1H-1,4-Diazepine, hexahydro-1-(5-isoquinolinylsulfonyl)-
| Title | Journal |
|---|---|
| Fasudil hydrochloride, a potent ROCK inhibitor, inhibits corneal neovascularization after alkali burns in mice. | Molecular vision 20150101 |
| Allelic Variants in Arhgef11 via the Rho-Rock Pathway Are Linked to Epithelial-Mesenchymal Transition and Contributes to Kidney Injury in the Dahl Salt-Sensitive Rat. | PloS one 20150101 |
| Identification of potent Yes1 kinase inhibitors using a library screening approach. | Bioorganic & medicinal chemistry letters 20130801 |
| Activation of RhoA/ROCK regulates NF-κB signaling pathway in experimental diabetic nephropathy. | Molecular and cellular endocrinology 20130430 |
| A broad activity screen in support of a chemogenomic map for kinase signalling research and drug discovery. | The Biochemical journal 20130415 |
| Fasudil, a Rho-kinase inhibitor, attenuates lipopolysaccharide-induced vascular hyperpermeability and colonic muscle relaxation in guinea pigs. | The Journal of surgical research 20121101 |
| Rho-kinase-dependent pathway mediates the hepatoprotective effects of sorafenib against ischemia/reperfusion liver injury in rats with nonalcoholic steatohepatitis. | Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society 20121101 |
| Genetic variants in Arhgef11 are associated with kidney injury in the Dahl salt-sensitive rat. | Hypertension (Dallas, Tex. : 1979) 20121101 |
| Fasudil ameliorates disease progression in experimental autoimmune encephalomyelitis, acting possibly through antiinflammatory effect. | CNS neuroscience & therapeutics 20121101 |
| RhoA/ROCK may involve in cardiac hypertrophy induced by experimental hyperthyroidism. | Toxicology and industrial health 20121001 |
| Rho-kinase inhibitor, fasudil, prevents neuronal apoptosis via the Akt activation and PTEN inactivation in the ischemic penumbra of rat brain. | Cellular and molecular neurobiology 20121001 |
| Effect of fasudil, a selective inhibitor of Rho kinase activity, in the secondary injury associated with the experimental model of spinal cord trauma. | The Journal of pharmacology and experimental therapeutics 20121001 |
| Retinal arteriolar responses to acute severe elevation in systemic blood pressure in cats: role of endothelium-derived factors. | Experimental eye research 20121001 |
| A Rho kinase (ROCK) inhibitor, fasudil, prevents matrix metalloproteinase-9-related hemorrhagic transformation in mice treated with tissue plasminogen activator. | Neuroscience 20120918 |
| Fasudil improves the endothelial dysfunction in the aorta of spontaneously hypertensive rats. | European journal of pharmacology 20120915 |
| Rho-kinase inhibition improves vasodilator responsiveness during hyperinsulinemia in the metabolic syndrome. | American journal of physiology. Endocrinology and metabolism 20120915 |
| Inhibition of sympathetic neuroeffector transmission in human corpus cavernosum. | BJU international 20120901 |
| Pharmacologic reduction of angiographic vasospasm in experimental subarachnoid hemorrhage: systematic review and meta-analysis. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20120901 |
| Stimulation of norepinephrine transporter function by fasudil, a Rho kinase inhibitor, in cultured bovine adrenal medullary cells. | Naunyn-Schmiedeberg's archives of pharmacology 20120901 |
| Prenatal fasudil exposure alleviates fetal growth but programs hyperphagia and overweight in the adult male rat. | European journal of pharmacology 20120815 |
| Fasudil, a Rho-kinase inhibitor, protects against excessive endurance exercise training-induced cardiac hypertrophy, apoptosis and fibrosis in rats. | European journal of applied physiology 20120801 |
| Evaluation of clinical efficacy of fasudil for the treatment of pulmonary arterial hypertension. | Recent patents on cardiovascular drug discovery 20120801 |
| [Effect of Fasudil on the phenotype conversion of LPS-stimulated BV-2 microglia]. | Xi bao yu fen zi mian yi xue za zhi = Chinese journal of cellular and molecular immunology 20120801 |
| Evidence of a direct cellular protective effect of Rho-kinase inhibitors on endothelin-induced cardiac myocyte hypertrophy. | Biochemical and biophysical research communications 20120727 |
| Infrasonic noise induces axonal degeneration of cultured neurons via a Ca²⁺ influx pathway. | Toxicology letters 20120720 |
| ROCK1 feedback regulation of the upstream small GTPase RhoA. | Cellular signalling 20120701 |
| The Rho kinase inhibitor azaindole-1 has long-acting vasodilator activity in the pulmonary vascular bed of the intact chest rat. | Canadian journal of physiology and pharmacology 20120701 |
| Efficacy of Rho kinase inhibitor fasudil in secondary Raynaud's phenomenon. | Arthritis care & research 20120601 |
| Long-term administration of fasudil improves cardiomyopathy in streptozotocin-induced diabetic rats. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20120601 |
| Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1. | Toxicology letters 20120601 |
| The Rho kinase inhibitor fasudil is involved in p53-mediated apoptosis in human hepatocellular carcinoma cells. | Cancer chemotherapy and pharmacology 20120601 |
| Cell-cell and cell-matrix dynamics in intraperitoneal cancer metastasis. | Cancer metastasis reviews 20120601 |
| Protein kinase G-I deficiency induces pulmonary hypertension through Rho A/Rho kinase activation. | The American journal of pathology 20120601 |
| Pyridylthiazole-based ureas as inhibitors of Rho associated protein kinases (ROCK1 and 2). | MedChemComm 20120601 |
| Conjugates of 5-isoquinolinesulfonylamides and oligo-D-arginine possess high affinity and selectivity towards Rho kinase (ROCK). | Bioorganic & medicinal chemistry letters 20120515 |
| Opening a new GATAway for treating KRAS-driven lung tumors. | Cancer cell 20120515 |
| Aorta-derived mesoangioblasts differentiate into the oligodendrocytes by inhibition of the Rho kinase signaling pathway. | Stem cells and development 20120501 |
| Early treatment with olmesartan prevents juxtamedullary glomerular podocyte injury and the onset of microalbuminuria in type 2 diabetic rats. | American journal of hypertension 20120501 |
| RhoA guanine exchange factor expression profile in arteries: evidence for a Rho kinase-dependent negative feedback in angiotensin II-dependent hypertension. | American journal of physiology. Cell physiology 20120501 |
| Fasudil inhibits lung carcinoma-conditioned endothelial cell viability and migration. | Oncology reports 20120501 |
| Administration of fasudil, a ROCK inhibitor, attenuates disease in lupus-prone NZB/W F1 female mice. | Lupus 20120501 |
| Coptisine exert cardioprotective effect through anti-oxidative and inhibition of RhoA/Rho kinase pathway on isoproterenol-induced myocardial infarction in rats. | Atherosclerosis 20120501 |
| The Rho-kinase inhibitor inhibits proliferation and metastasis of small cell lung cancer. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20120401 |
| Targeting RhoA/ROCK pathway in pulmonary arterial hypertension. | Expert opinion on therapeutic targets 20120401 |
| Transcriptomic profiling of astrocytes treated with the Rho kinase inhibitor fasudil reveals cytoskeletal and pro-survival responses. | Journal of cellular physiology 20120301 |
| [Progress in pharmacotherapy of pulmonary arterial hypertension in children]. | Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics 20120301 |
| Systematic assessment and meta-analysis of the efficacy and safety of fasudil in the treatment of cerebral vasospasm in patients with subarachnoid hemorrhage. | European journal of clinical pharmacology 20120201 |
| Fasudil decreases lesion burden in a murine model of cerebral cavernous malformation disease. | Stroke 20120201 |
| Suppression of microRNA-29 expression by TGF-β1 promotes collagen expression and renal fibrosis. | Journal of the American Society of Nephrology : JASN 20120201 |
| Effects of fasudil in patients with high-altitude pulmonary hypertension. | The European respiratory journal 20120201 |
| Changes in hippocampal synapses and learning-memory abilities in a streptozotocin-treated rat model and intervention by using fasudil hydrochloride. | Neuroscience 20120103 |
| Intracranial hemorrhage after intra-arterial administration of fasudil for treatment of cerebral vasospasm following subarachnoid hemorrhage: a serious adverse event. | Neuroradiology 20120101 |
| Rho inhibitor prevents ischemia-reperfusion injury in rat steatotic liver. | Journal of hepatology 20120101 |
| C3 peptide promotes axonal regeneration and functional motor recovery after peripheral nerve injury. | Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 20120101 |
| Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function. | Evidence-based complementary and alternative medicine : eCAM 20120101 |
| Targeting endothelial dysfunction in vascular complications associated with diabetes. | International journal of vascular medicine 20120101 |
| Cardioprotective effect of a combination of Rho-kinase inhibitor and p38 MAPK inhibitor on cardiovascular remodeling and oxidative stress in Dahl rats. | Journal of atherosclerosis and thrombosis 20120101 |
| Antivasospastic effects of hydroxyfasudil, a Rho-kinase inhibitor, after subarachnoid hemorrhage. | Journal of pharmacological sciences 20120101 |
| ER stress and apoptosis: a new mechanism for retinal cell death. | Experimental diabetes research 20120101 |
| Ultrasound biomicroscopy for longitudinal studies of carotid plaque development in mice: validation with histological endpoints. | PloS one 20120101 |
| Curcumin-arteether combination therapy of Plasmodium berghei-infected mice prevents recrudescence through immunomodulation. | PloS one 20120101 |
| [Fasudil improves erectile function of hypertensive rats]. | Zhonghua nan ke xue = National journal of andrology 20120101 |
| Protective Role of the ACE2/Ang-(1-9) Axis in Cardiovascular Remodeling. | International journal of hypertension 20120101 |
| Inhibition of the Rho/ROCK pathway enhances the efficacy of cisplatin through the blockage of hypoxia-inducible factor-1α in human ovarian cancer cells. | Cancer biology & therapy 20120101 |
| Fasudil improves survival and promotes skeletal muscle development in a mouse model of spinal muscular atrophy. | BMC medicine 20120101 |
| High-dose fasudil preserves postconditioning against myocardial infarction under hyperglycemia in rats: role of mitochondrial KATP channels. | Cardiovascular diabetology 20120101 |
| RhoA: a therapeutic target for chronic myeloid leukemia. | Molecular cancer 20120101 |
| Erectile properties of the Rho-kinase inhibitor SAR407899 in diabetic animals and human isolated corpora cavernosa. | Journal of translational medicine 20120101 |
| Protein phosphatase 1 dephosphorylates profilin-1 at Ser-137. | PloS one 20120101 |
| Vasodilator effects of cromakalim and HA 1077 in diabetic rat aorta. | Swiss medical weekly 20120101 |
| The role of sphingosine kinase 1/sphingosine-1-phosphate pathway in the myogenic tone of posterior cerebral arteries. | PloS one 20120101 |
| Pirfenidone inhibits transforming growth factor-β1-induced fibrogenesis by blocking nuclear translocation of Smads in human retinal pigment epithelial cell line ARPE-19. | Molecular vision 20120101 |
| ROCK inhibitor fasudil attenuated high glucose-induced MCP-1 and VCAM-1 expression and monocyte-endothelial cell adhesion. | Cardiovascular diabetology 20120101 |
| Therapy development for spinal muscular atrophy in SMN independent targets. | Neural plasticity 20120101 |
| Involvement of rho-kinase activation in the pathogenesis of coronary hyperconstricting responses induced by drug-eluting stents in patients with coronary artery disease. | Circulation journal : official journal of the Japanese Circulation Society 20120101 |
| Fasudil, a Rho-kinase inhibitor, attenuates bleomycin-induced pulmonary fibrosis in mice. | International journal of molecular sciences 20120101 |
| Fasudil protects the heart against ischemia-reperfusion injury by attenuating endoplasmic reticulum stress and modulating SERCA activity: the differential role for PI3K/Akt and JAK2/STAT3 signaling pathways. | PloS one 20120101 |
| Rhos and Rho kinases in the rat prostate: their possible functional roles and distributions. | Molecular and cellular biochemistry 20111201 |
