Metformin suppresses CYP1A1 and CYP1B1 expression in breast cancer cells by down-regulating aryl hydrocarbon receptor expression.

Toxicology and applied pharmacology 20141001

The activity of a novel mithramycin analog is related to its binding to DNA, cellular accumulation, and inhibition of Sp1-driven gene transcription.

Chemico-biological interactions 20140805

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis.

Oncogene 20140522

Sp1 and Sp3 transcription factors regulate the basal expression of human microsomal epoxide hydrolase (EPHX1) through interaction with the E1b far upstream promoter.

Gene 20140215

Paraoxonase enzyme protects retinal pigment epithelium from chlorpyrifos insult.

PloS one 20140101

Transcription factors Sp1 and Hif2α mediate induction of the copper-transporting ATPase (Atp7a) gene in intestinal epithelial cells during hypoxia.

The Journal of biological chemistry 20130816

Intervention in genotoxic stress-induced senescence by cordycepin through activation of eIF2α and suppression of Sp1.

Toxicological sciences : an official journal of the Society of Toxicology 20130801

Sp sites contribute to basal and inducible expression of the human TNIP1 (TNFα-inducible protein 3-interacting protein 1) promoter.

The Biochemical journal 20130615

Astaxanthin suppresses MPP(+)-induced oxidative damage in PC12 cells through a Sp1/NR1 signaling pathway.

Marine drugs 20130401

Estrogen receptor α (ESR1) over-expression mediated apoptosis in Hep3B cells by binding with SP1 proteins.

Journal of molecular endocrinology 20130101

Arf induction by Tgfβ is influenced by Sp1 and C/ebpβ in opposing directions.

PloS one 20130101

Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells.

PloS one 20130101

Aureolic acids from a marine-derived Streptomyces sp. WBF16.

Microbiological research 20121220

Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

Biochemical pharmacology 20121101

Cooperation of two bifunctional enzymes in the biosynthesis and attachment of deoxysugars of the antitumor antibiotic mithramycin.

Angewandte Chemie (International ed. in English) 20121015

Enhanced suppressor of cytokine signaling 3 in arthritic cartilage dysregulates human chondrocyte function.

Arthritis and rheumatism 20121001

Regulation of double-stranded RNA dependent protein kinase expression and attenuation of protein synthesis induced by bacterial toll-like receptors agonists in the absence of interferon.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20121001

Phorbol esters enhance 1α,25-dihydroxyvitamin D3-regulated 25-hydroxyvitamin D-24-hydroxylase (CYP24A1) gene expression through ERK-mediated phosphorylation of specific protein 3 (Sp3) in Caco-2 cells.

Molecular and cellular endocrinology 20120925

MicroRNA-21 represses human cystathionine gamma-lyase expression by targeting at specificity protein-1 in smooth muscle cells.

Journal of cellular physiology 20120901

Mithramycin represses basal and cigarette smoke-induced expression of ABCG2 and inhibits stem cell signaling in lung and esophageal cancer cells.

Cancer research 20120815

Cigarette smoke induces MUC5AC protein expression through the activation of Sp1.

The Journal of biological chemistry 20120810

A combined approach for β-thalassemia based on gene therapy-mediated adult hemoglobin (HbA) production and fetal hemoglobin (HbF) induction.

Annals of hematology 20120801

Cooling-increased phospho-β-arrestin-1 and β-arrestin-1 expression levels in 3T3-L1 adipocytes.

Cryobiology 20120801

Sp1 and Sp3 are involved in the full transcriptional activity of centromere protein H in human nasopharyngeal carcinoma cells.

The FEBS journal 20120801

Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells.

Biochimica et biophysica acta 20120701

Treatment of acute hypercalcemia.

Medicinal chemistry (Shariqah (United Arab Emirates)) 20120701

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Journal of medicinal chemistry 20120628

Regulatory mechanism of PAC1 gene expression via Sp1 by nerve growth factor in PC12 cells.

FEBS letters 20120612

Promoter cloning and characterization of the human programmed cell death protein 4 (pdcd4) gene: evidence for ZBP-89 and Sp-binding motifs as essential Pdcd4 regulators.

Bioscience reports 20120601

Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7.

Journal of biochemistry 20120601

Parathyroid carcinoma with lung metastasis in a thirteen-year-old girl.

Journal of the Korean Surgical Society 20120601

Hepatitis C virus promotes expression of the 3β-hydroxysterol δ24-reductase through Sp1.

Journal of medical virology 20120501

Association of aureolic acid antibiotic, chromomycin A3 with Cu2+ and its negative effect upon DNA binding property of the antibiotic.

Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine 20120401

Cortisol induces aromatase expression in human placental syncytiotrophoblasts through the cAMP/Sp1 pathway.

Endocrinology 20120401

CD1d induction in solid tumor cells by histone deacetylase inhibitors through inhibition of HDAC1/2 and activation of Sp1.

Epigenetics 20120401

Regulation of macroautophagy in ovarian cancer cells in vitro and in vivo by controlling glucose regulatory protein 78 and AMPK.

Oncotarget 20120401

Targeting pre-miRNA by peptide nucleic acids: a new strategy to interfere in the miRNA maturation.

Artificial DNA, PNA & XNA 20120401

Sp1king out cancer (....and fibrosis?).

Journal of cell communication and signaling 20120301

Elevated transcription factor specificity protein 1 in autistic brains alters the expression of autism candidate genes.

Biological psychiatry 20120301

Up-regulation of ATP binding cassette transporter A1 expression by very low density lipoprotein receptor and apolipoprotein E receptor 2.

The Journal of biological chemistry 20120203

Trichostatin A and sirtinol suppressed survivin expression through AMPK and p38MAPK in HT29 colon cancer cells.

Biochimica et biophysica acta 20120201

Histone deacetylase inhibitors upregulate MMP11 gene expression through Sp1/Smad complexes in human colon adenocarcinoma cells.

Biochimica et biophysica acta 20120201

c-Jun induction is independent of early growth response factor during cerebellar granule neuron apoptosis.

Neuroreport 20120125

Expression and regulation of CCL15 by human airway smooth muscle cells.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20120101

Protective action of mithramycin against neurodegeneration and impairment of synaptic plasticity in the hippocampal CA1 area after transient global ischemia.

Neurochemistry international 20120101

Mithramycin encapsulated in polymeric micelles by microfluidic technology as novel therapeutic protocol for beta-thalassemia.

International journal of nanomedicine 20120101

Transcription of promoter from the human APRIL gene regulated by Sp1 and NF-kB.

Neoplasma 20120101

Humoral hypercalcemic crisis in a pregnant woman with uterine leiomyoma.

Journal of emergencies, trauma, and shock 20120101

Cytogenetic characterization and genome size of the medicinal plant Catharanthus roseus (L.) G. Don.

AoB PLANTS 20120101

Conformational changes in DNA upon ligand binding monitored by circular dichroism.

International journal of molecular sciences 20120101

The Sp1 transcription factor is essential for the expression of gliostatin/thymidine phosphorylase in rheumatoid fibroblast-like synoviocytes.

Arthritis research & therapy 20120101

Full-Length Enrich c-DNA Libraries-Clear Cell-Renal Cell Carcinoma.

Journal of oncology 20120101

Modulation of the activity of Sp transcription factors by mithramycin analogues as a new strategy for treatment of metastatic prostate cancer.

PloS one 20120101

Regulation of hepatic paraoxonase-1 expression.

Journal of lipids 20120101

Prevention of chronic experimental colitis induced by dextran sulphate sodium (DSS) in mice treated with FR91.

Journal of biomedicine & biotechnology 20120101

The RIP140 gene is a transcriptional target of E2F1.

PloS one 20120101

The first European interdisciplinary ewing sarcoma research summit.

Frontiers in oncology 20120101

Expression of specificity protein transcription factors in pancreatic cancer and their association in prognosis and therapy.

Current medicinal chemistry 20120101

Natural diterpenes from coffee, cafestol and kahweol induce apoptosis through regulation of specificity protein 1 expression in human malignant pleural mesothelioma.

