Home Sulfos 6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)

6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)

CAS No.:
29608-49-9
Catalog Number:
AG00I5H1
Molecular Formula:
C28H37F2N7O6S2
Molecular Weight:
669.7635
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
In Stock USA
United States
$150
- +
25mg
98%
In Stock USA
United States
$279
- +
100mg
98%
In Stock USA
United States
$350
- +
250mg
98%
In Stock USA
United States
$600
- +
1g
98%
In Stock USA
United States
$1225
- +
Product Description
Catalog Number:
AG00I5H1
Chemical Name:
6-{4-[bis(4-fluorophenyl)methyl]piperazin-1-yl}-2-N,4-N-bis(prop-2-en-1-yl)-1,3,5-triazine-2,4-diamine; bis(methanesulfonic acid)
CAS Number:
29608-49-9
Molecular Formula:
C28H37F2N7O6S2
Molecular Weight:
669.7635
MDL Number:
MFCD01679060
IUPAC Name:
6-[4-[bis(4-fluorophenyl)methyl]piperazin-1-yl]-2-N,4-N-bis(prop-2-enyl)-1,3,5-triazine-2,4-diamine;methanesulfonic acid
InChI:
InChI=1S/C26H29F2N7.2CH4O3S/c1-3-13-29-24-31-25(30-14-4-2)33-26(32-24)35-17-15-34(16-18-35)23(19-5-9-21(27)10-6-19)20-7-11-22(28)12-8-20;2*1-5(2,3)4/h3-12,23H,1-2,13-18H2,(H2,29,30,31,32,33);2*1H3,(H,2,3,4)
InChI Key:
MRDBGMJEPGXQHJ-UHFFFAOYSA-N
SMILES:
CS(=O)(=O)O.CS(=O)(=O)O.C=CCNc1nc(nc(n1)NCC=C)N1CCN(CC1)C(c1ccc(cc1)F)c1ccc(cc1)F
EC Number:
249-726-1
UNII:
6RY6V6XM8T
Properties
Complexity:
694  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
669.221g/mol
Formal Charge:
0
Heavy Atom Count:
45  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
669.764g/mol
Monoisotopic Mass:
669.221g/mol
Rotatable Bond Count:
10  
Topological Polar Surface Area:
195A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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Stability-indicating methods for the determination of a mixture of almitrine and raubasine by derivative spectrophotometry. Drug testing and analysis 20090601
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Low-tidal-volume ventilation. The New England journal of medicine 20071213
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Low- vs high-dose almitrine combined with nitric oxide to prevent hypoxia during open-chest one-lung ventilation. British journal of anaesthesia 20050901
Treatment of hypoxemia during one-lung ventilation using intravenous almitrine. Anesthesia and analgesia 20040301
Assessment of the therapeutic activity of a combination of almitrine and raubasine on functional rehabilitation following ischaemic stroke. Current medical research and opinion 20040301
Orthodeoxia--an uncommon presentation following bilateral thoracic sympathectomy. Anaesthesia and intensive care 20031001
Long-term effects of almitrine bismesylate in COPD patients with chronic hypoxaemia. Respiratory medicine 20030601
Selective pulmonary vasodilation in acute respiratory distress syndrome. Critical care medicine 20030401
Effects of almitrine bismesylate on arterial blood gases in patients with chronic obstructive pulmonary disease and moderate hypoxaemia: a multicentre, randomised, double-blind, placebo-controlled study. Respiration; international review of thoracic diseases 20030101
pO2 - Do we treat the right thing? Respiration; international review of thoracic diseases 20030101
Effect of position, nitric oxide, and almitrine on lung perfusion in a porcine model of acute lung injury. Journal of applied physiology (Bethesda, Md. : 1985) 20021201
Primary alveolar hypoventilation and response to the respiratory stimulant almitrine. Internal medicine journal 20021201
Treatment of hypoxaemia during one-lung ventilation with almitrine. Lancet (London, England) 20020413
The effects of intravenous almitrine on oxygenation and hemodynamics during one-lung ventilation. Anesthesia and analgesia 20020401
[Effect of almitrine/raubasine on cerebral metabolism in the elderly]. Presse medicale (Paris, France : 1983) 20020330
Effects of almitrine on diaphragm contractile properties in young and old rats. Respiration; international review of thoracic diseases 20020101
An investigation into the mechanism of action of almitrine on isolated rat diaphragm muscle fatigue. Respiration; international review of thoracic diseases 20020101
High or low doses of almitrine bismesylate in ARDS patients responding to inhaled NO and receiving norepinephrine? Intensive care medicine 20011101
[Comparative changes in PaO2 in moderately hypoxemic COPD patients treated with almitrine versus placebo for one year]. Revue des maladies respiratoires 20010901
Association of oral almitrine and medroxyprogesterone acetate: effect on arterial blood gases in chronic obstructive pulmonary disease. Respiratory medicine 20010701
Effects of combined high-dose partial liquid ventilation and almitrine on pulmonary gas exchange and hemodynamics in an animal model of acute lung injury. Intensive care medicine 20010301
Effect of inhaled prostacyclin in combination with almitrine on ventilation-perfusion distributions in experimental lung injury. Anesthesiology 20010301
Effect of almitrine on upper airway muscle contraction in young and old rats. European journal of pharmacology 20010126
Right ventricular response to high-dose almitrine infusion in patients with severe hypoxemia related to acute respiratory distress syndrome. Critical care medicine 20010101
Peripheral neuropathy in patients treated with almitrine dimesylate. Lancet (London, England) 19850601
[Competitive study of the effects of naloxone and of almitrine on fentanyl analgesia in the anesthetized dog: effects on the muzzle opening reflex and blood gases]. Annales de l'anesthesiologie francaise 19800101
Properties