| Pulmonary vascular effects of serotonin and selective serotonin reuptake inhibitors in the late-gestation ovine fetus. | American journal of physiology. Lung cellular and molecular physiology 20111201 |
| Fasudil inhibits the proliferation and contractility and induces cell cycle arrest and apoptosis of human endometriotic stromal cells: a promising agent for the treatment of endometriosis. | The Journal of clinical endocrinology and metabolism 20111201 |
| Pretreatment of Rho kinase inhibitor inhibits systemic inflammation and prevents endotoxin-induced acute lung injury in mice. | The Journal of surgical research 20111201 |
| Wnt-signaling mediates the anti-adipogenic action of lysophosphatidic acid through cross talking with the Rho/Rho associated kinase (ROCK) pathway. | Biochemistry and cell biology = Biochimie et biologie cellulaire 20111201 |
| Recent progress in treatment of pulmonary arterial hypertension due to congenital heart disease. | Netherlands heart journal : monthly journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation 20111201 |
| Neuroprotective effects of NEP1-40 and fasudil on Nogo-A expression in neonatal rats with hypoxic-ischemic brain damage. | Genetics and molecular research : GMR 20111129 |
| Protective effects of L-type fatty acid-binding protein (L-FABP) in proximal tubular cells against glomerular injury in anti-GBM antibody-mediated glomerulonephritis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20111101 |
| Preventive effects of fasudil on adriamycin-induced cardiomyopathy: possible involvement of inhibition of RhoA/ROCK pathway. | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20111101 |
| Role for PKCβ in enhanced endothelin-1-induced pulmonary vasoconstrictor reactivity following intermittent hypoxia. | American journal of physiology. Lung cellular and molecular physiology 20111101 |
| Rho-kinase inhibition alleviates pulmonary hypertension in transgenic mice expressing a dominant-negative type II bone morphogenetic protein receptor gene. | American journal of physiology. Lung cellular and molecular physiology 20111101 |
| Wound contraction is attenuated by fasudil inhibition of Rho-associated kinase. | Plastic and reconstructive surgery 20111101 |
| Comprehensive assay of kinase catalytic activity reveals features of kinase inhibitor selectivity. | Nature biotechnology 20111101 |
| Vasospasm after aneurysmal subarachnoid hemorrhage: review of randomized controlled trials and meta-analyses in the literature. | World neurosurgery 20111101 |
| [Mechanism of diabetes-induced microvascular damage and therapeutic potential of ROCK inhibition]. | Nippon Ganka Gakkai zasshi 20111101 |
| [Fasudil(Rho-kinase inhibitor)]. | Nihon rinsho. Japanese journal of clinical medicine 20111101 |
| The effects of fasudil on the permeability of the rat blood-brain barrier and blood-spinal cord barrier following experimental autoimmune encephalomyelitis. | Journal of neuroimmunology 20111028 |
| Capsaicinoids regulate airway anion transporters through Rho kinase- and cyclic AMP-dependent mechanisms. | American journal of respiratory cell and molecular biology 20111001 |
| Immunoliposomal drug-delivery system targeting lectin-like oxidized low-density lipoprotein receptor-1 for carotid plaque lesions in rats. | Journal of neurosurgery 20111001 |
| Rho kinase inhibition by fasudil exerts antioxidant effects in hypercholesterolemic rats. | Clinical and experimental pharmacology & physiology 20111001 |
| Rho-associated kinase activity, endothelial function, and cardiovascular risk factors. | Arteriosclerosis, thrombosis, and vascular biology 20111001 |
| Rho-kinase regulates thrombin-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | International journal of molecular medicine 20111001 |
| Fasudil inhibits platelet-derived growth factor-induced human pulmonary artery smooth muscle cell proliferation by up-regulation of p27kip¹ via the ERK signal pathway. | Chinese medical journal 20111001 |
| Rho-kinase inhibition ameliorates peritoneal fibrosis and angiogenesis in a rat model of peritoneal sclerosis. | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 20110901 |
| The Rho kinase inhibitor fasudil augments the number of functional endothelial progenitor cells in ex vivo cultures. | International journal of molecular medicine 20110901 |
| [Rho-kinase inhibitors]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20110901 |
| Rho kinase as a therapeutic target in cardiovascular disease. | Future cardiology 20110901 |
| Subdose of fasudil suppresses myocardial fibrosis in aldosterone-salt-treated uninephrectomized rats. | Die Pharmazie 20110901 |
| Thrombin induces MCP-1 expression through Rho-kinase and subsequent p38MAPK/NF-κB signaling pathway activation in vascular endothelial cells. | Biochemical and biophysical research communications 20110812 |
| Agonist-induced periodic vasomotion in rat isolated pulmonary artery. | Fundamental & clinical pharmacology 20110801 |
| Intraradial administration of fasudil inhibits augmented Rho kinase activity to effectively dilate the spastic radial artery during coronary artery bypass grafting surgery. | The Journal of thoracic and cardiovascular surgery 20110801 |
| Fasudil, a Rho-associated protein kinase inhibitor, attenuates retinal ischemia and reperfusion injury in rats. | International journal of molecular medicine 20110801 |
| Endothelial microparticle formation by angiotensin II is mediated via Ang II receptor type I/NADPH oxidase/ Rho kinase pathways targeted to lipid rafts. | Arteriosclerosis, thrombosis, and vascular biology 20110801 |
| Rho-kinase: important new therapeutic target in cardiovascular diseases. | American journal of physiology. Heart and circulatory physiology 20110801 |
| Rosuvastatin prevents proteinuria and renal inflammation in nitric oxide-deficient rats. | Clinics (Sao Paulo, Brazil) 20110801 |
| Refractory coronary artery spasm after minimally invasive direct coronary artery bypass grafting. | The Korean journal of thoracic and cardiovascular surgery 20110801 |
| The effect of adrenergic β(2) receptor agonist on paraplegia following clamping of abdominal aorta. | Archives of medical science : AMS 20110801 |
| Preventive and therapeutic effects of the selective Rho-kinase inhibitor fasudil on experimental autoimmune neuritis. | Journal of the neurological sciences 20110715 |
| Design and synthesis of small molecule RhoA inhibitors: a new promising therapy for cardiovascular diseases? | Journal of medicinal chemistry 20110714 |
| Regulation of V-ATPase recycling via a RhoA- and ROCKII-dependent pathway in epididymal clear cells. | American journal of physiology. Cell physiology 20110701 |
| Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses isoproterenol-induced heart failure in rats via JNK and ERK1/2 pathways. | Journal of cellular biochemistry 20110701 |
| Rho GTPases as regulators of morphological neuroplasticity. | Annals of anatomy = Anatomischer Anzeiger : official organ of the Anatomische Gesellschaft 20110701 |
| Rho kinase inhibition by fasudil attenuates cyclosporine-induced kidney injury. | The Journal of pharmacology and experimental therapeutics 20110701 |
| Fasudil and ozagrel in combination show neuroprotective effects on cerebral infarction after murine middle cerebral artery occlusion. | The Journal of pharmacology and experimental therapeutics 20110701 |
| Inhalation of Stachybotrys chartarum evokes pulmonary arterial remodeling in mice, attenuated by Rho-kinase inhibitor. | Mycopathologia 20110701 |
| [The effect of fasudil via Rho/ROCK signaling pathway on the inflammation and fibrosis in human mesangial cells in high glucose medium]. | Zhonghua nei ke za zhi 20110701 |
| Rho kinase inhibitor fasudil suppresses migration and invasion though down-regulating the expression of VEGF in lung cancer cell line A549. | Medical oncology (Northwood, London, England) 20110601 |
| The Rho kinase inhibitor Fasudil up-regulates astrocytic glutamate transport subsequent to actin remodelling in murine cultured astrocytes. | British journal of pharmacology 20110601 |
| Rho kinase inhibitors stimulate the migration of human cultured osteoblastic cells by regulating actomyosin activity. | Cellular & molecular biology letters 20110601 |
| Caveolin-1 and force regulation in porcine airway smooth muscle. | American journal of physiology. Lung cellular and molecular physiology 20110601 |
| Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses high glucose-induced proliferation and collagen synthesis in rat cardiac fibroblasts. | Clinical and experimental pharmacology & physiology 20110601 |
| [Anti-hepatofibrosis effect of fasudil hydrochloride on Schistosoma japonicum-infected mice]. | Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases 20110601 |
| Neuronal T-type calcium channels: what's new? Iftinca: T-type channel regulation. | Journal of medicine and life 20110515 |
| New perspectives for the treatment of pulmonary hypertension. | British journal of pharmacology 20110501 |
| ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. | Microvascular research 20110501 |
| Involvement of Rho-kinase in collar-induced vasoconstriction and vascular hypersensitivity to serotonin in rat carotid. | International journal of cardiology 20110414 |
| Role of Rho-kinase signaling and endothelial dysfunction in modulating blood flow distribution in pulmonary hypertension. | Journal of applied physiology (Bethesda, Md. : 1985) 20110401 |
| Dependence of Golgi apparatus integrity on nitric oxide in vascular cells: implications in pulmonary arterial hypertension. | American journal of physiology. Heart and circulatory physiology 20110401 |
| Rho kinase inhibition activates the homologous angiotensin-converting enzyme-angiotensin-(1-9) axis in experimental hypertension. | Journal of hypertension 20110401 |
| Fasudil mesylate protects PC12 cells from oxidative stress injury via the Bax-mediated pathway. | Cellular and molecular neurobiology 20110301 |
| Rho-kinase in development and heart failure: insights from genetic models. | Pediatric cardiology 20110301 |
| Optimisation of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. | Bioorganic & medicinal chemistry letters 20110215 |
| Chronic treatment with an oral rho-kinase inhibitor restores erectile function by suppressing corporal apoptosis in diabetic rats. | The journal of sexual medicine 20110201 |
| Rho kinase inhibition protects kidneys from diabetic nephropathy without reducing blood pressure. | Kidney international 20110201 |
| Fasudil protects cultured N1E-115 cells against lysophosphatidic acid-induced neurite retraction through inhibition of Rho-kinase. | Brain research bulletin 20110201 |
| HA1077, a Rho kinase inhibitor, suppresses glioma-induced angiogenesis by targeting the Rho-ROCK and the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase (MEK/ERK) signal pathways. | Cancer science 20110201 |
| Rho and Rho-kinase activity in adipocytes contributes to a vicious cycle in obesity that may involve mechanical stretch. | Science signaling 20110125 |
| Effects of fasudil, a Rho-associated protein kinase inhibitor, on optic nerve head blood flow in rabbits. | Investigative ophthalmology & visual science 20110105 |
| Inhibition of Rho kinase by fasudil hydrochloride attenuates lung injury induced by intestinal ischemia and reperfusion. | Life sciences 20110103 |
| Attenuation of pulmonary hypertension secondary to left ventricular dysfunction in the rat by Rho-kinase inhibitor fasudil. | Pediatric pulmonology 20110101 |
| Effects of systemic inhibition of Rho kinase on blood pressure and renal haemodynamics in diabetic rats. | British journal of pharmacology 20110101 |
| Inhibition of the Rho/ROCK pathway prevents neuronal degeneration in vitro and in vivo following methylmercury exposure. | Toxicology and applied pharmacology 20110101 |
| Measurement of Rho-associated kinase (ROCK) activity in humans: validity of leukocyte p-MBS/t-MBS in comparison with vascular response to fasudil. | Atherosclerosis 20110101 |
| Inhibition of Rho-kinase abrogates migration of human transitional cell carcinoma cells: results of an in vitro study. | Urologia internationalis 20110101 |
| Rho kinase inhibition in diabetic nephropathy. | Current opinion in nephrology and hypertension 20110101 |
| Aberrant ROCK activation promotes the development of type I diabetes in NOD mice. | Cellular immunology 20110101 |
