Home Other Building Blocks RESORUFIN PENTYL ETHER

RESORUFIN PENTYL ETHER

CAS No.:
87687-03-4
Catalog Number:
AG00GV98
Molecular Formula:
C17H19NO2
Molecular Weight:
269.3383
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Product Description
Catalog Number:
AG00GV98
Chemical Name:
RESORUFIN PENTYL ETHER
CAS Number:
87687-03-4
Molecular Formula:
C17H19NO2
Molecular Weight:
269.3383
MDL Number:
MFCD00037664
IUPAC Name:
7-pentoxyphenoxazin-3-one
InChI:
InChI=1S/C17H17NO3/c1-2-3-4-9-20-13-6-8-15-17(11-13)21-16-10-12(19)5-7-14(16)18-15/h5-8,10-11H,2-4,9H2,1H3
InChI Key:
ZPSOKQFFOYYPKC-UHFFFAOYSA-N
SMILES:
CCCCCOc1ccc2c(c1)Oc1c(N2)cccc1
Properties
Complexity:
492  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
283.121g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
0
Isotope Atom Count:
0
Molecular Weight:
283.327g/mol
Monoisotopic Mass:
283.121g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
47.9A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
3.2  
Literature
Title Journal
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Immunochemical detection of cytochrome P450 enzymes in liver microsomes of 27 cynomolgus monkeys. The Journal of pharmacology and experimental therapeutics 20111101
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In vivo indirect measurement of cytochrome P450-associated activities in freshwater gastropod molluscs. Environmental toxicology 20101201
Phenethyl isocyanate is not the metabolite of phenethyl isothiocyanate responsible for mechanism-based inhibition of cytochrome P450. Archives of toxicology 20101001
Human blood concentrations of cotinine, a biomonitoring marker for tobacco smoke, extrapolated from nicotine metabolism in rats and humans and physiologically based pharmacokinetic modeling. International journal of environmental research and public health 20100901
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Comparison of cytochrome P450 3A enzymes in cynomolgus monkeys and humans. Drug metabolism and pharmacokinetics 20100101
The effects of selected flavonoids on cytochromes P450 in rat liver and small intestine. Interdisciplinary toxicology 20090901
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Developmental exposure to polychlorinated biphenyls interferes with experience-dependent dendritic plasticity and ryanodine receptor expression in weanling rats. Environmental health perspectives 20090301
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Precision-cut liver slices from rats of different ages: basal cytochrome P450-dependent monooxygenase activities and inducibility. Analytical and bioanalytical chemistry 20081101
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Modulation of steroidogenesis and xenobiotic biotransformation responses in zebrafish (Danio rerio) exposed to water-soluble fraction of crude oil. Environmental research 20080701
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The polybrominated diphenyl ether mixture DE-71 is mildly estrogenic. Environmental health perspectives 20080501
Developmental exposure to polychlorinated biphenyls influences stroke outcome in adult rats. Environmental health perspectives 20080401
Characterization of Phase I biotransformation enzymes in coho salmon (Oncorhynchus kisutch). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20080101
Mouse mammary tumor virus promoter-containing retroviral promoter conversion vectors for gene-directed enzyme prodrug therapy are functional in vitro and in vivo. Journal of biomedicine & biotechnology 20080101
Purification of CYP2B-like protein from feral leaping mullet (Liza saliens) liver microsomes and its biocatalytic, molecular, and immunological characterization. Journal of biochemical and molecular toxicology 20080101
[The optical biosensor study of the redox partners interactions within the cytochrome P450 2B4-containing monooxygenase system in hydroxylation conditions]. Biomeditsinskaia khimiia 20080101
Viral infection and PBDE exposure interact on CYP gene expression and enzyme activities in the mouse liver. Toxicology 20071205
Effect of perinatal low protein diets on the ontogeny of select hepatic cytochrome p450 enzymes and cytochrome p450 reductase in the rat. Drug metabolism and disposition: the biological fate of chemicals 20070701
Expression and characterization of cytochrome P450 2X1 in channel catfish (Ictalurus punctatus). Biochimica et biophysica acta 20070701
Development of three parallel cytochrome P450 enzyme affinity detection systems coupled on-line to gradient high-performance liquid chromatography. Drug metabolism and disposition: the biological fate of chemicals 20070401
Modulation of xenobiotic biotransformation system and hormonal responses in Atlantic salmon (Salmo salar) after exposure to tributyltin (TBT). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20070401
Chromatin remodeling agent trichostatin A: a key-factor in the hepatic differentiation of human mesenchymal stem cells derived of adult bone marrow. BMC developmental biology 20070101
Interactive effects of methyl tertiary-butyl ether (MTBE) and tertiary-amyl methyl ether (TAME), ethanol and some drugs: Triglyceridemia, liver toxicity and induction of CYP (2E1, 2B1) and phase II enzymes in female Wistar rats. Environmental toxicology and pharmacology 20070101
Heteromeric complex formation between CYP2E1 and CYP1A2: evidence for the involvement of electrostatic interactions. Biochemistry 20061226
Cooperation of the inducible nitric oxide synthase and cytochrome P450 1A1 in mediating lung inflammation and mutagenicity induced by diesel exhaust particles. Environmental health perspectives 20060801
Stability of cytochromes P450 and phase II conjugation systems in precision-cut rat lung slices cultured up to 72 h. Toxicology 20060705
Effect of sulfur dioxide inhalation on CYP2B1/2 and CYP2E1 in rat liver and lung. Inhalation toxicology 20060701
Enzymatic analysis of cDNA-expressed human CYP1A1, CYP1A2, and CYP1B1 with 7-ethoxyresorufin as substrate. Methods in molecular biology (Clifton, N.J.) 20060101
