Home Other Building Blocks 5-HYDROXY OMEPRAZOLE

5-HYDROXY OMEPRAZOLE

CAS No.:
92340-57-3
Catalog Number:
AG00GUQL
Molecular Formula:
C17H19N3O4S
Molecular Weight:
361.4155
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Product Description
Catalog Number:
AG00GUQL
Chemical Name:
5-HYDROXY OMEPRAZOLE
CAS Number:
92340-57-3
Molecular Formula:
C17H19N3O4S
Molecular Weight:
361.4155
MDL Number:
MFCD00869771
IUPAC Name:
[4-methoxy-6-[(6-methoxy-1H-benzimidazol-2-yl)sulfinylmethyl]-5-methylpyridin-3-yl]methanol
InChI:
InChI=1S/C17H19N3O4S/c1-10-15(18-7-11(8-21)16(10)24-3)9-25(22)17-19-13-5-4-12(23-2)6-14(13)20-17/h4-7,21H,8-9H2,1-3H3,(H,19,20)
InChI Key:
CMZHQFXXAAIBKE-UHFFFAOYSA-N
SMILES:
COc1c(CO)cnc(c1C)CS(=O)c1nc2c([nH]1)ccc(c2)OC
Properties
Complexity:
469  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
361.11g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
361.416g/mol
Monoisotopic Mass:
361.11g/mol
Rotatable Bond Count:
6  
Topological Polar Surface Area:
117A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
XLogP3:
1  
Literature
Title Journal
Variation in omeprazole pharmacokinetics in a random Iranian population: a pilot study. Biopharmaceutics & drug disposition 20120901
Evaluation of lansoprazole as a probe for assessing cytochrome P450 2C19 activity and genotype-phenotype correlation in childhood. European journal of clinical pharmacology 20120501
High-sensitivity liquid chromatography-tandem mass spectrometry for the simultaneous determination of five drugs and their cytochrome P450-specific probe metabolites in human plasma. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20120501
Omeprazole limited sampling strategies to predict area under the concentration-time curve ratios: implications for cytochrome P450 2C19 and 3A phenotyping. European journal of clinical pharmacology 20120401
[Effect of high altitude hypoxia on the activity and protein expression of CYP2C9 and CYP2C19]. Yao xue xue bao = Acta pharmaceutica Sinica 20120201
Prediction of relative in vivo metabolite exposure from in vitro data using two model drugs: dextromethorphan and omeprazole. Drug metabolism and disposition: the biological fate of chemicals 20120101
Chiral assay of omeprazole and metabolites and its application to a pharmacokinetics related to CYP2C19 genotypes. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20110815
Clinically significant CYP2C inhibition by noscapine but not by glucosamine. Clinical pharmacology and therapeutics 20100901
CYP2C19 haplotypes in Koreans as a marker of enzyme activity evaluated with omeprazole. Journal of clinical pharmacy and therapeutics 20090801
Clopidogrel inhibits CYP2C19-dependent hydroxylation of omeprazole related to CYP2C19 genetic polymorphisms. Journal of clinical pharmacology 20090501
Enantioseparation of omeprazole and its metabolite 5-hydroxyomeprazole using open tubular capillary electrochromatography with immobilized avidin as chiral selector. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20081101
Estimation of CYP2C19 activity by the omeprazole hydroxylation index at a single point in time after intravenous and oral administration. European journal of clinical pharmacology 20071101
Herbal medicine yin zhi huang induces CYP3A4-mediated sulfoxidation and CYP2C19-dependent hydroxylation of omeprazole. Acta pharmacologica Sinica 20071001
Validation of chromatographic methods: evaluation of detection and quantification limits in the determination of impurities in omeprazole. Journal of chromatography. A 20070713
Cyp2c19 genotype and omeprazole hydroxylation phenotype in Chinese Li population. Clinical and experimental pharmacology & physiology 20070101
Phenotype-genotype analysis of CYP2C19 in Colombian mestizo individuals. BMC clinical pharmacology 20070101
Enantiomeric separation of omeprazole and its metabolite 5-hydroxyomeprazole using non-aqueous capillary electrophoresis. Journal of chromatography. A 20061006
Determination of omeprazole, hydroxyomeprazole and omeprazole sulfone using automated solid phase extraction and micellar electrokinetic capillary chromatography. Journal of pharmaceutical and biomedical analysis 20060911
Analysis of omeprazole and 5-OH omeprazole in human plasma using hydrophilic interaction chromatography with tandem mass spectrometry (HILIC-MS/MS)--eliminating evaporation and reconstitution steps in 96-well liquid/liquid extraction. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20060102
Esomeprazole-induced healing of gastroesophageal reflux disease is unrelated to the genotype of CYP2C19: evidence from clinical and pharmacokinetic data. Clinical pharmacology and therapeutics 20051201
Analysis of omeprazole, midazolam and hydroxy-metabolites in plasma using liquid chromatography coupled to tandem mass spectrometry. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20050925
The effect of aging on the relationship between the cytochrome P450 2C19 genotype and omeprazole pharmacokinetics. Clinical pharmacokinetics 20050101
Metabolism of omeprazole after two oral doses in children 1 to 9 months old. Proceedings of the Western Pharmacology Society 20050101
Genetic polymorphism of cytochrome P450 2C19 in healthy Malaysian subjects. British journal of clinical pharmacology 20040901
Omeprazole treatment of Korean patients: effects on gastric pH and gastrin release in relation to CYP2C19 geno- and phenotypes. Basic & clinical pharmacology & toxicology 20040901
Omeprazole as a CYP2C19 marker in Chinese subjects: assessment of its gene-dose effect and intrasubject variability. Journal of clinical pharmacology 20040601
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