Novel protocol for the chemical synthesis of crustacean hyperglycemic hormone analogues--an efficient experimental tool for studying their functions.

PloS one 20120101

In vivo antinociception of potent mu opioid agonist tetrapeptide analogues and comparison with a compact opioid agonist-neurokinin 1 receptor antagonist chimera.

Molecular brain 20120101

Asymmetric synthesis and conformational analysis by NMR spectroscopy and MD of Aba- and α-MeAba-containing dermorphin analogues.

ChemMedChem 20111104

Synthesis, biological evaluation, and automated docking of constrained analogues of the opioid peptide H-Dmt-D-Ala-Phe-Gly-NH₂ using the 4- or 5-methyl substituted 4-amino-1,2,4,5-tetrahydro-2-benzazepin-3-one scaffold.

Journal of medicinal chemistry 20111013

Tight binding of transition-state analogues to a peptidyl-aminoacyl-L/D-isomerase from frog skin.

Chembiochem : a European journal of chemical biology 20110905

The influence of the stereochemistry of alanine residue on the solid state conformation and crystal packing of opioid peptides containing D-Ala or L-Ala in message domain--XRD and NMR study.

The journal of physical chemistry. B 20110818

Desirability function combining metabolic stability and functionality of peptides.

Journal of peptide science : an official publication of the European Peptide Society 20110501

Emerging knowledge of regulatory roles of D-amino acids in bacteria.

Cellular and molecular life sciences : CMLS 20110301

Dermorphin tetrapeptide analogs as potent and long-lasting analgesics with pharmacological profiles distinct from morphine.

Peptides 20110201

Involvement of mouse μ-opioid receptor splice variants in the spinal antinociception induced by the dermorphin tetrapeptide analog amidino-TAPA.

European journal of pharmacology 20110125

Ligand-directed functional selectivity at the mu opioid receptor revealed by label-free integrative pharmacology on-target.

PloS one 20110101

Analytical characterization and comparison of the blood-brain barrier permeability of eight opioid peptides.

Peptides 20100701

Opioid receptor internalization contributes to dermorphin-mediated antinociception.

Neuroscience 20100630

AntiBP2: improved version of antibacterial peptide prediction.

BMC bioinformatics 20100101

Discovery of dermorphin-based affinity labels with subnanomolar affinity for mu opioid receptors.

Journal of medicinal chemistry 20091210

Evaluation of side effects through selective ablation of the mu opioid receptor expressing descending nociceptive facilitatory neurons in the rostral ventromedial medulla with dermorphin-saporin.

Neurotoxicology 20091101

Synthesis and receptor binding of opioid peptide analogues containing beta3-homo-amino acids.

Journal of peptide science : an official publication of the European Peptide Society 20091101

Partial ablation of mu-opioid receptor rich striosomes produces deficits on a motor-skill learning task.

Neuroscience 20090929

Purification and functional reconstitution of monomeric mu-opioid receptors: allosteric modulation of agonist binding by Gi2.

The Journal of biological chemistry 20090925

Protective effect of dermorphin analogue sedatin on indomethacin-induced injury to the gastric mucosa.

Bulletin of experimental biology and medicine 20090701

D-amino acid detection in peptides by MALDI-TOF-TOF.

Analytical chemistry 20090601

[Significance of opioid receptors in regulation of cardiac tolerance in pathogenic impact of long-term ischemia-reperfusion in vivo].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20090601

Neuropathic pain is maintained by brainstem neurons co-expressing opioid and cholecystokinin receptors.

Brain : a journal of neurology 20090301

Conformation-activity relationships of cyclo-constrained mu/delta opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin.

Advances in experimental medicine and biology 20090101

Conformation-activity relationships of cyclo-constrained micro/delta opioid agonists derived from the N-terminal tetrapeptide segment of dermorphin/deltorphin.

Journal of peptide science : an official publication of the European Peptide Society 20080801

Amygdala intercalated neurons are required for expression of fear extinction.

Nature 20080731

Blood-brain barrier penetration by two dermorphin tetrapeptide analogues: role of lipophilicity vs structural flexibility.

