Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[(4-arylpiperazin-1-yl)methyl]-5-substituted-thiophenes. effect of the 5-modification on allosteric enhancer activity at the A1 adenosine receptor.

Journal of medicinal chemistry 20120913

Crosstalk between adenosine A1 and β1-adrenergic receptors regulates translocation of PKCε in isolated rat cardiomyocytes.

Journal of cellular physiology 20120901

Highly selective A(1) -adenosine-agonist (2-chloro-N6-cyclopentyladenosine) and reduction of flap necrosis in adipocutaneous flaps in rats.

Head & neck 20120801

Orally active adenosine A(1) receptor agonists with antinociceptive effects in mice.

Journal of medicinal chemistry 20120726

Modulation of bladder function by luminal adenosine turnover and A1 receptor activation.

American journal of physiology. Renal physiology 20120715

Noninvasive limb remote ischemic preconditioning contributes neuroprotective effects via activation of adenosine A1 receptor and redox status after transient focal cerebral ischemia in rats.

Brain research 20120612

The role of autophagy during coxsackievirus infection of neural progenitor and stem cells.

Autophagy 20120601

Endogenous adenosine contributes to renal sympathetic neurotransmission via postjunctional A1 receptor-mediated coincident signaling.

American journal of physiology. Renal physiology 20120215

Role of ω-hydroxylase in adenosine-mediated aortic response through MAP kinase using A2A-receptor knockout mice.

American journal of physiology. Regulatory, integrative and comparative physiology 20120215

Acute down-regulation of adenosine A(1) receptor activity in status epilepticus.

Epilepsia 20120101

The antinociceptive effect of electroacupuncture at different depths of acupoints and under the needling surface.

Chinese medicine 20120101

Neural acupuncture unit: a new concept for interpreting effects and mechanisms of acupuncture.

Evidence-based complementary and alternative medicine : eCAM 20120101

Sex differences and the effects of ovariectomy on the β-adrenergic contractile response.

American journal of physiology. Heart and circulatory physiology 20110901

Essential role of EGFR in cardioprotection and signaling responses to A1 adenosine receptors and ischemic preconditioning.

American journal of physiology. Heart and circulatory physiology 20110601

Differential recruitment of high affinity A1 and A2A adenosine receptors in the control of colonic neuromuscular function in experimental colitis.

European journal of pharmacology 20110115

A role for adenosine A(1) receptor blockade in the ability of caffeine to promote MDMA 'Ecstasy'-induced striatal dopamine release.

European journal of pharmacology 20110110

Involvement of adenosine signaling in controlling the release of ghrelin from the mouse stomach.

The Journal of pharmacology and experimental therapeutics 20110101

Autocrine signaling via A(1) adenosine receptors causes downregulation of M(2) receptors in adult rat atrial myocytes in vitro.

Pflugers Archiv : European journal of physiology 20110101

Chronic pharmacological preconditioning against ischemia.

Clinical hemorheology and microcirculation 20110101

Adenosine A(1) and A (3) receptor agonists reduce hypoxic injury through the involvement of P38 MAPK.

Molecular and cellular biochemistry 20101201

Involvement of A1 adenosine receptors in altered vascular responses and inflammation in an allergic mouse model of asthma.

American journal of physiology. Heart and circulatory physiology 20100701

Adenosine A(3) receptor stimulation induces protection of skeletal muscle from eccentric exercise-mediated injury.

American journal of physiology. Regulatory, integrative and comparative physiology 20100701

Adenosine A1 receptor activation reduces opening of mitochondrial permeability transition pores in hypoxic cardiomyocytes.

Clinical and experimental pharmacology & physiology 20100301

Adenosine A1 receptor blockage mediates theophylline-associated seizures.

Epilepsia 20100301

Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss.

Hearing research 20100201

The role of nucleus accumbens adenosine-opioid interaction in mediating palatable food intake.

Brain research 20100108

Activation of adenosine low-affinity A3 receptors inhibits the enteric short interplexus neural circuit triggered by histamine.

American journal of physiology. Gastrointestinal and liver physiology 20091201

Adenosine A(1) receptors selectively target protein kinase C isoforms to the caveolin-rich plasma membrane in cardiac myocytes.

Biochimica et biophysica acta 20091201

Adenosine-A1 receptors activation restores the suppressed cardioprotective effects of ischemic preconditioning in hyperhomocysteinemic rat hearts.

Journal of cardiovascular pharmacology 20090901

Adenoprotection of the heart involves phospholipase C-induced activation and translocation of PKC-epsilon to RACK2 in adult rat and mouse.

