Home Nitriles 2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile

2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile

CAS No.:
135459-87-9
Catalog Number:
AG00HU5I
Molecular Formula:
C12H6N2O8SSr2
Molecular Weight:
513.4896
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5g
95%
In Stock USA
United States
$22
- +
25g
95%
In Stock USA
United States
$60
- +
100g
95%
In Stock USA
United States
$100
- +
500g
95%
In Stock USA
United States
$350
- +
Product Description
Catalog Number:
AG00HU5I
Chemical Name:
2-(4,8-dioxo-1,3-dioxa-6-aza-2-strontacyclooctan-6-yl)-5,9-dioxo-4H,5H,9H-thieno[2,3-e]1,3-dioxa-2-strontacyclooctane-3-carbonitrile
CAS Number:
135459-87-9
Molecular Formula:
C12H6N2O8SSr2
Molecular Weight:
513.4896
MDL Number:
MFCD12031997
IUPAC Name:
distrontium;5-[bis(carboxylatomethyl)amino]-3-(carboxylatomethyl)-4-cyanothiophene-2-carboxylate
InChI:
InChI=1S/C12H10N2O8S.2Sr/c13-2-6-5(1-7(15)16)10(12(21)22)23-11(6)14(3-8(17)18)4-9(19)20;;/h1,3-4H2,(H,15,16)(H,17,18)(H,19,20)(H,21,22);;/q;2*+2/p-4
InChI Key:
XXUZFRDUEGQHOV-UHFFFAOYSA-J
SMILES:
N#Cc1c(sc(c1CC(=O)[O-])C(=O)[O-])N(CC(=O)[O-])CC(=O)[O-].[Sr+2].[Sr+2]
UNII:
04NQ160FRU
Properties
Complexity:
533  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
3  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
513.796g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
11  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
513.486g/mol
Monoisotopic Mass:
513.796g/mol
Rotatable Bond Count:
4  
Topological Polar Surface Area:
216A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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Strontium is incorporated in different levels into bones and teeth of rats treated with strontium ranelate. Calcified tissue international 20120901
Repeated supratherapeutic dosing of strontium ranelate over 15 days does not prolong QT(c) interval in healthy volunteers. British journal of clinical pharmacology 20120801
Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis and cartilage 20120701
Potential anti-catabolic and anabolic properties of strontium ranelate. Current molecular pharmacology 20120601
Strontium ranelate rebalances bone marrow adipogenesis and osteoblastogenesis in senescent osteopenic mice through NFATc/Maf and Wnt signaling. Aging cell 20120601
Strontium ranelate--a promising therapeutic principle in osteoporosis. Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS) 20120601
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Persistence and compliance of medications used in the treatment of osteoporosis--analysis using a large scale, representative, longitudinal German database. International journal of clinical pharmacology and therapeutics 20120501
Effects of strontium ranelate on cortical bone collagen integrity. Saudi medical journal 20120501
Oral bisphosphonate use increases the risk for inflammatory jaw disease: a cohort study. Journal of oral and maxillofacial surgery : official journal of the American Association of Oral and Maxillofacial Surgeons 20120401
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Individualizing osteoporosis therapy. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120301
Strontium ranelate prevents bone loss in a rat model of localized muscle paralysis. Annals of biomedical engineering 20120301
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Strontium ranelate: too many adverse effects. Prescrire international 20120301
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Extraskeletal benefits and risks of calcium, vitamin D and anti-osteoporosis medications. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120201
Hemorheological changes with strontium ranelate treatment do not seem to be related to its claimed prothrombotic effects. Archives of gerontology and geriatrics 20120101
The effect of prior bisphosphonate therapy on the subsequent therapeutic effects of strontium ranelate over 2 years. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101
Microarchitecture and nanomechanical properties of trabecular bone after strontium administration in osteoporotic goats. Biological trace element research 20120101
The intact strontium ranelate complex stimulates osteoblastogenesis and suppresses osteoclastogenesis by antagonizing NF-κB activation. Molecular and cellular biochemistry 20120101
Effects of strontium ranelate and alendronate on bone microstructure in women with osteoporosis. Results of a 2-year study. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20120101