Journal of biomedical science 20120101

C(5) modified uracil derivatives showing antiproliferative and erythroid differentiation inducing activities on human chronic myelogenous leukemia K562 cells.

European journal of pharmacology 20111215

Modulation of the biological activity of microRNA-210 with peptide nucleic acids (PNAs).

ChemMedChem 20111209

Cancer chemoprevention by targeting the epigenome.

Current drug targets 20111201

Investigating Mithramycin deoxysugar biosynthesis: enzymatic total synthesis of TDP-D-olivose.

Chembiochem : a European journal of chemical biology 20111125

Opposite effects of HIF-1α and HIF-2α on the regulation of IL-8 expression in endothelial cells.

Free radical biology & medicine 20111115

Specificity protein, Sp1-mediated increased expression of Prdx6 as a curcumin-induced antioxidant defense in lens epithelial cells against oxidative stress.

Cell death & disease 20111101

Secondary gliosarcoma after the treatment of primary glioblastoma multiforme.

North American journal of medical sciences 20111101

Topical mithramycin-A modulates submucosal collagen deposition after esophageal burn injury in rats.

Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery 20110901

2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced MUC5AC expression: aryl hydrocarbon receptor-independent/EGFR/ERK/p38-dependent SP1-based transcription.

American journal of respiratory cell and molecular biology 20110801

Sp1 is a transcription repressor to stanniocalcin-1 expression in TSA-treated human colon cancer cells, HT29.

Journal of cellular biochemistry 20110801

Combining betulinic acid and mithramycin a effectively suppresses pancreatic cancer by inhibiting proliferation, invasion, and angiogenesis.

Cancer research 20110801

Specificity protein-1 as a critical regulator of human cystathionine gamma-lyase in smooth muscle cells.

The Journal of biological chemistry 20110729

Aristolochic acid I and ochratoxin A differentially regulate VEGF expression in porcine kidney epithelial cells--the involvement of SP-1 and HIFs transcription factors.

Toxicology letters 20110728

Inhibition of myeloid cell leukemia-1 by tolfenamic acid induces apoptosis in mucoepidermoid carcinoma.

Oral diseases 20110701

Nrf2-dependent induction of NQO1 in mouse aortic endothelial cells overexpressing catalase.

Free radical biology & medicine 20110701

Identification of an inhibitor of the EWS-FLI1 oncogenic transcription factor by high-throughput screening.

Journal of the National Cancer Institute 20110622

Transcriptional regulation of pro-apoptotic protein kinase Cdelta: implications for oxidative stress-induced neuronal cell death.

The Journal of biological chemistry 20110603

Accessible chromatin structure permits factors Sp1 and Sp3 to regulate human TGFBI gene expression.

Biochemical and biophysical research communications 20110603

The Sp1 transcription factor is crucial for the expression of 11beta-hydroxysteroid dehydrogenase type 2 in human placental trophoblasts.

The Journal of clinical endocrinology and metabolism 20110601

Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20110504

Serpinin: a novel chromogranin A-derived, secreted peptide up-regulates protease nexin-1 expression and granule biogenesis in endocrine cells.

Molecular endocrinology (Baltimore, Md.) 20110501

Novel histone deacetylase inhibitor NCH-51 activates latent HIV-1 gene expression.

FEBS letters 20110406

A critical role of Sp1 transcription factor in regulating the human Ki-67 gene expression.

Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 20110401

Identification and characterization of human PCDH10 gene promoter.

Gene 20110401

Apoptotic effect of tolfenamic acid in androgen receptor-independent prostate cancer cell and xenograft tumor through specificity protein 1.

Cancer science 20110401

Mithramycin reduces expression of fibro-proliferative mRNAs in human gingival fibroblasts.

Cell proliferation 20110401

Combined treatment of pancreatic cancer with mithramycin a and tolfenamic Acid promotes sp1 degradation and synergistic antitumor activity--letter.

Cancer research 20110401

Egr-1 transactivates Bim gene expression to promote neuronal apoptosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20110330

Transcriptional regulation of ATP-binding cassette transporter A1 expression by a novel signaling pathway.

The Journal of biological chemistry 20110318

Natural glycoconjugates with antitumor activity.

Natural product reports 20110301

Chemopreventive effect of tolfenamic acid on KB human cervical cancer cells and tumor xenograft by downregulating specificity protein 1.

European journal of cancer prevention : the official journal of the European Cancer Prevention Organisation (ECP) 20110301

Heterogeneous sphingosine-1-phosphate lyase gene expression and its regulatory mechanism in human lung cancer cell lines.

Biochimica et biophysica acta 20110301

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.

Microbial biotechnology 20110301

Therapeutic effects of the Sp1 inhibitor mithramycin A in glioblastoma.

Journal of neuro-oncology 20110201

Platotex: an innovative and fully automated device for cell growth scale-up of agar-supported solid-state fermentation.

Journal of industrial microbiology & biotechnology 20110201

Trichostatin A inhibits TGF-β1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression.

Differentiation; research in biological diversity 20110201

Identification of a novel cell type-specific intronic enhancer of macrophage migration inhibitory factor (MIF) and its regulation by mithramycin.

Clinical and experimental immunology 20110201

Cysteinyl-leukotrienes induce vascular endothelial growth factor production in human monocytes and bronchial smooth muscle cells.

Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20110201

Human glycolipid transfer protein gene (GLTP) expression is regulated by Sp1 and Sp3: involvement of the bioactive sphingolipid ceramide.

The Journal of biological chemistry 20110114

N-Myc and SP regulate phosphatidylserine synthase-1 expression in brain and glial cells.

The Journal of biological chemistry 20110114

SAFB1 interacts with and suppresses the transcriptional activity of p53.

FEBS letters 20110103

Mithramycin A suppresses expression of the human melanoma-associated gene ABCB8.

Molecular genetics and genomics : MGG 20110101

Therapeutic targeting the loss of the birt-hogg-dube suppressor gene.

Molecular cancer therapeutics 20110101

Modulation of transforming growth factor beta signalling pathway genes by transforming growth factor beta in human osteoarthritic chondrocytes: involvement of Sp1 in both early and late response cells to transforming growth factor beta.

Arthritis research & therapy 20110101

Kalrn promoter usage and isoform expression respond to chronic cocaine exposure.

BMC neuroscience 20110101

HDAC inhibition decreases the expression of EGFR in colorectal cancer cells.

PloS one 20110101

Nanotechnology for the treatment of coronary in stent restenosis: a clinical perspective.

Vascular cell 20110101

Neuroprotective effect of mithramycin against endoplasmic reticulum stress-induced neurotoxicity in organotypic hippocampal slice cultures.

Neuropharmacology 20110101

NFATc1 regulation of TRAIL expression in human intestinal cells.

PloS one 20110101

Transcription factors Sp1 and Sp4 regulate TRPV1 gene expression in rat sensory neurons.

Molecular pain 20110101

Induction and flow cytometry identification of tetraploids from seed-derived explants through colchicine treatments in Catharanthus roseus (L.) G. Don.

Journal of biomedicine & biotechnology 20110101

Transcriptional activation of TINF2, a gene encoding the telomere-associated protein TIN2, by Sp1 and NF-κB factors.

PloS one 20110101

Karyotypic conservatism in samples of Characidium cf. zebra (Teleostei, Characiformes, Crenuchidae): Physical mapping of ribosomal genes and natural triploidy.

Genetics and molecular biology 20110101

Comparative genomics and transcriptomics of Propionibacterium acnes.

PloS one 20110101

Current review of in vivo GBM rodent models: emphasis on the CNS-1 tumour model.

ASN neuro 20110101

A novel function of apolipoprotein E: upregulation of ATP-binding cassette transporter A1 expression.

PloS one 20110101

Betulinic acid inhibits colon cancer cell and tumor growth and induces proteasome-dependent and -independent downregulation of specificity proteins (Sp) transcription factors.

BMC cancer 20110101

Biosynthetic gene cluster for the cladoniamides, bis-indoles with a rearranged scaffold.

