Home Sulfos 2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide

2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide

CAS No.:
15318-45-3
Catalog Number:
AG00HY3Z
Molecular Formula:
C12H15Cl2NO5S
Molecular Weight:
356.2222
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1g
98%(HPLC)
In Stock USA
United States
$48
- +
5g
98%(HPLC)
In Stock USA
United States
$85
- +
25g
98%(HPLC)
In Stock USA
United States
$279
- +
100g
98%(HPLC)
In Stock USA
United States
$946
- +
250g
98%(HPLC)
In Stock USA
United States
$1864
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Product Description
Catalog Number:
AG00HY3Z
Chemical Name:
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methanesulfonylphenyl)propan-2-yl]acetamide
CAS Number:
15318-45-3
Molecular Formula:
C12H15Cl2NO5S
Molecular Weight:
356.2222
MDL Number:
MFCD00467983
IUPAC Name:
2,2-dichloro-N-[(1R,2R)-1,3-dihydroxy-1-(4-methylsulfonylphenyl)propan-2-yl]acetamide
InChI:
InChI=1S/C12H15Cl2NO5S/c1-21(19,20)8-4-2-7(3-5-8)10(17)9(6-16)15-12(18)11(13)14/h2-5,9-11,16-17H,6H2,1H3,(H,15,18)/t9-,10-/m1/s1
InChI Key:
OTVAEFIXJLOWRX-NXEZZACHSA-N
SMILES:
OC[C@H]([C@@H](c1ccc(cc1)S(=O)(=O)C)O)NC(=O)C(Cl)Cl
EC Number:
239-355-3
UNII:
FLQ7571NPM
NSC Number:
758396
Properties
Complexity:
443  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
355.005g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
356.214g/mol
Monoisotopic Mass:
355.005g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
112A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.3  
Literature
Title Journal
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An insight into the drug resistance profile & mechanism of drug resistance in Neisseria gonorrhoeae. The Indian journal of medical research 20111001
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Antimicrobial resistance survey in a river receiving effluents from freshwater fish farms. Journal of applied microbiology 20070401
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Pharmacokinetics of florfenicol and its major metabolite, florfenicol amine, in rabbits. Journal of veterinary pharmacology and therapeutics 20070201
A competitive enzyme-linked immunosorbent assay for determination of chloramphenicol. Journal of veterinary pharmacology and therapeutics 20070201
Efflux-mediated resistance to florfenicol and/or chloramphenicol in Bordetella bronchiseptica: identification of a novel chloramphenicol exporter. The Journal of antimicrobial chemotherapy 20070201
Capillary electrophoretic determination of thiamphenicol in turkeys serum and its pharmacokinetic application. Journal of pharmaceutical and biomedical analysis 20070104
No detectable effect of RNA-binding protein Hfq absence in Staphylococcus aureus. BMC microbiology 20070101
Evaluation of the in vitro activity of six antimicrobial agents against Neisseria gonorrhoeae. Revista do Instituto de Medicina Tropical de Sao Paulo 20070101
A therapeutic approach in the treatment of infections of the upper airways: thiamphenicol glycinate acetylcysteinate in sequential treatment (systemic-inhalatory route). International journal of immunopathology and pharmacology 20070101
Residue depletion of florfenicol and its metabolite florfenicol amine in Swine tissues after intramuscular administration. Journal of agricultural and food chemistry 20061213
Treating experimentally induced vibriosis (Listonella anguillarum) in cod, Gadus morhua L., with florfenicol. Journal of fish diseases 20061201
Interferon-gamma mediates suppression of erythropoiesis but not reduced red cell survival following CpG-ODN administration in vivo. Experimental hematology 20061101
Epidemiologic cutoff values for antimicrobial agents against Aeromonas salmonicida isolates determined by frequency distributions of minimal inhibitory concentration and diameter of zone of inhibition data. American journal of veterinary research 20061101
Efficacy of N-acetyl-cysteine in combination with thiamphenicol in sequential (intramuscular/aerosol) therapy of upper respiratory tract infections even when sustained by bacterial biofilms. Journal of chemotherapy (Florence, Italy) 20061001
Bone marrow hypoplasia secondary to florfenicol toxicity in a Thomson's gazelle (Gazella thomsonii). Journal of veterinary pharmacology and therapeutics 20060801
Plasmid-mediated florfenicol resistance in Pasteurella trehalosi. The Journal of antimicrobial chemotherapy 20060701
Simultaneous analysis of thiamphenicol and its prodrug thiamphenicol glycinate in human plasma and urine by high performance liquid chromatography: application to pharmacokinetic study. Journal of pharmaceutical and biomedical analysis 20060607
Old dogs that learn new tricks: modified antimicrobial agents that escape pre-existing resistance mechanisms. International journal of medical microbiology : IJMM 20060601