Persistence with osteoporosis medications among postmenopausal women in the UK General Practice Research Database. Menopause (New York, N.Y.) 20120101
Weak effect of strontium on early implant fixation in rat tibia. Bone 20120101
Combination of Micronutrients for Bone (COMB) Study: bone density after micronutrient intervention. Journal of environmental and public health 20120101
Hip cortical thickness assessment in postmenopausal women with osteoporosis and strontium ranelate effect on hip geometry. Journal of clinical densitometry : the official journal of the International Society for Clinical Densitometry 20120101
Strontium ranelate treatment improves oxidative damage in osteoporotic rat model. Pharmacological reports : PR 20120101
Sequential osteoporosis treatments. Joint, bone, spine : revue du rhumatisme 20111201
Prevention of osteoporosis: one step forward, two steps back. Menopause international 20111201
A comparison of the acute effects of calcium and strontium ranelate on the serum marker of bone resorption. Clinical chemistry and laboratory medicine 20111114
Current options for the management of postmenopausal osteoporosis. Expert opinion on pharmacotherapy 20111101
Increased strontium uptake in trabecular bone of ovariectomized calcium-deficient rats treated with strontium ranelate or strontium chloride. Journal of synchrotron radiation 20111101
[Strontium ranelate promotes osteogenic differentiation of rat bone marrow mesenchymal stem cells by increasing bone morphogenetic protein-7 expression]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20111101
Stevens-Johnson syndrome due to strontium ranelate. Annals of the Academy of Medicine, Singapore 20111101
The mechanism of Cordyceps sinensis and strontium in prevention of osteoporosis in rats. Biological trace element research 20111001
[Adverse drug reactions of strontium ranelate(Protelos(®) in France]. Presse medicale (Paris, France : 1983) 20111001
[Strontium ranelate(Protelos®): who really benefits of the doubt?]. Presse medicale (Paris, France : 1983) 20111001
The action of Strontium ranelate: myth or reality. Journal of the Medical Association of Thailand = Chotmaihet thangphaet 20111001
The effect of PTH(1-84) or strontium ranelate on bone formation markers in postmenopausal women with primary osteoporosis: results of a randomized, open-label clinical trial. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110901
Distribution of strontium and mineralization in iliac bone biopsies from osteoporotic women treated long-term with strontium ranelate. European journal of endocrinology 20110901
Gastrointestinal tolerability and patterns of switching in patients treated for primary osteoporosis: the Swedish Adherence Register Analysis (SARA). Calcified tissue international 20110901
Effects of anti-osteoporosis medications on fracture healing. Current osteoporosis reports 20110901
Strontium ranelate inhibits key factors affecting bone remodeling in human osteoarthritic subchondral bone osteoblasts. Bone 20110901
Atypical femoral fractures during prolonged use of bisphosphonates: short-term responses to strontium ranelate and teriparatide. The Journal of clinical endocrinology and metabolism 20110901
Uses and misuses of statistics: the case of strontium ranelate and the number needed to treat. Journal of endocrinological investigation 20110901
Vertebral fractures. The New England journal of medicine 20110818
[Pharmacologic treatment of osteoporosis--2011]. Orvosi hetilap 20110814
Anabolic agents and bone quality. Clinical orthopaedics and related research 20110801
A meta-analysis of the effect of strontium ranelate on the risk of vertebral and non-vertebral fracture in postmenopausal osteoporosis and the interaction with FRAX(®). Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110801
Adverse reactions and drug-drug interactions in the management of women with postmenopausal osteoporosis. Calcified tissue international 20110801
An Akt-dependent increase in canonical Wnt signaling and a decrease in sclerostin protein levels are involved in strontium ranelate-induced osteogenic effects in human osteoblasts. The Journal of biological chemistry 20110708
[Osteoporosis]. Praxis 20110706
How strontium ranelate, via opposite effects on bone resorption and formation, prevents osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110601
Strontium ranelate: too many adverse effects. Prescrire international 20110601
Comparative effects of teriparatide and strontium ranelate in the periosteum of iliac crest biopsies in postmenopausal women with osteoporosis. Bone 20110501
