Home Other Building Blocks 2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE

2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE

CAS No.:
876310-60-0
Catalog Number:
AG00GV3S
Molecular Formula:
C26H38N6O3
Molecular Weight:
482.6183
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
1mg
98%
1 week
United States
$207
- +
5mg
98%
1 week
United States
$373
- +
Product Description
Catalog Number:
AG00GV3S
Chemical Name:
2-ADAMANTANECARBONYL-ARG-PHE-NH2 TRIFLUOROACETATE
CAS Number:
876310-60-0
Molecular Formula:
C26H38N6O3
Molecular Weight:
482.6183
IUPAC Name:
N-[(2S)-1-[[(2S)-1-amino-1-oxo-3-phenylpropan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]adamantane-1-carboxamide
InChI:
InChI=1S/C26H38N6O3/c27-22(33)21(12-16-5-2-1-3-6-16)31-23(34)20(7-4-8-30-25(28)29)32-24(35)26-13-17-9-18(14-26)11-19(10-17)15-26/h1-3,5-6,17-21H,4,7-15H2,(H2,27,33)(H,31,34)(H,32,35)(H4,28,29,30)/t17?,18?,19?,20-,21-,26?/m0/s1
InChI Key:
UMKHUSRDQFQHAK-RNJMTYCLSA-N
SMILES:
NC(=N)NCCC[C@@H](C(=O)N[C@H](C(=O)N)Cc1ccccc1)NC(=O)C12CC3CC(C2)CC(C1)C3
Properties
Complexity:
777  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
2  
Defined Bond Stereocenter Count:
0
Exact Mass:
482.301g/mol
Formal Charge:
0
Heavy Atom Count:
35  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
5  
Isotope Atom Count:
0
Molecular Weight:
482.629g/mol
Monoisotopic Mass:
482.301g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
166A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
1.4  
Literature
Title Journal
Selective mode of action of guanidine-containing non-peptides at human NPFF receptors. Journal of medicinal chemistry 20120712
RF9 powerfully stimulates gonadotrophin secretion in the ewe: evidence for a seasonal threshold of sensitivity. Journal of neuroendocrinology 20120501
Involvement of neuropeptide FF receptors in neuroadaptive responses to acute and chronic opiate treatments. British journal of pharmacology 20120101
Kisspeptin signaling is indispensable for neurokinin B, but not glutamate, stimulation of gonadotropin secretion in mice. Endocrinology 20120101
Modulation of neuropeptide FF (NPFF) receptors influences the expression of amphetamine-induced conditioned place preference and amphetamine withdrawal anxiety-like behavior in rats. Peptides 20120101
Neuropeptide FF receptor antagonist, RF9, attenuates the fever induced by central injection of LPS in mice. Peptides 20110401
Electrophysiological analysis of the inhibitory effects of FMRFamide-like peptides on the pacemaker activity of gonadotropin-releasing hormone neurons. Journal of neurophysiology 20101201
Opposite control of body temperature by NPFF1 and NPFF2 receptors in mice. Neuropeptides 20101001
Characterization of the potent gonadotropin-releasing activity of RF9, a selective antagonist of RF-amide-related peptides and neuropeptide FF receptors: physiological and pharmacological implications. Endocrinology 20100401
Pharmacological characterization of the mouse NPFF2 receptor. Peptides 20100201
Prolactin-releasing peptide effects in the rat brain are mediated through the Neuropeptide FF receptor. The European journal of neuroscience 20091001
Neuropeptide FF receptors antagonist, RF9, attenuates opioid-evoked hypothermia in mice. Peptides 20080701
Inhibition of neuropeptide FF (NPFF)-induced hypothermia and anti-morphine analgesia by RF9, a new selective NPFF receptors antagonist. Regulatory peptides 20080410
RF9, a potent and selective neuropeptide FF receptor antagonist, prevents opioid-induced tolerance associated with hyperalgesia. Proceedings of the National Academy of Sciences of the United States of America 20060110
[RF9, a powerful and selective antagonist of the neuropeptide FF receptors, prevents the development of the tolerance to opioids]. Medecine sciences : M/S 20060101
Properties