Home Other Building Blocks DESETHYLOXYBUTYNIN, HYDROCHLORIDE

DESETHYLOXYBUTYNIN, HYDROCHLORIDE

CAS No.:
81039-77-2
Catalog Number:
AG00G4SE
Molecular Formula:
Molecular Weight:
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Product Description
Catalog Number:
AG00G4SE
Chemical Name:
DESETHYLOXYBUTYNIN, HYDROCHLORIDE
CAS Number:
81039-77-2
MDL Number:
MFCD02682895
IUPAC Name:
4-(ethylamino)but-2-ynyl 2-cyclohexyl-2-hydroxy-2-phenylacetate;hydrochloride
InChI:
InChI=1S/C20H27NO3.ClH/c1-2-21-15-9-10-16-24-19(22)20(23,17-11-5-3-6-12-17)18-13-7-4-8-14-18;/h3,5-6,11-12,18,21,23H,2,4,7-8,13-16H2,1H3;1H
InChI Key:
DSWCYTSHCYXHGW-UHFFFAOYSA-N
Properties
Complexity:
452  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
2  
Defined Atom Stereocenter Count:
0
Defined Bond Stereocenter Count:
0
Exact Mass:
365.176g/mol
Formal Charge:
0
Heavy Atom Count:
25  
Hydrogen Bond Acceptor Count:
4  
Hydrogen Bond Donor Count:
3  
Isotope Atom Count:
0
Molecular Weight:
365.898g/mol
Monoisotopic Mass:
365.176g/mol
Rotatable Bond Count:
7  
Topological Polar Surface Area:
58.6A^2
Undefined Atom Stereocenter Count:
1  
Undefined Bond Stereocenter Count:
0
Literature
Title Journal
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The preparation and human muscarinic receptor profiling of oxybutynin and N-desethyloxybutynin enantiomers. Medicinal chemistry (Shariqah (United Arab Emirates)) 20071101
Binding activities by propiverine and its N-oxide metabolites of L-type calcium channel antagonist receptors in the rat bladder and brain. Life sciences 20070606
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Stereoselective pharmacokinetics of oxybutynin and N-desethyloxybutynin in vitro and in vivo. Xenobiotica; the fate of foreign compounds in biological systems 20070101
Transdermal oxybutynin in the treatment of overactive bladder. Clinical interventions in aging 20060601
Advantages for transdermal over oral oxybutynin to treat overactive bladder: Muscarinic receptor binding, plasma drug concentration, and salivary secretion. The Journal of pharmacology and experimental therapeutics 20060301
Muscarinic receptor binding, plasma concentration and inhibition of salivation after oral administration of a novel antimuscarinic agent, solifenacin succinate in mice. British journal of pharmacology 20050501
In vivo demonstration of muscarinic receptor binding activity of N-desethyl-oxybutynin, active metabolite of oxybutynin. Life sciences 20050408
[Effect of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl) glycolate, metabolite of oxybutynin, on intra-artery administered acetylcholine-induced urinary bladder contraction in anesthetized dogs]. Nihon yakurigaku zasshi. Folia pharmacologica Japonica 20040501
Effects of 4-ethylamino-2-butynyl(2-cyclohexyl-2-phenyl)glycolate hydrochloride, a metabolite of oxybutynin, on bladder specimens and rhythmic bladder contraction in rats in comparison with oxybutynin. Journal of pharmacological sciences 20040201
Oxybutynin extended-release: a review of its use in the management of overactive bladder. Drugs 20040101
Pharmacokinetics, metabolism, and saliva output during transdermal and extended-release oral oxybutynin administration in healthy subjects. Mayo Clinic proceedings 20030601
Sensitive determination of oxybutynin and desethyloxybutynin in dog plasma by LC-ESI/MS/MS. Journal of pharmaceutical and biomedical analysis 20030226
Transdermal oxybutynin: for overactive bladder. Drugs & aging 20030101
Transdermal oxybutynin. A viewpoint by Michael Chancellor. Drugs & aging 20030101
Transdermal oxybutynin. A viewpoint by Adrian Wagg. Drugs & aging 20030101
Binding study of desethyloxybutynin using high-performance frontal analysis method. Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 20020225
Pharmacokinetics, efficacy, and safety of intravesical formulation of oxybutynin in patients with detrusor overactivity. Scandinavian journal of urology and nephrology 20020201
Intravesical oxybutynin: mode of action assessed by passive diffusion and electromotive administration with pharmacokinetics of oxybutynin and N-desethyl oxybutynin. The Journal of urology 20011201
Pharmacokinetics of the R- and S-enantiomers of oxybutynin and N-desethyloxybutynin following oral and transdermal administration of the racemate in healthy volunteers. Pharmaceutical research 20010701
Properties