Increased bone strength is associated with improved bone microarchitecture in intact female rats treated with strontium ranelate: a finite element analysis study. Bone 20110501
Teriparatide [rhPTH (1-34)], but not strontium ranelate, demonstrated bone anabolic efficacy in mature, osteopenic, ovariectomized rats. Endocrinology 20110501
Strontium ranelate effect in postmenopausal women with different clinical levels of osteoarthritis. Climacteric : the journal of the International Menopause Society 20110401
The possible introduction of anti-osteoporosis drugs as an integrated treatment in total hip arthroplasty. Aging clinical and experimental research 20110401
Cost-effectiveness of Denosumab for the treatment of postmenopausal osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110301
Risk of femoral shaft and subtrochanteric fractures among users of bisphosphonates and raloxifene. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110301
Strontium ranelate-induced DRESS syndrome with persistent autoimmune hepatitis. Acta dermato-venereologica 20110301
The treatment of symptomatic osteoporotic spinal compression fractures. The Journal of the American Academy of Orthopaedic Surgeons 20110301
[Incidence of hip fractures due to osteoporosis in relation to the prescription of drugs for their prevention and treatment in Galicia, Spain]. Atencion primaria 20110201
Strontium ranelate and risk of vertebral fractures in frail osteoporotic women. Bone 20110201
Strontium is incorporated into the fracture callus but does not influence the mechanical strength of healing rat fractures. Calcified tissue international 20110201
[Strontium ranelate-induced DRESS syndrome]. Annales de dermatologie et de venereologie 20110201
Strontium ranelate decreases the incidence of new caudal vertebral fractures in a growing mouse model with spontaneous fractures by improving bone microarchitecture. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20110101
Effect of strontium ranelate on fracture healing in the osteoporotic rats. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20110101
Strontium ranelate in post-menopausal osteoporosis. Endokrynologia Polska 20110101
Activation of FGF receptors is a new mechanism by which strontium ranelate induces osteoblastic cell growth. Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 20110101
Trabecular reorganization in consecutive iliac crest biopsies when switching from bisphosphonate to strontium ranelate treatment. PloS one 20110101
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Positive impact of compliance to strontium ranelate on the risk of nonvertebral osteoporotic fractures. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101201
Effects of strontium ranelate administration on bisphosphonate-altered hydroxyapatite: Matrix incorporation of strontium is accompanied by changes in mineralization and microstructure. Acta biomaterialia 20101201
Impact of treatments for postmenopausal osteoporosis (bisphosphonates, parathyroid hormone, strontium ranelate, and denosumab) on bone quality: a systematic review. Calcified tissue international 20101201
Strontium ranelate: a look back at its use for osteoporosis. Expert opinion on pharmacotherapy 20101201
Systemic treatment with strontium ranelate promotes tibial fracture healing in ovariectomized rats. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20101101
Sustained vertebral antifracture efficacy of oral anti-osteoporotic therapies in postmenopausal osteoporosis. Current medical research and opinion 20101101
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Strontium ranelate decreases receptor activator of nuclear factor-ΚB ligand-induced osteoclastic differentiation in vitro: involvement of the calcium-sensing receptor. Molecular pharmacology 20101001
Strontium ranelate in osteoporosis and beyond: identifying molecular targets in bone cell biology. Molecular interventions 20101001
Use of bisphosphonates and raloxifene and risk of deep venous thromboembolism and pulmonary embolism. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100901
Spotlight on strontium ranelate: in postmenopausal osteoporosis. Drugs & aging 20100901
Essential role of nuclear factor of activated T cells (NFAT)-mediated Wnt signaling in osteoblast differentiation induced by strontium ranelate. The Journal of biological chemistry 20100813
Strontium ranelate and alendronate have differing effects on distal tibia bone microstructure in women with osteoporosis. Rheumatology international 20100801