PloS one 20110101

In Silico discovery of transcription factors as potential diagnostic biomarkers of ovarian cancer.

BMC systems biology 20110101

D-β-hydroxybutyrate is protective in mouse models of Huntington's disease.

PloS one 20110101

Prognostic and predictive value of clinical and biochemical factors in breast cancer patients with bone metastases receiving 'metronomic' zoledronic acid.

BMC cancer 20110101

Systematic in-vitro evaluation of the NCI/NIH Developmental Therapeutics Program Approved Oncology Drug Set for the identification of a candidate drug repertoire for MLL-rearranged leukemia.

OncoTargets and therapy 20110101

VEGFR2 translocates to the nucleus to regulate its own transcription.

PloS one 20110101

Huntington's Disease and Striatal Signaling.

Frontiers in neuroanatomy 20110101

Parallel screening of FDA-approved antineoplastic drugs for identifying sensitizers of TRAIL-induced apoptosis in cancer cells.

BMC cancer 20110101

Effect of DNA groove binder distamycin A upon chromatin structure.

PloS one 20110101

Identification of Binding Mode of a Platinum (II) Complex, PtCl(2)(DIP), and Calf Thymus DNA.

Bioinorganic chemistry and applications 20110101

Nanoparticulate formulations of mithramycin analogs for enhanced cytotoxicity.

International journal of nanomedicine 20110101

Factors Affecting EWS-FLI1 Activity in Ewing's Sarcoma.

Sarcoma 20110101

The nuclear events guiding successful nerve regeneration.

Frontiers in molecular neuroscience 20110101

Transcription factor Sp1 is involved in expressional regulation of coxsackie and adenovirus receptor in cancer cells.

Journal of biomedicine & biotechnology 20110101

Mechanisms of MEOX1 and MEOX2 regulation of the cyclin dependent kinase inhibitors p21 and p16 in vascular endothelial cells.

PloS one 20110101

Enhanced expression of tissue inhibitor of metalloproteinases-4 gene in human osteoarthritic synovial membranes and its differential regulation by cytokines in chondrocytes.

The open rheumatology journal 20110101

DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis.

Biochemistry 20101214

MDM2-related responses in 3T3-L1 adipocytes exposed to cooling and subsequent rewarming.

Cryobiology 20101201

Hepatitis C virus nonstructural protein-5A activates sterol regulatory element-binding protein-1c through transcription factor Sp1.

Biochemical and biophysical research communications 20101119

Structural and functional characterization of the mouse tescalcin promoter.

Gene 20100915

A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development.

Cancer cell 20100914

Sp1 plays an important role in regulating the transcription of ZNF313.

Cell biology international 20100901

Sp1 upregulates the four and half lim 2 (FHL2) expression in gastrointestinal cancers through transcription regulation.

Molecular carcinogenesis 20100901

Inhibition of Sp1-dependent transcription and antitumor activity of the new aureolic acid analogues mithramycin SDK and SK in human ovarian cancer xenografts.

Gynecologic oncology 20100801

Overexpression of antioxidant enzymes upregulates aryl hydrocarbon receptor expression via increased Sp1 DNA-binding activity.

Free radical biology & medicine 20100801

Induction of p53-independent apoptosis by a novel synthetic hexahydrocannabinol analog is mediated via Sp1-dependent NSAID-activated gene-1 in colon cancer cells.

Biochemical pharmacology 20100701

Estrogen regulated expression of the p21 Waf1/Cip1 gene in estrogen receptor positive human breast cancer cells.

Journal of cellular physiology 20100701

Sp1 binds to the external promoter of the p73 gene and induces the expression of TAp73gamma in lung cancer.

The FEBS journal 20100701

Cellular response and activation of apoptosis by mithramycin SK in p21(WAF1)-deficient HCT116 human colon carcinoma cells.

Cancer letters 20100601

Low-dose mithramycin exerts its anticancer effect via the p53 signaling pathway and synergizes with nutlin-3 in gynecologic cancers.

Cancer science 20100601

Negative regulation of the oncogenic transcription factor FoxM1 by thiazolidinediones and mithramycin.

Cancer biology & therapy 20100601

Transcription factor Sp1 regulates expression of cancer-associated molecule CD147 in human lung cancer.

Cancer science 20100601

The neurological safety of epidural pamidronate in rats.

The Korean journal of pain 20100601

Sp1 regulates chromatin looping between an intronic enhancer and distal promoter of the human heme oxygenase-1 gene in renal cells.

The Journal of biological chemistry 20100528

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships.

Biochemical pharmacology 20100515

E-cadherin mediates the aggregation of breast cancer cells induced by tamoxifen and epidermal growth factor.

Breast cancer research and treatment 20100501

Upregulation of parathyroid VDR expression by extracellular calcium is mediated by ERK1/2-MAPK signaling pathway.

American journal of physiology. Renal physiology 20100501

Foxo3a expression and acetylation regulate cancer cell growth and sensitivity to cisplatin.

Cancer science 20100501

Associations of MDM2 SNP309, transcriptional activity, mRNA expression, and survival in stage I non-small-cell lung cancer patients with wild-type p53 tumors.

Annals of surgical oncology 20100401

Skp2 overexpression increases the expression of MMP-2 and MMP-9 and invasion of lung cancer cells.

Cancer letters 20100227

Primary gliosarcoma: key clinical and pathologic distinctions from glioblastoma with implications as a unique oncologic entity.

Journal of neuro-oncology 20100201

Combined treatment of pancreatic cancer with mithramycin A and tolfenamic acid promotes Sp1 degradation and synergistic antitumor activity.

Cancer research 20100201

Pharmacological impairment of s-nitrosoglutathione or thioredoxin reductases augments protein S-Nitrosation in human hepatocarcinoma cells.

Anticancer research 20100201

Sp1 coordinately regulates de novo lipogenesis and proliferation in cancer cells.

International journal of cancer 20100115

Mithramycin inhibits human epithelial carcinoma cell proliferation and migration involving downregulation of Eps8 expression.

Chemico-biological interactions 20100105

Profiling and comparing transcription factors activated in non-metastatic and metastatic nasopharyngeal carcinoma cells.

Journal of cellular biochemistry 20100101

PPARbeta/delta regulates the human SIRT1 gene transcription via Sp1.

Endocrine journal 20100101

Transcription of human resistin gene involves an interaction of Sp1 with peroxisome proliferator-activating receptor gamma (PPARgamma).

PloS one 20100101

RNA interference (RNAi) screening approach identifies agents that enhance paclitaxel activity in breast cancer cells.

Breast cancer research : BCR 20100101

Induction of phospho-Thr-172 AMPK in 3T3-L1 adipocytes exposed to cold or treated with anisomycin, mithramycin A, and ionic compounds.

Cryo letters 20100101

Genetic diversity and striatal gene networks: focus on the heterogeneous stock-collaborative cross (HS-CC) mouse.

BMC genomics 20100101

PMA up-regulates the transcription of Axl by AP-1 transcription factor binding to TRE sequences via the MAPK cascade in leukaemia cells.

Biology of the cell 20100101

Transcriptional activation of REST by Sp1 in Huntington's disease models.

PloS one 20100101

[Lung carcinoma with paraneoplastic hyponatremia and hypercalcemia].

Medicinski pregled 20100101

Mithramycin protects against dopaminergic neurotoxicity in the mouse brain after administration of methamphetamine.

Brain research 20091208

Reactive oxygen species-generating mitochondrial DNA mutation up-regulates hypoxia-inducible factor-1alpha gene transcription via phosphatidylinositol 3-kinase-Akt/protein kinase C/histone deacetylase pathway.

The Journal of biological chemistry 20091127

Identification and characterization of the human xylosyltransferase I gene promoter region.

The Journal of biological chemistry 20091106

Adenosine diphosphate-ribosylation factor 6 is required for epidermal growth factor-induced glioblastoma cell proliferation.

Cancer 20091101

Valproic acid induces functional heat-shock protein 70 via Class I histone deacetylase inhibition in cortical neurons: a potential role of Sp1 acetylation.