Comparison of the efficacy of four antimicrobial treatment schemes against experimental Ornithobacterium rhinotracheale infection in turkey poults pre-infected with avian pneumovirus. Avian pathology : journal of the W.V.P.A 20060601
[Female urogenital mycoplasma infection and drug sensitivity status in Changsha]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20060601
Pharmacokinetics of florfenicol after a single intramuscular dose in white-spotted bamboo sharks (Chiloscyllium plagiosum). Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20060601
Microsphere-based protease assays and screening application for lethal factor and factor Xa. Cytometry. Part A : the journal of the International Society for Analytical Cytology 20060501
Pharmacokinetics of florfenicol in pigs following intravenous, intramuscular or oral administration and the effects of feed intake on oral dosing. Journal of veterinary pharmacology and therapeutics 20060401
Three cases of occupational asthma induced by thiamphenicol: detection of serum-specific IgE. Allergy 20060301
Pharmacokinetics of florfenicol and its metabolite, florfenicol amine, in the Korean catfish (Silurus asotus). Journal of veterinary pharmacology and therapeutics 20060201
Role of coresistance in the development of resistance to chloramphenicol in Escherichia coli isolated from sick cattle and pigs. American journal of veterinary research 20060201
Placental transfer of antibiotics administered to the mother: a review. International journal of clinical pharmacology and therapeutics 20060201
Differential stability of mitochondrial mRNA in HeLa cells. Acta biochimica Polonica 20060101
[Fluimucyl-antibiotic IT: ability of antioxidant therapy for patients with acute attack of infectious chronic obstructive lung disease]. Likars'ka sprava 20060101
[Simultaneous determination of chloramphenicol, thiamphenicol, and florfenicol residues in animal tissues by gas chromatography/mass spectrometry]. Se pu = Chinese journal of chromatography 20060101
Nuclear and mitochondrial genome responses in HeLa cells treated with inhibitors of mitochondrial DNA expression. Acta biochimica Polonica 20060101
Simultaneous determination of florfenicol and florfenicol amine in fish, shrimp, and swine muscle by gas chromatography with a microcell electron capture detector. Journal of AOAC International 20060101
Comparative evaluation between capillary electrophoresis and high-performance liquid chromatography for the analysis of florfenicol in plasma. Journal of pharmaceutical and biomedical analysis 20051004
Molecular basis of florfenicol-induced increase in adherence of Staphylococcus aureus strain Newman. The Journal of antimicrobial chemotherapy 20050801
Fusobacterium nucleatum apoptosis-inducing outer membrane protein. Journal of dental research 20050801
A new mechanism for chloramphenicol, florfenicol and clindamycin resistance: methylation of 23S ribosomal RNA at A2503. Molecular microbiology 20050801
Pharmacokinetics of florfenicol in the red pacu (Piaractus brachypomus) after single dose intramuscular administration. Journal of veterinary pharmacology and therapeutics 20050601
Plasmid-borne florfenicol resistance in Pasteurella multocida. The Journal of antimicrobial chemotherapy 20050501
Evaluation of the antimicrobial activity of florfenicol against bacteria isolated from bovine and porcine respiratory disease. Veterinary microbiology 20050320
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Efficacy of tulathromycin compared with tilmicosin and florfenicol for the control of respiratory disease in cattle at high risk of developing bovine respiratory disease. Veterinary therapeutics : research in applied veterinary medicine 20050101
Comparative efficacy of tulathromycin, tilmicosin, and florfenicol in the treatment of bovine respiratory disease in stocker cattle. Veterinary therapeutics : research in applied veterinary medicine 20050101
Comparative efficacy of tulathromycin versus florfenicol and tilmicosin against undifferentiated bovine respiratory disease in feedlot cattle. Veterinary therapeutics : research in applied veterinary medicine 20050101
Evaluation of the therapeutic activity of tulathromycin against swine respiratory disease on farms in Europe. Veterinary therapeutics : research in applied veterinary medicine 20050101
Assessing the effect of a single dose florfenicol treatment in feedlot cattle on the antimicrobial resistance patterns in faecal Escherichia coli. Veterinary research 20050101
Gene cloning and properties of the RND-type multidrug efflux pumps MexPQ-OpmE and MexMN-OprM from Pseudomonas aeruginosa. Microbiology and immunology 20050101
Determination of florfenicol in fish feed by liquid chromatography. Journal of AOAC International 20050101
Optimization and validation of a micellar electrokinetic chromatographic method for the analysis of florfenicol. Journal of pharmaceutical and biomedical analysis 20041115