| Advances in treatment of cerebral vasospasm: an update. | Acta neurochirurgica. Supplement 20110101 |
| Clinical trial of nicardipine prolonged-release implants for preventing cerebral vasospasm: multicenter cooperative study in Tokyo. | Acta neurochirurgica. Supplement 20110101 |
| Intra-arterial Administration of Fasudil Hydrochloride for Vasospasm Following Subarachnoid Haemorrhage: Experience of 90 Cases. | Acta neurochirurgica. Supplement 20110101 |
| Synthesis and biological evaluation of 7-substituted-1-(3-bromophenylamino)isoquinoline-4-carbonitriles as inhibitors of myosin light chain kinase and epidermal growth factor receptor. | Bioorganic & medicinal chemistry 20110101 |
| Fragment-based discovery of 6-substituted isoquinolin-1-amine based ROCK-I inhibitors. | Bioorganic & medicinal chemistry letters 20110101 |
| Atorvastatin prevents Plasmodium falciparum cytoadherence and endothelial damage. | Malaria journal 20110101 |
| The plant-based immunomodulator curcumin as a potential candidate for the development of an adjunctive therapy for cerebral malaria. | Malaria journal 20110101 |
| Whole plant extracts versus single compounds for the treatment of malaria: synergy and positive interactions. | Malaria journal 20110101 |
| Continuous intravertebral artery injection of fasudil hydrochloride in the treatment of cerebral vasospasm. | Neurology India 20110101 |
| Continuous intravertebral injection of fasudil hydrochloride in the treatment of cerebral vasospasm. | Neurology India 20110101 |
| Role of rho kinase in microvascular damage following cerebral ischemia reperfusion in rats. | International journal of molecular sciences 20110101 |
| Therapeutic strategies in pulmonary hypertension. | Frontiers in pharmacology 20110101 |
| Multichannel near-infrared spectroscopy as a tool for assisting intra-arterial fasudil therapy for diffuse vasospasm after subarachnoid hemorrhage. | Surgical neurology international 20110101 |
| Inhibition of MLC phosphorylation restricts replication of influenza virus--a mechanism of action for anti-influenza agents. | PloS one 20110101 |
| Recent progress in the management of pulmonary hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20110101 |
| A proposed definition of symptomatic vasospasm based on treatment of cerebral vasospasm after subarachnoid hemorrhage in Japan: Consensus 2009, a project of the 25 Spasm Symposium. | Surgical neurology international 20110101 |
| Potassium-induced intermittent vasomotion in rat isolated pulmonary artery. | Journal of smooth muscle research = Nihon Heikatsukin Gakkai kikanshi 20110101 |
| Vasodilatation produced by fasudil mesylate in vivo and in vitro. | Vascular pharmacology 20110101 |
| Fasudil ameliorates rhabdomyolysis-induced acute kidney injury via inhibition of apoptosis. | Renal failure 20110101 |
| Tyrosine kinases in rheumatoid arthritis. | Journal of inflammation (London, England) 20110101 |
| Co-crystal structures of inhibitors with MRCKβ, a key regulator of tumor cell invasion. | PloS one 20110101 |
| Comparison of ROCK and EGFR activation pathways in the progression of glomerular injuries in AngII-infused rats. | Renal failure 20110101 |
| Efficacy and safety of fasudil in patients with subarachnoid hemorrhage: final results of a randomized trial of fasudil versus nimodipine. | Neurologia medico-chirurgica 20110101 |
| VIP and endothelin receptor antagonist: an effective combination against experimental pulmonary arterial hypertension. | Respiratory research 20110101 |
| Hydroxyfasudil-mediated inhibition of ROCK1 and ROCK2 improves kidney function in rat renal acute ischemia-reperfusion injury. | PloS one 20110101 |
| Rho kinase inhibition by fasudil has anti-inflammatory effects in hypercholesterolemic rats. | Biological & pharmaceutical bulletin 20110101 |
| ROCKing Regeneration: Rho Kinase Inhibition as Molecular Target for Neurorestoration. | Frontiers in molecular neuroscience 20110101 |
| Vascular involvement in systemic sclerosis (scleroderma). | Journal of inflammation research 20110101 |
| The genetics of pulmonary arterial hypertension in the post-BMPR2 era. | Pulmonary circulation 20110101 |
| S1P(4) receptor mediates S1P-induced vasoconstriction in normotensive and hypertensive rat lungs. | Pulmonary circulation 20110101 |
| Sedative and antiepileptic effects of Anthocephalus cadamba Roxb. in mice and rats. | Indian journal of pharmacology 20110101 |
| The chemical basis of pharmacology. | Biochemistry 20101207 |
| Rescue treatment with a Rho-kinase inhibitor normalizes right ventricular function and reverses remodeling in juvenile rats with chronic pulmonary hypertension. | American journal of physiology. Heart and circulatory physiology 20101201 |
| Urotensin II alters vascular reactivity in animals subjected to volume overload. | Peptides 20101101 |
| Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis. | Bioorganic & medicinal chemistry letters 20101101 |
| Identification of small molecules enhancing autophagic function from drug network analysis. | Autophagy 20101101 |
| [Molecular mechanisms of preretinal membrane contraction in proliferative vitreoretinal diseases and ROCK as a therapeutic target]. | Nippon Ganka Gakkai zasshi 20101101 |
| [Effect of notch signaling on differentiation of rat marrow mesenchymal stem cells into neurons induced by fasudil hydrochloride]. | Zhongguo ying yong sheng li xue za zhi = Zhongguo yingyong shenglixue zazhi = Chinese journal of applied physiology 20101101 |
| The DOCA-Salt Hypertensive Rat as a Model of Cardiovascular Oxidative and Inflammatory Stress. | Current cardiology reviews 20101101 |
| Characterization of Fasudil in preclinical models of pain. | The journal of pain : official journal of the American Pain Society 20101001 |
| Fasudil reduces monocrotaline-induced pulmonary arterial hypertension: comparison with bosentan and sildenafil. | The European respiratory journal 20101001 |
| ROCK2 is involved in accelerated fetal lung development induced by in vivo lung distension. | Pediatric pulmonology 20101001 |
| Effect of tongxinluo on vasoconstriction induced by the chronic injury of the adventitia in the rat carotid artery. | Journal of ethnopharmacology 20100915 |
| Antinociceptive effects of AS1892802, a novel Rho kinase inhibitor, in rat models of inflammatory and noninflammatory arthritis. | The Journal of pharmacology and experimental therapeutics 20100901 |
| Rho-kinase signalling regulates CXC chemokine formation and leukocyte recruitment in colonic ischemia-reperfusion. | International journal of colorectal disease 20100901 |
| Beneficial effects of a combination of Rho-kinase inhibitor and ACE inhibitor on tubulointerstitial fibrosis induced by unilateral ureteral obstruction. | Hypertension research : official journal of the Japanese Society of Hypertension 20100901 |
| Rho-kinase/ROCK: A key regulator of the cytoskeleton and cell polarity. | Cytoskeleton (Hoboken, N.J.) 20100901 |
| Fasudil protects hippocampal neurons against hypoxia-reoxygenation injury by suppressing microglial inflammatory responses in mice. | Journal of neurochemistry 20100901 |
| Effect of fasudil on growth, adhesion, invasion, and migration of 95D lung carcinoma cells in vitro. | Canadian journal of physiology and pharmacology 20100901 |
| NFATc3 contributes to intermittent hypoxia-induced arterial remodeling in mice. | American journal of physiology. Heart and circulatory physiology 20100801 |
| Deletion of the receptor for advanced glycation end products reduces glomerulosclerosis and preserves renal function in the diabetic OVE26 mouse. | Diabetes 20100801 |
| Simvastatin improves clinical scores in a rabbit multiple infarct ischemic stroke model: synergism with a ROCK inhibitor but not the thrombolytic tissue plasminogen activator. | Brain research 20100716 |
| Rho kinase activation and ROS production contributes to the cooling enhanced contraction in cutaneous equine digital veins. | Journal of applied physiology (Bethesda, Md. : 1985) 20100701 |
| Simultaneous quantitative analysis of fasudil and its active metabolite in human plasma by liquid chromatography electro-spray tandem mass spectrometry. | Journal of pharmaceutical and biomedical analysis 20100605 |
| Synergistic effects of bone marrow stromal cells and a Rho kinase (ROCK) inhibitor, fasudil on axon regeneration in rat spinal cord injury. | Neuropathology : official journal of the Japanese Society of Neuropathology 20100601 |
| Therapeutic potential of experimental autoimmune encephalomyelitis by Fasudil, a Rho kinase inhibitor. | Journal of neuroscience research 20100601 |
| Modulation of cerebral malaria by fasudil and other immune-modifying compounds. | Experimental parasitology 20100601 |
| Rho-kinase inhibitor, fasudil, suppresses glioblastoma cell line progression in vitro and in vivo. | Cancer biology & therapy 20100601 |
| Emerging medical treatment for angina pectoris. | Expert opinion on emerging drugs 20100601 |
| Substituted 2H-isoquinolin-1-one as potent Rho-Kinase inhibitors. Part 1: Hit-to-lead account. | Bioorganic & medicinal chemistry letters 20100601 |
| Comparative effects of cilostazol and aspirin on the impairment of endothelium-dependent cerebral vasodilation caused by acute cigarette smoking in rats. | Journal of thrombosis and thrombolysis 20100501 |
| Vasospasm after aneurysmal subarachnoid hemorrhage: recent advances in endovascular management. | Current opinion in critical care 20100401 |
| Rho-kinase limits FGF-2-stimulated VEGF release in osteoblasts. | Bone 20100401 |
| Rho kinase and protein kinase C involvement in vascular smooth muscle myofilament calcium sensitization in arteries from diabetic rats. | British journal of pharmacology 20100401 |
| Fasudil attenuates lipopolysaccharide-induced acute lung injury in mice through the Rho/Rho kinase pathway. | Medical science monitor : international medical journal of experimental and clinical research 20100401 |
| Increased RhoA/ROK mRNA expression and function in diabetic vein grafts compared with nondiabetic vein grafts and diabetic arterial grafts. | The Thoracic and cardiovascular surgeon 20100401 |
| A comparative study of alpha-adrenergic receptor mediated Ca(2+) signals and contraction in intact human and mouse vascular smooth muscle. | European journal of pharmacology 20100310 |
| Presence of a ROCK inhibitor in extracellular matrix supports more undifferentiated growth of feeder-free human embryonic and induced pluripotent stem cells upon passaging. | Stem cell reviews 20100301 |
| BMPER is upregulated by statins and modulates endothelial inflammation by intercellular adhesion molecule-1. | Arteriosclerosis, thrombosis, and vascular biology 20100301 |
| Rho-kinase regulates negatively the epidermal growth factor-stimulated colon cancer cell proliferation. | International journal of oncology 20100301 |
| Acute vasodilator effects of inhaled fasudil, a specific Rho-kinase inhibitor, in patients with pulmonary arterial hypertension. | Heart and vessels 20100301 |
| Role of Rho kinase and oxidative stress in cardiac fibrosis induced by aldosterone and salt in angiotensin type 1a receptor knockout mice. | Regulatory peptides 20100225 |
| Fasudil, a Rho-kinase inhibitor, attenuates induction and progression of cerebral aneurysms: experimental study in rats using vascular corrosion casts. | Neuroscience letters 20100205 |
| Effects of rho-kinase inhibition on pulmonary hypertension, lung growth, and structure in neonatal rats chronically exposed to hypoxia. | Pediatric research 20100201 |
| Fasudil, a Rho kinase inhibitor, drives mobilization of adult neural stem cells after hypoxia/reoxygenation injury in mice. | Molecular and cellular neurosciences 20100201 |
| The influence of fasudil on the epithelial-mesenchymal transdifferentiation of renal tubular epithelial cells from diabetic rats. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100201 |
| Protective effects of cold spinoplegia with fasudil against ischemic spinal cord injury in rabbits. | Journal of vascular surgery 20100201 |
| Angina in Women without Obstructive Coronary Artery Disease. | Current cardiology reviews 20100201 |
| Hit to lead account of the discovery of bisbenzamide and related ureidobenzamide inhibitors of Rho kinase. | Journal of medicinal chemistry 20100128 |