The Calcium-sensing Receptor (CaR) is involved in strontium ranelate-induced osteoblast differentiation and mineralization. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20100801
The relationship of inflammation to systemic diseases and chronic periodontitis. International journal of dental hygiene 20100801
Cost-effectiveness of strontium ranelate for the prevention and treatment of osteoporosis. Expert review of pharmacoeconomics & outcomes research 20100801
Osteoporosis and venous thromboembolism: a retrospective cohort study in the UK General Practice Research Database. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100701
Bladder rupture following osteoporotic pubic ramus and sacral insufficiency fractures. Age and ageing 20100701
Incidence of venous thromboembolism in users of strontium ranelate: an analysis of data from a prescription-event monitoring study in England. Drug safety 20100701
Relationship between 3-month changes in biochemical markers of bone remodelling and changes in bone mineral density and fracture incidence in patients treated with strontium ranelate for 3 years. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601
The effects of strontium ranelate on biochemical markers of bone turnover and their relationship with bone mineral density. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601
Effects of alendronate and strontium ranelate on cancellous and cortical bone mass in glucocorticoid-treated adult rats. Calcified tissue international 20100601
Addressing the age-related needs of osteoporotic patients with strontium ranelate. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601
Strontium ranelate: an effective solution for diverse fracture risks. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601
Comparing and contrasting the effects of strontium ranelate and other osteoporosis drugs on microarchitecture. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100601
Strontium is incorporated into mineral crystals only in newly formed bone during strontium ranelate treatment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100501
Strontium ranelate treatment enhances hydroxyapatite-coated titanium screws fixation in osteoporotic rats. Journal of orthopaedic research : official publication of the Orthopaedic Research Society 20100501
Absolute risk reduction in osteoporosis: assessing treatment efficacy by number needed to treat. Rheumatology international 20100501
Strontium ranelate improves implant osseointegration. Bone 20100501
The effects of strontium-substituted bioactive glasses on osteoblasts and osteoclasts in vitro. Biomaterials 20100501
Severe exfoliative dermatitis caused by strontium ranelate: two cases of a new drug reaction. Age and ageing 20100501
Strontium ranelate: a review of its use in the treatment of postmenopausal osteoporosis. Drugs 20100416
In osteoporotic women treated with strontium ranelate, strontium is located in bone formed during treatment with a maintained degree of mineralization. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100401
Five years treatment with strontium ranelate reduces vertebral and nonvertebral fractures and increases the number and quality of remaining life-years in women over 80 years of age. Bone 20100401
[Preventive and therapeutic effect of strontium ranelate on osteoporosis in rats subjected to simulated weightlessness]. Nan fang yi ke da xue xue bao = Journal of Southern Medical University 20100401
Bone material quality in transiliac bone biopsies of postmenopausal osteoporotic women after 3 years of strontium ranelate treatment. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100401
Effect of osteoporosis treatment on mortality: a meta-analysis. The Journal of clinical endocrinology and metabolism 20100301
The effect of prior bisphosphonate therapy on the subsequent BMD and bone turnover response to strontium ranelate. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100301
Short-term bone marker responses to teriparatide and strontium ranelate in patients with osteoporosis previously treated with bisphosphonates. Arquivos brasileiros de endocrinologia e metabologia 20100301
Vertebral anti-fracture efficacy of strontium ranelate according to pre-treatment bone turnover. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100201
The cost-effectiveness of strontium ranelate in the UK for the management of osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100201
Prospective assessment of thoracic kyphosis in postmenopausal women with osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20100201