American journal of physiology. Heart and circulatory physiology 20090801

[Metallothionein mediates cardioprotection induced by delayed preconditioning with adenosine A1 receptor agonist in rabbits].

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences 20090701

Regulation of somatostatin release by adenosine in the mouse stomach.

The Journal of pharmacology and experimental therapeutics 20090501

Autophagy is required for preconditioning by the adenosine A1 receptor-selective agonist CCPA.

Basic research in cardiology 20090301

Adenosine A1 and A3 receptor agonists inhibit nonadrenergic, noncholinergic relaxations in the guinea pig isolated trachea.

Respiration; international review of thoracic diseases 20090101

Drug-eluting stent for delivery of signal pathway-specific 1,3-dipropyl-8-cyclopentyl xanthine.

Molecular pharmaceutics 20090101

Adenosine and adenosine uptake inhibitors potentiate the neuromuscular blocking action of rocuronium mediated by adenosine A(1) receptors in isolated rat diaphragms.

Acta anaesthesiologica Scandinavica 20081101

Synthesis and biological evaluation of 2-amino-3-(4-chlorobenzoyl)-4-[N-(substituted) piperazin-1-yl]thiophenes as potent allosteric enhancers of the A1 adenosine receptor.

Journal of medicinal chemistry 20080925

Ribose-modified purine nucleosides as ribonucleotide reductase inhibitors. Synthesis, antitumor activity, and molecular modeling of N6-substituted 3'-C-methyladenosine derivatives.

Journal of medicinal chemistry 20080724

Effect of purines on calcium-independent acetylcholine release at the mouse neuromuscular junction.

Neuroscience 20080717

Ischaemic and pharmacological preconditionings protect liver via adenosine and redox status following hepatic ischaemia/reperfusion in rats.

Clinical science (London, England : 1979) 20080701

Sex differences in the neurotoxic effects of adenosine A1 receptor antagonism during ethanol withdrawal: reversal with an A1 receptor agonist or an NMDA receptor antagonist.

Alcoholism, clinical and experimental research 20080701

Endogenous A1 adenosine receptors protect against hepatic ischemia reperfusion injury in mice.

Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20080601

Activity of adenosine receptors type 1 Is required for CX3CL1-mediated neuroprotection and neuromodulation in hippocampal neurons.

Journal of immunology (Baltimore, Md. : 1950) 20080601

Adenosine actions are preserved in corpus cavernosum from obese and type II diabetic db/db mouse.

The journal of sexual medicine 20080501

Altered heart rate control in transgenic mice carrying the KCNJ6 gene of the human chromosome 21.

Physiological genomics 20080422

Ozone oxidative preconditioning is mediated by A1 adenosine receptors in a rat model of liver ischemia/ reperfusion.

Transplant international : official journal of the European Society for Organ Transplantation 20080101

5'-Carbamoyl derivatives of 2'-C-methyl-purine nucleosides as selective A1 adenosine receptor agonists: affinity, efficacy, and selectivity for A1 receptor from different species.

Bioorganic & medicinal chemistry 20080101

Oxidative stress and adenosine A1 receptor activation differentially modulate subcellular cardiomyocyte MAPKs.

American journal of physiology. Heart and circulatory physiology 20080101

Adenosine reduces the reverse mode of the Na+/Ca(2+) exchanger in ferret cardiac fibres.

Canadian journal of physiology and pharmacology 20080101

Altered ATP release and metabolism in dorsal root ganglia of neuropathic rats.

Molecular pain 20080101

Protective roles of adenosine A1, A2A, and A3 receptors in skeletal muscle ischemia and reperfusion injury.

American journal of physiology. Heart and circulatory physiology 20071201

Acute and delayed renal protection against renal ischemia and reperfusion injury with A1 adenosine receptors.

American journal of physiology. Renal physiology 20071201

The antinociceptive effect of 2-chloro-2'-C-methyl-N6-cyclopentyladenosine (2'-Me-CCPA), a highly selective adenosine A1 receptor agonist, in the rat.

Pain 20071001

G protein-independent neuromodulatory action of adenosine on metabotropic glutamate signalling in mouse cerebellar Purkinje cells.

The Journal of physiology 20070601

The protective effect of prior ischemia reperfusion adenosine A1 or A3 receptor activation in the normal and hypertrophied heart.

Interactive cardiovascular and thoracic surgery 20070601

Role of NO and COX pathways in mediation of adenosine A1 receptor-induced renal vasoconstriction.

Experimental biology and medicine (Maywood, N.J.) 20070501

Adenosine A1 and A2 receptor agonists reduce endotoxin-induced cellular energy depletion and oedema formation in the lung.

