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RO 9187

CAS No.:
876708-03-1
Catalog Number:
AG00GU65
Molecular Formula:
C9H12N6O5
Molecular Weight:
284.2288
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
98%
1 week
United States
$396
- +
10mg
98%
1 week
United States
$500
- +
50mg
98%
1 week
United States
$1264
- +
Product Description
Catalog Number:
AG00GU65
Chemical Name:
RO 9187
CAS Number:
876708-03-1
Molecular Formula:
C9H12N6O5
Molecular Weight:
284.2288
MDL Number:
MFCD22665689
IUPAC Name:
4-amino-1-[(2R,3S,4S,5R)-5-azido-3,4-dihydroxy-5-(hydroxymethyl)oxolan-2-yl]pyrimidin-2-one
InChI:
InChI=1S/C9H12N6O5/c10-4-1-2-15(8(19)12-4)7-5(17)6(18)9(3-16,20-7)13-14-11/h1-2,5-7,16-18H,3H2,(H2,10,12,19)/t5-,6-,7+,9+/m0/s1
InChI Key:
ODLGMSQBFONGNG-XZMZPDFPSA-N
SMILES:
[N-]=[N+]=NC1(CO)OC(C(C1O)O)n1ccc(nc1=O)N
Properties
Complexity:
529  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
4  
Defined Bond Stereocenter Count:
0
Exact Mass:
284.087g/mol
Formal Charge:
0
Heavy Atom Count:
20  
Hydrogen Bond Acceptor Count:
7  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
284.232g/mol
Monoisotopic Mass:
284.087g/mol
Rotatable Bond Count:
3  
Topological Polar Surface Area:
143A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
1  
XLogP3:
-1.8  
Literature
Title Journal
Defibrotide interferes with several steps of the coagulation-inflammation cycle and exhibits therapeutic potential to treat severe malaria. Arteriosclerosis, thrombosis, and vascular biology 20120301
The design, synthesis, and antiviral activity of monofluoro and difluoro analogues of 4'-azidocytidine against hepatitis C virus replication: the discovery of 4'-azido-2'-deoxy-2'-fluorocytidine and 4'-azido-2'-dideoxy-2',2'-difluorocytidine. Journal of medicinal chemistry 20090514
The design, synthesis, and antiviral activity of 4'-azidocytidine analogues against hepatitis C virus replication: the discovery of 4'-azidoarabinocytidine. Journal of medicinal chemistry 20090108
2'-deoxy-4'-azido nucleoside analogs are highly potent inhibitors of hepatitis C virus replication despite the lack of 2'-alpha-hydroxyl groups. The Journal of biological chemistry 20080125
Properties