Cost-effectiveness of strontium ranelate versus risedronate in the treatment of postmenopausal osteoporotic women aged over 75 years. Bone 20100201
[Rash and renal failure secondary to strontium ranelate]. Medicina clinica 20100130
Cost-utility of long-term strontium ranelate treatment for postmenopausal osteoporotic women. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20100101
Strontium ranelate enhances callus strength more than PTH 1-34 in an osteoporotic rat model of fracture healing. Calcified tissue international 20100101
[Impact of a health safety warning on strontium ranelate utilization]. Gaceta sanitaria 20100101
[Diagnosis and treatment of osteoporosis in persons aged more than 75 years]. Revista espanola de geriatria y gerontologia 20100101
Therapeutic options in osteoporosis. Acta bio-medica : Atenei Parmensis 20100101
Efficacy of strontium ranelate on bone mineral density in men with osteoporosis. Arzneimittel-Forschung 20100101
A comparison between bisphosphonates and other treatments for osteoporosis. Current pharmaceutical design 20100101
Receptor activator of nuclear factor-κB ligand and osteoprotegerin: maintaining the balance to prevent bone loss. Clinical interventions in aging 20100101
Bisphosphonate use and hip fracture epidemiology: ecologic proof from the contrary. Clinical interventions in aging 20100101
Long-term treatment of postmenopausal osteoporosis with strontium ranelate: results at 8 years. Bone 20091201
Effects of strontium ranelate, raloxifene and misoprostol on bone mineral density in ovariectomized rats. European journal of obstetrics, gynecology, and reproductive biology 20091201
About the comparison of two anabolic agents, teriparatide and strontium ranelate, in treated osteoporotic women. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20091201
Re: 'Effect of long-term treatment with strontium ranelate on bone strontium content' by Bärenholdt et al. (Bone, 2009). Bone 20091101
Effects of long-term strontium ranelate treatment on vertebral fracture risk in postmenopausal women with osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20091001
Bullous DRESS in a patient on strontium ranelate. Clinical and experimental dermatology 20091001
Strontium ranelate: new perspectives for the management of osteoporosis. Rheumatology (Oxford, England) 20091001
Osteoporosis: from early fracture prevention to better bone health with strontium ranelate. Rheumatology (Oxford, England) 20091001
Continuous broad protection against osteoporotic fractures with strontium ranelate. Rheumatology (Oxford, England) 20091001
Strontium ranelate improves bone microarchitecture in osteoporosis. Rheumatology (Oxford, England) 20091001
Strontium: confusion and hallucinations. Do not use strontium. Prescrire international 20091001
Efficacy and safety of 2 g/day of strontium ranelate in Asian women with postmenopausal osteoporosis. Bone 20090901
Strontium ranelate as a cause of acute renal failure and dress syndrome. Nephrology (Carlton, Vic.) 20090901
Strontium ranelate: new data on fracture prevention and mechanisms of action. Current osteoporosis reports 20090901
Strontium ranelate improves bone strength in ovariectomized rat by positively influencing bone resistance determinants. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090801
Comparative effects of teriparatide and strontium ranelate on bone biopsies and biochemical markers of bone turnover in postmenopausal women with osteoporosis. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090801
Effect of long-term treatment with strontium ranelate on bone strontium content. Bone 20090801
The new frontier of bone formation: a breakthrough in postmenopausal osteoporosis? Climacteric : the journal of the International Menopause Society 20090801
Could strontium ranelate have a synergistic role in the treatment of osteoporosis? Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20090801
Osteoblasts play key roles in the mechanisms of action of strontium ranelate. British journal of pharmacology 20090801
Calcium sensing receptor-dependent and receptor-independent activation of osteoblast replication and survival by strontium ranelate. Journal of cellular and molecular medicine 20090801
Effect of strontium ranelate on lumbar spine bone mineral density in women with established osteoporosis previously treated with teriparatide. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme 20090701
