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Solithromycin

CAS No.:
760981-83-7
Catalog Number:
AG00G3RL
Molecular Formula:
C43H65FN6O10
Molecular Weight:
845.0088
Pack Size
Purity
Availability
Location
Price(USD)
Quantity
  
5mg
≥98%
1 week
United States
$94
- +
10mg
≥98%
1 week
United States
$125
- +
25mg
≥98%
1 week
United States
$189
- +
Product Description
Catalog Number:
AG00G3RL
Chemical Name:
Solithromycin
CAS Number:
760981-83-7
Molecular Formula:
C43H65FN6O10
Molecular Weight:
845.0088
MDL Number:
MFCD28411434
IUPAC Name:
(1S,2R,5S,7R,8R,9R,11R,13R,14R)-15-[4-[4-(3-aminophenyl)triazol-1-yl]butyl]-8-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-5-fluoro-9-methoxy-1,5,7,9,11,13-hexamethyl-3,17-dioxa-15-azabicyclo[12.3.0]heptadecane-4,6,12,16-tetrone
InChI:
InChI=1S/C43H65FN6O10/c1-12-32-43(8)35(50(40(55)60-43)19-14-13-18-49-23-30(46-47-49)28-16-15-17-29(45)21-28)26(4)33(51)24(2)22-41(6,56-11)37(27(5)36(53)42(7,44)39(54)58-32)59-38-34(52)31(48(9)10)20-25(3)57-38/h15-17,21,23-27,31-32,34-35,37-38,52H,12-14,18-20,22,45H2,1-11H3/t24-,25-,26+,27+,31+,32-,34-,35-,37-,38+,41-,42+,43-/m1/s1
InChI Key:
IXXFZUPTQVDPPK-ZAWHAJPISA-N
SMILES:
CC[C@H]1OC(=O)[C@@](C)(F)C(=O)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C[C@H](C(=O)[C@@H]([C@@H]2[C@]1(C)OC(=O)N2CCCCn1nnc(c1)c1cccc(c1)N)C)C)(C)OC
UNII:
9U1ETH79CK
Properties
Complexity:
1530  
Compound Is Canonicalized:
Yes
Covalently-Bonded Unit Count:
1  
Defined Atom Stereocenter Count:
13  
Defined Bond Stereocenter Count:
0
Exact Mass:
844.475g/mol
Formal Charge:
0
Heavy Atom Count:
60  
Hydrogen Bond Acceptor Count:
15  
Hydrogen Bond Donor Count:
2  
Isotope Atom Count:
0
Molecular Weight:
845.023g/mol
Monoisotopic Mass:
844.475g/mol
Rotatable Bond Count:
11  
Topological Polar Surface Area:
198A^2
Undefined Atom Stereocenter Count:
0
Undefined Bond Stereocenter Count:
0
XLogP3:
4.3  
Literature
Title Journal
Managing community acquired pneumonia in the elderly - the next generation of pharmacotherapy on the horizon. Expert opinion on pharmacotherapy 20170801
Antimicrobial characterisation of solithromycin (CEM-101), a novel fluoroketolide: activity against staphylococci and enterococci. International journal of antimicrobial agents 20110101
The in vitro evaluation of solithromycin (CEM-101) against pathogens isolated in the United States and Europe (2009). The Journal of infection 20101201
Binding and action of CEM-101, a new fluoroketolide antibiotic that inhibits protein synthesis. Antimicrobial agents and chemotherapy 20101201
Antimicrobial characterisation of CEM-101 activity against respiratory tract pathogens, including multidrug-resistant pneumococcal serogroup 19A isolates. International journal of antimicrobial agents 20100601
CEM-101, a novel fluoroketolide: antimicrobial activity against a diverse collection of Gram-positive and Gram-negative bacteria. Diagnostic microbiology and infectious disease 20100401
In vitro activity of CEM-101 against Streptococcus pneumoniae and Streptococcus pyogenes with defined macrolide resistance mechanisms. Antimicrobial agents and chemotherapy 20100101
Clinical efficacy of ketolides in the treatment of respiratory tract infections. The Journal of antimicrobial chemotherapy 20040601
Replacement therapy in patients with hereditary antithrombin III deficiency. Seminars in hematology 19910101
Properties