Journal of neurochemistry 20091101

Increased expression of IL-33 in severe asthma: evidence of expression by airway smooth muscle cells.

Journal of immunology (Baltimore, Md. : 1950) 20091015

Increase in gamma-globin mRNA content in human erythroid cells treated with angelicin analogs.

International journal of hematology 20091001

Response of the ABCG2 promoter in T47D cells and BeWo cells to sex hormone treatment.

Molecular biology reports 20090901

Mutated ras induced PLD1 gene expression through increased Sp1 transcription factor.

Nagoya journal of medical science 20090901

Expression of miR-210 during erythroid differentiation and induction of gamma-globin gene expression.

BMB reports 20090831

Potential of DNMT and its Epigenetic Regulation for Lung Cancer Therapy.

Current genomics 20090801

Epidermal growth factor increases claudin-4 expression mediated by Sp1 elevation in MDCK cells.

Biochemical and biophysical research communications 20090703

Effects of polyamines on the DNA-reactive properties of dimeric mithramycin complexed with cobalt(II): implications for anticancer therapy.

Biochemistry 20090609

Crystal structure of Baeyer-Villiger monooxygenase MtmOIV, the key enzyme of the mithramycin biosynthetic pathway .

Biochemistry 20090602

Fetal Hemoglobin Inducers from the Natural World: A Novel Approach for Identification of Drugs for the Treatment of {beta}-Thalassemia and Sickle-Cell Anemia.

Evidence-based complementary and alternative medicine : eCAM 20090601

Antitumor compounds from marine actinomycetes.

Marine drugs 20090601

ZBP-89 and Sp3 down-regulate while NF-Y up-regulates SOX18 promoter activity in HeLa cells.

Molecular biology reports 20090501

Spermatogenesis-related ring finger gene ZNF230 promoter: identification and functional analysis.

Molecular biology reports 20090501

Cancer-induced hypercalcemia.

Anticancer research 20090501

The penetrative abilities of liposomal mithramycin in explanted keloids.

Clinical and experimental dermatology 20090401

Single and double emulsion manufacturing techniques of an amphiphilic drug in PLGA nanoparticles: formulations of mithramycin and bioactivity.

Journal of pharmaceutical sciences 20090401

Structural and functional analysis of the bovine Mx1 promoter.

Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 20090401

Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells.

The Journal of biological chemistry 20090313

Inhibition of a Zn(II)-containing enzyme, alcohol dehydrogenase, by anticancer antibiotics, mithramycin and chromomycin A3.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20090301

Endothelin-1 stimulates interleukin-6 secretion from 3T3-L1 adipocytes.

Biochimica et biophysica acta 20090301

Peroxisome proliferator-activated receptor gamma activates fas ligand gene promoter inducing apoptosis in human breast cancer cells.

Breast cancer research and treatment 20090201

Pitavastatin induces PON1 expression through p44/42 mitogen-activated protein kinase signaling cascade in Huh7 cells.

Atherosclerosis 20090201

Mechanism of inhibition of tumor angiogenesis by beta-hydroxyisovalerylshikonin.

Cancer science 20090201

Identification of a cigarette smoke-responsive region in the distal MMP-1 promoter.

American journal of respiratory cell and molecular biology 20090101

TRIP-Br2 promotes oncogenesis in nude mice and is frequently overexpressed in multiple human tumors.

Journal of translational medicine 20090101

High tandem repeat content in the genome of the short-lived annual fish Nothobranchius furzeri: a new vertebrate model for aging research.

Genome biology 20090101

Binding of PFOS to serum albumin and DNA: insight into the molecular toxicity of perfluorochemicals.

BMC molecular biology 20090101

Transcriptional regulation of neutral sphingomyelinase 2 gene expression of a human breast cancer cell line, MCF-7, induced by the anti-cancer drug, daunorubicin.

Biochimica et biophysica acta 20090101

Overexpression of transcription factor Sp1 leads to gene expression perturbations and cell cycle inhibition.

PloS one 20090101

Evaluation of molecular descriptors for antitumor drugs with respect to noncovalent binding to DNA and antiproliferative activity.

BMC pharmacology 20090101

Anti-leukemia activity of MS-275 histone deacetylase inhibitor implicates 4-1BBL/4-1BB immunomodulatory functions.

PloS one 20090101

Transcription factor Sp1 induces ADAM17 and contributes to tumor cell invasiveness under hypoxia.

Journal of experimental & clinical cancer research : CR 20090101

Akt and SHIP modulate Francisella escape from the phagosome and induction of the Fas-mediated death pathway.

PloS one 20090101

Drug-induced hematologic syndromes.

Advances in hematology 20090101

Overexpression of Prdx6 and resistance to peroxide-induced death in Hepa1-6 cells: Prdx suppression increases apoptosis.

Redox report : communications in free radical research 20090101

Ocular surface tumors.

Oman journal of ophthalmology 20090101

Pharmacologic and nonpharmacologic options for the management of HIV infection during pregnancy.

HIV/AIDS (Auckland, N.Z.) 20090101

Quercetin sensitizes human hepatoma cells to TRAIL-induced apoptosis via Sp1-mediated DR5 up-regulation and proteasome-mediated c-FLIPS down-regulation.

Journal of cellular biochemistry 20081215

Retinoic acid-dependent activation of the polycystic kidney disease-1 (PKD1) promoter.

American journal of physiology. Renal physiology 20081201

High glucose induces transactivation of the human paraoxonase 1 gene in hepatocytes.

Metabolism: clinical and experimental 20081201

Involvement of epigenetic mechanisms in the regulation of secreted phospholipase A2 expressions in Jurkat leukemia cells.

Neoplasia (New York, N.Y.) 20081101

Hypoxia upregulates expression of human endosialin gene via hypoxia-inducible factor 2.

British journal of cancer 20081021

Studies on the synthesis of durhamycin A: stereoselective synthesis of a model aglycone.

Organic letters 20081016

p53-independent mechanisms regulate the P2-MDM2 promoter in adult astrocytic tumours.

British journal of cancer 20081007

DAPK2 is a novel E2F1/KLF6 target gene involved in their proapoptotic function.

Oncogene 20080925

Generation of new derivatives of the antitumor antibiotic mithramycin by altering the glycosylation pattern through combinatorial biosynthesis.

Chembiochem : a European journal of chemical biology 20080922

Epigenetic silencing of cell adhesion molecule 1 in different cancer progenitor cells of transgenic c-Myc and c-Raf mouse lung tumors.

Cancer research 20080915

NFkappaB mediates IL-1beta-induced down-regulation of TbetaRII through the modulation of Sp3 expression.

Journal of cellular and molecular medicine 20080901

E1AF promotes mithramycin A-induced Huh-7 cell apoptosis depending on its DNA-binding domain.

Archives of biochemistry and biophysics 20080901

Mithramycin SK modulates polyploidy and cell death in colon carcinoma cells.

Molecular cancer therapeutics 20080901

Transcriptional regulation of autocrine IL-6 expression in multiple myeloma cells.

Cellular signalling 20080801

The effects of local DNA sequence on the interaction of ligands with their preferred binding sites.

Biochimie 20080701

Transcriptional regulation of the human CYP46A1 brain-specific expression by Sp transcription factors.

Journal of neurochemistry 20080701

Targeted inhibition of Sp1-mediated transcription for antiangiogenic therapy of metastatic human gastric cancer in orthotopic nude mouse models.

International journal of oncology 20080701

Peroxisome proliferator-activated receptor gamma inhibits follicular and anaplastic thyroid carcinoma cells growth by upregulating p21Cip1/WAF1 gene in a Sp1-dependent manner.

Endocrine-related cancer 20080601

The human receptor tyrosine kinase Axl gene--promoter characterization and regulation of constitutive expression by Sp1, Sp3 and CpG methylation.

Bioscience reports 20080601

Studies of sequence-specific DNA binding, DNA cleavage, and topoisomerase I inhibition by the dimeric chromomycin A3 complexed with Fe(II).