Molecular basis of bacterial resistance to chloramphenicol and florfenicol. FEMS microbiology reviews 20041101
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In vitro activity of thiamphenicol, erythromycin and fluoroquinolones against Legionella pneumophila. Journal of chemotherapy (Florence, Italy) 20041001
Monitoring of florfenicol susceptibility among bovine and porcine respiratory tract pathogens collected in Germany during the years 2002 and 2003. The Journal of antimicrobial chemotherapy 20040801
Intravenous and subcutaneous pharmacokinetics of florfenicol in sheep. Journal of veterinary pharmacology and therapeutics 20040801
Effects of subinhibitory concentrations of florfenicol on morphology, growth, and viability of Staphylococcus aureus. Journal of veterinary medicine. B, Infectious diseases and veterinary public health 20040801
The effect of testosterone propionate supplement on testicular toxicity with thiamphenicol in male Sprague-Dawley rats. The Journal of toxicological sciences 20040801
Pharmacokinetics and bioavailability of florfenicol following intravenous, intramuscular and oral administrations in rabbits. Veterinary research communications 20040801
Characterization of florfenicol resistance among calf pathogenic Escherichia coli. FEMS microbiology letters 20040715
Subinhibitory concentrations of florfenicol enhance the adherence of florfenicol-susceptible and florfenicol-resistant Staphylococcus aureus. The Journal of antimicrobial chemotherapy 20040701
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Use of florfenicol in non-human primates. Journal of medical primatology 20040601
Bioavailability and pharmacokinetics of florfenicol in healthy sheep. Journal of veterinary pharmacology and therapeutics 20040601
Rickettsia felis, Bartonella henselae, and B. clarridgeiae, New Zealand. Emerging infectious diseases 20040501
Plasmid-mediated florfenicol and ceftriaxone resistance encoded by the floR and bla(CMY-2) genes in Salmonella enterica serovars Typhimurium and Newport isolated in the United States. FEMS microbiology letters 20040415
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In vitro evaluation of the susceptibility of Edwardsiella ictaluri, etiological agent of enteric septicemia in channel catfish, Ictalurus punctatus (Rafinesque), to florfenicol. Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc 20031101
Serogroup A Neisseria meningitidis outside meningitis belt in southwest Cameroon. Emerging infectious diseases 20031001
Bioavailability and pharmacokinetics of florfenicol in broiler chickens. Journal of veterinary pharmacology and therapeutics 20031001
Pharmacokinetics of florfenicol in cod Gadus morhua and in vitro antibacterial activity against Vibrio anguillarum. Diseases of aquatic organisms 20030924
Mobile genes coding for efflux-mediated antimicrobial resistance in Gram-positive and Gram-negative bacteria. International journal of antimicrobial agents 20030901
Comparative plasma pharmacokinetics and tolerance of florfenicol following intramuscular and intravenous administration to camels, sheep and goats. Veterinary research communications 20030901
Rickettsia felis in the United Kingdom. Emerging infectious diseases 20030801
Effect of oral enrofloxacin and florfenicol on pigs experimentally infected with Actinobacillus pleuropneumoniae serotype 1. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20030601
Florfenicol resistance in Salmonella enterica serovar Newport mediated by a plasmid related to R55 from Klebsiella pneumoniae. The Journal of antimicrobial chemotherapy 20030401
Pharmacokinetics of florfenicol in loggerhead sea turtles (Caretta caretta) after single intravenous and intramuscular injections. Journal of zoo and wildlife medicine : official publication of the American Association of Zoo Veterinarians 20030301
Antimicrobial susceptibilities of Neisseria gonorrhoeae strains isolated in Java, Indonesia. Sexually transmitted diseases 20030101
Stability of florfenicol in drinking water. Journal of AOAC International 20030101
Simultaneous determination of residues of chloramphenicol, thiamphenicol, florfenicol, and florfenicol amine in farmed aquatic species by liquid chromatography/mass spectrometry. Journal of AOAC International 20030101
Determination of florfenicol amine in channel catfish muscle by liquid chromatography. Journal of AOAC International 20030101
Safety of Aquaflor (florfenicol, 50% type A medicated article), administered in feed to channel catfish, Ictalurus punctatus. Toxicologic pathology 20030101
Chloramphenicol and florfenicol susceptibility of fish-pathogenic bacteria isolated in France: comparison of minimum inhibitory concentration, using recommended provisory standards for fish bacteria. Journal of applied microbiology 20030101