Journal of medicinal chemistry 20080424

The use of tritium-labeled dermorphin for studying the interactions of C-terminal dermorphin fragment Tyr-Pro-Ser-NH2 and its stereoisomer Tyr-D-Pro-Ser-NH2 with opioid receptors.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20080101

Multiple ligands in opioid research.

Protein and peptide letters 20080101

Methylnaltrexone in the treatment of opioid-induced constipation.

Clinical and experimental gastroenterology 20080101

Effect of synthetic dermorphin analogues on tissue homeostasis in the myocardium of newborn albino rats.

Bulletin of experimental biology and medicine 20071001

Effect of sedatin (synthetic dermorphin analog) on the development of Acipenser schrenckii young fish.

Bulletin of experimental biology and medicine 20071001

Mechanisms for the effect of arginine-containing dermorphin analogue on proliferative processes in the gastric mucosa of albino rats.

Bulletin of experimental biology and medicine 20070901

Ureido group containing cyclic dermorphin(1-7) analogues: synthesis, biology and conformation.

Journal of peptide science : an official publication of the European Peptide Society 20070801

Receptor binding properties and antinociceptive effects of chimeric peptides consisting of a micro-opioid receptor agonist and an ORL1 receptor antagonist.

Biological & pharmaceutical bulletin 20070701

Supranodose vagotomy eliminates respiratory depression evoked by dermorphin in anaesthetized rats.

European journal of pharmacology 20070601

Involvement of endogenous opioid peptides in the antinociception induced by the novel dermorphin tetrapeptide analog amidino-TAPA.

European journal of pharmacology 20070410

Novel glycosylated [Lys(7)]-dermorphin analogues: synthesis, biological activity and conformational investigations.

Journal of peptide science : an official publication of the European Peptide Society 20070301

[Comparative analysis of analgesic activities of dermorphin, [DPro6]-dermorphin, and their C-terminal tripeptides].

Izvestiia Akademii nauk. Seriia biologicheskaia 20070101

[Synthesis, pharmacokinetics, and metabolism of the C-terminal tripeptide of dermorphin and its diastereomer].

Bioorganicheskaia khimiia 20070101

Dependence of the analgesic activities of dermorphin, metenkephalin, and dynorphin A on the ambient temperature.

Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections 20070101

[The relationship between the structure of dermorphines and their thermoregulatory activity].

Izvestiia Akademii nauk. Seriia biologicheskaia 20070101

Effects of the intravenous administration of [Lys7]dermorphin on local cerebral glucose utilization in the rat.

European journal of pharmacology 20060821

Descending facilitation from the rostral ventromedial medulla maintains nerve injury-induced central sensitization.

Neuroscience 20060721

Involvement of spinal mu1-opioid receptors on the Tyr-d-Arg-Phe-sarcosine-induced antinociception.

European journal of pharmacology 20060701

Targeted drug delivery crossing cytoplasmic membranes of intended cells via ligand-grafted sterically stabilized liposomes.

Journal of controlled release : official journal of the Controlled Release Society 20060221

Cyclic dermorphin tetrapeptide analogues obtained via ring-closing metathesis.

Acta biochimica Polonica 20060101

Conversion of the potent delta-opioid agonist H-Dmt-Tic-NH-CH(2)-bid into delta-opioid antagonists by N(1)-benzimidazole alkylation(1).

Journal of medicinal chemistry 20051229

Synthesis and biological evaluation of constrained analogues of the opioid peptide H-Tyr-D-Ala-Phe-Gly-NH2 using the 4-amino-2-benzazepin-3-one scaffold.

The journal of peptide research : official journal of the American Peptide Society 20051101

Inhibitory control of the acute mu-withdrawal response by indirectly activated adenosine A1 and kappa-opioid systems in the Guinea-pig ileum; reversal by cholecystokinin.

Neurotoxicology 20051001

Distinguishing and quantifying peptides and proteins containing D-amino acids by tandem mass spectrometry.