Biochemistry 20080520

SP1-regulated p27/Kip1 gene expression is involved in terbinafine-induced human A431 cancer cell differentiation: an in vitro and in vivo study.

Biochemical pharmacology 20080501

SP1 regulates a human SNAP-25 gene expression.

Journal of neurochemistry 20080401

Multiple functions of generic drugs: future perspectives of aureolic acid group of anti-cancer antibiotics and non-steroidal anti-inflammatory drugs.

Mini reviews in medicinal chemistry 20080401

Self-association of the anionic form of the DNA-binding anticancer drug mithramycin.

The journal of physical chemistry. B 20080313

Histone deacetylase inhibitors upregulate p57Kip2 level by enhancing its expression through Sp1 transcription factor.

Carcinogenesis 20080301

Regulation of RON tyrosine kinase-mediated invasion of breast cancer cells.

The Journal of biological chemistry 20080227

Cloning and characterization of the promoter of Hugl-2, the human homologue of Drosophila lethal giant larvae (lgl) polarity gene.

Biochemical and biophysical research communications 20080222

Bortezomib induces DNA hypomethylation and silenced gene transcription by interfering with Sp1/NF-kappaB-dependent DNA methyltransferase activity in acute myeloid leukemia.

Blood 20080215

Mithramycin analogues generated by combinatorial biosynthesis show improved bioactivity.

Journal of natural products 20080201

Lipopolysaccharide induces hypoxia-inducible factor-1 alpha mRNA expression and activation via NADPH oxidase and Sp1-dependent pathway in BV2 murine microglial cells.

Neuroscience letters 20080131

Expression and regulation of CCR1 by airway smooth muscle cells in asthma.

Journal of immunology (Baltimore, Md. : 1950) 20080115

Sp1-mediated transcriptional regulation of NFBD1/MDC1 plays a critical role in DNA damage response pathway.

Genes to cells : devoted to molecular & cellular mechanisms 20080101

Medical treatment of malignancy-associated hypercalcemia.

Current medicinal chemistry 20080101

DNA demethylation-dependent enhancement of toll-like receptor-2 gene expression in cystic fibrosis epithelial cells involves SP1-activated transcription.

BMC molecular biology 20080101

Glutamine induces heat shock protein expression via O-glycosylation and phosphorylation of HSF-1 and Sp1.

JPEN. Journal of parenteral and enteral nutrition 20080101

Sp1 is involved in H2O2-induced PUMA gene expression and apoptosis in colorectal cancer cells.

Journal of experimental & clinical cancer research : CR 20080101

M-CSF signals through the MAPK/ERK pathway via Sp1 to induce VEGF production and induces angiogenesis in vivo.

PloS one 20080101

Synergistic induction of CX3CL1 by TNF alpha and IFN gamma in osteoblasts from rheumatoid arthritis: involvement of NF-kappa B and STAT-1 signaling pathways.

Journal of inflammation research 20080101

Therapeutic inhibition of Sp1 expression in growing tumors by mithramycin a correlates directly with potent antiangiogenic effects on human pancreatic cancer.

Cancer 20071215

Control of core 2 beta1,6 N-acetylglucosaminyltransferase-I transcription by Sp1 in lymphocytes and epithelial cells.

Glycoconjugate journal 20071201

REST is a key regulator in brain-specific homeobox gene expression during neuronal differentiation.

Journal of neurochemistry 20071201

Evolutionary cytogenetics of the Hoplias lacerdae, Miranda Ribeiro, 1908 group. A particular pathway concerning the other Erythrinidae fish.

Brazilian journal of biology = Revista brasleira de biologia 20071201

PMA stimulates MUC5B gene expression through an Sp1-based mechanism in airway epithelial cells.

American journal of respiratory cell and molecular biology 20071101

K(v)1.5 potassium channel gene regulation by Sp1 transcription factor and oxidative stress.

American journal of physiology. Heart and circulatory physiology 20071101

Critical roles of Sp1 in gene expression of human and rat H+/organic cation antiporter MATE1.

American journal of physiology. Renal physiology 20071101

Mithramycin A inhibits DNA methyltransferase and metastasis potential of lung cancer cells.

Anti-cancer drugs 20071101

Mithramycin inhibits etoposide resistance in glucose-deprived HT-29 human colon carcinoma cells.

Journal of microbiology and biotechnology 20071101

Physical and functional interactions between liver X receptor/retinoid X receptor and Sp1 modulate the transcriptional induction of the human ATP binding cassette transporter A1 gene by oxysterols and retinoids.

Biochemistry 20071016

Characterization of the SOCS3 promoter response to prostaglandin E2 in T47D cells.

Molecular endocrinology (Baltimore, Md.) 20071001

Specificity protein 1 and Smad-dependent regulation of human heme oxygenase-1 gene by transforming growth factor-beta1 in renal epithelial cells.

American journal of physiology. Renal physiology 20070901

TNF-alpha induces MUC1 gene transcription in lung epithelial cells: its signaling pathway and biological implication.

American journal of physiology. Lung cellular and molecular physiology 20070901

Transcriptional control of human T-BET expression: the role of Sp1.

European journal of immunology 20070901

Involvement of a chromomycin ABC transporter system in secretion of a deacetylated precursor during chromomycin biosynthesis.

Microbiology (Reading, England) 20070901

Analysis of CCN2 promoter activity in PANC-1 cells: regulation by ras/MEK/ERK.

Journal of cell communication and signaling 20070901

Hypoxic condition- and high cell density-induced expression of Redd1 is regulated by activation of hypoxia-inducible factor-1alpha and Sp1 through the phosphatidylinositol 3-kinase/Akt signaling pathway.

Cellular signalling 20070701

Glucose enhances protein tyrosine phosphatase 1B gene transcription in hepatocytes.

Molecular and cellular endocrinology 20070615

Modulation of nucleosome dynamics in Huntington's disease.

Human molecular genetics 20070515

Molecular basis of the synergistic antiangiogenic activity of bevacizumab and mithramycin A.

Cancer research 20070515

Identification and characterization of a novel antisense RNA transcribed from the opposite strand of the human blood group ABO gene.

Transfusion 20070501

Sp1 and Sp3 regulate basal transcription of the survivin gene.

Biochemical and biophysical research communications 20070427

Structure of the human 5-HT7 receptor gene and characterization of its promoter region.

Gene 20070415

PKCepsilon is essential for gelsolin expression by histone deacetylase inhibitor apicidin in human cervix cancer cells.

Biochemical and biophysical research communications 20070316

Decitabine and vitamin D3 differentially affect hematopoietic transcription factors to induce monocytic differentiation.

International journal of oncology 20070201

Molecular mechanisms of transactivation and doxorubicin-mediated repression of survivin gene in cancer cells.

The Journal of biological chemistry 20070126

Elevated gadd153/chop expression during resveratrol-induced apoptosis in human colon cancer cells.

Biochemical pharmacology 20070101

Association of antitumor antibiotics, mithramycin and chromomycin, with Zn(II).

Journal of inorganic biochemistry 20070101

Distinctive epidermal growth factor receptor/extracellular regulated kinase-independent and -dependent signaling pathways in the induction of airway mucin 5B and mucin 5AC expression by phorbol 12-myristate 13-acetate.

The American journal of pathology 20070101

Sp1 is essential for p16 expression in human diploid fibroblasts during senescence.

PloS one 20070101

Rad9 modulates the P21WAF1 pathway by direct association with p53.

BMC molecular biology 20070101

Identification of potential therapeutic drugs for huntington's disease using Caenorhabditis elegans.

PloS one 20070101

Sp1 expression is disrupted in schizophrenia; a possible mechanism for the abnormal expression of mitochondrial complex I genes, NDUFV1 and NDUFV2.

PloS one 20070101

LPS induces IL-10 production by human alveolar macrophages via MAPKinases- and Sp1-dependent mechanisms.

Respiratory research 20070101

Responses of hyperthermophilic crenarchaea to UV irradiation.

Genome biology 20070101

Role of SP-1 in SDS-induced adipose differentiation related protein synthesis in human keratinocytes.