Haemotoxicity of thiamphenicol in the BALB/c mouse and Wistar Hanover rat. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20021201
A comparative kinetic study of thiamphenicol in pre-ruminant lambs and calves. Research in veterinary science 20021201
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An evaluation of the relative efficacy of a new formulation of oxytetracycline for the treatment of undifferentiated fever in feedlot calves in western Canada. The Canadian veterinary journal = La revue veterinaire canadienne 20021201
In vitro activity of thiamphenicol against multiresistant Streptococcus pneumoniae, Haemophilus influenzae and Staphylococcus aureus in Italy. Journal of chemotherapy (Florence, Italy) 20021201
Liquid chromatographic determination of florfenicol in the plasma of multiple species of fish. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20021115
Pharmacokinetics of florfenicol in healthy and Escherichia coli-infected broiler chickens. Research in veterinary science 20021001
Relationship of vitamin E supplementation and antimicrobial treatment with acute-phase protein responses in cattle affected by naturally acquired respiratory tract disease. American journal of veterinary research 20020801
An open, comparative pilot study of thiamphenicol glycinate hydrochloride vs clarithromycin in the treatment of acute lower respiratory tract infections due to Chlamydia pneumoniae. Journal of chemotherapy (Florence, Italy) 20020601
Recent clinical evidence of the efficacy and safety of thiamphenicol glycinate acetylcysteinate and thiamphenicol glycinate. Journal of chemotherapy (Florence, Italy) 20020601
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The effects of certain antibiotics on biogas production in the anaerobic digestion of pig waste slurry. Bioresource technology 20020401
Effects of vaccination prior to transit and administration of florfenicol at time of arrival in a feedlot on the health of transported calves and detection of Mannheimia haemolytica in nasal secretions. American journal of veterinary research 20020201
Residue depletion of thiamphenicol in the sea-bass. Journal of veterinary pharmacology and therapeutics 20020201
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Molecular analysis of chromosomally florfenicol-resistant Escherichia coli isolates from France and Germany. The Journal of antimicrobial chemotherapy 20020101
Comparative in vitro activity of 16 antimicrobial agents against Actinobacillus pleuropneumoniae. Veterinary research communications 20020101
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Tissue pharmacokinetics of florfenicol in pigs experimentally infected with Actinobacillus pleuropneumoniae. European journal of drug metabolism and pharmacokinetics 20020101
Evaluation of certain veterinary drug residues in food. World Health Organization technical report series 20020101
Effects of florfenicol injection on the meat characteristics of the cervical muscles in cattle. American journal of veterinary research 20020101
An optimized system for studies of EPO-dependent murine pro-erythroblast development. Experimental hematology 20011101
Retrospective analysis of drug-induced urticaria and angioedema: a survey of 2287 patients. Immunopharmacology and immunotoxicology 20011101
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Pharmacodisposition of thiamphenicol in rabbits. DTW. Deutsche tierarztliche Wochenschrift 20010901
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Allometric analysis of thiamphenicol disposition among seven mammalian species. Journal of veterinary pharmacology and therapeutics 20010601
Chronotoxicology of florfenicol. Chronobiology international 20010501
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Disposition kinetics of florfenicol in goats by using two analytical methods. Journal of veterinary medicine. A, Physiology, pathology, clinical medicine 20010401
Antimicrobial susceptibilities and plasmid patterns of Neisseria gonorrhoeae in Bénin. International journal of STD & AIDS 20010201
Molecular features determining lymphocyte reactivity in allergic contact dermatitis to chloramphenicol and azidamphenicol. Allergy 20010101
Antimicrobial activity of thiamphenicol-glycinate-acetylcysteinate and other drugs against Chlamydia pneumoniae. Arzneimittel-Forschung 20010101
A simple classification method for residual antibiotics using E. coli cells transformed by the calcium chloride method and drug resistance plasmid DNA. Microbios 20010101
Comparative in vitro activity of thiamphenicol-glycinate and thiamphenicol-glycinate-acetylcysteinate and other antimicrobials against respiratory pathogens. Arzneimittel-Forschung 20010101
An assessment of chloramphenicol and thiamphenicol in the induction of aplastic anaemia in the BALB/c mouse. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20001001
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