Analytical chemistry 20050715

Cyclic enkephalin and dermorphin analogues containing a carbonyl bridge.

Journal of peptide science : an official publication of the European Peptide Society 20050601

Abbreviated nomenclature for cyclic and branched homo- and hetero-detic peptides.

The journal of peptide research : official journal of the American Peptide Society 20050601

6-Hydroxy-1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid mimics active conformation of tyrosine in opioid peptides.

Bioorganic & medicinal chemistry letters 20050516

New tris-alkoxycarbonyl arginine derivatives for peptide synthesis.

Journal of peptide science : an official publication of the European Peptide Society 20050101

Synthesis of dermorphin-(1-4) derivatives catalyzed by proteases in organic solvents.

The journal of peptide research : official journal of the American Peptide Society 20050101

[Study of thermoregulatory activity of a fragment of natural dermorphin precursor Arg-dermorphin and its analogs].

Izvestiia Akademii nauk. Seriia biologicheskaia 20050101

[Analgesic activity of dermorphin and its proline analogs].

Eksperimental'naia i klinicheskaia farmakologiia 20050101

[Comparative study of the physical dependence on proline analog of dermorphin and morphine].

Eksperimental'naia i klinicheskaia farmakologiia 20050101

[Comparative study of the antiarrhythmic activity of mu- and delta-opioid receptor agonists during acute cardiac ischemia and reperfusion models in rats].

Eksperimental'naia i klinicheskaia farmakologiia 20050101

Tolerance develops in spinal cord, but not in brain with chronic [Dmt1]DALDA treatment.

British journal of pharmacology 20041201

Blood-brain barrier permeability of novel [D-arg2]dermorphin (1-4) analogs: transport property is related to the slow onset of antinociceptive activity in the central nervous system.

The Journal of pharmacology and experimental therapeutics 20040701

[Thermoregulatory activity of dermorphin fragments].

Izvestiia Akademii nauk. Seriia biologicheskaia 20040101

Human brain cathepsin H as a neuropeptide and bradykinin metabolizing enzyme.

Peptides 20031201

Synthesis, conformation and biological activity of dermorphin and deltorphin I analogues containing N-alkylglycine in place of residues in position 1, 3, 5 and 6.

Journal of peptide science : an official publication of the European Peptide Society 20031001

Potent side-chain to side-chain cyclized dermorphin analogues containing a carbonyl bridge.

Journal of peptide science : an official publication of the European Peptide Society 20031001

Enhanced evoked excitatory transmitter release in experimental neuropathy requires descending facilitation.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20030910

Opioid peptides: synthesis and biological properties of [(N gamma-glucosyl,N gamma-methoxy)-alpha, gamma-diamino-(S)-butanoyl]4-deltorphin-1-neoglycopeptide and related analogues.

Organic & biomolecular chemistry 20030907

Expression of EGFP-amino-tagged human mu opioid receptor in Drosophila Schneider 2 cells: a potential expression system for large-scale production of G-protein coupled receptors.

Protein expression and purification 20030901

Endogenous opioid peptides contribute to antinociceptive potency of intrathecal [Dmt1]DALDA.

The Journal of pharmacology and experimental therapeutics 20030501

Dermorphin tetrapeptide analogues with 2',6'-dimethylphenylalanine (Dmp) substituted for aromatic amino acids have high mu opioid receptor binding and biological activities.

Bioorganic & medicinal chemistry letters 20030407

In vitro and in vivo opioid activity of [DPro(6)]dermorphin, a new dermorphin analogue.

Peptides 20030301

Dermorphin-based potential affinity labels for mu-opioid receptors.

The journal of peptide research : official journal of the American Peptide Society 20030101

Vas deferens response to selective opioid receptor agonists in adult mice is impaired following postnatal repeated mild stress.

European journal of pharmacology 20030101

Dmt and opioid peptides: a potent alliance.

Biopolymers 20030101

Enhanced spontaneous activity of the mu opioid receptor by cysteine mutations: characterization of a tool for inverse agonist screening.