Gene regulation and systems biology 20070101

Regulation of the prepronociceptin gene and its effect on neuronal differentiation.

Gene 20061215

ESET/SETDB1 gene expression and histone H3 (K9) trimethylation in Huntington's disease.

Proceedings of the National Academy of Sciences of the United States of America 20061212

Estrogen receptor regulates insulin-like growth factor-I receptor gene expression in breast tumor cells: involvement of transcription factor Sp1.

The Journal of endocrinology 20061201

Sp1 elements regulate transcriptional activity within the murine Toll-like receptor 4 promoter.

Surgical infections 20061201

The aureolic acid family of antitumor compounds: structure, mode of action, biosynthesis, and novel derivatives.

Applied microbiology and biotechnology 20061101

Mithramycin A sensitizes cancer cells to TRAIL-mediated apoptosis by down-regulation of XIAP gene promoter through Sp1 sites.

Molecular cancer therapeutics 20061101

Involvement of Sp1 in lipopolysaccharide-induced expression of HDC mRNA in RAW 264 cells.

Biochemical and biophysical research communications 20061020

SP1 and SP3 mediate progesterone-dependent induction of the 17beta hydroxysteroid dehydrogenase type 2 gene in human endometrium.

Biology of reproduction 20061001

Sp1 mediates repression of the resistin gene by PPARgamma agonists in 3T3-L1 adipocytes.

Biochemical and biophysical research communications 20060915

Premithramycinone G, an early shunt product of the mithramycin biosynthetic pathway accumulated upon inactivation of oxygenase MtmOII.

Angewandte Chemie (International ed. in English) 20060825

Regulation of heme oxygenase-1 gene expression through the phosphatidylinositol 3-kinase/PKC-zeta pathway and Sp1.

Free radical biology & medicine 20060715

GC-selective DNA-binding antibiotic, mithramycin A, reveals multiple points of control in the regulation of Hdm2 protein synthesis.

Oncogene 20060713

Sp1 is up-regulated in cellular and transgenic models of Huntington disease, and its reduction is neuroprotective.

The Journal of biological chemistry 20060616

Sp1 family of transcription factors regulates the human alpha2 (XI) collagen gene (COL11A2) in Saos-2 osteoblastic cells.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20060501

Histone deacetylase inhibitor apicidin induces cyclin E expression through Sp1 sites.

Biochemical and biophysical research communications 20060421

Endogenous S-nitrosoglutathione modifies 5-lipoxygenase expression in airway epithelial cells.

American journal of respiratory cell and molecular biology 20060401

Tandem Sp1/Sp3 sites together with an Ets-1 site cooperate to mediate alpha11 integrin chain expression in mesenchymal cells.

Matrix biology : journal of the International Society for Matrix Biology 20060301

Expression of myelin basic protein in two oligodendroglial cell lines is modulated by apotransferrin through different transcription factors.

Journal of neuroscience research 20060301

Transforming growth factor-beta1 induces tissue inhibitor of metalloproteinase-1 expression via activation of extracellular signal-regulated kinase and Sp1 in human fibrosarcoma cells.

Molecular cancer research : MCR 20060301

Anti-tumour activity in non-small cell lung cancer models and toxicity profiles for novel ruthenium(II) based organo-metallic compounds.

Biochemical pharmacology 20060214

7,12-Dimethylbenzanthracene-dependent transcriptional regulation of adenomatous polyposis coli (APC) gene expression in normal breast epithelial cells is mediated by GC-box binding protein Sp3.

Carcinogenesis 20060201

Role of receptor for advanced glycation end-products and signalling events in advanced glycation end-product-induced monocyte chemoattractant protein-1 expression in differentiated mouse podocytes.

Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20060201

Peroxisome proliferator-activated receptor-gamma transcriptionally up-regulates hormone-sensitive lipase via the involvement of specificity protein-1.

Endocrinology 20060201

Distinct pathways regulate proapoptotic Nix and BNip3 in cardiac stress.

The Journal of biological chemistry 20060120

Mithramycin A activates Fas death pathway in leukemic cell lines.

Apoptosis : an international journal on programmed cell death 20060101

The induction of CCN2 by TGFbeta1 involves Ets-1.

Arthritis research & therapy 20060101

Normocalcemic parathyroid carcinoma: an unusual clinical presentation.

World journal of surgical oncology 20060101

Novel GC-rich DNA-binding compound produced by a genetically engineered mutant of the mithramycin producer Streptomyces argillaceus exhibits improved transcriptional repressor activity: implications for cancer therapy.

Nucleic acids research 20060101

Cellular response to 5-fluorouracil (5-FU) in 5-FU-resistant colon cancer cell lines during treatment and recovery.

Molecular cancer 20060101

Wild-type huntingtin ameliorates striatal neuronal atrophy but does not prevent other abnormalities in the YAC128 mouse model of Huntington disease.

BMC neuroscience 20060101

GC-rich sequences in the 5-lipoxygenase gene promoter are required for expression in Mono Mac 6 cells, characterization of a novel Sp1 binding site.

Biochimica et biophysica acta 20051230

Characterization of kinetics and products of the Baeyer-Villiger oxygenase MtmOIV, the key enzyme of the biosynthetic pathway toward the natural product anticancer drug mithramycin from Streptomyces argillaceus.

Journal of the American Chemical Society 20051221

Inhibition of collagen gene expression in systemic sclerosis dermal fibroblasts by mithramycin.

Annals of the rheumatic diseases 20051201

Ciglitazone-induced p27 gene transcriptional activity is mediated through Sp1 and is negatively regulated by the MAPK signaling pathway.

Cellular signalling 20051201

DNA structural similarity in the 2:1 complexes of the antitumor drugs trabectedin (Yondelis) and chromomycin A3 with an oligonucleotide sequence containing two adjacent TGG binding sites on opposing strands.

Molecular pharmacology 20051201

Prostaglandin E2 enhances neurotrophin-4 production via EP3 receptor in human keratinocytes.

The Journal of pharmacology and experimental therapeutics 20051101

Crystallization and X-ray diffraction properties of Baeyer-Villiger monooxygenase MtmOIV from the mithramycin biosynthetic pathway in Streptomyces argillaceus.

Acta crystallographica. Section F, Structural biology and crystallization communications 20051101

COX-2 inhibitors suppress integrin alpha5 expression in human lung carcinoma cells through activation of Erk: involvement of Sp1 and AP-1 sites.

International journal of cancer 20050910

Characterization of the human peptide transporter PEPT1 promoter: Sp1 functions as a basal transcriptional regulator of human PEPT1.

American journal of physiology. Gastrointestinal and liver physiology 20050901

Alpha-tocopherol-mediated caspase-3 up-regulation enhances susceptibility to apoptotic stimuli.

Biochemical and biophysical research communications 20050826

Upregulation of MUC6 mucin gene expression by NFkappaB and Sp factors.

Biochemical and biophysical research communications 20050812

Neutrophil elastase stimulates MUC1 gene expression through increased Sp1 binding to the MUC1 promoter.

American journal of physiology. Lung cellular and molecular physiology 20050801

Monoamine oxidase-A is a major target gene for glucocorticoids in human skeletal muscle cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20050801

Regulation of human resistin gene expression in cell systems: an important role of stimulatory protein 1 interaction with a common promoter polymorphic site.

Diabetologia 20050601

Analysis of human UDP-glucose dehydrogenase gene promoter: identification of an Sp1 binding site crucial for the expression of the large transcript.

Journal of biochemistry 20050601

Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells.

FEBS letters 20050523

Molecular dynamics study on the interaction of a mithramycin dimer with a decanucleotide duplex.

The journal of physical chemistry. B 20050519

Garlic arrests MDA-MB-435 cancer cells in mitosis, phosphorylates the proapoptotic BH3-only protein BimEL and induces apoptosis.

British journal of cancer 20050509

TGF-beta-induced expression of tissue inhibitor of metalloproteinases-3 gene in chondrocytes is mediated by extracellular signal-regulated kinase pathway and Sp1 transcription factor.

