sales@angenesci.com
Login | Register
logo
Structures Search
Home Other Building Blocks Mk-0893

Mk-0893

CAS No.:
870823-12-4
Catalog Number:
AG00GU4C
Molecular Formula:
C32H27Cl2N3O4
Molecular Weight:
588.4805
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
99%
1 week
United States
$582
- +
10mg
99%
1 week
United States
$1007
- +
50mg
99%
1 week
United States
$2432
- +
Product Description
Catalog Number:
AG00GU4C
Chemical Name:
Mk-0893
CAS Number:
870823-12-4
Molecular Formula:
C32H27Cl2N3O4
Molecular Weight:
588.4805
MDL Number:
MFCD11616198
IUPAC Name:
3-[[4-[(1S)-1-[3-(3,5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)pyrazol-1-yl]ethyl]benzoyl]amino]propanoic acid
InChI:
InChI=1S/C32H27Cl2N3O4/c1-19(20-3-5-21(6-4-20)32(40)35-12-11-31(38)39)37-30(18-29(36-37)25-14-26(33)17-27(34)15-25)24-8-7-23-16-28(41-2)10-9-22(23)13-24/h3-10,13-19H,11-12H2,1-2H3,(H,35,40)(H,38,39)/t19-/m0/s1
InChI Key:
DNTVJEMGHBIUMW-IBGZPJMESA-N
SMILES:
COc1ccc2c(c1)ccc(c2)c1cc(nn1[C@H](c1ccc(cc1)C(=O)NCCC(=O)O)C)c1cc(Cl)cc(c1)Cl
UNII:
CCP2U6LWTP
Properties
Complexity:
877  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
1  
Defined Bond Stereocenter Count:
0
Exact Mass:
587.138g/mol
Formal Charge:
0
Heavy Atom Count:
41  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
588.485g/mol
Monoisotopic Mass:
587.138g/mol
Rotatable Bond Count:
9  
Topological Polar Surface Area:
93.4A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
6.8  
Literature
Title Journal
Extra-helical binding site of a glucagon receptor antagonist. Nature 20160512
Discovery of a novel glucagon receptor antagonist N-[(4-{(1S)-1-[3-(3, 5-dichlorophenyl)-5-(6-methoxynaphthalen-2-yl)-1H-pyrazol-1-yl]ethyl}phenyl)carbonyl]-β-alanine (MK-0893) for the treatment of type II diabetes. Journal of medicinal chemistry 20120712
A novel series of glucagon receptor antagonists with reduced molecular weight and lipophilicity. Bioorganic & medicinal chemistry letters 20120101
Properties