BMC pharmacology 20030101

Potent delta-opioid receptor agonists containing the Dmt-Tic pharmacophore.

Journal of medicinal chemistry 20021205

The mu-selective heptapeptide opioid dermorphin has two conformations around Phe3 psi with no head-to-tail interaction. A quantitative 2-D NMR and molecular modeling analysis.

Journal of biomolecular structure & dynamics 20021201

Efferent projections from the striatal patch compartment: anterograde degeneration after selective ablation of neurons expressing mu-opioid receptor in rats.

Neuroscience letters 20021025

Urinary peptides in Rett syndrome.

Autism : the international journal of research and practice 20020901

Lack of involvement of mu(1) opioid receptors in dermorphin-induced inhibition of hypoxic and hypercapnic ventilation in rat pups.

Respiratory physiology & neurobiology 20020801

mu-Opioid receptors: Ligand-dependent activation of potassium conductance, desensitization, and internalization.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020701

Time-dependent descending facilitation from the rostral ventromedial medulla maintains, but does not initiate, neuropathic pain.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20020615

mu-1 opioid receptor stimulation decreases body temperature in conscious, unrestrained neonatal rats.

Experimental biology and medicine (Maywood, N.J.) 20020601

Long time dynamics of Met-enkephalin: comparison of explicit and implicit solvent models.

Biophysical journal 20020401

Dermorphin and deltorphin heptapeptide analogues: replacement of Phe residue by Dmp greatly improves opioid receptor affinity and selectivity.

Bioorganic & medicinal chemistry letters 20020325

Evaluation of the Dmt-Tic pharmacophore: conversion of a potent delta-opioid receptor antagonist into a potent delta agonist and ligands with mixed properties.

Journal of medicinal chemistry 20020131

[Dmt(1)]DALDA is highly selective and potent at mu opioid receptors, but is not cross-tolerant with systemic morphine.

Current medicinal chemistry 20020101

[Dermorphins--a natural opioids with unique primary structure that determines their biological specificity].

Izvestiia Akademii nauk. Seriia biologicheskaia 20020101

[Effect of dermorphin analogs on thermoregulation of rats under various thermal conditions].

Izvestiia Akademii nauk. Seriia biologicheskaia 20020101

[Effect of structural changes of Pro6 in dermorphin molecule on its antinociceptive activity].

Izvestiia Akademii nauk. Seriia biologicheskaia 20020101

[Dependence of neuropeptide physiological effects on a route of administration].

Rossiiskii fiziologicheskii zhurnal imeni I.M. Sechenova 20011101

Fetal alveolar epithelial cells contain [D-Ala(2)]-deltorphin I-like immunoreactivity: delta- and mu-opiate receptors mediate opposite effects in developing lung.

American journal of respiratory cell and molecular biology 20011001

[2',6'-Dimethyltyrosine]dynorphin A(1-11)-NH2 analogues lacking an N-terminal amino group: potent and selective kappa opioid antagonists.

Journal of medicinal chemistry 20010913

Modulation of breathing by mu1 and mu2 opioid receptor stimulation in neonatal and adult rats.

Respiration physiology 20010901

HS-599: a novel long acting opioid analgesic does not induce place-preference in rats.

British journal of pharmacology 20010901

Inhibition of neuropathic pain by selective ablation of brainstem medullary cells expressing the mu-opioid receptor.

The Journal of neuroscience : the official journal of the Society for Neuroscience 20010715

Pharmacological characterization of the dermorphin analog [Dmt(1)]DALDA, a highly potent and selective mu-opioid peptide.

European journal of pharmacology 20010504

Activity of mu- and delta-opioid agonists in vas deferens from mice deficient in MOR gene.

British journal of pharmacology 20010401

Receptor binding and biological activity of the dermorphin analog Tyr-D-Arg(2)-Phe-Sar (TAPS).

European journal of pharmacology 20010323

Effects of opiate receptor ligands on DNA synthesis in tracheal epitheliocytes and smooth muscle cells of newborn albino rats.