Journal of cellular physiology 20050501

Characterization of the basal promoter element of the human type 5 17beta-hydroxysteroid dehydrogenase gene.

Biochimica et biophysica acta 20050501

Elucidation of the glycosylation sequence of mithramycin biosynthesis: isolation of 3A-deolivosylpremithramycin B and its conversion to premithramycin B by glycosyltransferase MtmGII.

Chembiochem : a European journal of chemical biology 20050401

Expression of the human melanocortin-4 receptor gene is controlled by several members of the Sp transcription factor family.

Journal of molecular endocrinology 20050401

Sp1 and Sp3 transcription factors upregulate the proximal promoter of the human prostate-specific antigen gene in prostate cancer cells.

Archives of biochemistry and biophysics 20050315

Binding of (MTR)2Zn2+ complex to chromatin: a comparison with (MTR)2Mg2+ complex.

Journal of inorganic biochemistry 20050301

Effect of pitavastatin on transactivation of human serum paraoxonase 1 gene.

Metabolism: clinical and experimental 20050201

Ets1 is an effector of protein kinase Calpha in cancer cells.

Oncogene 20050120

Transcriptional regulation of the human DNA methyltransferase 3A and 3B genes by Sp3 and Sp1 zinc finger proteins.

The Biochemical journal 20050115

Calculation of binding length of base-specific DNA dyes by comparison of sequence and flow cytometric data. Application to Oryza sativa and Arabidopsis thaliana.

Journal of theoretical biology 20050107

Both Sp1 and Smad participate in mediating TGF-beta1-induced HGF receptor expression in renal epithelial cells.

American journal of physiology. Renal physiology 20050101

Effect of complex formation between Zn2+ ions and the anticancer drug mithramycin upon enzymatic activity of zinc(II)-dependent alcohol dehydrogenase.

Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry 20050101

Mithramycin downregulates proinflammatory cytokine-induced matrix metalloproteinase gene expression in articular chondrocytes.

Arthritis research & therapy 20050101

Bioactive C-glycosides from bacterial secondary metabolism.

Current topics in medicinal chemistry 20050101

Inhibition of p53-mediated transcriptional responses by mithramycin A.

Oncogene 20041209

Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells.

Biochemical and biophysical research communications 20041126

Chemotherapy for the brain: the antitumor antibiotic mithramycin prolongs survival in a mouse model of Huntington's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20041117

Transforming growth factor beta stimulation of biglycan gene expression is potentially mediated by sp1 binding factors.

Journal of cellular biochemistry 20041015

Transforming growth factor-beta1-dependent activation of Smad2/3 and up-regulation of PAI-1 expression is negatively regulated by Src in SKOV-3 human ovarian cancer cells.

Journal of cellular biochemistry 20041015

Roles of Sp1 and protein kinase C in regulation of human serum paraoxonase 1 (PON1) gene transcription in HepG2 cells.

Atherosclerosis 20041001

Transcriptional regulation of the human beta-1,4-galactosyltransferase V gene in cancer cells: essential role of transcription factor Sp1.

The Journal of biological chemistry 20040917

Tailoring modification of deoxysugars during biosynthesis of the antitumour drug chromomycin A by Streptomyces griseus ssp. griseus.

Molecular microbiology 20040801

Rapamycin-mediated induction of gamma-globin mRNA accumulation in human erythroid cells.

British journal of haematology 20040801

Involvement of Sp1 and SREBP-1a in transcriptional activation of the LDL receptor gene by insulin and LH in cultured porcine granulosa-luteal cells.

American journal of physiology. Endocrinology and metabolism 20040701

Regulation of the human secretin gene is controlled by the combined effects of CpG methylation, Sp1/Sp3 ratio, and the E-box element.

Molecular endocrinology (Baltimore, Md.) 20040701

Systematic review of bisphosphonates for hypercalcaemia of malignancy.

Palliative medicine 20040701

The anticancer drug mithramycin A sensitises tumour cells to apoptosis induced by tumour necrosis factor (TNF).

British journal of cancer 20040517

Concentration-dependent effects of endogenous S-nitrosoglutathione on gene regulation by specificity proteins Sp3 and Sp1.

The Biochemical journal 20040515

Tumor necrosis factor-alpha induces fractalkine expression preferentially in arterial endothelial cells and mithramycin A suppresses TNF-alpha-induced fractalkine expression.

The American journal of pathology 20040501

SP-transcription factors are involved in basal MVP promoter activity and its stimulation by HDAC inhibitors.

Biochemical and biophysical research communications 20040423

N-terminal tail domains of core histones in nucleosome block the access of anticancer drugs, mithramycin and daunomycin, to the nucleosomal DNA.

Biophysical chemistry 20040401

Identification and characterization of a phorbol ester-responsive element in the murine 8S-lipoxygenase gene.

The Journal of biological chemistry 20040319

Tenascin-C upregulation by transforming growth factor-beta in human dermal fibroblasts involves Smad3, Sp1, and Ets1.

Oncogene 20040304

MtmMII-mediated C-methylation during biosynthesis of the antitumor drug mithramycin is essential for biological activity and DNA-drug interaction.

The Journal of biological chemistry 20040227

bcl-2 induction of urokinase plasminogen activator receptor expression in human cancer cells through Sp1 activation: involvement of ERK1/ERK2 activity.

The Journal of biological chemistry 20040220

Bucillamine induces the synthesis of vascular endothelial growth factor dose-dependently in systemic sclerosis fibroblasts via nuclear factor-kappaB and simian virus 40 promoter factor 1 pathways.

Molecular pharmacology 20040201

Cloning, characterisation and identification of several polymorphisms in the promoter region of the human alpha2B-adrenergic receptor gene.

Biochemical pharmacology 20040201

A systematic review of the role of bisphosphonates in metastatic disease.

Health technology assessment (Winchester, England) 20040101

Aureolic acids: similar antibiotics with different biosynthetic gene clusters.

Chemistry & biology 20040101

Biosynthesis of the antitumor chromomycin A3 in Streptomyces griseus: analysis of the gene cluster and rational design of novel chromomycin analogs.

Chemistry & biology 20040101

Asbestos induces tissue factor in Beas-2B human lung bronchial epithelial cells in vitro.

Lung 20040101

[Metabolic emergencies in the oncology patient].

Anales del sistema sanitario de Navarra 20040101

Involvement of reactive oxygen species and SP-1 in fibronectin production by oxidized LDL.

Biochemical and biophysical research communications 20031017

Modulation of Sp1 and Sp3 in lung epithelial cells regulates ClC-2 chloride channel expression.

American journal of respiratory cell and molecular biology 20031001

Expression of p21(WAF1/Cip1) through Sp1 sites by histone deacetylase inhibitor apicidin requires PI 3-kinase-PKC epsilon signaling pathway.

Oncogene 20030904

Accumulation of gamma-globin mRNA in human erythroid cells treated with angelicin.

European journal of haematology 20030901

Mithramycin induces fetal hemoglobin production in normal and thalassemic human erythroid precursor cells.

Blood 20030815

Enhanced binding of Sp1/Sp3 transcription factors mediates the hyperoxia-induced increased expression of the lung type I cell gene T1alpha.

Journal of cellular biochemistry 20030801

Inhibition of c-src transcription by mithramycin: structure-activity relationships of biosynthetically produced mithramycin analogues using the c-src promoter as target.

Biochemistry 20030715

Association of chromatin with anticancer antibiotics, mithramycin and chromomycin A3.

Bioorganic & medicinal chemistry 20030703

The large linear plasmid pSLA2-L of Streptomyces rochei has an unusually condensed gene organization for secondary metabolism.

Molecular microbiology 20030601

Furoquinoline alkaloids and cytotoxic constituents from the leaves of Melicope semecarpifolia.

Planta medica 20030601

Stereoselective synthesis of functionalized precursors of the CDEF and CDE 2,6-dideoxy-tetra- and trisaccharide units of durhamycins A and B.

Organic letters 20030529

Sp family of transcription factors is involved in valproic acid-induced expression of Galphai2.