European journal of anaesthesiology 20070301

Adenosine enhances cytosolic phosphorylation potential and ventricular contractility in stunned guinea pig heart: receptor-mediated and metabolic protection.

Journal of applied physiology (Bethesda, Md. : 1985) 20070301

Pretreatment with adenosine and adenosine A1 receptor agonist protects against intestinal ischemia-reperfusion injury in rat.

World journal of gastroenterology 20070128

The A2a/A2b receptor antagonist ZM-241385 blocks the cardioprotective effect of adenosine agonist pretreatment in in vivo rat myocardium.

American journal of physiology. Heart and circulatory physiology 20070101

Differential effect of serum from bipolar versus schizophrenic patients on spontaneous acetylcholine release at mammalian neuromuscular junction.

Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology 20061201

Evidence for both adenosine A1 and A2A receptors activating single vagal sensory C-fibres in guinea pig lungs.

The Journal of physiology 20060901

Role of adenosine A1 receptors in the modulation of dopamine D1 and adenosine A2A receptor signaling in the neostriatum.

Neuroscience 20060811

Role of the second transmembrane domain of rat adenosine A1 receptor in ligand-receptor interaction.

Biochemical pharmacology 20060314

Adenosine receptors as therapeutic targets.

Nature reviews. Drug discovery 20060301

Contractile effects of adenosine A1 and A2A receptors in isolated murine hearts.

American journal of physiology. Heart and circulatory physiology 20060101

Anesthetic preconditioning as the alternative to ischemic preconditioning.

The Journal of thoracic and cardiovascular surgery 20060101

Semi-rational design of (north)-methanocarba nucleosides as dual acting A(1) and A(3) adenosine receptor agonists: novel prototypes for cardioprotection.

Journal of medicinal chemistry 20051229

Late preconditioning induced by NO donors, adenosine A1 receptor agonists, and delta1-opioid receptor agonists is mediated by iNOS.

American journal of physiology. Heart and circulatory physiology 20051101

A novel A1 adenosine receptor antagonist, L-97-1 [3-[2-(4-aminophenyl)-ethyl]-8-benzyl-7-{2-ethyl-(2-hydroxy-ethyl)-amino]-ethyl}-1-propyl-3,7-dihydro-purine-2,6-dione], reduces allergic responses to house dust mite in an allergic rabbit model of asthma.

The Journal of pharmacology and experimental therapeutics 20051001

Indirect activation of adenosine A1 receptors in cultured rat hippocampal neurons by volatile anaesthetics.

European journal of anaesthesiology 20050901

Delayed adenosine A1 receptor preconditioning in rat myocardium is MAPK dependent but iNOS independent.

American journal of physiology. Heart and circulatory physiology 20050801

Pretreatment with an adenosine A1 receptor agonist and lidocaine: a possible alternative to myocardial ischemic preconditioning.

The Journal of thoracic and cardiovascular surgery 20050801

Role of adenosine A1 and A3 receptors in regulation of cardiomyocyte homeostasis after mitochondrial respiratory chain injury.

American journal of physiology. Heart and circulatory physiology 20050601

New adenosine A2A receptor antagonists: actions on Parkinson's disease models.

European journal of pharmacology 20050411

Modulation of short-term social memory in rats by adenosine A1 and A(2A) receptors.

Neuroscience letters 20050316

The role of adenosine A2A and A2B receptors in the regulation of TNF-alpha production by human monocytes.

Biochemical pharmacology 20050315

Role of A1 adenosine receptors in regulation of vascular tone.

American journal of physiology. Heart and circulatory physiology 20050301

Genetic essential tremor in gamma-aminobutyric acidA receptor alpha1 subunit knockout mice.

The Journal of clinical investigation 20050301

Modulating effect of adenosine deaminase on function of adenosine A1 receptors.

Acta pharmacologica Sinica 20050201

2-Chloro-N6-cyclopentyladenosine enhances the anticonvulsant action of carbamazepine in the mouse maximal electroshock-induced seizure model.

Pharmacological reports : PR 20050101

Adenosine A1 receptors modulate the anxiolytic-like effect of ethanol in the elevated plus-maze in mice.

European journal of pharmacology 20040919

Comparative analysis of putative agonist-binding modes in the human A1 adenosine receptor.

Chembiochem : a European journal of chemical biology 20040607

Presynaptic inhibition of spontaneous acetylcholine release induced by adenosine at the mouse neuromuscular junction.

British journal of pharmacology 20040501

Transient mitochondrial permeability transition pore opening mediates preconditioning-induced protection.

Circulation 20040413

Role of adenosine receptor activation in antioxidant enzyme regulation during ischemia-reperfusion in the isolated rat heart.