| Amelioration of endothelial damage/dysfunction is a possible mechanism for the neuroprotective effects of Rho-kinase inhibitors against ischemic brain damage. | Brain research bulletin 20100115 |
| The Rho kinase inhibitor fasudil inhibits the migratory behaviour of 95-D lung carcinoma cells. | Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 20100101 |
| Inhibition of NF-kappaB signaling by fasudil as a potential therapeutic strategy for rheumatoid arthritis. | Arthritis and rheumatism 20100101 |
| Convulsion during intra-arterial infusion of fasudil hydrochloride for the treatment of cerebral vasospasm following subarachnoid hemorrhage. | Neurologia medico-chirurgica 20100101 |
| Fasudil hydrochloride induces osteoblastic differentiation of stromal cell lines, C3H10T1/2 and ST2, via bone morphogenetic protein-2 expression. | Endocrine journal 20100101 |
| HA1077 enhances the cytokeratin expression of mesenchymal stem cells. | Journal of burn care & research : official publication of the American Burn Association 20100101 |
| Novel approaches to treat experimental pulmonary arterial hypertension: a review. | Journal of biomedicine & biotechnology 20100101 |
| The role of rho kinase in sex-dependent vascular dysfunction in type 1 diabetes. | Experimental diabetes research 20100101 |
| ERK-MAPK signaling opposes rho-kinase to reduce cardiomyocyte apoptosis in heart ischemic preconditioning. | Molecular medicine (Cambridge, Mass.) 20100101 |
| Little ROCK is a ROCK1 pseudogene expressed in human smooth muscle cells. | BMC genetics 20100101 |
| Recent achievements in the management of Raynaud's phenomenon. | Vascular health and risk management 20100101 |
| Increased dendrite branching in AbetaPP/PS1 mice and elongation of dendrite arbors by fasudil administration. | Journal of Alzheimer's disease : JAD 20100101 |
| Advances in the treatment of Raynaud's phenomenon. | Vascular health and risk management 20100101 |
| ROCK as a Therapeutic Target of Diabetic Retinopathy. | Journal of ophthalmology 20100101 |
| Modification of the detrimental effect of TNF-α on human endothelial progenitor cells by fasudil and Y27632. | Journal of biochemical and molecular toxicology 20100101 |
| Recent advances in the management of chronic stable angina II. Anti-ischemic therapy, options for refractory angina, risk factor reduction, and revascularization. | Vascular health and risk management 20100101 |
| Characterization of dysferlin deficient SJL/J mice to assess preclinical drug efficacy: fasudil exacerbates muscle disease phenotype. | PloS one 20100101 |
| Inhalational therapy for pulmonary arterial hypertension: current status and future prospects. | Critical reviews in therapeutic drug carrier systems 20100101 |
| Inhibition of Plasmodium falciparum field isolates-mediated endothelial cell apoptosis by Fasudil: therapeutic implications for severe malaria. | PloS one 20100101 |
| Apoptosis induced by parasitic diseases. | Parasites & vectors 20100101 |
| Matrix rigidity induces osteolytic gene expression of metastatic breast cancer cells. | PloS one 20100101 |
| Statins inhibit angiotensin II/Smad pathway and related vascular fibrosis, by a TGF-β-independent process. | PloS one 20100101 |
| The role of RhoA/Rho kinase pathway in endothelial dysfunction. | Journal of cardiovascular disease research 20100101 |
| Clinical and experimental advances in regeneration of spinal cord injury. | Journal of tissue engineering 20100101 |
| Role of rho-kinase in the regulation of vascular tone in hypertensive renal transplant recipients. | Atherosclerosis 20091201 |
| Actin-binding rho activating protein (Abra) is essential for fluid shear stress-induced arteriogenesis. | Arteriosclerosis, thrombosis, and vascular biology 20091201 |
| Effects of fasudil, a Rho-kinase inhibitor, on contraction of pig bladder tissues with or without urothelium. | International journal of urology : official journal of the Japanese Urological Association 20091201 |
| Fasudil inhibits lysophosphatidic acid-induced invasiveness of human ovarian cancer cells. | International journal of gynecological cancer : official journal of the International Gynecological Cancer Society 20091201 |
| Vascular responses to nitrite are mediated by xanthine oxidoreductase and mitochondrial aldehyde dehydrogenase in the rat. | Canadian journal of physiology and pharmacology 20091201 |
| A Rho-kinase inhibitor, fasudil, attenuates progressive glomerulosclerosis induced by daunorubicin in rats. | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban 20091201 |
| Recent insights into the mechanisms of vasospastic angina. | Korean circulation journal 20091201 |
| Involvement of Rho-kinase in tumor necrosis factor-alpha-induced interleukin-6 release from C6 glioma cells. | Neurochemistry international 20091101 |
| Rho kinase inhibitor Fasudil induces neuroprotection and neurogenesis partially through astrocyte-derived G-CSF. | Brain, behavior, and immunity 20091101 |
| Effects of fasudil on early atherosclerotic plaque formation and established lesion progression in apolipoprotein E-knockout mice. | Atherosclerosis 20091101 |
| Involvement of Rho-kinase in prostaglandin E(1)-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblast-like MC3T3-E1 cells. | Prostaglandins & other lipid mediators 20091101 |
| Reflex vasoconstriction in aged human skin increasingly relies on Rho kinase-dependent mechanisms during whole body cooling. | American journal of physiology. Heart and circulatory physiology 20091101 |
| [Effects of fasudil on the expression of Rho kinase-1 and airway inflammation in a mouse model of asthma.]. | Zhonghua jie he he hu xi za zhi = Zhonghua jiehe he huxi zazhi = Chinese journal of tuberculosis and respiratory diseases 20091101 |
| Treatment of rat spinal cord injury with a Rho-kinase inhibitor and bone marrow stromal cell transplantation. | Brain research 20091027 |
| Suppression of hepatitis C virus replication by protein kinase C-related kinase 2 inhibitors that block phosphorylation of viral RNA polymerase. | Journal of viral hepatitis 20091001 |
| Current status of rho-associated kinases (ROCKs) in coronary atherosclerosis and vasospasm. | Cardiovascular & hematological agents in medicinal chemistry 20091001 |
| Sex-dependent differences in Rho activation contribute to contractile dysfunction in type 2 diabetic mice. | American journal of physiology. Heart and circulatory physiology 20091001 |
| Pharmacological characterization of SAR407899, a novel rho-kinase inhibitor. | Hypertension (Dallas, Tex. : 1979) 20090901 |
| Can we improve outcome of congenital diaphragmatic hernia? | Pediatric surgery international 20090901 |
| [Experimental study on rho-kinase inhibitor by intravenous injection inhibiting intimal hyperplasia in vein grafts]. | Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery 20090901 |
| [Fasudil promotes migration and vasculogenesis of endothelial cells differentiated from rat bone marrow mesenchymal stem cells in vitro]. | Sheng li xue bao : [Acta physiologica Sinica] 20090825 |
| Macrolide antibiotics inhibit respiratory syncytial virus infection in human airway epithelial cells. | Antiviral research 20090801 |
| Rho-kinase inhibitors Y-27632 and fasudil prevent agonist-induced vasospasm in human radial artery. | Canadian journal of physiology and pharmacology 20090801 |
| Inhibition of RhoA pathway rescues the endocytosis defects in Oligophrenin1 mouse model of mental retardation. | Human molecular genetics 20090715 |
| [Changes of contractility and relaxation of corpus cavernosum in hyperlipidemic rabbit in vitro]. | Zhonghua yi xue za zhi 20090714 |
| Analysis of pulmonary vasodilator responses to SB-772077-B [4-(7-((3-amino-1-pyrrolidinyl)carbonyl)-1-ethyl-1H-imidazo(4,5-c)pyridin-2-yl)-1,2,5-oxadiazol-3-amine], a novel aminofurazan-based Rho kinase inhibitor. | The Journal of pharmacology and experimental therapeutics 20090701 |
| Involvement of Rho-kinase in sphingosine 1-phosphate-stimulated HSP27 induction in osteoblasts. | International journal of molecular medicine 20090701 |
| RhoA and Rho kinase activation in human pulmonary hypertension: role of 5-HT signaling. | American journal of respiratory and critical care medicine 20090615 |
| Lysophosphatidylcholine induces glial cell activation: role of rho kinase. | Glia 20090601 |
| Rho kinase inhibitors prevent endothelium-dependent contractions in the rat aorta. | The Journal of pharmacology and experimental therapeutics 20090501 |
| Rho kinase inhibition attenuates LPS-induced renal failure in mice in part by attenuation of NF-kappaB p65 signaling. | American journal of physiology. Renal physiology 20090501 |
| Air pollution and cardiac remodeling: a role for RhoA/Rho-kinase. | American journal of physiology. Heart and circulatory physiology 20090501 |
| Vascular dysfunction in septic shock--any ROCKing news? | Critical care medicine 20090501 |
| Adhesion of Plasmodium falciparum-infected erythrocytes to human cells: molecular mechanisms and therapeutic implications. | Expert reviews in molecular medicine 20090501 |
| [Change of Rho kinase activity in brain tissue in high altitude condition and its relationship with high altitude cerebral edema: experiment with rats]. | Zhonghua yi xue za zhi 20090407 |
| Acute inhibition of Rho-kinase attenuates pulmonary hypertension in patients with congenital heart disease. | Pediatric cardiology 20090401 |
| Rho GTPases in hepatocellular carcinoma. | Biochimica et biophysica acta 20090401 |
| Neuroprotective potential of fasudil mesylate in brain ischemia-reperfusion injury of rats. | Cellular and molecular neurobiology 20090301 |
| Glucose-dependent enhancement of diabetic bladder contraction is associated with a rho kinase-regulated protein kinase C pathway. | The Journal of pharmacology and experimental therapeutics 20090301 |
| Inhibition of the activity of Rho-kinase reduces cardiomyocyte apoptosis in heart ischemia/reperfusion via suppressing JNK-mediated AIF translocation. | Clinica chimica acta; international journal of clinical chemistry 20090301 |
| [Preventive strategy for the treatment of diabetic vitreoretinopathy]. | Nippon Ganka Gakkai zasshi 20090301 |
| Increased leukocyte ROCK activity in patients after acute ischemic stroke. | Brain research 20090227 |
| Activation of Rho kinase isoforms in lung endothelial cells during inflammation. | Journal of immunology (Baltimore, Md. : 1950) 20090215 |
| Importance of Rac1 signaling pathway inhibition in the pleiotropic effects of HMG-CoA reductase inhibitors. | Circulation journal : official journal of the Japanese Circulation Society 20090201 |
| Peripheral delivery of a ROCK inhibitor improves learning and working memory. | Behavioral neuroscience 20090201 |
| Myelin-mediated inhibition of oligodendrocyte precursor differentiation can be overcome by pharmacological modulation of Fyn-RhoA and protein kinase C signalling. | Brain : a journal of neurology 20090201 |
| Contribution of RhoA kinase and protein kinase C to weak relaxant effect of pinacidil on carbachol-induced contractions in sensitized guinea-pig trachealis. | Archives of pharmacal research 20090201 |
| Effect of RhoA signaling transduction on expression of Ezrin in breast cancer cell lines. | Ai zheng = Aizheng = Chinese journal of cancer 20090201 |
| Rho-kinase inhibitors decrease TGF-beta-stimulated VEGF synthesis through stress-activated protein kinase/c-Jun N-terminal kinase in osteoblasts. | Biochemical pharmacology 20090115 |
| Inhibition of intracellular Ca2+ release by a Rho-kinase inhibitor for the treatment of ischemic damage in primary cultured rat hippocampal neurons. | European journal of pharmacology 20090114 |
| Rho kinase inhibition by fasudil ameliorates diabetes-induced microvascular damage. | Diabetes 20090101 |
| Activation of AMP kinase and inhibition of Rho kinase induce the mineralization of osteoblastic MC3T3-E1 cells through endothelial NOS and BMP-2 expression. | American journal of physiology. Endocrinology and metabolism 20090101 |
| Fasudil hydrochloride hydrate, a Rho-kinase inhibitor, suppresses 5-hydroxytryptamine-induced pulmonary artery smooth muscle cell proliferation via JNK and ERK1/2 pathway. | Pharmacology 20090101 |
| In vivo dilatation of the ductus arteriosus by Rho kinase inhibition in the rat. | Neonatology 20090101 |
| Collateral circulation: past and present. | Basic research in cardiology 20090101 |
