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Phleomycin

CAS No.:
11006-33-0
Catalog Number:
AG00HBO1
Molecular Formula:
C51H75N17O21S2
Molecular Weight:
1326.3725
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥95%
1 week
United States
$125
- +
10mg
≥95%
1 week
United States
$172
- +
25mg
≥95%
1 week
United States
$278
- +
50mg
≥95%
1 week
United States
$465
- +
Product Description
Catalog Number:
AG00HBO1
Chemical Name:
Phleomycin
CAS Number:
11006-33-0
Molecular Formula:
C51H75N17O21S2
Molecular Weight:
1326.3725
MDL Number:
MFCD30738212
IUPAC Name:
2-[2-[2-[[2-[[4-[[2-[[6-amino-2-[3-amino-1-[(2,3-diamino-3-oxopropyl)amino]-3-oxopropyl]-5-methylpyrimidine-4-carbonyl]amino]-3-[(2R,3S,4S,5S,6S)-3-[(2S,3R,4R,5S)-4-carbamoyl-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4,5-dihydroxy-6-(hydroxymethyl)-3-methyloxan-2-yl]oxy-3-(1H-imidazol-5-yl)propanoyl]amino]-3-hydroxy-2-methylpentanoyl]amino]-3-oxobutanoyl]amino]ethyl]-4,5-dihydro-1,3-thiazol-4-yl]-1,3-thiazole-4-carboxamide
InChI:
InChI=1S/C51H75N17O21S2/c1-16-29(65-41(68-38(16)54)21(8-27(53)72)60-9-20(52)39(55)78)44(82)67-31(34(22-10-58-15-61-22)88-49-50(5,36(76)33(74)25(11-69)87-49)89-47-37(77)51(85,48(57)84)35(75)26(12-70)86-47)45(83)62-18(3)32(73)17(2)42(80)66-30(19(4)71)43(81)59-7-6-28-63-24(14-90-28)46-64-23(13-91-46)40(56)79/h10,13,15,17-18,20-21,24-26,30-37,47,49,60,69-70,73-77,85H,6-9,11-12,14,52H2,1-5H3,(H2,53,72)(H2,55,78)(H2,56,79)(H2,57,84)(H,58,61)(H,59,81)(H,62,83)(H,66,80)(H,67,82)(H2,54,65,68)/t17?,18?,20?,21?,24?,25-,26?,30?,31?,32?,33+,34?,35-,36-,37-,47-,49-,50-,51+/m0/s1
InChI Key:
QRBLKGHRWFGINE-UGWAGOLRSA-N
SMILES:
OCC1OC(OC(C(C(=O)NC(C(C(C(=O)NC(C(=O)NCCC2=NC(CS2)c2scc(n2)C(=O)N)C(=O)C)C)O)C)NC(=O)c2nc(nc(c2C)N)C(CC(=O)N)NCC(C(=O)N)N)c2[nH]cnc2)C(C(C1O)O)(C)OC1OC(CO)C(C(C1O)(O)C(=O)N)O
UNII:
BN3E7WJN9X
Properties
Complexity:
2650  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
9  
Defined Bond Stereocenter Count:
0
Exact Mass:
1325.476g/mol
Formal Charge:
0
Heavy Atom Count:
91  
Hydrogen Bond Acceptor Count:
31  
Hydrogen Bond Donor Count:
20  
Isotope Atom Count:
0
Molecular Weight:
1326.379g/mol
Monoisotopic Mass:
1325.476g/mol
Rotatable Bond Count:
31  
Topological Polar Surface Area:
702A^2
Undefined Atom Stereocenter Count:
10  
Undefined Bond Stereocenter Count:
0
XLogP3:
-10.2  
Literature
Title Journal
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Investigating dominant selection markers for Coprinopsis cinerea: a carboxin resistance system and re-evaluation of hygromycin and phleomycin resistance vectors. Current genetics 20091001
Inositol pyrophosphates modulate hydrogen peroxide signalling. The Biochemical journal 20090914
Poly(ADP-ribose)-dependent regulation of DNA repair by the chromatin remodeling enzyme ALC1. Science (New York, N.Y.) 20090904
DNA-damage response in the basidiomycete fungus Ustilago maydis relies in a sole Chk1-like kinase. DNA repair 20090604
Chemical induction of the bystander effect in normal human lymphoblastoid cells. Mutation research 20090531
Gene targeting in a nonhomologous end joining deficient Hypocrea jecorina. Journal of biotechnology 20090115
A comparison of synthetic oligodeoxynucleotides, DNA fragments and AAV-1 for targeted episomal and chromosomal gene repair. BMC biotechnology 20090101
The heterologous overexpression of hsp23, a small heat-shock protein gene from Trichoderma virens, confers thermotolerance to T. harzianum. Current genetics 20070701
Improved protocols for functional analysis in the pathogenic fungus Aspergillus flavus. BMC microbiology 20070101
Deletion of the chromatin remodeling gene SPT10 sensitizes yeast cells to a subclass of DNA-damaging agents. Environmental and molecular mutagenesis 20061201
The fission yeast DNA structure checkpoint protein Rad26ATRIP/LCD1/UVSD accumulates in the cytoplasm following microtubule destabilization. BMC cell biology 20060101
hnRNP K: an HDM2 target and transcriptional coactivator of p53 in response to DNA damage. Cell 20051216
Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid. Fungal genetics and biology : FG & B 20031101
NMR study of the interaction between Zn(II) ligated bleomycin and Streptoalloteichus hindustanus bleomycin resistance protein. Biochemistry 20030128
Inactivation of Mre11 does not affect VSG gene duplication mediated by homologous recombination in Trypanosoma brucei. The Journal of biological chemistry 20020719
Ku is important for telomere maintenance, but not for differential expression of telomeric VSG genes, in African trypanosomes. The Journal of biological chemistry 20020614
Expression site activation in Trypanosoma brucei with three marked variant surface glycoprotein gene expression sites. Molecular and biochemical parasitology 20020409
Properties