Antioxidants & redox signaling 20040401

2-(N-acyl) and 2-N-acyl-N(6)-substituted analogues of adenosine and their affinity at the human adenosine receptors.

Bioorganic & medicinal chemistry letters 20040322

Adenosine A1 receptor agonists block the neuropathological changes in rat retrosplenial cortex after administration of the NMDA receptor antagonist dizocilpine.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology 20040301

A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion.

American journal of physiology. Renal physiology 20040201

Beta-adrenergic and antiadrenergic modulation of cardiac adenylyl cyclase is influenced by phosphorylation.

American journal of physiology. Heart and circulatory physiology 20031001

Interactive role of adenosine and dopamine in the opiate withdrawal syndrome.

Naunyn-Schmiedeberg's archives of pharmacology 20030801

Comparison of effects of MgCl2 and Gpp(NH)p on antagonist and agonist radioligand binding to adenosine A1 receptors.

Acta pharmacologica Sinica 20030801

Adenosine and opioid receptor-mediated cardioprotection in the rat: evidence for cross-talk between receptors.

American journal of physiology. Heart and circulatory physiology 20030701

Seizure suppression by adenosine A1 receptor activation in a mouse model of pharmacoresistant epilepsy.

Epilepsia 20030701

A role of protein kinase C mu in signalling from the human adenosine A1 receptor to the nucleus.

British journal of pharmacology 20030601

N6-cyclopentyl-2-(3-phenylaminocarbonyltriazene-1-yl)adenosine (TCPA), a very selective agonist with high affinity for the human adenosine A1 receptor.

Journal of medicinal chemistry 20030410

Modulation of agonist responses at the A(1) adenosine receptor by an irreversible antagonist, receptor-G protein uncoupling and by the G protein activation state.

Biochemical pharmacology 20021015

Administration of adenosine receptor agonists or antagonists after controlled cortical impact in mice: effects on function and histopathology.

Brain research 20021004

Structural determinants of A(3) adenosine receptor activation: nucleoside ligands at the agonist/antagonist boundary.

Journal of medicinal chemistry 20020926

Seizure suppression by adenosine A(2A) receptor activation in a rat model of audiogenic brainstem epilepsy.

Neuroscience letters 20020906

Reperfusion duration paradox with late myocardial preconditioning in rabbits.

European journal of pharmacology 20020823

Effects of A(1) and A(2A) adenosine receptor ligands in mouse acute models of pain.

Neuroscience letters 20020816

Inhibiting mitochondrial permeability transition pore opening: a new paradigm for myocardial preconditioning?

Cardiovascular research 20020815

Pharmacological preconditioning in rabbit myocardium is blocked by chloride channel inhibition.

Cardiovascular research 20020815

Adenosine A(1) receptor mediates late preconditioning via activation of PKC-delta signaling pathway.

American journal of physiology. Heart and circulatory physiology 20020701

Effects of adenosine A1 and A2A receptor activation on the evoked release of glutamate from rat cerebrocortical synaptosomes.

British journal of pharmacology 20020601

Synergistic up-regulation of vascular endothelial growth factor expression in murine macrophages by adenosine A(2A) receptor agonists and endotoxin.

The American journal of pathology 20020601

2-Chloro-N(6)-cyclopentyladenosine, adenosine A(1) receptor agonist, antagonizes the adenosine A(3) receptor.

European journal of pharmacology 20020517

Preconditioning of rat hearts by adenosine A1 or A3 receptor activation.

European journal of pharmacology 20020426

Human A(2A) adenosine receptors: high-affinity agonist binding to receptor-G protein complexes containing Gbeta(4).

Molecular pharmacology 20020201

Nitric oxide as a mediator of delayed pharmacological (A(1) receptor triggered) preconditioning; is eNOS masquerading as iNOS?

Cardiovascular research 20020201

Mechanisms of glutamate release in the rat spinal cord slices during metabolic inhibition.

Journal of neurotrauma 20020201

Lipopolysaccharide binds to and activates A(1) adenosine receptors on human pulmonary artery endothelial cells.

Journal of endotoxin research 20020101

Adenosine A1 receptors control dopamine D1-dependent [(3)H]GABA release in slices of substantia nigra pars reticulata and motor behavior in the rat.

Neuroscience 20020101

Molecular modeling the human A1 adenosine receptor and study of the mechanisms of its selective ligand binding.

Doklady. Biochemistry and biophysics 20020101

Mechanisms of delayed preconditioning with A1 adenosine receptor activation in porcine coronary smooth muscle cells.