The Journal of biological chemistry 20030516

Mithramycin SK, a novel antitumor drug with improved therapeutic index, mithramycin SA, and demycarosyl-mithramycin SK: three new products generated in the mithramycin producer Streptomyces argillaceus through combinatorial biosynthesis.

Journal of the American Chemical Society 20030514

Induction of nonmuscle myosin heavy chain II-C by butyrate in RAW 264.7 mouse macrophages.

The Journal of biological chemistry 20030425

Apoptosis enzyme-linked immunosorbent assay distinguishes anticancer drugs from toxic chemicals and predicts drug synergism.

Chemico-biological interactions 20030306

Expression of the hypoxia marker carbonic anhydrase IX is critically dependent on SP1 activity. Identification of a novel type of hypoxia-responsive enhancer.

Cancer research 20030301

Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells.

The Journal of biological chemistry 20030207

Association of anticancer drug mithramycin with H1-depleted chromatin: a comparison with native chromatin.

Journal of inorganic biochemistry 20030201

Essential role of an activator protein-2 (AP-2)/specificity protein 1 (Sp1) cluster in the UVB-mediated induction of the human vascular endothelial growth factor in HaCaT keratinocytes.

The Biochemical journal 20030115

Sp1 and Sp3 transcription factors synergistically regulate HGF receptor gene expression in kidney.

American journal of physiology. Renal physiology 20030101

The diagnosis and management of hypercalcaemia.

Annals of the Academy of Medicine, Singapore 20030101

c-Myc oncoprotein: cell cycle-related events and new therapeutic challenges in cancer and cardiovascular diseases.

Cell cycle (Georgetown, Tex.) 20030101

Pervilleine F, a new tropane alkaloid aromatic ester that reverses multidrug resistance.

Anticancer research 20030101

Anthracyclines.

Cancer chemotherapy and biological response modifiers 20030101

Current management strategies for hypercalcemia.

Treatments in endocrinology 20030101

Engaged urokinase receptors enhance tumor breast cell migration and invasion by upregulating alpha(v)beta5 vitronectin receptor cell surface expression.

International journal of cancer 20021220

The Sp1 transcription factor contributes to the tumor necrosis factor-induced expression of the angiogenic factor thymidine phosphorylase in human colon carcinoma cells.

Oncogene 20021205

Transcriptional regulation of the rat type IIA phospholipase A2 gene by cAMP and interleukin-1beta in vascular smooth muscle cells: interplay of the CCAAT/enhancer binding protein (C/EBP), nuclear factor-kappaB and Ets transcription factors.

The Biochemical journal 20021201

Functional role of Egr-1 mediating VEGF-induced tissue factor expression in the retinal capillary endothelium.

Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie 20021201

Expression of estrogen receptor subtypes and neuronal nitric oxide synthase in neutrophils from women and men: regulation by estrogen.

Cardiovascular research 20021001

Vascular smooth muscle alpha-actin gene transcription during myofibroblast differentiation requires Sp1/3 protein binding proximal to the MCAT enhancer.

The Journal of biological chemistry 20020927

The role of Sp1 in BMP2-up-regulated Erk2 gene expression.

Biochemical and biophysical research communications 20020913

Sp1 and Sp3 transcription factors mediate malondialdehyde-induced collagen alpha 1(I) gene expression in cultured hepatic stellate cells.

The Journal of biological chemistry 20020823

Durhamycin A, a potent inhibitor of HIV Tat transactivation.

Journal of natural products 20020801

Rationally designed glycosylated premithramycins: hybrid aromatic polyketides using genes from three different biosynthetic pathways.

Journal of the American Chemical Society 20020529

Ubiquitin (UbC) expression in muscle cells is increased by glucocorticoids through a mechanism involving Sp1 and MEK1.

The Journal of biological chemistry 20020510

Treatment of malignant hypercalcaemia.

Expert opinion on pharmacotherapy 20020501

Activation of dynamin I gene expression by Sp1 and Sp3 is required for neuronal differentiation of N1E-115 cells.

The Journal of biological chemistry 20020405

Identification and functional analysis of the rat caspase-3 gene promoter.

The Journal of biological chemistry 20020308

Ketopremithramycins and ketomithramycins, four new aureolic acid-type compounds obtained upon inactivation of two genes involved in the biosynthesis of the deoxysugar moieties of the antitumor drug mithramycin by Streptomyces argillaceus, reveal novel insights into post-PKS tailoring steps of the mithramycin biosynthetic pathway.

Journal of the American Chemical Society 20020227

Chemotherapeutic stress mediated by certain antitumor antibiotics induces an atypical CD69+ surface phenotype in peripheral T-lymphocytes.

International immunopharmacology 20020201

Modern therapy for Paget's disease of bone: focus on bisphosphonates.

Treatments in endocrinology 20020101

The transcription factors Sp1 and Sp3 are required for human angiotensin II type 1 receptor gene expression in H295-R cells.

Biochimica et biophysica acta 20011230

Local delivery of mithramycin restores vascular reactivity and inhibits neointimal formation in injured arteries and vascular grafts.

Journal of controlled release : official journal of the Controlled Release Society 20011213

Conventional treatment of hypercalcemia of malignancy.

American journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists 20011115

Transactivation via RAR/RXR-Sp1 interaction: characterization of binding between Sp1 and GC box motif.

Molecular endocrinology (Baltimore, Md.) 20011001

Use of isogenic human cancer cells for high-throughput screening and drug discovery.

Nature biotechnology 20011001

Paget's disease of the spine and its management.

European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society 20011001

Reversion of transcriptional repression of Sp1 by 5 aza-2' deoxycytidine restores TGF-beta type II receptor expression in the pancreatic cancer cell line MIA PaCa-2.

Cancer research 20010815

Spl phosphorylation induced by serum stimulates the human alpha2(I) collagen gene expression.

The Journal of investigative dermatology 20010801

Sp1 involvement in the 4beta-phorbol 12-myristate 13-acetate (TPA)-mediated increase in resistance to methotrexate in Chinese hamster ovary cells.

European journal of biochemistry 20010601

Accumulation of gamma-globin mRNA and induction of erythroid differentiation after treatment of human leukaemic K562 cells with tallimustine.

British journal of haematology 20010601

Sp1 and Smad proteins cooperate to mediate transforming growth factor-beta 1-induced alpha 2(I) collagen expression in human glomerular mesangial cells.

The Journal of biological chemistry 20010309

Sequence-selective DNA binding drugs mithramycin A and chromomycin A3 are potent inhibitors of neuronal apoptosis induced by oxidative stress and DNA damage in cortical neurons.

Annals of neurology 20010301

Identification of a sugar flexible glycosyltransferase from Streptomyces olivaceus, the producer of the antitumor polyketide elloramycin.

Chemistry & biology 20010301

The mtmVUC genes of the mithramycin gene cluster in Streptomyces argillaceus are involved in the biosynthesis of the sugar moieties.

Molecular & general genetics : MGG 20010201

Intra- and intermolecular triplex DNA formation in the murine c-myb proto-oncogene promoter are inhibited by mithramycin.

Biological chemistry 20010201

The Sp family of transcription factors in the regulation of the human and mouse MUC2 gene promoters.

Cancer research 20010115

Interaction of antitumor drug, mithramycin, with chromatin.

Biochemical and biophysical research communications 20010112

Staining and measurement of DNA in bacteria.

Methods in cell biology 20010101

Alterations in osteoclast morphology following long-term 17beta-estradiol administration in the mouse.

BMC cell biology 20010101

Differential interactions of antitumor antibiotics chromomycin A(3) and mithramycin with d(TATGCATA)(2) in presence of Mg(2+).

Biopolymers 20010101

Hydroxyl radical footprinting.

Methods in molecular biology (Clifton, N.J.) 20010101

Interactions of chromomycin A3 and mithramycin with the sequence d(TAGCTAGCTA)2.

Indian journal of biochemistry & biophysics 20010101

Interaction of mithramycin with chromatin.

Indian journal of biochemistry & biophysics 20010101

The structure of mithramycin reinvestigated.

Journal of natural products 19990101

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