Bulletin of experimental biology and medicine 20010201

The delta-selective opioid peptide dermenkephalin and the mu-selective hybrid peptide dermenkephalin-[1-4]-dermophin-[5-7] display strikingly different conformations despite identical tetrapeptide N-termini. A quantitative 2-D NMR and molecular modeling analysis.

Journal of biomolecular structure & dynamics 19991201

A new opioid peptide predicted from cloned cDNAs from skin of Pachymedusa dacnicolor and Agalychnis annae.

FEBS letters 19980605

Opioid peptides from frog skin.

EXS 19980101

Tachykinins and other biologically active peptides from the skin of the Costa Rican phyllomedusid frog Agalychnis callidryas.

Peptides 19970101

Synthesis and opioid activity of tyrosine sulfate containing dermorphin and deltorphin peptides.

Arzneimittel-Forschung 19950201

Comparative conformational analyses of mu-selective dermorphin and delta-selective deltorphin-II in aqueous solution by 1H-NMR spectroscopy.

International journal of peptide and protein research 19940901

Opioid activity of dermenkephalin analogues in the guinea-pig myenteric plexus and the hamster vas deferens.

British journal of pharmacology 19911001

Identification of a D-alanine-containing polypeptide precursor for the peptide opioid, dermorphin.

The Journal of biological chemistry 19910405

Different profile of electrocortical power spectrum changes after micro-infusion into the locus coeruleus of selective agonists at various opioid receptor subtypes in rats.

British journal of pharmacology 19901101

Characterisation and visualisation of [3H]dermorphin binding to mu opioid receptors in the rat brain. Combined high selectivity and affinity in a natural peptide agonist for the morphine (mu) receptor.

European journal of biochemistry 19900520

Molecular determinants of receptor affinity and selectivity of the natural delta-opioid agonist, dermenkephalin.

The Journal of biological chemistry 19891015

Differential contribution of C-terminal regions of dermorphin and dermenkephalin to opioid-sites selection and binding potency.

Biochemical and biophysical research communications 19890915

Dermenkephalin (Tyr-D-Met-Phe-His-Leu-Met-Asp-NH2): a potent and fully specific agonist for the delta opioid receptor.

Molecular pharmacology 19890601

Conformational properties of deltorphin: new features of the delta-opioid receptor.

FEBS letters 19890424

Opioid peptides. Biological study of [D-MetO2] dermorphin analogues in relation to the plurality of opioid receptors. XI.

Il Farmaco; edizione scientifica 19870201

Synthesis and opioid activity of dermorphin tetrapeptides bearing D-methionine S-oxide at position 2.

Journal of medicinal chemistry 19860601

Opioid peptides. Structure-activity relationships in [OGly4] dermorphin tetrapeptides. X.

Il Farmaco; edizione scientifica 19860201

Opioid peptides. VIII. Synthesis and preliminary biological activity of [D-Phe3]- or [alpha,beta-dehydro-Phe3]dermorphin tetrapeptides.

Il Farmaco; edizione scientifica 19850601

A comparison of the antinociceptive and behavioral effects of D-Arg substituted dipeptides and tetrapeptides in mice.

Peptides 19850101

Structure-activity relationships of dermorphin tetrapeptides carrying a ketomethylene linkage.

Arzneimittel-Forschung 19850101

Comparison of the antinociceptive effect between D-Arg containing dipeptides and tetrapeptides in mice.

Neuropeptides 19840601

D-Arg2-dermorphin tetrapeptide analogs: a potent and long-lasting analgesic activity after subcutaneous administration.

Biochemical and biophysical research communications 19840416

Stimulatory effect of dermorphin, a new synthetic potent opiate-like peptide, on human growth hormone secretion.

Neuroendocrinology 19831001

Opioid peptides. Structure-activity relationships in [beta-Ala4]dermorphin tetrapeptides. V.

Il Farmaco; edizione scientifica 19830901

Synthesis and pharmacological activity of dermorphin and its N-terminal sequences.

International journal of peptide and protein research 19820501

Synthesis of dermorphins, a new class of opiate-like peptides.

International journal of peptide and protein research 19810201