Polish journal of pharmacology 20020101

Distinct myoprotective roles of cardiac sarcolemmal and mitochondrial KATP channels during metabolic inhibition and recovery.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20011201

Effect of aging on the ability of preconditioning to protect rat hearts from ischemia-reperfusion injury.

American journal of physiology. Heart and circulatory physiology 20011001

Role of adenosine in ischemic preconditioning in rats depends critically on the duration of the stimulus and involves both A(1) and A(3) receptors.

Cardiovascular research 20010901

5'-O-alkyl ethers of N,2-substituted adenosine derivatives: partial agonists for the adenosine A1 and A3 receptors.

Journal of medicinal chemistry 20010830

Delayed or second window preconditioning induced by adenosine A1 receptor activation is independent of early generation of nitric oxide or late induction of inducible nitric oxide synthase.

Journal of cardiovascular pharmacology 20010801

Activation of A(3)adenosine receptor protects against doxorubicin-induced cardiotoxicity.

Journal of molecular and cellular cardiology 20010601

2-chloro-N(6)-cyclopentyladenosine-elicited attenuation of evoked glutamate release is not sufficient to give complete protection against pilocarpine-induced seizures in rats.

Neuropharmacology 20010401

A(1) or A(3) adenosine receptors induce late preconditioning against infarction in conscious rabbits by different mechanisms.

Circulation research 20010316

Adenosine enhances neuroexcitability by inhibiting a slow postspike afterhyperpolarization in rabbit vagal afferent neurons.

Circulation 20010306

Adenosine-induced late preconditioning in mouse hearts: role of p38 MAP kinase and mitochondrial K(ATP) channels.

American journal of physiology. Heart and circulatory physiology 20010301

Antiarrhythmic effects of adenosine on ischemia-induced ventricular fibrillation.

Journal of critical care 20010301

Adenosine inhibits norepinephrine release in the postischemic rat heart: the mechanism of neuronal stunning.

Cardiovascular research 20010301

Antiadrenergic effects of adenosine in pressure overload hypertrophy.

Hypertension (Dallas, Tex. : 1979) 20010301

Seizure activity produces differential changes in adenosine A1 receptors within rat hippocampus.

Neurochemical research 20010301

Role of adenosine and glycogen in ischemic preconditioning of rat hearts.

European journal of pharmacology 20010223

The calcium-dependent [3H]acetylcholine release from synaptosomes of brown trout (Salmo trutta) optic tectum is inhibited by adenosine A1 receptors: effects of enucleation on A1 receptor density and cholinergic markers.

Brain research 20010216

Characterization of a G protein-coupled receptor for nicotinic acid.

Molecular pharmacology 20010201

Adenosine A1 receptor activation reduces reactive oxygen species and attenuates stunning in ventricular myocytes.

Journal of molecular and cellular cardiology 20010101

Cardioprotective effects of adenosine A1 and A3 receptor activation during hypoxia in isolated rat cardiac myocytes.

Molecular and cellular biochemistry 20010101

[Comparative characteristics of A1-receptor agonists as neuroprotective agents].

Eksperimental'naia i klinicheskaia farmakologiia 20010101

Inducible nitric oxide synthase mediates delayed myocardial protection induced by activation of adenosine A(1) receptors: evidence from gene-knockout mice.

Circulation 20000822

N-cycloalkyl derivatives of adenosine and 1-deazaadenosine as agonists and partial agonists of the A(1) adenosine receptor.

Journal of medicinal chemistry 20000127

Characterization of human A(2B) adenosine receptors: radioligand binding, western blotting, and coupling to G(q) in human embryonic kidney 293 cells and HMC-1 mast cells.

Molecular pharmacology 19991001

Mechanisms of inhibitory effects of zinc and cadmium ions on agonist binding to adenosine A1 receptors in rat brain.

Biochemical pharmacology 19990815

Identification of the adenine binding site of the human A1 adenosine receptor.

The Journal of biological chemistry 19990205

2'-C-Methyl analogues of selective adenosine receptor agonists: synthesis and binding studies.

Journal of medicinal chemistry 19980507

Comparative pharmacology of human adenosine receptor subtypes - characterization of stably transfected receptors in CHO cells.

Naunyn-Schmiedeberg's archives of pharmacology 19980101

2-Substitution of N6-benzyladenosine-5'-uronamides enhances selectivity for A3 adenosine receptors.

Journal of medicinal chemistry 19941014

Anticonvulsant doses of 2-chloro-N6-cyclopentyladenosine, an adenosine A1 receptor agonist, reduce GABAergic transmission in different areas of the mouse brain.

The Journal of pharmacology and experimental therapeutics 19931101