Modulation of hepatic cytochromes P450 and phase II enzymes by dietary doses of sulforaphane in rats: Implications for its chemopreventive activity. International journal of cancer 20051110
Induction of rat hepatic cytochrome P-450 by ketamine and its toxicological implications. Journal of toxicology and environmental health. Part A 20050901
Effects of light and dark beer on hepatic cytochrome P-450 expression in male rats receiving alcoholic beverages as part of total enteral nutrition. Alcoholism, clinical and experimental research 20050501
Effects of ionic strength on the functional interactions between CYP2B4 and CYP1A2. Biochemistry 20050222
Lack of strain-related differences in drug metabolism and efflux transporter characteristics between CD-1 and athymic nude mice. Cancer chemotherapy and pharmacology 20050201
Black tea intake modulates the excretion of urinary mutagens in rats exposed to 6-aminochrysene: induction of cytochromes P450 by 6-aminochrysene in the rat. Mutagenesis 20050101
Mechanism to study 1:1 stoichiometry of NADPH and alkoxyphenoxazones metabolism spectrophotometrically in subcellular biological preparations. Biochimica et biophysica acta 20041118
In vitro biotransformation of 3,4-dihydro-6-hydroxy-2,2-dimethyl-7-methoxy-1(2H)-benzopyran (CR-6), a potent lipid peroxidation inhibitor and nitric oxide scavenger, in rat liver microsomes. Chemical research in toxicology 20040701
Quantitative structure-activity relationships within a homologous series of 7-alkoxyresorufins exhibiting activity towards CYP1A and CYP2B enzymes: molecular modelling studies on key members of the resorufin series with CYP2C5-derived models of human CYP1A1, CYP1A2, CYP2B6 and CYP3A4. Xenobiotica; the fate of foreign compounds in biological systems 20040601
Effects of propranolol on xenobiotic enzyme activities in rat type II pneumocytes and alveolar macrophages in vivo. Methods and findings in experimental and clinical pharmacology 20031201
Hepatic and intestinal cytochrome P450 and conjugase activities in rats treated with black tea theafulvins and theaflavins. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20030801
Characterization of substrate binding to cytochrome P450 1A1 using molecular modeling and kinetic analyses: case of residue 382. Drug metabolism and disposition: the biological fate of chemicals 20030401
Catalytic activities of cytochrome P450 enzymes and UDP-glucuronosyltransferases involved in drug metabolism in rat everted sacs and intestinal microsomes. Xenobiotica; the fate of foreign compounds in biological systems 20030101
Alteration of pulmonary cytochrome p-450 system: effects of asphalt fume condensate exposure. Journal of toxicology and environmental health. Part A 20020913
Biochemical factors underlying the age-related sensitivity of turkeys to aflatoxin B(1). Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 20020601
A spectrophotometric method to monitor the catalytic activity of microsomal cytochrome P-450 IIB1/2: comparison with fluorometric assay. Indian journal of biochemistry & biophysics 20020601
Evidence for the presence of active cytochrome P450 systems in Schistosoma mansoni and Schistosoma haematobium adult worms. FEBS letters 20020522
A novel approach to study the activity and stoichiometry simultaneously for microsomal pentoxyresorufin-O-dealkylase reaction. FEBS letters 20020213
Detection of the embryotoxic potential of cyclophosphamide by using a combined system of metabolic competent cells and embryonic stem cells. Alternatives to laboratory animals : ATLA 20020101
Effects of trivalent chromium on hepatic CYP-linked monooxygenases in laying hens. Journal of applied toxicology : JAT 20020101
Xenobiotic-metabolizing enzyme activities in primary cultures of rat type II pneumocytes and alveolar macrophages. Drug metabolism and disposition: the biological fate of chemicals 20011001
Role of induction of specific hepatic cytochrome P450 isoforms in epoxidation of 4-vinylcyclohexene. Drug metabolism and disposition: the biological fate of chemicals 20010901
Inhibition of rat liver microsomal CYP1A2 and CYP2B1 activity by N-(2-heptyl)-N-methyl-propargylamine and by N-(2-heptyl)-propargylamine. Drug metabolism and disposition: the biological fate of chemicals 20010801
Effect of alpha-methyldopa on pentoxyresorufin O-dealkylation in liver microsomes from rats treated with phenobarbital. Archives of biochemistry and biophysics 20010801
Induction of rat brain cytochrome P450s (P450s) by deltamethrin: regional specificity and correlation with neurobehavioral toxicity. Neurotoxicity research 20010801
Inhibition of cytochrome P450 isozymes by curcumins in vitro and in vivo. Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 20010601
Co-expression of human cytochrome P4501A1 (CYP1A1) variants and human NADPH-cytochrome P450 reductase in the baculovirus/insect cell system. Xenobiotica; the fate of foreign compounds in biological systems 20010601
Propofol-induced cytochrome P450 inhibition: an in vitro and in vivo study in rats. Life sciences 20010518
The role of actin filaments and microtubules in hepatocyte spheroid self-assembly. Cell motility and the cytoskeleton 20010301
Probing enhanced cytochrome P450 2B1/2 activity in rat hepatocyte spheroids through confocal laser scanning microscopy. Cell transplantation 20010101
Induction of hepatic cytochrome P-450 by phenobarbital in semi-aquatic frog (Rana pipiens). Biochemical and biophysical research communications 19980327
Cytochrome P450-dependent drug oxidation activities in liver microsomes of various animal species including rats, guinea pigs, dogs, monkeys, and humans. Archives of toxicology 19970101
Stable expression and coexpression of human cytochrome P450 oxidoreductase and cytochrome P450 1A2 in V79 Chinese hamster cells: sensitivity to quinones and biotransformation of 7-alkoxyresorufins and triazines. Drug metabolism and disposition: the biological fate of chemicals 19961201
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