Monitoring strontium ranelate therapy in patients with osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090701
Effects of bone anabolic agents on bone ultrastructure. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090601
Synthesis, characterization of strontium-bile acid salts and their bioactivity vs. the anti-osteoporosis drug strontium ranelate. Journal of inorganic biochemistry 20090601
Efficacy and safety of pharmacological agents in managing osteoporosis in the old old: review of the evidence. Bone 20090501
[Drugs under development for osteoporosis ]. Nihon rinsho. Japanese journal of clinical medicine 20090501
[Efficacy of strontium ranelate for the mineralization of bone in postmenopausal women]. Ginecologia y obstetricia de Mexico 20090501
Strontium ranelate may cause alopecia. BMJ (Clinical research ed.) 20090422
No difference between strontium ranelate (SR) and calcium/vitamin D on bone turnover markers in women with established osteoporosis previously treated with teriparatide: a randomized controlled trial. Clinical endocrinology 20090401
Strontium ranelate treatment of human primary osteoblasts promotes an osteocyte-like phenotype while eliciting an osteoprotegerin response. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090401
Pregnancy- and lactation-associated osteoporosis with severe vertebral deformities: can strontium ranelate be a new alternative for the treatment? The spine journal : official journal of the North American Spine Society 20090401
Strontium ranelate-induced DRESS syndrome: first two case reports. Allergy 20090401
Generalized cutaneous drug eruption due to strontium ranelate. Journal of the European Academy of Dermatology and Venereology : JEADV 20090301
New findings with old drugs for osteoporosis. Expert opinion on pharmacotherapy 20090201
The calcium-sensing receptor is involved in strontium ranelate-induced osteoclast apoptosis. New insights into the associated signaling pathways. The Journal of biological chemistry 20090102
Strontium ranelate-induced toxic epidermal necrolysis in a patient with post-menopausal osteoporosis. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20090101
Strontium ranelate decreases plasma homocysteine levels in postmenopausal osteoporotic women. Rheumatology international 20090101
[How to prevent early postmenopausal fracture risk? Proposition of a strategy]. Gynecologie, obstetrique & fertilite 20090101
[Current approaches to the diagnosis and treatment of postmenopausal osteoporosis]. Terapevticheskii arkhiv 20090101
Strontium ranelate reduces the risk of vertebral fracture in young postmenopausal women with severe osteoporosis. Annals of the rheumatic diseases 20081201
Effective doses for strontium ranelate. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20081201
Rash, strontium ranelate and DRESS syndrome put into perspective. European Medicine Agency on the alert. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20081201
Strontium ranelate: the first agent of a new therapeutic class in osteoporosis. Advances in therapy 20081201
The effect of strontium ranelate on serum insulin like growth factor-1 and leptin levels in osteoporotic post-menopausal women: a prospective study. Archives of gynecology and obstetrics 20081101
Post-marketing assessment of the safety of strontium ranelate; a novel case-only approach to the early detection of adverse drug reactions. British journal of clinical pharmacology 20081101
The effects of strontium ranelate in Asian women with postmenopausal osteoporosis. Calcified tissue international 20081101
[Newly developed drugs for osteoporosis in overseas and their future roles for the therapy]. Clinical calcium 20081001
Bone-forming agents in the management of osteoporosis. Best practice & research. Clinical endocrinology & metabolism 20081001
Strontium ranelate does not stimulate bone formation in ovariectomized rats. Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA 20080901
Treatment of osteoporosis: all the questions we still cannot answer. The American journal of medicine 20080901
Cytotoxicity analysis of strontium ranelate on cultured human periodontal ligament fibroblasts: a preliminary report. Journal of the Formosan Medical Association = Taiwan yi zhi 20080801
Rebalancing bone turnover in favour of formation with strontium ranelate: implications for bone strength. Rheumatology (Oxford, England) 20080701
Strontium ranelate: short- and long-term benefits for post-menopausal women with osteoporosis. Rheumatology (Oxford, England) 20080701
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