| The effect of the Rho-associated protein kinase inhibitor, HA-1077, in the rabbit ocular hypertension model induced by water loading. | Current eye research 20090101 |
| Signaling through Rho GTPase pathway as viable drug target. | Current medicinal chemistry 20090101 |
| Therapeutic approach against intimal hyperplasia of vein grafts through endothelial nitric oxide synthase/nitric oxide (eNOS/NO) and the Rho/Rho-kinase pathway. | Surgery today 20090101 |
| Losartan counteracts the hyper-reactivity to angiotensin II and ROCK1 over-activation in aortas isolated from streptozotocin-injected diabetic rats. | Cardiovascular diabetology 20090101 |
| Treatment of pediatric pulmonary hypertension. | Vascular health and risk management 20090101 |
| RhoA/ROK pathway related to the mechanism of higher susceptibility to spasm in RA than in IMA. | Journal of cardiac surgery 20090101 |
| Rho kinase (ROCK) inhibitors and their application to inflammatory disorders. | Current topics in medicinal chemistry 20090101 |
| RhoA/Rho-kinase signaling: a therapeutic target in pulmonary hypertension. | Vascular health and risk management 20090101 |
| Involvement of Rho-kinase in TGF-β-stimulated heat shock protein 27 induction in osteoblasts. | Molecular medicine reports 20090101 |
| Treatment of cerebral vasospasm with biocompatible controlled-release systems for intracranial drug delivery. | Neurosurgery 20081201 |
| A Rho-kinase inhibitor improves cardiac function after 24-hour heart preservation. | The Journal of thoracic and cardiovascular surgery 20081201 |
| A molecular mechanism of P-loop pliability of Rho-kinase investigated by molecular dynamic simulation. | Journal of computer-aided molecular design 20081101 |
| Analysis of pulmonary vasodilator responses to the Rho-kinase inhibitor fasudil in the anesthetized rat. | American journal of physiology. Lung cellular and molecular physiology 20081101 |
| Mechanisms mediating the oxygen-induced vasoreactivity of the ductus arteriosus in the chicken embryo. | American journal of physiology. Regulatory, integrative and comparative physiology 20081101 |
| Rho-associated kinase inhibitor Y-27632 promotes survival of cynomolgus monkey embryonic stem cells. | Molecular human reproduction 20081101 |
| Antiinflammatory effect of Rho kinase blockade via inhibition of NF-kappaB activation in rheumatoid arthritis. | Arthritis and rheumatism 20081101 |
| [The role of Rho-kinase pathway on PAH]. | Nihon rinsho. Japanese journal of clinical medicine 20081101 |
| Experimental benefits of sex hormones on vascular function and the outcome of hormone therapy in cardiovascular disease. | Current cardiology reviews 20081101 |
| Demonstration of elevation and localization of Rho-kinase activity in the brain of a rat model of cerebral infarction. | European journal of pharmacology 20081010 |
| Air pollution exposure potentiates hypertension through reactive oxygen species-mediated activation of Rho/ROCK. | Arteriosclerosis, thrombosis, and vascular biology 20081001 |
| Calcium sensitization in human esophageal muscle: role for RhoA kinase in maintenance of lower esophageal sphincter tone. | The Journal of pharmacology and experimental therapeutics 20081001 |
| Pharmacological modulation of epithelial mesenchymal transition caused by angiotensin II. Role of ROCK and MAPK pathways. | Pharmaceutical research 20081001 |
| Fasudil inhibits the myogenic response in the fetal pulmonary circulation. | American journal of physiology. Heart and circulatory physiology 20081001 |
| [Role of coil embolization and arterial injection in elderly subarachnoid hemorrhage patients: preliminary report]. | No shinkei geka. Neurological surgery 20081001 |
| Detection of myosin light chain phosphorylation--a cell-based assay for screening Rho-kinase inhibitors. | Biochemical and biophysical research communications 20080919 |
| Involvement of Rho-kinase in prostaglandin F2alpha-stimulated interleukin-6 synthesis via p38 mitogen-activated protein kinase in osteoblasts. | Molecular and cellular endocrinology 20080910 |
| G12/13 and Gq mediate S1P2-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase. | Cardiovascular research 20080901 |
| Antiepileptic effects of two Rho-kinase inhibitors, Y-27632 and fasudil, in mice. | British journal of pharmacology 20080901 |
| Aldosterone induces interleukin-18 through endothelin-1, angiotensin II, Rho/Rho-kinase, and PPARs in cardiomyocytes. | American journal of physiology. Heart and circulatory physiology 20080901 |
| Fasudil, a Rho-kinase inhibitor, reverses L-NAME exacerbated severe nephrosclerosis in spontaneously hypertensive rats. | Journal of hypertension 20080901 |
| Chronic stable angina pectoris. | Disease-a-month : DM 20080901 |
| Role of Rho kinase pathway in chondroitin sulfate proteoglycan-mediated inhibition of neurite outgrowth in PC12 cells. | Journal of neuroscience research 20080801 |
| Aldosterone and angiotensin II synergistically stimulate migration in vascular smooth muscle cells through c-Src-regulated redox-sensitive RhoA pathways. | Arteriosclerosis, thrombosis, and vascular biology 20080801 |
| Administration of the Rho-kinase inhibitor fasudil before ischemia or just after reperfusion, but not 30 min after reperfusion, protects the stunned myocardium in swine. | Cardiovascular drugs and therapy 20080801 |
| Activated RHOA and peripheral axon regeneration. | Experimental neurology 20080801 |
| Rho-kinase signalling mediates endotoxin hypersensitivity after partial hepatectomy. | The British journal of surgery 20080801 |
| Utility of ranolazine in chronic stable angina patients. | Vascular health and risk management 20080801 |
| Serotonin induces vasoconstriction of smooth muscle cell-rich neointima through 5-hydroxytryptamine2A receptor in rabbit femoral arteries. | Journal of thrombosis and haemostasis : JTH 20080701 |
| Signal transduction underlying the control of urinary bladder smooth muscle tone by muscarinic receptors and beta-adrenoceptors. | Naunyn-Schmiedeberg's archives of pharmacology 20080601 |
| RhoA/Rho-kinase contribute to the pathogenesis of diabetic renal disease. | Diabetes 20080601 |
| Rho-kinase inhibitors augment the inhibitory effect of propofol on rat bronchial smooth muscle contraction. | Anesthesia and analgesia 20080601 |
| Fasudil-induced hypoxia-inducible factor-1alpha degradation disrupts a hypoxia-driven vascular endothelial growth factor autocrine mechanism in endothelial cells. | Molecular cancer therapeutics 20080601 |
| Safety and efficacy of fasudil monotherapy and fasudil-ozagrel combination therapy in patients with subarachnoid hemorrhage: sub-analysis of the post-marketing surveillance study. | Neurologia medico-chirurgica 20080601 |
| Rho-kinase inhibitor and nicotinamide adenine dinucleotide phosphate oxidase inhibitor prevent impairment of endothelium-dependent cerebral vasodilation by acute cigarette smoking in rats. | Journal of the renin-angiotensin-aldosterone system : JRAAS 20080601 |
| [Optic nerve regeneration in adult mammals]. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20080601 |
| The therapeutic effects of Rho-ROCK inhibitors on CNS disorders. | Therapeutics and clinical risk management 20080601 |
| Chronic hypoxia induces Rho kinase-dependent myogenic tone in small pulmonary arteries. | American journal of physiology. Lung cellular and molecular physiology 20080401 |
| Applications for ROCK kinase inhibition. | Current opinion in cell biology 20080401 |
| Central role of rho kinase in lipopolysaccharide-induced platelet capture on venous endothelium. | Journal of investigative medicine : the official publication of the American Federation for Clinical Research 20080401 |
| Rho kinase inhibition in severe malaria: thwarting parasite-induced collateral damage to endothelia. | The Journal of infectious diseases 20080401 |
| Differential effects of two ROCK inhibitors, Fasudil and Y-27632, on optic nerve regeneration in adult cats. | Brain research 20080327 |
| Targeting of RhoA/ROCK signaling ameliorates progression of diabetic nephropathy independent of glucose control. | Diabetes 20080301 |
| Rho-kinase-dependent F-actin rearrangement is involved in the inhibition of PI3-kinase/Akt during ischemia-reperfusion-induced endothelial cell apoptosis. | Apoptosis : an international journal on programmed cell death 20080301 |
| Defective endothelial nitric oxide synthase signaling is mediated by rho-kinase activation in rats with secondary biliary cirrhosis. | Hepatology (Baltimore, Md.) 20080301 |
| Selectivity of ROCK inhibitors in the spontaneously tonic smooth muscle. | American journal of physiology. Gastrointestinal and liver physiology 20080301 |
| Amelioration of crescentic glomerulonephritis by RhoA kinase inhibitor, Fasudil, through podocyte protection and prevention of leukocyte migration. | The American journal of pathology 20080301 |
| Administration of the Rho-kinase inhibitor, fasudil, following nitroglycerin additionally dilates the site of coronary spasm in patients with vasospastic angina. | Coronary artery disease 20080301 |
| Rho kinase inhibition: a new approach for treating diabetic nephropathy? | Diabetes 20080301 |
| Long-term inhibition of Rho-kinase ameliorates diastolic heart failure in hypertensive rats. | Journal of cardiovascular pharmacology 20080301 |
| Wide therapeutic time window for Rho-kinase inhibition therapy in ischemic brain damage in a rat cerebral thrombosis model. | Brain research 20080208 |
| Acute vasodilator effects of Rho-kinase inhibitors in neonatal rats with pulmonary hypertension unresponsive to nitric oxide. | American journal of physiology. Lung cellular and molecular physiology 20080201 |
| [Basic research and treatment for cerebral vasospasm after subarachnoid hemorrhage: the present and future prospects]. | No shinkei geka. Neurological surgery 20080201 |
| Nitric oxide does not downregulate Rho-kinase (ROCK-2) expression in rat coronary endothelial cells. | Journal of cardiovascular pharmacology 20080201 |
| Increased static pressure promotes migration of vascular smooth muscle cells: involvement of the Rho-kinase pathway. | Journal of cardiovascular pharmacology 20080101 |
| High concentrations of landiolol, a beta(1)-adrenoceptor antagonist, stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway. | Journal of anesthesia 20080101 |
| Mechanical stretch induced interleukin-18 (IL-18) expression through Angiotensin subtype 1 receptor (AT1R) and endothelin-1 in cardiomyocytes. | Preparative biochemistry & biotechnology 20080101 |
| Antiangiogenic properties of fasudil, a potent Rho-Kinase inhibitor. | Japanese journal of ophthalmology 20080101 |
| In vitro and in vivo assays to analyze the contribution of Rho kinase in angiogenesis. | Methods in enzymology 20080101 |
| Deleted in liver cancer 1 (DLC1) negatively regulates Rho/ROCK/MLC pathway in hepatocellular carcinoma. | PloS one 20080101 |
| Function of Rho-kinase in prostaglandin D2-induced interleukin-6 synthesis in osteoblasts. | Prostaglandins, leukotrienes, and essential fatty acids 20080101 |
| Prediction of specificity-determining residues for small-molecule kinase inhibitors. | BMC bioinformatics 20080101 |
| [Recent treatment of postischaemic anoxic brain damage after cardiac arrest by using therapeutic hypothermia]. | Srpski arhiv za celokupno lekarstvo 20080101 |
| TRAIL and Taurolidine induce apoptosis and decrease proliferation in human fibrosarcoma. | Journal of experimental & clinical cancer research : CR 20080101 |
| A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases. | Proceedings of the National Academy of Sciences of the United States of America 20071218 |
| The selectivity of protein kinase inhibitors: a further update. | The Biochemical journal 20071215 |
| Rho-kinase regulates endothelin-1-stimulated IL-6 synthesis via p38 MAP kinase in osteoblasts. | Biochemical and biophysical research communications 20071103 |
| Rho kinase and Ca2+ entry mediate increased pulmonary and systemic vascular resistance in L-NAME-treated rats. | American journal of physiology. Lung cellular and molecular physiology 20071101 |
| Inhibition of Rho kinase (ROCK) increases neurite outgrowth on chondroitin sulphate proteoglycan in vitro and axonal regeneration in the adult optic nerve in vivo. | Journal of neurochemistry 20071001 |
