Home Other Building Blocks HA-1004 DIHYDROCHLORIDE

HA-1004 DIHYDROCHLORIDE

CAS No.:
92564-34-6
Catalog Number:
AG00GRT0
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00GRT0
Chemical Name:
HA-1004 DIHYDROCHLORIDE
CAS Number:
92564-34-6
MDL Number:
MFCD00069285
IUPAC Name:
2-[2-(isoquinolin-5-ylsulfonylamino)ethyl]guanidine;hydrochloride
InChI:
InChI=1S/C12H15N5O2S.ClH/c13-12(14)16-6-7-17-20(18,19)11-3-1-2-9-8-15-5-4-10(9)11;/h1-5,8,17H,6-7H2,(H4,13,14,16);1H
InChI Key:
GUGJQAFPKZZOIV-UHFFFAOYSA-N
Properties
Complexity:
441  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
329.071g/mol
Formal Charge:
0
Heavy Atom Count:
21  
Hydrogen Bond Acceptor Count:
5  
Hydrogen Bond Donor Count:
4  
Isotope Atom Count:
0
Molecular Weight:
329.803g/mol
Monoisotopic Mass:
329.071g/mol
Rotatable Bond Count:
5  
Topological Polar Surface Area:
132A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
Lidocaine-induced apoptosis of gingival fibroblasts: participation of cAMP and PKC activity. Cell biology international 20110801
Genetic mapping of targets mediating differential chemical phenotypes in Plasmodium falciparum. Nature chemical biology 20091001
Cross-talk between protein kinase A and mitogen-activated protein kinases signalling in the adaptive changes observed during morphine withdrawal in the heart. The Journal of pharmacology and experimental therapeutics 20090901
Osteocalcin attenuates T3- and increases vitamin D3-induced expression of MMP-13 in mouse osteoblasts. Endocrine journal 20090101
The PKs PKA and ERK 1/2 are involved in phosphorylation of TH at Serine 40 and 31 during morphine withdrawal in rat hearts. British journal of pharmacology 20080901
Differential involvement of 3', 5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos and tyrosine hydroxylase expression in the heart after naloxone induced morphine withdrawal. Naunyn-Schmiedeberg's archives of pharmacology 20070101
Thyroid hormone-induced morphological differentiation and maturation of astrocytes involves activation of protein kinase A and ERK signalling pathway. The European journal of neuroscience 20051001
Nur77 nuclear import and its NBRE-binding activity in thymic lymphoma cells are regulated by different mechanisms sensitive to FK506 or HA1004. Biochemical and biophysical research communications 20050909
Involvement of 3',5'-cyclic adenosine monophosphate-dependent protein kinase in regulation of Fos expression and tyrosine hydroxylase levels during morphine withdrawal in the hypothalamic paraventricular nucleus and medulla oblongata catecholaminergic cell groups. Journal of neurochemistry 20050101
Group II metabotropic glutamate receptor modulation of excitatory transmission in rat subthalamic nucleus. The Journal of physiology 20031201
Free fatty acids induce cell differentiation to infective forms in Trypanosoma cruzi. The Biochemical journal 20031101
Implication of the signal transduction pathways in the enhancement of noradrenaline turnover induced by morphine withdrawal in the heart. European journal of pharmacology 20030620
Inhibition of histamine H1 receptor downregulation by KT5823, a protein kinase G inhibitor. Methods and findings in experimental and clinical pharmacology 20030601
FK506 restores sensitivity of thymic lymphomas to calcium-mediated apoptosis and the inducible expression of Fas ligand. Anticancer research 20030101
Inhibition of protein kinase C but not protein kinase A attenuates morphine withdrawal excitation of rat hypothalamus-pituitary-adrenal axis. European journal of pharmacology 20020927
HA1004, an inhibitor of serine/threonine protein kinases, restores the sensitivity of thymic lymphomas to Ca2+-mediated apoptosis through a protein kinase A-independent mechanism. International immunopharmacology 20020301
The signalling pathway for BCG-induced interleukin-6 production in human bladder cancer cells. Biochemical pharmacology 20020115
cGMP-mediated facilitation in nerve terminals by enhancement of the spike afterhyperpolarization. Neuron 20010927
Oxidized low-density lipoprotein downregulates endothelial basic fibroblast growth factor through a pertussis toxin-sensitive G-protein pathway: mediator role of platelet-activating factor-like phospholipids. Circulation 20010731
Inhibition of oxotremorine-induced desensitization of guinea-pig ileal longitudinal muscle in Ca2+-free conditions. The Journal of pharmacy and pharmacology 20010201
Heparin selectively inhibits the transcription of tissue-type plasminogen activator in primate arterial smooth muscle cells during mitogenesis. The Journal of biological chemistry 19920215
Properties