Name: Name:GDC-0152
Brand: Angene
SKU: AG00GU8I
Rating: 90 (10 reviews)

GDC-0152

CAS No.:

873652-48-3

Catalog Number:

AG00GU8I

Molecular Formula:

C25H34N6O3S

Molecular Weight:

498.6409

Pack Size

Purity

Availability

Location

Price(USD)

Quantity

1mg

≥95%

1 week

United States

$105

- +

5mg

≥95%

1 week

United States

$264

- +

10mg

99%

1 week

United States

$265

- +

50mg

99%

1 week

United States

$682

- +

100mg

99%

1 week

United States

$1098

- +

Product Description

Catalog Number:

AG00GU8I

Chemical Name:

GDC-0152

CAS Number:

873652-48-3

Molecular Formula:

C25H34N6O3S

Molecular Weight:

498.6409

MDL Number:

MFCD26142660

IUPAC Name:

(2S)-1-[(2S)-2-cyclohexyl-2-[[(2S)-2-(methylamino)propanoyl]amino]acetyl]-N-(4-phenylthiadiazol-5-yl)pyrrolidine-2-carboxamide

InChI:

InChI=1S/C25H34N6O3S/c1-16(26-2)22(32)27-21(18-12-7-4-8-13-18)25(34)31-15-9-14-19(31)23(33)28-24-20(29-30-35-24)17-10-5-3-6-11-17/h3,5-6,10-11,16,18-19,21,26H,4,7-9,12-15H2,1-2H3,(H,27,32)(H,28,33)/t16-,19-,21-/m0/s1

InChI Key:

WZRFLSDVFPIXOV-LRQRDZAKSA-N

SMILES:

CNC(C(=O)NC(C(=O)N1CCCC1C(=O)Nc1snnc1c1ccccc1)C1CCCCC1)C

UNII:

4KW1M48SHS

Properties

Complexity:

743

Compound Is Canonicalized:

Yes

Covalently-Bonded Unit Count:

Defined Atom Stereocenter Count:

Defined Bond Stereocenter Count:

Exact Mass:

498.241g/mol

Formal Charge:

Heavy Atom Count:

Hydrogen Bond Acceptor Count:

Hydrogen Bond Donor Count:

Isotope Atom Count:

Molecular Weight:

498.646g/mol

Monoisotopic Mass:

498.241g/mol

Rotatable Bond Count:

Topological Polar Surface Area:

145A^2

Undefined Atom Stereocenter Count:

Undefined Bond Stereocenter Count:

XLogP3:

3.4

Literature

Title	Journal
Toxicity profile of small-molecule IAP antagonist GDC-0152 is linked to TNF-α pharmacology.	Toxicological sciences : an official journal of the Society of Toxicology 20130101
Discovery of a potent small-molecule antagonist of inhibitor of apoptosis (IAP) proteins and clinical candidate for the treatment of cancer (GDC-0152).	Journal of medicinal chemistry 20120510

Properties