| Rho-kinase inhibitor prevents hepatocyte damage in acute liver injury induced by carbon tetrachloride in rats. | American journal of physiology. Gastrointestinal and liver physiology 20071001 |
| Rho kinase activation and gene expression related to vascular remodeling in normotensive rats with high angiotensin I converting enzyme levels. | Hypertension (Dallas, Tex. : 1979) 20071001 |
| [Advances in the study of Rho kinase and its inhibitors]. | Yao xue xue bao = Acta pharmaceutica Sinica 20071001 |
| [Exercise-induced vasospastic angina]. | Nihon rinsho. Japanese journal of clinical medicine 20070928 |
| Fasudil attenuates sympathetic nervous activity in the adrenal medulla of spontaneously hypertensive rats. | Life sciences 20070922 |
| Evaluation of broad spectrum protein kinase inhibitors to probe the architecture of the malarial cyclin dependent protein kinase Pfmrk. | Bioorganic & medicinal chemistry letters 20070901 |
| Role of alpha2C-adrenoceptors in the reduction of skin blood flow induced by local cooling in mice. | British journal of pharmacology 20070901 |
| Rho kinase inhibitor improves motor dysfunction and hypoalgesia in a rat model of lumbar spinal canal stenosis. | Spine 20070901 |
| Cooling augments vasoconstriction mediated by 5-HT1 and alpha2-adrenoceptors in the isolated equine digital vein: involvement of Rho kinase. | European journal of pharmacology 20070827 |
| Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia. | Journal of neuroscience research 20070815 |
| Comparative pharmacological analysis of Rho-kinase inhibitors and identification of molecular components of Ca2+ sensitization in the rat lower urinary tract. | Biochemical pharmacology 20070815 |
| The rho-kinase inhibitors Y-27632 and fasudil act synergistically with imatinib to inhibit the expansion of ex vivo CD34(+) CML progenitor cells. | Leukemia 20070801 |
| A postmarketing surveillance study of fasudil treatment after aneurysmal subarachnoid hemorrhage. | Surgical neurology 20070801 |
| Small-molecule therapies for cardiac hypertrophy: moving beneath the cell surface. | Nature reviews. Drug discovery 20070801 |
| Fasudil attenuates myocardial fibrosis in association with inhibition of monocyte/macrophage infiltration in the heart of DOCA/salt hypertensive rats. | Journal of cardiovascular pharmacology 20070801 |
| Effects of combined therapy with a Rho-kinase inhibitor and prostacyclin on monocrotaline-induced pulmonary hypertension in rats. | Journal of cardiovascular pharmacology 20070801 |
| [Effects of fasudil on neuropathic pain-like state in mice]. | Nihon shinkei seishin yakurigaku zasshi = Japanese journal of psychopharmacology 20070801 |
| The Rho-kinase inhibitor, fasudil, attenuates diabetic nephropathy in streptozotocin-induced diabetic rats. | European journal of pharmacology 20070730 |
| Rho kinase contributes to basal vascular tone in humans: role of endothelium-derived nitric oxide. | American journal of physiology. Heart and circulatory physiology 20070701 |
| Crucial role of Rho-nuclear factor-kappaB axis in angiotensin II-induced renal injury. | American journal of physiology. Renal physiology 20070701 |
| Rho kinase-mediated local cold-induced cutaneous vasoconstriction is augmented in aged human skin. | American journal of physiology. Heart and circulatory physiology 20070701 |
| Fasudil, a Rho kinase (ROCK) inhibitor, protects against ischemic neuronal damage in vitro and in vivo by acting directly on neurons. | Brain research 20070618 |
| Rho kinase activation plays a major role as a mediator of irreversible injury in reperfused myocardium. | American journal of physiology. Heart and circulatory physiology 20070601 |
| The RISK of ROCK. | American journal of physiology. Heart and circulatory physiology 20070601 |
| Pulmonary arterial hypertension: current therapeutic strategies. | Nature clinical practice. Cardiovascular medicine 20070601 |
| Vasodilator effects of fasudil, a Rho-kinase inhibitor, on retinal arterioles in stroke-prone spontaneously hypertensive rats. | Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 20070601 |
| Inhibition of Rho-kinase attenuates nephrosclerosis and improves survival in salt-loaded spontaneously hypertensive stroke-prone rats. | Journal of hypertension 20070501 |
| Fasudil inhibits vascular endothelial growth factor-induced angiogenesis in vitro and in vivo. | Molecular cancer therapeutics 20070501 |
| Oxygen activates the Rho/Rho-kinase pathway and induces RhoB and ROCK-1 expression in human and rabbit ductus arteriosus by increasing mitochondria-derived reactive oxygen species: a newly recognized mechanism for sustaining ductal constriction. | Circulation 20070403 |
| Cold-induced cutaneous vasoconstriction is mediated by Rho kinase in vivo in human skin. | American journal of physiology. Heart and circulatory physiology 20070401 |
| Rosiglitazone attenuates hypoxia-induced pulmonary arterial remodeling. | American journal of physiology. Lung cellular and molecular physiology 20070401 |
| Recent progress in the treatment of pulmonary arterial hypertension: expectation for rho-kinase inhibitors. | The Tohoku journal of experimental medicine 20070401 |
| Effects of Rho-kinase inactivation on eosinophilia and hyper-reactivity in murine airways by allergen challenges. | Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology 20070401 |
| Rho kinase-mediated vasoconstriction is important in severe occlusive pulmonary arterial hypertension in rats. | Circulation research 20070330 |
| RhoA/Rho kinase up-regulate Bax to activate a mitochondrial death pathway and induce cardiomyocyte apoptosis. | The Journal of biological chemistry 20070316 |
| Progress of the study of rho-kinase and future perspective of the inhibitor. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20070301 |
| A Rho-kinase inhibitor, fasudil, prevents development of diabetes and nephropathy in insulin-resistant diabetic rats. | The Journal of endocrinology 20070301 |
| Anti-ischemic effects of fasudil, a specific Rho-kinase inhibitor, in patients with stable effort angina. | Journal of cardiovascular pharmacology 20070301 |
| Yale University School of Medicine: 2007 student thesis abstracts. | The Yale journal of biology and medicine 20070301 |
| Roles of rho-associated kinase and oxidative stress in the pathogenesis of aortic stiffness. | Journal of the American College of Cardiology 20070213 |
| The Rho-associated kinase inhibitor fasudil hydrochloride enhances neural regeneration after axotomy in the peripheral nervous system. | Plastic and reconstructive surgery 20070201 |
| Acute vasodilator effect of fasudil, a Rho-kinase inhibitor, in monocrotaline-induced pulmonary hypertension in rats. | Journal of cardiovascular pharmacology 20070201 |
| [Perspectives in the treatment of subarachnoid-hemorrhage-induced cerebral vasospasm]. | Neurocirugia (Asturias, Spain) 20070201 |
| Design and synthesis of rho kinase inhibitors (III). | Bioorganic & medicinal chemistry 20070115 |
| Microarray-based kinase inhibition assay by gold nanoparticle probes. | Analytical chemistry 20070115 |
| Wide therapeutic time window for fasudil neuroprotection against ischemia-induced delayed neuronal death in gerbils. | Brain research 20070112 |
| Inhibition of rho kinase attenuates high flow induced pulmonary hypertension in rats. | Chinese medical journal 20070105 |
| Novel Rho kinase inhibitors with anti-inflammatory and vasodilatory activities. | The Journal of pharmacology and experimental therapeutics 20070101 |
| Long-term inhibition of Rho kinase with fasudil attenuates high flow induced pulmonary artery remodeling in rats. | Pharmacological research 20070101 |
| Transforming growth factor-beta2 and connective tissue growth factor in proliferative vitreoretinal diseases: possible involvement of hyalocytes and therapeutic potential of Rho kinase inhibitor. | Diabetes 20070101 |
| Systemic availability of the active metabolite hydroxy-fasudil after administration of fasudil to different sites of the human gastrointestinal tract. | Journal of clinical pharmacology 20070101 |
| Fasudil: a potential addition to the anti-arthritis weaponry. | Medical hypotheses 20070101 |
| Neural differentiation of human neuroblastoma GOTO cells via a Rho-Rho kinase-phosphorylation signal transduction and continuous observation of a single GOTO cell during differentiation. | The Journal of veterinary medical science 20070101 |
| RhoA/Rho kinase-mediated Ca2+ sensitization in the contraction of human prostate. | Neurourology and urodynamics 20070101 |
| Rho kinase in the regulation of cell death and survival. | Archivum immunologiae et therapiae experimentalis 20070101 |
| Recent advances in the pathogenesis and treatment of persistent pulmonary hypertension of the newborn. | Neonatology 20070101 |
| Involvement of the Rho/Rho kinase signaling pathway in platelet-derived growth factor BB-induced vascular endothelial growth factor expression in diabetic rat retina. | Japanese journal of ophthalmology 20070101 |
| Rho kinase inhibition improves endothelial function in human subjects with coronary artery disease. | Circulation research 20061208 |
| Androgens potentiate renal vascular responses to angiotensin II via amplification of the Rho kinase signaling pathway. | Cardiovascular research 20061201 |
| Long-term inhibition of Rho-kinase ameliorates hypoxia-induced pulmonary hypertension in mice. | Journal of cardiovascular pharmacology 20061201 |
| [Effects of intervention with Rho kinase inhibitor fasudil on rats with hypoxic pulmonary hypertension]. | Zhonghua er ke za zhi = Chinese journal of pediatrics 20061201 |
| Marked increase of insulin gene transcription by suppression of the Rho/Rho-kinase pathway. | Biochemical and biophysical research communications 20061110 |
| Rho kinase activation maintains high pulmonary vascular resistance in the ovine fetal lung. | American journal of physiology. Lung cellular and molecular physiology 20061101 |
| The selective Rho-kinase inhibitor Fasudil is protective and therapeutic in experimental autoimmune encephalomyelitis. | Journal of neuroimmunology 20061101 |
| Chronic administration of an oral Rho kinase inhibitor prevents the development of vasculogenic erectile dysfunction in a rat model. | The journal of sexual medicine 20061101 |
| [Fasudil inhibits HSC adhesion, migration and proliferation via Rho/ROCK pathway]. | Zhonghua gan zang bing za zhi = Zhonghua ganzangbing zazhi = Chinese journal of hepatology 20061101 |
| Rho-kinase as a potential therapeutic target for the treatment of pulmonary hypertension. | Drug news & perspectives 20061101 |
| ROCK controls matrix synthesis in vascular smooth muscle cells: coupling vasoconstriction to vascular remodeling. | Circulation research 20061013 |
| Update on endovascular therapies for cerebral vasospasm induced by aneurysmal subarachnoid hemorrhage. | Neurosurgical focus 20060915 |
| Rho-kinase inhibition enhances axonal regeneration after peripheral nerve injury. | Journal of the peripheral nervous system : JPNS 20060901 |
| [Role of the Rho/Rho-kinase pathway in the development of hypertensive glomerulosclerosis: renoprotective effect of Rho-kinase inhibitor in hypertensive glomerulosclerosis and its molecular mechanism]. | Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20060901 |
| The Rho kinase inhibitor fasudil inhibits tumor progression in human and rat tumor models. | Molecular cancer therapeutics 20060901 |
| Effect of fasudil hydrochloride, a protein kinase inhibitor, on cerebral vasospasm and delayed cerebral ischemic symptoms after aneurysmal subarachnoid hemorrhage. | Neurologia medico-chirurgica 20060901 |
| Rho kinase contributes to androgen amplification of renal vasoconstrictor responses in the spontaneously hypertensive rat. | Journal of cardiovascular pharmacology 20060901 |
| Fasudil, a Rho-kinase inhibitor, inhibits leukocyte adhesion in inflamed large blood vessels in vivo. | Inflammation research : official journal of the European Histamine Research Society ... [et al.] 20060901 |
| Structural analysis of protein kinase A mutants with Rho-kinase inhibitor specificity. | The Journal of biological chemistry 20060825 |
| Delayed treatment with Rho-kinase inhibitor does not enhance axonal regeneration or functional recovery after spinal cord injury in rats. | Experimental neurology 20060801 |
