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Home Halogens Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-

Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-

CAS No.:
325457-89-4
Catalog Number:
AG00I65V
Molecular Formula:
C12H7ClF2N2O
Molecular Weight:
268.6466
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Product Description
Catalog Number:
AG00I65V
Chemical Name:
Benzamide, N-(6-chloro-3-pyridinyl)-3,4-difluoro-
CAS Number:
325457-89-4
Molecular Formula:
C12H7ClF2N2O
Molecular Weight:
268.6466
MDL Number:
MFCD17166959
IUPAC Name:
N-(6-chloropyridin-3-yl)-3,4-difluorobenzamide
InChI:
InChI=1S/C12H7ClF2N2O/c13-11-4-2-8(6-16-11)17-12(18)7-1-3-9(14)10(15)5-7/h1-6H,(H,17,18)
InChI Key:
GDGUOCFTHNGPBK-UHFFFAOYSA-N
SMILES:
Clc1ccc(cn1)NC(=O)c1ccc(c(c1)F)F
UNII:
VU7278D853
Properties
Complexity:
306  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
268.021g/mol
Formal Charge:
0
Heavy Atom Count:
18  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
1  
Isotope Atom Count:
0
Molecular Weight:
268.648g/mol
Monoisotopic Mass:
268.021g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
42A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
2.8  
Literature
Title Journal
K(v) 7 (KCNQ) channel openers normalize central 2-deoxyglucose uptake in a mouse model of mania and increase prefrontal cortical and hippocampal serine-9 phosphorylation levels of GSK3β. Journal of neurochemistry 20120501
The pharmacological effect of positive KCNQ (Kv7) modulators on dopamine release from striatal slices. Basic & clinical pharmacology & toxicology 20111101
Kv7 (KCNQ) channel openers induce hypothermia in the mouse. Neuroscience letters 20110120
Differential effects of ICA-27243 on cloned K(V)7 channels. Pharmacology 20100101
The KCNQ2/3 selective channel opener ICA-27243 binds to a novel voltage-sensor domain site. Neuroscience letters 20091113
Effects of neuronal Kv7 potassium channel activators on hyperactivity in a rodent model of mania. Behavioural brain research 20090317
In vivo profile of ICA-27243 [N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide], a potent and selective KCNQ2/Q3 (Kv7.2/Kv7.3) activator in rodent anticonvulsant models. The Journal of pharmacology and experimental therapeutics 20080901
N-(6-chloro-pyridin-3-yl)-3,4-difluoro-benzamide (ICA-27243): a novel, selective KCNQ2/Q3 potassium channel activator. Molecular pharmacology 20080301
Properties