automated solid phase extraction and liquid chromatographic method for the determination of piperaquine in urine.

Journal of pharmaceutical and biomedical analysis 20060411

A new approach to evaluate regression models during validation of bioanalytical assays.

Journal of pharmaceutical and biomedical analysis 20060411

Treatment of falciparum malaria in the age of drug resistance.

Journal of postgraduate medicine 20060101

The use of genotyping in antimalarial clinical trials: a systematic review of published studies from 1995-2005.

Malaria journal 20060101

Some considerations in the design and interpretation of antimalarial drug trials in uncomplicated falciparum malaria.

Malaria journal 20060101

High throughput assay for the determination of piperaquine in plasma.

Journal of pharmaceutical and biomedical analysis 20050915

An open randomized clinical trial of Artekin vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria.

The Southeast Asian journal of tropical medicine and public health 20050901

A randomized, controlled study of a simple, once-daily regimen of dihydroartemisinin-piperaquine for the treatment of uncomplicated, multidrug-resistant falciparum malaria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815

Once-daily combination therapy for uncomplicated malaria: is this the way forward?

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20050815

Dictyostelium discoideum expresses a malaria chloroquine resistance mechanism upon transfection with mutant, but not wild-type, Plasmodium falciparum transporter PfCRT.

The Journal of biological chemistry 20050708

Efficacy comparison between anti-malarial drugs in Africans presenting with mild malaria in the Central Republic of Africa: a preliminary study.

Parasite (Paris, France) 20050301

Artemisinin-based combination therapies for uncomplicated malaria.

The Medical journal of Australia 20050221

Piperaquine: a resurgent antimalarial drug.

Drugs 20050101

Intermittent presumptive treatment for malaria.

PLoS medicine 20050101

Randomized, controlled dose-optimization studies of dihydroartemisinin-piperaquine for the treatment of uncomplicated multidrug-resistant falciparum malaria in Thailand.

The Journal of infectious diseases 20041115

Automated solid-phase extraction method for the determination of piperaquine in capillary blood applied onto sampling paper by liquid chromatography.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20040925

Population pharmacokinetics of piperaquine in adults and children with uncomplicated falciparum or vivax malaria.

British journal of clinical pharmacology 20040301

CV8, a new combination of dihydroartemisinin, piperaquine, trimethoprim and primaquine, compared with atovaquone-proguanil against falciparum malaria in Vietnam.

Tropical medicine & international health : TM & IH 20040201

Dihydroartemisinin-piperaquine against multidrug-resistant Plasmodium falciparum malaria in Vietnam: randomised clinical trial.

Lancet (London, England) 20040103

Safety evaluation of fixed combination piperaquine plus dihydroartemisinin (Artekin) in Cambodian children and adults with malaria.

British journal of clinical pharmacology 20040101

Association of house spraying with suppressed levels of drug resistance in Zimbabwe.

Malaria journal 20040101

Automated solid-phase extraction method for the determination of piperaquine in whole blood by rapid liquid chromatography.

Therapeutic drug monitoring 20031001

Measurement of piperaquine in plasma by liquid chromatography with ultraviolet absorbance detection.

Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20030705

Automated solid-phase extraction method for the determination of piperaquine in plasma by peak compression liquid chromatography.

Journal of chromatographic science 20030101

[Factors affecting the in vitro microtest for drug sensitivity of Plasmodium falciparum].

Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20030101

Efficacy and safety of dihydroartemisinin-piperaquine (Artekin) in Cambodian children and adults with uncomplicated falciparum malaria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America 20021215

An open randomized clinical trial of Artecom vs artesunate-mefloquine in the treatment of acute uncomplicated falciparum malaria in Thailand.

The Southeast Asian journal of tropical medicine and public health 20020901

Histopathological changes of Macaca mulatta infected with Plasmodium knowlesi.

Chinese medical journal 20011001