| Involvements of Rho-kinase and TGF-beta pathways in aldosterone-induced renal injury. | Journal of the American Society of Nephrology : JASN 20060801 |
| In vivo X-ray angiography in the mouse brain using synchrotron radiation. | Stroke 20060701 |
| Long-term administration of rho-kinase inhibitor ameliorates renal damage in malignant hypertensive rats. | Hypertension (Dallas, Tex. : 1979) 20060601 |
| Long-term inhibition of Rho kinase suppresses intimal thickening in autologous vein grafts in rabbits. | Journal of vascular surgery 20060601 |
| [Mechanism of signal transduction of differentiation of mesenchymal stem cells into cytokeratin-expressing epidermoid cells]. | Zhonghua yi xue za zhi 20060516 |
| Protective effect of fasudil, a Rho-kinase inhibitor, on chemokine expression, leukocyte recruitment, and hepatocellular apoptosis in septic liver injury. | Journal of leukocyte biology 20060501 |
| Anticholinesterase drugs stimulate smooth muscle contraction of the rat trachea through the Rho-kinase pathway. | Anesthesia and analgesia 20060401 |
| Attenuation of contractility in rat epididymal vas deferens by Rho kinase inhibitors. | Autonomic & autacoid pharmacology 20060401 |
| Vasodilatory effect of subsequent administration of fasudil, a rho-kinase inhibitor, surpasses that of nitroglycerin at the concentric coronary stenosis in patients with stable angina pectoris. | Circulation journal : official journal of the Japanese Circulation Society 20060401 |
| Involvement of RhoA/Rho kinase signaling in pulmonary hypertension of the fawn-hooded rat. | Journal of applied physiology (Bethesda, Md. : 1985) 20060301 |
| Fluvastatin ameliorates podocyte injury in proteinuric rats via modulation of excessive Rho signaling. | Journal of the American Society of Nephrology : JASN 20060301 |
| Safe and efficient drug delivery system with liposomes for intrathecal application of an antivasospastic drug, fasudil. | Biological & pharmaceutical bulletin 20060301 |
| Molecular mechanism for the regulation of rho-kinase by dimerization and its inhibition by fasudil. | Structure (London, England : 1993) 20060301 |
| Involvement of rho kinase in the ouabain-induced contractions of the rat renal arteries. | Biochemical and biophysical research communications 20060210 |
| Mechanisms of endothelin-1-induced contraction in pulmonary arteries from chronically hypoxic rats. | American journal of physiology. Lung cellular and molecular physiology 20060201 |
| M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. I. Normal rat bladder. | The Journal of pharmacology and experimental therapeutics 20060201 |
| M2 and M3 muscarinic receptor activation of urinary bladder contractile signal transduction. II. Denervated rat bladder. | The Journal of pharmacology and experimental therapeutics 20060201 |
| Beneficial acute effects of rho-kinase inhibitor in patients with pulmonary arterial hypertension. | Circulation journal : official journal of the Japanese Circulation Society 20060201 |
| Involvement of Rho-kinase in experimental vascular endothelial dysfunction. | Molecular and cellular biochemistry 20060201 |
| The structure of dimeric ROCK I reveals the mechanism for ligand selectivity. | The Journal of biological chemistry 20060106 |
| Rho-kinase as a molecular target for insulin resistance and hypertension. | FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20060101 |
| Molecular mechanisms and therapeutic strategies of chronic renal injury: role of rho-kinase in the development of renal injury. | Journal of pharmacological sciences 20060101 |
| Molecular mechanisms and therapeutic strategies of chronic renal injury: renoprotective effect of rho-kinase inhibitor in hypertensive glomerulosclerosis. | Journal of pharmacological sciences 20060101 |
| Atorvastatin reduces the expression of prostaglandin E2 receptors in human carotid atherosclerotic plaques and monocytic cells: potential implications for plaque stabilization. | Journal of cardiovascular pharmacology 20060101 |
| Expression, purification, and characterization of an enzymatically active truncated human rho-kinase I (ROCK I) domain expressed in Sf-9 insect cells. | Protein and peptide letters 20060101 |
| Differential role of rho-kinase in pathological and physiological cardiac hypertrophy in rats. | Pharmacology 20060101 |
| Effect of fasudil on macrovascular disorder-induced endothelial dysfunction. | Canadian journal of physiology and pharmacology 20060101 |
| Development of specific Rho-kinase inhibitors and their clinical application. | Biochimica et biophysica acta 20051230 |
| Effects of fasudil, a Rho-kinase inhibitor, on myocardial preconditioning in anesthetized rats. | European journal of pharmacology 20051219 |
| Inhibition of RhoA/Rho kinase pathway is involved in the beneficial effect of sildenafil on pulmonary hypertension. | British journal of pharmacology 20051201 |
| Smoking, endothelial function, and Rho-kinase in humans. | Arteriosclerosis, thrombosis, and vascular biology 20051201 |
| Effects of fasudil in acute ischemic stroke: results of a prospective placebo-controlled double-blind trial. | Journal of the neurological sciences 20051115 |
| Efficacy and safety of fasudil in patients with stable angina: a double-blind, placebo-controlled, phase 2 trial. | Journal of the American College of Cardiology 20051115 |
| Relative contribution of Rho kinase and protein kinase C to myogenic tone in rat cerebral arteries in hypertension. | American journal of physiology. Heart and circulatory physiology 20051101 |
| Rho kinase inhibitors reduce neurally evoked contraction of the rat tail artery in vitro. | British journal of pharmacology 20051101 |
| Inhibition of Rho kinase (ROCK) leads to increased cerebral blood flow and stroke protection. | Stroke 20051001 |
| Rho-kinase is an important therapeutic target in cardiovascular medicine. | Arteriosclerosis, thrombosis, and vascular biology 20050901 |
| Rho-kinase inhibitors show promise in pulmonary hypertension. | Expert opinion on investigational drugs 20050901 |
| [Cerebral circulation dynamics following fasudil intravenous infusion: a CT perfusion study]. | No to shinkei = Brain and nerve 20050901 |
| Fasudil hydrochloride hydrate, a Rho-kinase (ROCK) inhibitor, suppresses collagen production and enhances collagenase activity in hepatic stellate cells. | Liver international : official journal of the International Association for the Study of the Liver 20050801 |
| Rho kinase as potential therapeutic target for cardiovascular diseases: opportunities and challenges. | Expert opinion on therapeutic targets 20050801 |
| Statins decrease Toll-like receptor 4 expression and downstream signaling in human CD14+ monocytes. | Arteriosclerosis, thrombosis, and vascular biology 20050701 |
| Activation of Rho-associated kinase during augmented contraction of the basilar artery to serotonin after subarachnoid hemorrhage. | American journal of physiology. Heart and circulatory physiology 20050601 |
| Fasudil prevents KATP channel-induced improvement in postischemic functional recovery. | American journal of physiology. Heart and circulatory physiology 20050601 |
| The role of calcium desensitization in vascular hyporeactivity and its regulation after hemorrhagic shock in the rat. | Shock (Augusta, Ga.) 20050601 |
| Rho-kinase inhibitor improves increased vascular resistance and impaired vasodilation of the forearm in patients with heart failure. | Circulation 20050531 |
| Fasudil, a Rho-kinase inhibitor, attenuates angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice by inhibiting apoptosis and proteolysis. | Circulation 20050503 |
| Negative regulation of RhoA/Rho kinase by angiotensin II type 2 receptor in vascular smooth muscle cells: role in angiotensin II-induced vasodilation in stroke-prone spontaneously hypertensive rats. | Journal of hypertension 20050501 |
| ROCKs as therapeutic targets in cardiovascular diseases. | Expert review of cardiovascular therapy 20050501 |
| Inhibition of Rho-kinase by fasudil attenuated angiotensin II-induced cardiac hypertrophy in apolipoprotein E deficient mice. | European journal of pharmacology 20050411 |
| Long term Rho-kinase inhibition ameliorates endothelial dysfunction in LDL-Receptor deficient mice. | European journal of pharmacology 20050411 |
| Role of Rho-kinase and p27 in angiotensin II-induced vascular injury. | Hypertension (Dallas, Tex. : 1979) 20050401 |
| Inhaled Rho kinase inhibitors are potent and selective vasodilators in rat pulmonary hypertension. | American journal of respiratory and critical care medicine 20050301 |
| Acute vasodilator effects of a Rho-kinase inhibitor, fasudil, in patients with severe pulmonary hypertension. | Heart (British Cardiac Society) 20050301 |
| Small guanine nucleotide-binding protein Rho and myocardial function. | Acta pharmacologica Sinica 20050301 |
| High-throughput screening for kinase inhibitors. | Chembiochem : a European journal of chemical biology 20050301 |
| Prostacyclin does not inhibit rho-kinase: an implication for the treatment of pulmonary hypertension. | Journal of cardiovascular pharmacology 20050201 |
| Rho-kinase and myosin II activities are required for cell type and environment specific migration. | Genes to cells : devoted to molecular & cellular mechanisms 20050201 |
| [Intra-arterial administration of fasudil hydrochloride: duration of action]. | No shinkei geka. Neurological surgery 20050201 |
| Stent implantation activates RhoA in human arteries: inhibitory effect of rapamycin. | Journal of vascular research 20050101 |
| Therapeutic potential of rho-kinase inhibitors in cardiovascular diseases. | American journal of cardiovascular drugs : drugs, devices, and other interventions 20050101 |
| [Role of calcium desensitization in vascular hyporeactivity in hemorrhagic shock]. | Zhongguo wei zhong bing ji jiu yi xue = Chinese critical care medicine = Zhongguo weizhongbing jijiuyixue 20050101 |
| [The expression of Rho/Rho kinase of cardiac muscle in heart failure rats caused by pressure overload and the intervention of fasudil]. | Zhonghua xin xue guan bing za zhi 20050101 |
| Rho-kinase inhibition in the therapy of cardiovascular disease. | Cardiology in review 20050101 |
| Pharmacological reversal of endothelin-1 mediated constriction of the spiral modiolar artery: a potential new treatment for sudden sensorineural hearing loss. | BMC ear, nose, and throat disorders 20050101 |
| Inhibition of protein kinase C-mediated contraction by Rho kinase inhibitor fasudil in rabbit aorta. | Naunyn-Schmiedeberg's archives of pharmacology 20041101 |
| Inhibition of Rho-kinase leads to rapid activation of phosphatidylinositol 3-kinase/protein kinase Akt and cardiovascular protection. | Arteriosclerosis, thrombosis, and vascular biology 20041001 |
| Expression of Rho-kinase (ROCK-1 and ROCK-2) and its substantial role in the contractile activity of the sheep ureter. | British journal of pharmacology 20041001 |
| [Inhibition of Rho-kinase by fasudil preventing anginal attacks associated with spastic angina: a case report]. | Journal of cardiology 20041001 |
| Rho-kinase, a potential therapeutic target for the treatment of hypertension. | Drug news & perspectives 20041001 |
| Mechanisms underlying postjunctional synergism between responses of the vas deferens to noradrenaline and ATP. | European journal of pharmacology 20040913 |
| Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats. | Journal of hypertension 20040901 |
| Usefulness of fasudil, a Rho-kinase inhibitor, to treat intractable severe coronary spasm after coronary artery bypass surgery. | Journal of cardiovascular pharmacology 20040901 |
| Involvement of RhoA and possible neuroprotective effect of fasudil, a Rho kinase inhibitor, in NMDA-induced neurotoxicity in the rat retina. | Brain research 20040820 |
| Involvement of Rho-kinase in cold ischemia-reperfusion injury after liver transplantation in rats. | Transplantation 20040815 |
| [Development of drug delivery system for intrathecal administration and its therapeutic effect on cerebral vasospasm and ischemia]. | Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan 20040801 |
| Rho kinase mediates cold-induced constriction of cutaneous arteries: role of alpha2C-adrenoceptor translocation. | Circulation research 20040528 |
| Long-term inhibition of Rho-kinase suppresses left ventricular remodeling after myocardial infarction in mice. | Circulation 20040511 |
