MLN4924
| Title | Journal |
|---|---|
| Thalidomide promotes degradation of SALL4, a transcription factor implicated in Duane Radial Ray syndrome. | eLife 20180101 |
| Rictor Undergoes Glycogen Synthase Kinase 3 (GSK3)-dependent, FBXW7-mediated Ubiquitination and Proteasomal Degradation. | The Journal of biological chemistry 20150529 |
| The Nedd8-activating enzyme inhibitor MLN4924 thwarts microenvironment-driven NF-κB activation and induces apoptosis in chronic lymphocytic leukemia B cells. | Clinical cancer research : an official journal of the American Association for Cancer Research 20140315 |
| NEDD8 overexpression results in neddylation of ubiquitin substrates by the ubiquitin pathway. | Journal of molecular biology 20120803 |
| Initial testing of the investigational NEDD8-activating enzyme inhibitor MLN4924 by the pediatric preclinical testing program. | Pediatric blood & cancer 20120801 |
| The Nedd8-activating enzyme inhibitor MLN4924 induces autophagy and apoptosis to suppress liver cancer cell growth. | Cancer research 20120701 |
| Inhibition of NEDD8-conjugation pathway by novel molecules: potential approaches to anticancer therapy. | Molecular oncology 20120601 |
| A gatekeeper residue for NEDD8-activating enzyme inhibition by MLN4924. | Cell reports 20120419 |
| Treatment-emergent mutations in NAEβ confer resistance to the NEDD8-activating enzyme inhibitor MLN4924. | Cancer cell 20120320 |
| The ubiquitin E1 enzyme Ube1 mediates NEDD8 activation under diverse stress conditions. | Cell cycle (Georgetown, Tex.) 20120315 |
| Characterization of MRFAP1 turnover and interactions downstream of the NEDD8 pathway. | Molecular & cellular proteomics : MCP 20120301 |
| Inhibition of the Nedd8 system sensitizes cells to DNA interstrand cross-linking agents. | Molecular cancer research : MCR 20120301 |
| Radiosensitization of human pancreatic cancer cells by MLN4924, an investigational NEDD8-activating enzyme inhibitor. | Cancer research 20120101 |
| The p21-dependent radiosensitization of human breast cancer cells by MLN4924, an investigational inhibitor of NEDD8 activating enzyme. | PloS one 20120101 |
| The NEDD8-activating enzyme inhibitor, MLN4924, cooperates with TRAIL to augment apoptosis through facilitating c-FLIP degradation in head and neck cancer cells. | Molecular cancer therapeutics 20111201 |
| Quantitative proteomic analysis of cellular protein modulation upon inhibition of the NEDD8-activating enzyme by MLN4924. | Molecular & cellular proteomics : MCP 20111101 |
| Multimodal imaging with (18)F-FDG PET and Cerenkov luminescence imaging after MLN4924 treatment in a human lymphoma xenograft model. | Journal of nuclear medicine : official publication, Society of Nuclear Medicine 20111101 |
| Global identification of modular cullin-RING ligase substrates. | Cell 20111014 |
| MLN4924 is an efficient inhibitor of NEDD8 conjugation in plants. | Plant physiology 20110601 |
| Induction of p21-dependent senescence by an NAE inhibitor, MLN4924, as a mechanism of growth suppression. | Neoplasia (New York, N.Y.) 20110601 |
| Stereoselective synthesis of MLN4924, an inhibitor of NEDD8-activating enzyme. | The Journal of organic chemistry 20110506 |
| The steady-state repertoire of human SCF ubiquitin ligase complexes does not require ongoing Nedd8 conjugation. | Molecular & cellular proteomics : MCP 20110501 |
| Inhibition of NEDD8-activating enzyme induces rereplication and apoptosis in human tumor cells consistent with deregulating CDT1 turnover. | Cancer research 20110415 |
| A natural product-like inhibitor of NEDD8-activating enzyme. | Chemical communications (Cambridge, England) 20110307 |
| Inactivation of SAG E3 ubiquitin ligase blocks embryonic stem cell differentiation and sensitizes leukemia cells to retinoid acid. | PloS one 20110101 |
| NEDD8-targeting drug MLN4924 elicits DNA rereplication by stabilizing Cdt1 in S phase, triggering checkpoint activation, apoptosis, and senescence in cancer cells. | Cancer research 20101215 |
| Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. | Cell 20101210 |
| MLN4924, a NEDD8-activating enzyme inhibitor, is active in diffuse large B-cell lymphoma models: rationale for treatment of NF-{kappa}B-dependent lymphoma. | Blood 20100902 |
| Biochemical and cellular effects of inhibiting Nedd8 conjugation. | Biochemical and biophysical research communications 20100730 |
| Inhibition of NEDD8-activating enzyme: a novel approach for the treatment of acute myeloid leukemia. | Blood 20100506 |
| SUMO, Ubiquitin, UBL Proteins: Implications For Human Diseases - Fifth International Conference. | IDrugs : the investigational drugs journal 20100401 |
| Substrate-assisted inhibition of ubiquitin-like protein-activating enzymes: the NEDD8 E1 inhibitor MLN4924 forms a NEDD8-AMP mimetic in situ. | Molecular cell 20100115 |
| Targeting NEDD8-activated cullin-RING ligases for the treatment of cancer. | Clinical cancer research : an official journal of the American Association for Cancer Research 20090615 |
| An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer. | Nature 20090409 |