1-[4-(3,4-dichlorophenyl)-3-fluorophenyl]cyclopropane-1-carboxylic acid
| Title | Journal |
|---|---|
| CHF5074 reduces biomarkers of neuroinflammation in patients with mild cognitive impairment: a 12-week, double-blind, placebo-controlled study. | Current Alzheimer research 20130901 |
| Therapeutic effect of CHF5074, a new γ-secretase modulator, in a mouse model of scrapie. | Prion 20120101 |
| Discovery of 4-aminomethylphenylacetic acids as γ-secretase modulators via a scaffold design approach. | Bioorganic & medicinal chemistry letters 20111215 |
| The γ-secretase modulator CHF5074 reduces the accumulation of native hyperphosphorylated tau in a transgenic mouse model of Alzheimer's disease. | Journal of molecular neuroscience : MN 20110901 |
| Inhibition of amyloidogenesis by nonsteroidal anti-inflammatory drugs and their hybrid nitrates. | Journal of medicinal chemistry 20110414 |
| The γ-secretase modulator CHF5074 restores memory and hippocampal synaptic plasticity in plaque-free Tg2576 mice. | Journal of Alzheimer's disease : JAD 20110101 |
| CHF5074, a novel gamma-secretase modulator, restores hippocampal neurogenesis potential and reverses contextual memory deficit in a transgenic mouse model of Alzheimer's disease. | Journal of Alzheimer's disease : JAD 20100101 |
| Secretase-independent and RhoGTPase/PAK/ERK-dependent regulation of cytoskeleton dynamics in astrocytes by NSAIDs and derivatives. | Journal of Alzheimer's disease : JAD 20100101 |
| CHF5074, a novel gamma-secretase modulator, attenuates brain beta-amyloid pathology and learning deficit in a mouse model of Alzheimer's disease. | British journal of pharmacology 20090301 |
| 1-(3',4'-Dichloro-2-fluoro[1,1'-biphenyl]-4-yl)-cyclopropanecarboxylic acid (CHF5074), a novel gamma-secretase modulator, reduces brain beta-amyloid pathology in a transgenic mouse model of Alzheimer's disease without causing peripheral toxicity. | The Journal of pharmacology and experimental therapeutics 20071201 |
| In vitro and in vivo profiling of CHF5022 and CHF5074 Two beta-amyloid1-42 lowering agents. | Pharmacological research 20070401 |
| Synthesis and biological activity of flurbiprofen analogues as selective inhibitors of beta-amyloid(1)(-)(42) secretion. | Journal of medicinal chemistry 20050908 |