| Regulation of osteoblast differentiation by Pasteurella multocida toxin (PMT): a role for Rho GTPase in bone formation. | Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 20040401 |
| Rho kinase inhibition initiates apoptosis in human airway epithelial cells. | American journal of respiratory cell and molecular biology 20040301 |
| Involvement of RhoA and Rho kinase in neutrophil-stimulated endothelial hyperpermeability. | American journal of physiology. Heart and circulatory physiology 20040301 |
| [Involvement of small GTPase Rho and Rho-kinase in the pathogenesis of hypertension and hypertensive target organ damage]. | Nihon rinsho. Japanese journal of clinical medicine 20040301 |
| Long-term treatment with a Rho-kinase inhibitor improves monocrotaline-induced fatal pulmonary hypertension in rats. | Circulation research 20040220 |
| Rho-kinase expression and its contribution to the control of perfusion pressure in the isolated rat mesenteric vascular bed. | European journal of pharmacology 20040206 |
| [Rho-kinase inhibitor]. | Nihon rinsho. Japanese journal of clinical medicine 20040201 |
| Long-term treatment with a specific Rho-kinase inhibitor suppresses cardiac allograft vasculopathy in mice. | Circulation research 20040109 |
| Long-term inhibition of Rho-kinase suppresses neointimal formation after stent implantation in porcine coronary arteries: involvement of multiple mechanisms. | Arteriosclerosis, thrombosis, and vascular biology 20040101 |
| Differential effects of Rho-kinase inhibition on artery wall mass and remodeling. | Journal of vascular surgery 20040101 |
| The Rho-ROCK system as a new therapeutic target for preventing interstitial fibrosis. | Drug news & perspectives 20040101 |
| Role of the Rhoa/Rho kinase system in flow-related remodeling of rat mesenteric small arteries in vivo. | Journal of vascular research 20040101 |
| Effects of HA-1077 and Y-27632, two rho-kinase inhibitors, in the human umbilical artery. | Cell biochemistry and biophysics 20040101 |
| Rho kinase inhibitors block activation of pancreatic stellate cells. | British journal of pharmacology 20031201 |
| Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats. | Kidney international 20031201 |
| Protein kinase A in complex with Rho-kinase inhibitors Y-27632, Fasudil, and H-1152P: structural basis of selectivity. | Structure (London, England : 1993) 20031201 |
| Long-term inhibition of Rho-kinase suppresses angiotensin II-induced cardiovascular hypertrophy in rats in vivo: effect on endothelial NAD(P)H oxidase system. | Circulation research 20031017 |
| Expression of Rho-kinase and its functional role in the contractile activity of the mouse vas deferens. | British journal of pharmacology 20031001 |
| Hyperosmotic-induced protein kinase N 1 activation in a vesicular compartment is dependent upon Rac1 and 3-phosphoinositide-dependent kinase 1. | The Journal of biological chemistry 20030822 |
| Effects of the Rho-kinase inhibitors, Y-27632 and fasudil, on the corpus cavernosum from diabetic mice. | European journal of pharmacology 20030711 |
| Astrocyte stellation induced by Rho kinase inhibitors in culture. | Brain research. Developmental brain research 20030612 |
| Variations in cell signaling pathways for different vasoconstrictor agonists in renal circulation of the rat. | Kidney international 20030601 |
| P2X7 receptor-dependent blebbing and the activation of Rho-effector kinases, caspases, and IL-1 beta release. | Journal of immunology (Baltimore, Md. : 1950) 20030601 |
| Smoking activates rho-kinase in smooth muscle cells of forearm vasculature in humans. | Hypertension (Dallas, Tex. : 1979) 20030501 |
| Functional roles of the rho/rho kinase pathway and protein kinase C in the regulation of cerebrovascular constriction mediated by hemoglobin: relevance to subarachnoid hemorrhage and vasospasm. | Circulation research 20030418 |
| Involvement of Rho/Rho-kinase signalling in the contractile activity and acetylcholine release in the mouse gastric fundus. | Biochemical and biophysical research communications 20030411 |
| Kinase inhibitors: not just for kinases anymore. | Journal of medicinal chemistry 20030410 |
| Synthesis and pharmacological study of Rho-kinase inhibitors: pharmacomodulations on the lead compound Fasudil. | Journal of enzyme inhibition and medicinal chemistry 20030401 |
| Protein kinase C is necessary for recovery from the thyrotropin-releasing hormone-induced r-ERG current reduction in GH3 rat anterior pituitary cells. | The Journal of physiology 20030315 |
| Essential role of rho kinase in the Ca2+ sensitization of prostaglandin F(2alpha)-induced contraction of rabbit aortae. | The Journal of physiology 20030201 |
| A possible role of RhoA/Rho-kinase in experimental spinal cord injury in rat. | Brain research 20030103 |
| Comparison of signalling mechanisms involved in rat mesenteric microvessel contraction by noradrenaline and sphingosylphosphorylcholine. | British journal of pharmacology 20030101 |
| Rho-kinase inhibition with intracoronary fasudil prevents myocardial ischemia in patients with coronary microvascular spasm. | Journal of the American College of Cardiology 20030101 |
| Vessel- and vasoconstrictor-dependent role of rho/rho-kinase in renal microvascular tone. | Journal of vascular research 20030101 |
| Hypoxia and Rho/Rho-kinase signaling. Lung development versus hypoxic pulmonary hypertension. | Advances in experimental medicine and biology 20030101 |
| RhoA kinase and protein kinase C participate in regulation of rabbit stomach fundus smooth muscle contraction. | British journal of pharmacology 20021201 |
| [Basic and clinical studies on coronary vasospasm]. | Masui. The Japanese journal of anesthesiology 20021201 |
| Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction. | European journal of pharmacology 20021129 |
| Effects of Rho-kinase inhibitor on vasopressin-induced chronic myocardial damage in rats. | Life sciences 20021122 |
| Anti-anginal effect of fasudil, a Rho-kinase inhibitor, in patients with stable effort angina: a multicenter study. | Journal of cardiovascular pharmacology 20021101 |
| The mechanism of excitation-contraction coupling in phenylephrine-stimulated human saphenous vein. | American journal of physiology. Heart and circulatory physiology 20021001 |
| Nitric oxide-induced motility in aortic smooth muscle cells: role of protein tyrosine phosphatase SHP-2 and GTP-binding protein Rho. | Circulation research 20020906 |
| Occupation of the prostaglandin E2-type 1 receptor increases rat atrial contractility via a Y-27632-sensitive pathway. | Prostaglandins & other lipid mediators 20020901 |
| [Involvement of Rho-kinase in hypertensive vascular disease--a novel therapeutic target in hypertension]. | Fukuoka igaku zasshi = Hukuoka acta medica 20020801 |
| Inhibition of Rho/Rho-kinase signaling downregulates plasminogen activator inhibitor-1 synthesis in cultured human monocytes. | Biochimica et biophysica acta 20020612 |
| Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. | The Biochemical journal 20020601 |
| Enhanced contractile mechanisms in vasospasm: is endothelial dysfunction the whole story? | Circulation 20020402 |
| Suppression of coronary artery spasm by the Rho-kinase inhibitor fasudil in patients with vasospastic angina. | Circulation 20020402 |
| Protein kinases--the major drug targets of the twenty-first century? | Nature reviews. Drug discovery 20020401 |
| Comparison of angiotensin II (Ang II) effects in the internal anal sphincter (IAS) and lower esophageal sphincter smooth muscles. | Life sciences 20020322 |
| Rho-kinase as a novel therapeutic target in treatment of cardiovascular diseases. | Journal of cardiovascular pharmacology 20020301 |
| Encapsulation of an antivasospastic drug, fasudil, into liposomes, and in vitro stability of the fasudil-loaded liposomes. | International journal of pharmaceutics 20020131 |
| The novel and specific Rho-kinase inhibitor (S)-(+)-2-methyl-1-[(4-methyl-5-isoquinoline)sulfonyl]-homopiperazine as a probing molecule for Rho-kinase-involved pathway. | Pharmacology & therapeutics 20020101 |
| Antianginal effects of hydroxyfasudil, a Rho-kinase inhibitor, in a canine model of effort angina. | British journal of pharmacology 20011201 |
| Possible involvement of Rho-kinase in the pathogenesis of hypertension in humans. | Hypertension (Dallas, Tex. : 1979) 20011201 |
| Investigation of the inhibitory effects of HA-1077 and Y-32885 on the translocation of PKCbetaI, PKCbetaII and PKCzeta in human neutrophils. | Mediators of inflammation 20011201 |
| Intrathecal application with liposome-entrapped Fasudil for cerebral vasospasm following subarachnoid hemorrhage in rats. | Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia 20011101 |
| Involvement of Rho-kinase in vascular remodeling caused by long-term inhibition of nitric oxide synthesis in rats. | European journal of pharmacology 20010907 |
| Dependency of detrusor contractions on calcium sensitization and calcium entry through LOE-908-sensitive channels. | British journal of pharmacology 20010901 |
| Antiischemic properties of fasudil in experimental models of vasospastic angina. | Japanese journal of pharmacology 20010901 |
| Pharmacological profile of hydroxy fasudil as a selective rho kinase inhibitor on ischemic brain damage. | Life sciences 20010810 |
| Effects of protein kinase inhibitor, HA1077, on intraocular pressure and outflow facility in rabbit eyes. | Archives of ophthalmology (Chicago, Ill. : 1960) 20010801 |
| Calyculin-A induces focal adhesion assembly and tyrosine phosphorylation of p125(Fak), p130(Cas), and paxillin in Swiss 3T3 cells. | Journal of cellular physiology 20010701 |
| Long-term inhibition of Rho-kinase induces a regression of arteriosclerotic coronary lesions in a porcine model in vivo. | Cardiovascular research 20010701 |
| Hydroxyfasudil, an active metabolite of fasudil hydrochloride, relaxes the rabbit basilar artery by disinhibition of myosin light chain phosphatase. | Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism 20010701 |
| Y-27632, an inhibitor of Rho-associated kinases, prevents tyrosine phosphorylation of focal adhesion kinase and paxillin induced by bombesin: dissociation from tyrosine phosphorylation of p130(CAS). | Experimental cell research 20010610 |
| Efficacy of intrathecal liposomal fasudil for experimental cerebral vasospasm after subarachnoid hemorrhage. | Neurosurgery 20010401 |
| Myotonic dystrophy protein kinase phosphorylates the myosin phosphatase targeting subunit and inhibits myosin phosphatase activity. | FEBS letters 20010330 |
| Neuroprotection by intrathecal application of liposome-entrapped fasudil in a rat model of ischemia. | Neurologia medico-chirurgica 20010301 |
| Rho-associated kinase phosphorylates MARCKS in human neuronal cells. | Biochemical and biophysical research communications 20010126 |
| Microtubule disruption modulates the Rho-kinase pathway in vascular smooth muscle. | Journal of muscle research and cell motility 20010101 |
| Effect of Fasudil HCl, a protein kinase inhibitor, on cerebral vasospasm. | Acta neurochirurgica. Supplement 20010101 |
| Combined administration of Fasudil hydrochloride and nitroglycerin for treatment of cerebral vasospasm. | Acta neurochirurgica. Supplement 20010101 |
| A novel drug delivery system as prophylaxis for cerebral vasospasm. | Acta neurochirurgica. Supplement 20010101 |
| Specificity and mechanism of action of some commonly used protein kinase inhibitors. | The Biochemical journal 20001001 |
| Isoquinolinesulphonamide derivatives inhibit transcriptional elongation of human immunodeficiency virus type 1 RNA in a promyelocytic model of latency. | Antiviral chemistry & chemotherapy 19990901 |
| Inhibition of human immunodeficiency virus type 1 replication by a bioavailable serine/threonine kinase inhibitor, fasudil hydrochloride. | AIDS research and human retroviruses 19980301 |
| Pretreatment of transient focal cerebral ischemia in rats with the calcium antagonist AT877. | Stroke 19940601 |
| [Treatment of cerebral vasospasm by a protein kinase inhibitor AT 877]. | No to shinkei = Brain and nerve 19930901 |
| Vasodilator actions of HA1077 in vitro and in vivo putatively mediated by the inhibition of protein kinase. | British journal of pharmacology 19891201 |