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Home Other Building Blocks 2',3'-DIDEOXY-3'-FLUORO-GUANOSINE

2',3'-DIDEOXY-3'-FLUORO-GUANOSINE

CAS No.:
92562-88-4
Catalog Number:
AG00GTMD
Molecular Formula:
C10H12FN5O3
Molecular Weight:
269.2324
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Product Description
Catalog Number:
AG00GTMD
Chemical Name:
2',3'-DIDEOXY-3'-FLUORO-GUANOSINE
CAS Number:
92562-88-4
Molecular Formula:
C10H12FN5O3
Molecular Weight:
269.2324
MDL Number:
MFCD00882020
IUPAC Name:
2-amino-9-[(2R,4S,5R)-4-fluoro-5-(hydroxymethyl)oxolan-2-yl]-1H-purin-6-one
InChI:
InChI=1S/C10H12FN5O3/c11-4-1-6(19-5(4)2-17)16-3-13-7-8(16)14-10(12)15-9(7)18/h3-6,17H,1-2H2,(H3,12,14,15,18)/t4-,5+,6+/m0/s1
InChI Key:
RTJUXLYUUDBAJN-KVQBGUIXSA-N
SMILES:
OC[C@H]1O[C@H](C[C@@H]1F)n1cnc2c1nc(N)[nH]c2=O
UNII:
UU109JJU0U
Properties
Complexity:
420  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
3  
Defined Bond Stereocenter Count:
0
Exact Mass:
269.092g/mol
Formal Charge:
0
Heavy Atom Count:
19  
Hydrogen Bond Acceptor Count:
6  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
269.236g/mol
Monoisotopic Mass:
269.092g/mol
Rotatable Bond Count:
2  
Topological Polar Surface Area:
115A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
-0.9  
Literature
Title Journal
Profound antiviral effect of oral administration of MIV-210 on chronic hepadnaviral infection in a woodchuck model of hepatitis B. Antimicrobial agents and chemotherapy 20090901
In vitro characterization of the anti-hepatitis B virus activity and cross-resistance profile of 2',3'-dideoxy-3'-fluoroguanosine. Antimicrobial agents and chemotherapy 20060301
In vitro activity of structurally diverse nucleoside analogs against human immunodeficiency virus type 1 with the K65R mutation in reverse transcriptase. Antimicrobial agents and chemotherapy 20050301
Ribavirin and mycophenolic acid potentiate the activity of guanine- and diaminopurine-based nucleoside analogues against hepatitis B virus. Antiviral research 20001101
Inhibition of duck hepatitis B virus replication by 2',3'-dideoxy-3'-fluoroguanosine in vitro and in vivo. Antimicrobial agents and chemotherapy 19960301
Enhanced in vitro inhibition of HIV-1 replication by 3'-fluoro-3'-deoxythymidine compared to several other nucleoside analogs. AIDS research and human retroviruses 19881201
Potent and selective activity of 3'-azido-2,6-diaminopurine-2',3'-dideoxyriboside, 3'-fluoro-2,6-diaminopurine-2',3'-dideoxyriboside, and 3'-fluoro-2',3'-dideoxyguanosine against human immunodeficiency virus. Molecular pharmacology 19880301
Properties